Assuntos
Tumor Carcinoide/diagnóstico por imagem , Fluordesoxiglucose F18 , Neoplasias Pulmonares/diagnóstico por imagem , Nódulos Pulmonares Múltiplos/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Compostos Radiofarmacêuticos , Tumor Carcinoide/metabolismo , Tumor Carcinoide/patologia , Fluordesoxiglucose F18/farmacocinética , Humanos , Neoplasias Pulmonares/metabolismo , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Nódulos Pulmonares Múltiplos/metabolismo , Nódulos Pulmonares Múltiplos/patologia , Compostos Radiofarmacêuticos/farmacocinéticaAssuntos
Adenocarcinoma de Pulmão/diagnóstico por imagem , Adenocarcinoma de Pulmão/radioterapia , Fluordesoxiglucose F18 , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/radioterapia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Compostos Radiofarmacêuticos , Humanos , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Resultado do TratamentoAssuntos
Neoplasias Ósseas/diagnóstico por imagem , Radioisótopos de Carbono , Colina , Hiperparatireoidismo Secundário/complicações , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Neoplasias da Próstata/diagnóstico por imagem , Compostos Radiofarmacêuticos , Idoso , Neoplasias Ósseas/metabolismo , Colina/farmacocinética , Clavícula/diagnóstico por imagem , Clavícula/metabolismo , Humanos , Falência Renal Crônica/diagnóstico por imagem , Falência Renal Crônica/metabolismo , Masculino , Neoplasias da Próstata/metabolismo , Compostos Radiofarmacêuticos/farmacocinética , Tíbia/diagnóstico por imagem , Tíbia/metabolismoRESUMO
AIM: To compare bone scan (BS) with (11)C-Choline PET/CT for the detection of bone metastases in patients with biochemical recurrence of prostate cancer (PC). MATERIAL AND METHODS: A total of 169 patients with biochemical recurrence of PC(PSA:2.4-58 ng/ml) who were referred for both exams (0-15 days-in-between) were included. Lesion-detection-rate per patients and lesions were analyzed for both BS and (11)C-Choline PET/CT. Metastasis diagnosis was reached by: biopsy, CT/(18)F-Fluoride PET/MRI confirmation, or evidence of progression in subsequent imaging procedures. RESULTS: A total of 91 lesions were found to be active in BS and/or (11)C-choline PET/CT (40 patients), with 78 of which were metastatic. BS detected 38 blastic, 2 lytic and 10 non-CT-evident lesions. (11)C-Choline PET/CT detected 41 blastic, 4 lytic and 29 non-CT-evident lesions. BS and (11)C-Choline PET/CT sensitivities were 65.4% and 96.1%; specificities ere 38.5 and 92.3% (χ(2) 8.27, p<0.04). Both imaging techniques were negative in 118 patients. Tracer avid lesions were found in 51 patients: with 30/51 being BS and (11)C-Choline PET/CT concordant; in 21/51 patients had discordant lesions (kappa 0.712, p=0.00). Lesions were absolutely discordant in 10/19 patients,: 5 FN BS, 2 FP BS (degenerative changes; dysplasia), 1 FN (11)C-Choline PET/CT (blastic), 1 FP (11)C-Choline PET/CT (degenerative), 1 out of field-of-view lesion with (11)C-Choline PET/CT (tibia alone). (11)C-Choline PET/CT showed extraosseous involvement in 26/51 patients with bone metastases: 9 local recurrences, 5 infra-diaphragmatic-lymph-nodes, 2 supra-diaphragmatic, 5 local and infra-diaphragmatic, 4 infra- and supra-diaphragmatic, 1 supra-diaphragmatic and lung metastases. CONCLUSION: (11)C-Choline PET/CT yielded better sensitivity and specificity than BS for the detection of bone involvement in patients with biochemical recurrence of PC and allowed extraosseous restaging, with an impact in the clinical management of these patients.
Assuntos
Adenocarcinoma/secundário , Neoplasias Ósseas/secundário , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Neoplasias da Próstata/sangue , Adenocarcinoma/diagnóstico por imagem , Idoso , Neoplasias Ósseas/diagnóstico por imagem , Radioisótopos de Carbono , Colina , Reações Falso-Negativas , Reações Falso-Positivas , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias da Próstata/terapia , Compostos Radiofarmacêuticos , Sensibilidade e Especificidade , Medronato de Tecnécio Tc 99m/análogos & derivadosAssuntos
Neoplasias Brônquicas/diagnóstico , Carcinoma Pulmonar de Células não Pequenas/diagnóstico , Fluordesoxiglucose F18 , Neoplasias Pulmonares/diagnóstico , Imagem Multimodal , Tomografia por Emissão de Pósitrons , Compostos Radiofarmacêuticos , Tomografia Computadorizada por Raios X , Idoso , Humanos , Achados Incidentais , MasculinoAssuntos
Tecido Adiposo/diagnóstico por imagem , Radioisótopos de Flúor , Fluordesoxiglucose F18 , Septos Cardíacos/diagnóstico por imagem , Imagem Multimodal , Tomografia por Emissão de Pósitrons , Compostos Radiofarmacêuticos , Tomografia Computadorizada por Raios X , Tecido Adiposo/patologia , Carcinoma/diagnóstico por imagem , Carcinoma/tratamento farmacológico , Carcinoma/radioterapia , Diagnóstico Diferencial , Neoplasias Esofágicas/diagnóstico por imagem , Neoplasias Esofágicas/tratamento farmacológico , Neoplasias Esofágicas/radioterapia , Feminino , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/patologia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/secundário , Septos Cardíacos/patologia , Humanos , Hipertrofia , Pessoa de Meia-IdadeRESUMO
AIM: To determine the impact of an additional inspiration CT scan on the conventional ¹8F-FDG PET-CT protocol in the detection of small pulmonary nodules. METHOD: One hundred consecutive patients who presented with one or various nodules were studied. Whole-body PET-CT was performed using Gemini (Philips). CT acquisition parameters were 120 kV/25 mAs, the same as those for the transmission/fusion CT (mild expiration) and inspiratory CT. RESULTS: A total of 188 nodules were detected in the inspiratory CT with sizes between 0.3-3 cm. Non-inspiratory CT did not show 20/188 nodules (10.6%) with sizes between 0.3-1cm, this corresponding to 17 patients. The most frequent localization of non-detectable nodules in non-inspiratory CT was the lower lobes. ¹8F-FDG uptake was detected by the PET in 83.9% and 72% of nodules with > 1 cm and between 0.7 and 1cm, respectively. However, only 10.5% of nodules <0.7 cm showed increased metabolic activity. CONCLUSION: In selected patients, inspiratory CT added to conventional PET-CT significantly improves the detection of small nodules (10.6%), especially in those lesions located in the lower lobes, due to respiratory movements, and may have an impact on patient management.
Assuntos
Radioisótopos de Flúor , Fluordesoxiglucose F18 , Neoplasias Pulmonares/diagnóstico por imagem , Compostos Radiofarmacêuticos , Tomografia Computadorizada por Raios X/métodos , Adulto , Idoso , Artefatos , Carcinoma/diagnóstico por imagem , Carcinoma/secundário , Reações Falso-Negativas , Feminino , Humanos , Inalação , Neoplasias Pulmonares/secundário , Masculino , Pessoa de Meia-Idade , Movimento , Estudos Prospectivos , Cintilografia , Sensibilidade e Especificidade , Nódulo Pulmonar Solitário/diagnóstico por imagemAssuntos
Doenças do Ducto Colédoco/diagnóstico , Cistos/diagnóstico , Compostos de Organotecnécio , Criança , Pré-Escolar , Colangiografia , Feminino , Humanos , Iminoácidos , Lactente , Masculino , Pessoa de Meia-Idade , Compostos Organometálicos , Tomografia Computadorizada por Raios X , UltrassonografiaRESUMO
The pregnancy specific beta-1-glycoprotein (SP1) was measured by radioimmunoassay in 854 persons (control group 103, non-tumoral diseases 212, germinal tumors 30, and non-germinal tumors 509). Amounts higher than 2.5 ng/ml (upper normal limit) were observed in 35 cases with non tumoral diseases (specially chronic liver diseases), 97 of the non-germinal tumors (specially mammary, respiratory and digestive tumors), and 10 of the germinal tumors (pure and mixed choriocarcinomas, and embryonic carcinoma with yolk sac component). SP1 rarely is higher than 5 ng/ml in non-tumoral diseases and non-germinal tumors, while it is higher than 5 ng/ml in germinal tumors. SP1 is a good marker for trophoblastic neoplasms and shows a correlation with HCG-beta.
Assuntos
Proteínas de Neoplasias/sangue , Proteínas da Gravidez/sangue , Glicoproteínas beta 1 Específicas da Gravidez/sangue , Neoplasias Trofoblásticas/sangue , Neoplasias Uterinas/sangue , Fatores Etários , Doença/sangue , Feminino , Humanos , Neoplasias/sangue , Gravidez , Neoplasias Trofoblásticas/diagnósticoRESUMO
Creatine kinase B (CK-B) was evaluated as a tumor marker by radioimmunoassay determination of the isoenzyme in 518 persons (control group, malignant tumors, and several other diseases). Amounts higher than 8 ng/ml (upper normal limit) was observed in 12.6 per 100 of the digestive tumors, 6.1 per 100 of the mammary tumors, 37.7 per 100 of the respiratory tumors, and 22.2 per 100 of the prostatic tumors. A relation exists between CK-B and sigmoid flexure, liver, pancreas and esophagus tumors, between CK-B and acid phosphatase in prostate tumors, and between CK-B and evolution of digestive tumor. The determination of CK-B is useful in the case of tumors lacking known tumor markers, and also as a complementary sign in the diagnosis and evolution of sigmoid flexure and prostate neoplasms.
Assuntos
Creatina Quinase/sangue , Proteínas de Neoplasias/sangue , Neoplasias/enzimologia , Adolescente , Adulto , Ensaios Enzimáticos Clínicos , Feminino , Humanos , Isoenzimas , Masculino , Pessoa de Meia-Idade , Neoplasias/diagnósticoRESUMO
A study ia mde of 15 patients with a known neoplasia: 2 retroperitoneal tumours, 5 lymphomas, 3 prostate neoplasias, 3 seminomas and 2 uterus neoplasias; with displacement of the ureter and in some cases ectasia of the excretion system. The displacement was always one-sided and most frequently found in the lower third of the ureter. Ectasia was found in two patients; we have never found this in any patients without a known neoplasia. Adenopathies were the most frequent cause of inferior ureter deviation but in only one case did they infiltrate into the wall and they were more constant on the right side. These cases are compared with other patients suffering from different pathologies, some of which are also neoplastic but in which no displacement or ectasia appeared even when the retroperitoneum was affected, and with another group of patients in whom there was found to be ureteral displacement or ectasia without any retro- or intraperitoneal pathology.
Assuntos
Doenças Ureterais/etiologia , Neoplasias Urogenitais/complicações , Feminino , Humanos , Masculino , Radiografia , Doenças Ureterais/diagnóstico por imagemRESUMO
The authors present a case of myeloproliferative syndrome with an exceptional clinical picture of pain in the right hypochondrium and right iliac fossa, with no mictional syndrome or hematuria, caused by the appearance of a spontaneous subcapsular hematoma. They discuss the frequency of the different kinds of kidney hematomas and their causes. They also describe the typical radiological signs of the subcapsular hematoma in comparison with the other forms of kidney hematomas.