[Combined application of magnetolaserotherapy and polyunsaturated fatty acids for the treatment of patients with hypertensive disease].

The authors report the results of combined treatment including application of magnetolaserotherapy and n-3 polyunsaturated fatty acids for the management of patients presenting with hypertensive disease. These data give evidence of the accumulation of atherogenic fractions of plasma lipids and pathological modification of the fatty acid composition in erythrocyte membranes. They suggest the appropriateness of lipid-correcting and membrane-protective treatment for patients presenting with hypertensive disease. It is concluded that the proposed combination of magnetolaserotherapy and polyunsaturated fatty acids may be instrumental in the normalization of the serum lipid profile and the correction of the cellular fatty acid composition.

[Role of tumor necrosis factor in the development of metabolic syndrome].

AIM: to study a relationship of the proinflammatory cytokine - alpha-tumor necrosis factor (alpha-TNF) to the values of carbohydrate and lipid metabolisms, lipid peroxidation, and hemorheology in patients with components of the metabolic syndrome (MS). SUBJECTS AND METHODS: Eighty-seven patients (35 males and 52 females) aged 21 to 69 years were examined. Groups were formed depending on the number of components of MS and its existing complications. Physical examination was conducted; the values of lipid and carbohydrate metabolisms, lipid peroxidation, and hemorheology were estimated. The serum alpha-TNF levels were measured by enzyme immunoassay. The neural network technique was used to analyze the factor correlations of different types of MS. RESULTS: The estimation of a diversity of homeostatic parameters could ascertain the significance of the level of alpha-TNF in different types of MS. Its high level is associated with the elevated concentrations of low-density lipoprotein cholesterol (LDL-C) and apolipoprotein A1 (apoA1) in the presence of 1-2 risk factors for MS. In the individuals with 3 components of MS or more, as well as in the presence of its complications, the levels of alpha-TNF were closely related to those of LDL-C and apoA1, insulin resistance, and the changes in lipid peroxidation and hemostasis. CONCLUSION: The early stage of MS is marked by the higher alpha-TNF level, its correlation with the changes in lipid metabolism and insulin concentrations. Alpha-TNF may be considered not only as an early marker of a systemic inflammatory reaction in the development of cardiovascular events, as well as a risk factor for MS.

[Antiatherogenic properies of various types of carbonate mineral drinking waters]. / Antiaterogennye svoistva razlichnykh tipov uglekislykh mineral'nykh vod pri vnutrennem ikh primenenii.

Carbonate mineral waters of different types (Shmakovskaya, Sinegorskaya, Utserskaya) were examined in experimental model of hyperlipidemia for action on atherogenically altered lipid spectrum of blood and oxidative resistance of plasma. The above waters differ in mineralization and specific components. Carbonate waters were found to have antiatherogenic properties and positive action on lipid indices and antiradical defense. Specific features of different carbonate waters enable a differentiated approach to correction of different variants of lipid disorders.

[Combined use of drinking mineral water and the natural enterosorbent zosterine in kidney stones (an experimental study)]. / K voprosy kompleksnogo ispol'zovaniia pit'evykh mineral'nykh vod i prirodnogo énterosorbenta zosterina pri nefrokal'tsinoze (éksperimental'noe issledovanie).

A combined action of carbonic mineral waters of Shmakovsky and Mukhensky deposits and natural enterosorbent zosterin was studied in nephrocalcinosis in experiment. Taking carbonic mineral waters reduced intoxication, stimulates filtration and excretory renal functions. Zosterin delays calcium in the renal tissue in nephrocalcinosis. Therefore, these two factors were incompatible in animals with experimental renal affection.

[The iron carbonate waters of the Maritime Territory]. / Uglekislye zhelezistye vody Primorskogo kraia.

Balneological and experimental examinations were made of physiological properties of carbonate iron mineral waters of the Primorskiy Territory. The waters were found perspective as a source of ecologically healthy water, to prevent diseases, to raise nonspecific resistance of the body.

[The effect of the internal intake of carbonate mineral waters on lipid and carbohydrate metabolism in the development of experimental obesity]. / Vliianie vnutrennego priema uglekislykh mineral'nykh vod na obmen lipidov i uglevodov pri razvitii éksperimental'nogo ozhireniia.

Experimental alimentary obesity was treated with hydrocarbonate magnesium-calcium water from Shmakovskoe deposit and hydrocarbonate-chloride sodium arsenous boric iodine-bromine water from springs in Sinegorsk. The study of lipid and carbohydrate metabolism proved the ability of the waters to prevent complex metabolic disorders typical for obesity.