[Historic review of minimally invasive surgery in Romania--a new surgical era]. / Scurt istoric al chirurgiei miniminvazive in România--o noua era chirurgicala.

The minimally-invasive surgery developed during the last decades, having an important place within the operating techniques of many surgical specialities once high-performing instruments and devices were created. It is represented by laparoscopic, thoracoscopic, arthroscopic and endoscopic techniques (diagnostical and therapeutical). The introduction and development of such techniques at the global level allowed for them to be introduced in our country in a rather short period of time after their usage abroad. This article consists of a brief description of the minimally-invasive surgery both at the global and national level.

[Cancer of the head of pancreas--resection vs. palliative surgery]. / Cancerul de cap de pancreas--rezectie vs. paleatie.

Pancreatic cancer remains a disease with high mortality. The unspecific symptoms for a long time make the diagnostic difficult. Between 1995-2004, only 85 from 465 patients with this diagnosis, had pancreatic resection. To them, we performed Whipple pancreaticoduodenectomy (60), pylorus preserving pancreaticoduodenectomy (15), pancreatico-duodenectomy with preserving of duodenum (2), pancreaticoduodenectomy with associated resections (5), subtotal pancreatico-duodenectomy (30). The reconstruction after pancreatic resection was pancreatico-jejuno anastomosis (26) and pancreatico-gastro-anastomosis (59). Morbidity was about 34% and the mortality was about 9%.

[Therapeutic options in gallstone ileus]. / Optiuni terapeutice în ileusul biliar.

Gallstone ileus is a rare, serious condition, requiring emergency surgery, specific to elderly age. The present study deals with 16 cases operated in 25 years period, with median age about 64 years old. The patients had clinical evidence of intestinal obstruction, confirmed by radiological examination and ultrasonography. Emergency operations were performed. In 7 cases had been treated radically both the obstruction (entero-lithotomy) and the bilio-digestive fistula (cholecystectomy, duodenal closure, enteral closure, colon-suture) with good results (only one death). In 9 cases, it had been treated only the intestinal obstruction, with only 2 cases of persistent cholangitis. Generally, we have used biliary drainage with Kehr tube in the presence of biliary stones and cholangitis. The biliodigestive fistula may close in evolution or become a harmless secondary route for internal biliary drainage.

[Therapeutic approach in locally advanced and complicated rectosigmoid and genital cancers]. / Atitudinea terapeutica în cancerele rectosigmoidiene si genitale local avansate si complicate.

Locally advanced and complicated rectosigmoidian and genital cancers raise many therapeutic problems for surgeons. The most frequently used therapeutic methods nowadays are: radiotherapy, chemotherapy, surgical procedures, immunotherapy and other modern methods that aren't in the current clinical use yet. In a trial of 456 patients with locally advanced and complicated rectosigmoidian cancers and 632 patients with genital cancers we performed 573 (52.6%) radical surgical procedures and 515 (47.4%) palliative procedures, 301 (27.6%) of these being permanent colostomy (257 terminal and 44 in continuity). All of the patients received radiotherapy or chemotherapy pre and/or after surgery. The survival was between 5-7 months in the trial of patients with permanent colostomy, between 12-36 months in the trial of patients with palliative surgical procedures and adjuvant treatment and between 5-17 years in the trial of patients with radical surgical procedures and neo- and adjuvant therapy.

[The rectal cancer--between resection and amputation. Surgeon's decalogue]. / Cancerul rectal--între rezectie si amputatie. Decalogul chirurgului.

The surgeon has the opportunity to use a lot of treatment choices taking into account the site, the progression and the aggressiveness of the rectal tumors. If the treatment of anal cancer have been the same over the last years there are a few problems regarding the rectal cancer, especially for the one, which is distal and locally advanced. The therapeutic choice must take into account the following factors: the site of the tumor, the circumferential invasion, the local and distant spread, the complications and loco-regional recurrences, the anatomical shape of the pelvis, the possibility of developing tumor implants on the residual rectum, the equipment of the hospital, the experience of the surgical team, the accuracy of stoma technique, and the previous results in patients survival. In a trial of 381 patients with recto-sigmoidian and anal cancers we performed 171 rectal amputations, 29 Hartmann procedures and 76 laparotomies and colostomies. From the 276 patients with colostomy 172 (62.31%) were followed. The survival rate was: 6-10 months for the patients with laparotomy and colostomy, 16-24 months for those with palliative procedures (55.8%) and 5-17 years for those with radical procedures. From the point of view of the authors the rectal amputation with colostomy it is an alternative between oncological safety and patients comfort. This kind of surgical procedure must be done in specialized centers excepting the emergencies.

[One case of multiple abdominal hydatidosis]. / Un caz de chist hidatic abdominal cu localizari multiple.

It is presented the case of a 45 years old female patient transferred in our clinic from Parasitology Clinic with the diagnosis of hepato-splenic hydatidosis. Preoperative echography presented 3 abdominal hydatid cysts (hepatic, splenic and free in the peritoneal cavity--greater omentum). Intraoperative exam confirmed the preoperative evaluation. The operation consisted in two ideal cystectomies associated with one partial cystectomy with evacuation and drainage. Postoperative evolution was simple.

Characterization of renal parenchymal perfusion during experimental infrarenal aortic clamping and declamping with enhanced thermodiffusion electrodes.

Despite multiple previous experimental and clinical investigations, it has not been fully clarified until now whether infrarenal aortic cross-clamping (IRAC) induces a significant disturbance of renal parenchymal perfusion. Most renal cortical flow data collected thus far have been heterogenous because of inherent limitations of available measurement technology. The enhanced thermal diffusion (TD) electrode is a newly developed and previously validated prototype device that allows continuous quantification of parenchymal kidney perfusion after local probe implantation. We monitored renal perfusion during experimental IRAC with TD for the first time, thereby also evaluating the potential applicability of the method in clinical aortic surgery. IRAC (20 min) followed by sudden declamping was performed in pigs under general anesthesia (n = 14). Renal cortical blood flow (RCBF) was continuously quantified by TD, total aortic flow (TABF) and renal artery flow (RABF) were measured by ultrasonic flow probes, and parameters of systemic circulation were determined by Swan-Ganz catheter. Our results showed that kidney perfusion can be continuously quantified using TD electrodes during experimental aortic surgery in a porcine model. IRAC does not lead to a significant impairment of RCBF in young pigs as measured by TD. Renal perfusion appears to be predominantly pressure driven. Consequently, abrubt aortic declamping can bring about prolonged renal ischemia. Transfer of the TD method to RCBF monitoring during clinical aortic surgery appears to be feasible and should be investigated in selected cases.

[Late results after the Mark Belsey IV antireflux procedure in achalasia]. / Rezultate tardive dupa procedeul Mark Belsey IV în achalazie.

Cardial achalasia (cardiospasm, megaesophagus) represents the failure or lack of relaxation capacity of the inferior esophageal sphincter; it is the second esophageal disease and is considered a premalignant lesion. Treatment of achalasia is surgical but palliative, considering the lack of an etiopathogenic therapy for this moment. We present a retrospective study done on 19 patients (10 males and 9 females, with a mean age of 49 years) operated in "Colentina" Surgical Clinic in the period of 1996-1999 for achalasia (presenting symptoms-dysphagia, regurgitation, weight loss) by extramucosal esocardiomyotomy practiced on a length of 5-10 cm, by thoracic approach, followed by the Mark Belsey IV antireflux procedure. Results were good, without reflux pathology or dysphagia in the postoperative evolution.

[Pancreatic insulinomas]. / Insulinoamele pancreatice.

In the period of 1980-1999 (20 years) were operated 18 patients (8 males and 10 females) in "Colentina" Surgical Clinic, the average age being of 45 years, with hystopathologically confirmed insulinomas. The topography of these lesions was in the head of the pancreas (4), in the isthmus (5), in the body and tail (9). The classical clinical and biochemical signs were presented in 13 cases, the rest of the patients presenting atypical signs of disease. These patients had benefit from the surgical treatment. The approach was bi-subcostal in 11 cases and by upper and lower midline incision in the rest of cases. We practiced enucleation in 5 cases, corporeal-caudal pancreatico-splenectomy in 10 cases and cephalic pancreatico-duodenectomy in 3 cases. The malignancy of the tumour was hystopathologically confirmed in 30% of the situations. The postoperative mortality was in 3 cases, by acute pancreatitis, MSOF and myocardial infarction. We consider that in case of these generally benign tumours the most efficient therapy is the surgical one.

[Surgical procedures in penis cancer]. / Optiuni terapeutice în cancerele peniene.

In the period of 1980-1999 (20 years) in Colentina Surgical Clinic were admitted and operated 16 patients with the diagnosis of pennial cancer (histopathology--squamocellular carcinoma), 13 of whom being from Colentina Dermatological Clinic. The mean age was about 64 years old, 10 cases presenting phimosis. Surgical procedures undergone were represented by partial pennial amputation with bilateral superficial inguinal lymphadenectomy (10 cases), total pennial amputation with superficial inguinal lymphadenectomy (4 cases), respectively emasculation with bilateral inguinal-iliopelvic lymphadenectomy (2 cases). In the postoperative period 3 patients presented lymphedema and lymphorrhagia, solved by conservative management. All the patients benefited of favorable evolution on the period they have responded to the controlled postoperative follow up (1-3 years).

[Therapeutical options in pancreatic pseudocysts]. / Optiuni terapeutice în pseudochistele pancreatice.

This paper presents the "N.Gh.Lupu" surgical clinic's experience, that consists in 65 cases of pancreatic pseudocysts operated in the last 10 years (1989-1998), 30 females and 35 males, with a mean age of 52 years old. The diagnosis was mainly based on the classical echography and CT-scanner, the clinical picture being non specific in the majority of cases. Although the predominant use of the nonsurgical interventional procedures is recommended, this presents the maiden attempts of the authors in this field, the surgical techniques used being as it follows: cephalic pancreaticoduodenectomy, distal pancreatectomy, cystodigestive anastomosis, external drainage. The perioperative mortality was null, the postoperative one consisting in 3 cases (2 cases in the early period and 1 case in the later period).

[Surgical treatment of pelvic subperitoneal tumors]. / Tratamentul chirurgical al tumorilor pelvisubperitoneale.

In the last 5 years in our hospital was operated 25 patients with pelvisubperitoneal tumors. Major clinical symptoms are compression and body mass effect. The localization and tumors dimensions, are established by CT and RMI. Surgical resection, difficult by the relations with iliac vessels and nerves, was do it in sub capsular manners and followed by chemo and radiotherapy. Our results are good, with 6 patients who passed 4 years postoperatively.

[Klatskin unresectable tumour. Palliative treatment or no surgical operation?]. / Tumora Klatskin nerezecabila. Interventie paleativa sau neinterventie?

The Klatskin tumor is a neoplasy of the proximate main biliary duet whose initial manifestation, and most of the time, the single one, consist in the appliance of an obstructive nature jaundice. This usually coincides with the spreading of the tumor beyond the walls of the tumors that have reached this state with a usually intraoperating made diagnosis, certain palliative technical surgery solutions could still exist. The author submits to your attention a retrospective survey on 85 tumors out of which only 3 were removable. For the remaining 82 he performed only exploratory laparotomy. Of these biopsy was made for 11 cases and palliative surgery for the other 71 (biliodigestive derivations on one or both liver lobes, or Huguet, Terblanche or Kehr tube surgery prosthesis operations). If the patient's living conditions are very good, his survival chances might be extended from 2 to 18 months, with no appearance of jaundice or pruritus. There is no doubt that if the pre-operations imagery testing results in the diagnosis "inoperable medical condition", the retrograde endoscopic transtumoral surgery prosthesis operation or the transparietal liver one, is recommended.

[The remaining indications for open surgery in common bile duct lithiasis]. / Indicatii reziduale ale chirurgiei deschise în litiaza caii biliare principale.

Once with the continuous development of mini-invasive procedures, the open surgery indications in the treatment of CBD stones are decreasing. Between January 1986 and December 1987, 514 patients with average age 60 years old (18-94) were treated for suspected or confirmed CBDS. Three distinctive periods were studied function of how the conventional surgery were either exclusive (group I), either together with the beginning era of laparoscopy (group II), or together with institutionalised laparoscopy (group III). Group I had 110 cases, group II--207 cases and group III--197 cases. The conventional surgery were 100% performed in group I, 26% (52 cases) performed in group II, 14% (28 cases) performed in group III. If the laparotomy was the only therapeutical option in patients with CBDS from group I, the therapeutical procedures become more various after 1990. It was done endoscopic sphincterotomy in 59% (124 cases) in group II and in 64% (126 cases) in group III. The laparoscopic extraction of CBDS was 12% (cases) in group II and 19% (37 cases) in group III. The overall mortality in conventional surgery was 1.5% with 1.8% in group I and 0% in group II and III. The complications rate was 13% with 8% in group II and 21% in group III. The postoperative hospitalisation time average was 16 days for laparotomy of the 3 groups. The conventional surgery is main indicated when laparoscopic surgery for CBDS extractions or endoscopic sphincterotomy is contraindicated or failed; also it is useful in some complicated forms of CBDS.

[Disorders of hepatic microcirculation as early manifestation of rejection in clinical liver transplantation]. / Störung der hepatischen Mikrozirkulation als Frühmanifestation der Rejektion bei klinischer Lebertransplantation.

By means of thermodiffusion, monitoring of hepatic microcirculation was performed in 43 patients during the first week after liver transplantation. A significant decrease of liver perfusion was registered in 15 patients with early rejection. The disturbance of hepatic microcirculation preceded the increase of transaminases by 36 hours and the subsequent biopsy by 60 hours. Already 12 hours after the beginning of corticoid therapy liver perfusion started to recover. The quantification of hepatic microcirculation may facilitate faster diagnosis and treatment of early rejection following liver transplantation.