Mechanisms, screening modalities and treatment options for individuals with non-alcoholic fatty liver disease and type 2 diabetes.

Non-alcoholic fatty liver disease (NAFLD) exists as a spectrum of disease ranging from excessive accumulation of fat within the liver (simple steatosis), inflammation (non-alcoholic steatohepatitis) through to fibrosis, cirrhosis and end-stage liver disease. There is also an increased risk of hepatocellular carcinoma. The principal risk factor for NAFLD is overweight or obesity, along with type 2 diabetes, and NAFLD itself is also a risk factor for incident type 2 diabetes. Overweight/obesity is synergistic with alcohol consumption in causing progressive and insidious liver damage. Recent consensus advocates a change in nomenclature from NAFLD to 'metabolic associated fatty liver disease' (MAFLD), reflective of the associated metabolic abnormalities (insulin resistance/type 2 diabetes and metabolic syndrome components). Additional extra-hepatic manifestations of NAFLD include cardiovascular disease, chronic kidney disease and certain cancers. Unlike other micro- and macrovascular complications of type 2 diabetes, systematic screening or surveillance protocols have not been widely adopted in routine diabetes care to assess for presence/severity of NAFLD. Various screening tools are available (non-invasive tests and biochemical indices) combined with imaging techniques (e.g. transient elastography) to detect steatosis and more importantly advanced fibrosis/cirrhosis to facilitate appropriate surveillance. Liver biopsy may be sometimes necessary. Treatment options for type 2 diabetes, including lifestyle interventions (dietary change and physical activity), glucose-lowering therapies and metabolic surgery, can modulate hepatic steatosis and to a lesser extent fibrosis. Awareness of the impact of liver disease on the choice of glucose-lowering medications in individuals with type 2 diabetes is also critical.

Latent autoimmune diabetes of adulthood (LADA) is associated with small fibre neuropathy.

AIM: To assess if latent autoimmune diabetes of adulthood (LADA) is associated with small fibre neuropathy. METHODS: Participants with LADA (n=31), Type 2 diabetes (n=31) and healthy control participants without diabetes (n=31) underwent a detailed assessment of neurologic deficits, quantitative sensory testing, electrophysiology, skin biopsy and corneal confocal microscopy. RESULTS: The groups were matched for age (healthy control without diabetes: 53.5±9.1 vs. Type 2 diabetes: 58.0±6.5 vs. LADA: 53.2±11.6 years), duration of diabetes (Type 2 diabetes: 10.0±8.3 vs. LADA: 11.0±9.1 years) and blood pressure. However, BMI (P=0.01) and triglycerides (P=0.0008) were lower and HbA1c (P=0.0005), total cholesterol (P=0.01) and HDL (P=0.002) were higher in participants with LADA compared with Type 2 diabetes. Peroneal motor nerve conduction velocity (P=0.04) and sural sensory nerve conduction velocity (P=0.008) were lower in participants with latent autoimmune diabetes in adults compared with Type 2 diabetes. Intra-epidermal nerve fibre density (P=0.008), corneal nerve fibre density (P=0.003) and corneal nerve branch density (P=0.006) were significantly lower in participants with LADA compared with Type 2 diabetes. There were no significant differences in the other neuropathy parameters. CONCLUSIONS: Despite comparable age and duration of diabetes, participants with LADA demonstrate more severe neuropathy and particularly small fibre neuropathy, compared with participants with Type 2 diabetes.

Survey of palliative care concepts among medical students in India.

BACKGROUND: Students must develop a "tension for change" before new material is learned. Therefore, a needs assessment generally precedes curriculum change in order to identify what the target population thinks they already know about a subject. Undergraduate medical education in India is a 4(1/2) -year course. This is followed by a 1-year internship before the new physician can practice independently. AIM: To assess the level of awareness in palliative care concepts among final-year students at Kasturba Medical College, Manipal, India. MATERIALS AND METHODS: One hundred eleven final-year students participated in a survey study 6 months before graduation. The data were collected after the survey and the responses were analyzed. RESULTS: The reported theoretical knowledge of palliative care concepts was better than the level of confidence in performing practical aspects of palliative care. CONCLUSION: Before this survey, we hypothesized that medical students in India would have low levels of self-reported understanding of palliative care and its components. In contrast, they reported a high level of understanding of palliative care but very little understanding and confidence in performing the associated skills. From this, we conclude that these medical students are ready for instruction in the practical skills of palliative care.

Survey of palliative care concepts among medical interns in India.

BACKGROUND: Medical knowledge, if theoretical, will fade away if not reinforced especially if not clinically implemented. We conducted a survey study amongst interns to assess awareness and confidence of common palliative care issues. Undergraduate medical education in India is a 4(1/2) -year course. This is followed by a 1-year internship before the new physician can practice independently. AIM: To compare the level of awareness in palliative care concepts among interns to that of final-year medical students at Kasturba Medical College, Manipal, India. MATERIALS AND METHODS: Forty-four interns participated in a survey study. The data were collected after the survey and the responses were analyzed. We compared these data with those obtained from conducting the same survey among medical students. RESULTS: The reported theoretical knowledge of palliative care concepts was better than the level of confidence in performing practical aspects of palliative care. The interns, overall, did not out-perform the students. CONCLUSION: Before this survey, we hypothesized that interns in India would have low levels of self-reported understanding of palliative care and its components. We were hoping to see an improvement in knowledge and confidence with training. In contrast, there was not much of an improvement but rather a decline in some areas. From this, we conclude that when medical students become interns, they need reinforcement of knowledge and more hands-on experience.