Physiological and biochemical parameters among a population of bakers exposed to environmental heat.

OBJECTIVES: The aim of this study was to determine the physiological and biochemical changes among bakers, induced by heat exposure at the workplace. MATERIAL AND METHODS: Information was collected by means of a self-administered questionnaire. Vital signs were measured and recorded by a trained nurse before and after each work shift. A venous blood sample was drawn at the end of each work shift. The mean wet-bulb globe temperature (WBGT) index in the bakeries and offices was measured. RESULTS: This was a cross-sectional study involving 137 bakers working in 20 bakeries, and 107 control subjects comparable in terms of age, race, marital status, years of service, income, and cigarette smoking. There was a significant weight loss and increase in the respiratory rate, the heart rate, and oral body temperature among the bakers compared to the control group. Sodium levels were significantly lower, while blood urea nitrogen levels were significantly higher, among the bakers than in the control group. There were unfavorably hot working conditions in the bakeries: the WBGT index in the bakeries was 37.4°C while the average WBGT for the offices was 25.5°C. CONCLUSIONS: The changes in the physiological and biochemical parameters among the bakers were found to be associated with exposure to high environmental heat in the bakeries, as judged by the WBGT index. Preventive measures should be aimed at reducing the adverse effects of heat exposure among bakers and should be directed towards the man-machine-environment triad. Int J Occup Med Environ Health. 2022;35(3):265-72.

Temporal trends in the incidence and demographics of cancers, communicable diseases, and non-communicable diseases in Saudi Arabia over the last decade.

OBJECTIVES: To describe the trends in the incidence rates of 5 most common cancers, communicable diseases, and non-communicable diseases in Saudi Arabia over the last decade.  Methods: The incidence rates of cancers (2001-2014), communicable diseases (2003-2016), and non-communicable diseases (1990-2017) were retrieved, classified, and analyzed retrospectively during November 2017, based on data available with the Ministry of Health and were analyzed at the Imam Abdulrahman Bin Faisal University in Dammam, Kingdom of Saudi Arabia. Results: Age-standardized incidence rate (ASR) (per 100,000 population) of breast cancer among women increased dramatically from 11.8 in 2001 to 22.7 in 2014, indicating a 92.4% increase over the decade. Colorectal cancer incidence was the highest among men, and its ASR per 100,000 population increased from 5.0 to 10.6 in men and from 5.0 to 8.2 in women. Among communicable diseases, incidences of hepatitis B, measles, chickenpox, and brucellosis decreased while dengue fever increased. An alarming increase was observed in the incidence rate of non-communicable diseases namely, obesity, diabetes, and hypertension. Conclusion: The incidence rate of non-communicable diseases increased over the decade and was associated with increased mortality and disability, reduced quality of life, and increased health-care costs, indicating an urgent need to establish prevention and control programs. The rising trend in the incidence of cancers may also become a health care issue in Saudi Arabia in the coming years.

Low Back Pain among Workers in a Paint Factory.

BACKGROUND: Back pain is common among factory workers and is responsible for about 25% of workers' compensation cases. However, data on back pain among workers from paint industry in Saudi Arabia are limited. OBJECTIVES: The objective of this study is to estimate the prevalence of low back pain and to evaluate the associated risk factors among workers of a paint factory. MATERIALS AND METHODS: This cross-sectional study used a self-administered questionnaire to elicit data regarding demography, job characteristics and prevalence of low back pain in the past 12 months among workers of a paint factory (n = 102) in the Eastern Province of Saudi Arabia. In addition, a scale of low back pain risk was generated for each department by occupational health professionals using interviews and observations. RESULTS: The annual prevalence of low back pain was 44.1%, and it was more common among Saudi workers (67.9%) compared with non-Saudi workers (35.1%). Multivariate analysis indicated significant associations between low back pain and nationality (relative risk [RR] = 1.93; 95% confidence interval [CI] = 1.29-2.88), smoking (RR = 1.85; 95% CI = 1.20-2.83) and aerobic exercise (RR = 2.37; 95% CI = 1.19-4.71). Spearman rank correlation showed correlation between the symptom pain scale and smoking (r s = 0.259; P = 0.008), and exercise was associated with lower pain scale scores (r s = -0.241, P = 0.015). CONCLUSION: This study found that low back pain is common among paint factory workers in the Eastern Province of Saudi Arabia. Nationality and smoking are risk factors for low back pain and are associated with each other. Many workers did not exercise, and lack of exercise was associated with an increased risk of low back pain. Reducing smoking and increasing exercise in addition to workplace ergonomic intervention may reduce this frequently occurring problem.

Neonatal maternal deprivation impairs localized de novo activity-induced protein translation at the synapse in the rat hippocampus.

Neonatal neuropsychiatric stress induces alterations in neurodevelopment that can lead to irreversible damage to neuronal physiology, and social, behavioral, and cognitive skills. In addition, this culminates to an elevated vulnerability to stress and anxiety later in life. Developmental deficits in hippocampal synaptic function and plasticity are among the primary contributors of detrimental alterations in brain function induced by early-life stress. However, the underlying molecular mechanisms are not completely understood. Localized protein translation, occurring at the synapse and triggered by neuronal activity, is critical for synapse function, maintenance, and plasticity. We used a rodent model of chronic maternal deprivation to characterize the effects of early-life neuropsychiatric stress on localized de novo protein translation at synaptic connections between neurons. Synaptoneurosomal preparations isolated biochemically from the hippocampi of rat pups that were subjected to maternal deprivation were deficient in depolarization-induced activity-dependent protein translation when compared with littermate controls. Conversely, basal unstimulated protein translation was not affected. Moreover, deficits in activity-driven synaptic protein translation were significantly correlated with a reduction in phosphorylated cell survival protein kinase protein B or Akt (p473 Ser and p308 Thr), but not phosphorylated extracellular signal-regulated kinase.

Male infertility among bakers associated with exposure to high environmental temperature at the workplace.

OBJECTIVE: This study aimed to evaluate the prevalence of male infertility among bakers exposed to high environmental temperature. METHODS: This cross-sectional study was conducted to obtain information using a validated questionnaire administered through an interview. The mean wet bulb globe temperature (WBGT) index in the bakeries was measured. A new statistical formula was used to estimate the prevalence of infertility among bakers. RESULTS: A total of 137 bakers working in 20 bakeries and 107 individuals included in the comparable control group with variations in age, race, marital status, and income and with history of cigarette smoking were recruited. Using a newly devised formula, the prevalence of infertility among the exposed group was 22.7%, compared with 3.0% in the control group (p = 0.013). All possible confounding factors associated with infertility among bakers were excluded such as cigarette smoking, age, and race. There were unfavorable hot working conditions in bakeries, with a WBGT index of 37.4 °C, while the average WBGT for offices was 25.5 °C (p < 0.0001). CONCLUSION: Our study showed that the rate of infertility among bakers was high, which resulted from exposure to high environmental temperature at the workplace as evidenced by the WBGT index. This finding should alert the healthcare authorities to take necessary measures under the labor code to curtail infertility among bakers.

Evaluation of disability of occupational illness claims for workers' compensation.

Occupational physicians are faced with the challenge of estimating the contribution of occupational and non-occupational risk factors to a particular work-related illness for workers' compensation. This paper proposes guidelines for occupational physicians to evaluate claims for presentation to a compensation board. Occupational bladder cancer was taken as an example. Relevant literature was obtained and reviewed. A worksheet was designed to record pertinent information on occupational illness. The procedure for handling a claim is described. Failure to follow such an approach may lead to gross inequities.