RESUMO
BACKGROUND: It is important for physicians to be aware of the radiation doses as well as the risks associated with diagnostic imaging procedures that they are ordering. METHODS: A survey was administered to patients, medical students, and referring physicians from a number of specialties to determine background knowledge regarding radiation exposure and risk associated with commonly ordered medical imaging tests. RESULTS: A total of 127 patients, 32 referring physicians, and 30 medical students completed the survey. The majority of patients (92%) were not informed of the radiation risks associated with tests that they were scheduled to receive and had false perceptions about the use of radiation and its associated risks. Physicians and medical students had misconceptions about the use of ionizing radiation in a number of radiologic examinations; for example, 25% and 43% of physicians and medical students, respectively, were unaware that interventional procedures used ionizing radiation, and 28% of physicians were unaware that mammography used ionizing radiation. Computed tomographies and barium studies were thought to be associated with the least ionizing radiation among physicians. CONCLUSION: There is a need for educating the public, medical students, and referring physicians about radiation exposure and associated risk so that (1) patients receiving multiple medical imaging tests are aware of the radiation that they are receiving and (2) physicians and future physicians will make informed decisions when ordering such tests to limit the amount of radiation that patients receive and to promote informed consent among patients.
Assuntos
Competência Clínica/estatística & dados numéricos , Diagnóstico por Imagem/efeitos adversos , Conhecimentos, Atitudes e Prática em Saúde , Médicos/estatística & dados numéricos , Doses de Radiação , Estudantes de Medicina/estatística & dados numéricos , Atitude do Pessoal de Saúde , Canadá , Estudos Transversais , Feminino , Pesquisas sobre Atenção à Saúde/métodos , Pesquisas sobre Atenção à Saúde/estatística & dados numéricos , Hospitais Comunitários/métodos , Humanos , Masculino , Segurança do Paciente/estatística & dados numéricos , Recursos Humanos em Hospital/estatística & dados numéricos , Lesões por Radiação , Encaminhamento e Consulta , Medição de Risco/métodos , Medição de Risco/estatística & dados numéricos , Atenção Terciária à Saúde/métodosRESUMO
PURPOSE: To evaluate pathologically the effectiveness of radiofrequency (RF) ablation in the treatment of pulmonary metastases. MATERIALS AND METHODS: Patients with multiple pulmonary metastases scheduled for surgical resection were prospectively enrolled. Patients underwent RF ablation of one percutaneously accessible tumor and within 2-4 weeks underwent surgical resection of the ablated tumor and any additional lesions. Resected tumors all were assessed by routine light microscopy, and selected tumors were assessed by immunohistochemistry with MIB1 and proliferative cell nuclear antigen (PCNA). Relationship of ablation zone to the tumor and viability of the ablated tumors were assessed. RESULTS: Nine patients (four men and five women) 46-76 years of age were included in the study. Four patients had metastatic colorectal carcinoma, and five patients had metastases from soft tissue sarcomas. Ablated tumors ranged from 1.0-3.0 cm in diameter. Each target lesion was completely encompassed by the ablation zone. All tumor tissue within the ablation zone showed characteristic changes of coagulative necrosis with hematoxylin and eosin staining. Tumors showed preservation of MIB1 staining but loss of PCNA protein staining. RF ablation resulted in complete coagulative necrosis of all the pulmonary metastases treated in the study. CONCLUSIONS: Although this series is small, it provides histologic support for RF ablation as an effective treatment for selected pulmonary metastases.
Assuntos
Carcinoma/cirurgia , Ablação por Cateter , Neoplasias Colorretais/patologia , Neoplasias Pulmonares/cirurgia , Sarcoma/cirurgia , Idoso , Carcinoma/química , Carcinoma/secundário , Sobrevivência Celular , Corantes , Amarelo de Eosina-(YS) , Feminino , Hematoxilina , Humanos , Imuno-Histoquímica , Antígeno Ki-67/análise , Neoplasias Pulmonares/química , Neoplasias Pulmonares/secundário , Masculino , Pessoa de Meia-Idade , Necrose , Ontário , Estudos Prospectivos , Sarcoma/química , Sarcoma/secundário , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Ubiquitina-Proteína Ligases/análiseRESUMO
The spleen is the most commonly injured visceral organ in blunt abdominal trauma in both adults and children. Nonoperative management is the current standard of practice for patients who are hemodynamically stable. However, simple observation alone has been reported to have a failure rate as high as 34%; the rate is even higher among patients with high-grade splenic injuries (American Association for the Surgery of Trauma [AAST] grade III-V). Over the past decade, angiography with transcatheter splenic artery embolization, an alternative nonoperative treatment for splenic injuries, has increased splenic salvage rates to as high as 97%. With the help of splenic artery embolization, success rates of more than 80% have also been described for high-grade splenic injuries. We discuss the role of computed tomography and transcatheter splenic artery embolization in the diagnosis and treatment of blunt splenic trauma. We review technical considerations, indications, efficacy and complication rates. We also propose an algorithm to guide the use of angiography and splenic embolization in patients with traumatic splenic injury.
Assuntos
Traumatismos Abdominais/diagnóstico por imagem , Traumatismos Abdominais/terapia , Embolização Terapêutica/métodos , Baço/diagnóstico por imagem , Artéria Esplênica/diagnóstico por imagem , Algoritmos , Humanos , Radiografia , Baço/lesões , Artéria Esplênica/lesões , Ferimentos e Lesões/complicaçõesRESUMO
OBJECTIVE: To provide evidence-based guidelines regarding the appropriate use of gastrointestinal stents for oncologic indications. This document describes the use of gastrointestinal stents by appropriately trained physicians. METHODS: This document is based on a review of the published evidence and supplemented by consensus expert opinion. Gastrointestinal stenting has been evaluated in terms of technical success, complications, patient satisfaction, clinical outcome, and cost-benefit analysis. This document was approved by the Canadian Interventional Radiology Association; approval from the other relevant Canadian societies is pending. CONCLUSION: Gastrointestinal stenting has a valuable role in the management of gastrointestinal malignancy. The decision to use such devices should be taken after comprehensive multidisciplinary clinical, endoscopic, and radiologic evaluation.
Assuntos
Endoscopia Gastrointestinal , Neoplasias Gastrointestinais/complicações , Trato Gastrointestinal/cirurgia , Metais , Stents , Ligas , Canadá , Constrição Patológica/etiologia , Constrição Patológica/cirurgia , Endoscopia Gastrointestinal/efeitos adversos , Endoscopia Gastrointestinal/métodos , Trato Gastrointestinal/fisiopatologia , Humanos , Comunicação Interdisciplinar , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Stents/efeitos adversos , Stents/tendênciasRESUMO
OBJECTIVE: Increasing scientific evidence supports the use of self-expanding metallic gastrointestinal (GI) stents. The commonly accepted primary indications are their usefulness as a bridge to surgery and for palliation to avoid surgery. These stents have been shown to have high technical success and low complication rates, leading to improved quality of life for patients. They have also been shown to be cost-effective when compared with alternative therapies. The objective of this study is to present a retrospective review of our local experience. METHODS: Attempts were made to place 23 GI stents in 16 patients for palliative cancer indications. RESULTS: Follow-up was 5-352 days (mean 81.9 d). Presenting symptoms included abdominal distention or pain (81%), nausea or vomiting (69%), constipation (31%) and weight loss (19%). Stents were placed in the colon (11 patients), duodenum (4 patients) or esophagus (1 patient). The technical success rate was 91.3%, the clinical success rate (defined as any improvement in symptoms in patients successfully receiving a stent) was 85.7%, and the complication rate was 21.4% among patients successfully receiving a stent, or 18.8% overall. Of 14 patients successfully receiving at least 1 stent, 10 (71%) were discharged home after a mean of 11.5 days (range 1-26 d). Of patients successfully receiving at least 1 stent, 12 (86%) had passed away at the time of last follow-up. Patients who successfully received a stent but who have since passed away (either in hospital or out of hospital) had their stent(s) in situ for a mean of 57 days (range 5-180 d). CONCLUSION: On the basis of our data, we believe that GI stents may be safely and effectively used in a community hospital setting and that they provide benefit in the palliative care population.
Assuntos
Neoplasias do Colo/terapia , Neoplasias Duodenais/terapia , Segurança de Equipamentos , Neoplasias Esofágicas/terapia , Estenose Esofágica/terapia , Obstrução Intestinal/terapia , Cuidados Paliativos , Complicações Pós-Operatórias/etiologia , Radiologia Intervencionista , Stents , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias do Colo/mortalidade , Neoplasias Duodenais/mortalidade , Falha de Equipamento/estatística & dados numéricos , Neoplasias Esofágicas/mortalidade , Estenose Esofágica/mortalidade , Feminino , Fluoroscopia , Seguimentos , Mortalidade Hospitalar , Hospitais Comunitários/estatística & dados numéricos , Humanos , Obstrução Intestinal/mortalidade , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Ontário , Complicações Pós-Operatórias/mortalidade , Taxa de Sobrevida , Resultado do TratamentoRESUMO
OBJECTIVE: To determine the percentage of interventional radiologists who currently perform 3 interventional procedures: carotid stenting, vertebroplasty, and endovascular aneurysm repair (EVAR) in Canada, and impediments to their future performance by other interventional radiologists. METHODS: An anonymous online survey was emailed to all members of the Canadian Interventional Radiology Association (CIRA). The survey was open for a period of 2 months. RESULTS: A total of 75 survey responses were received (of an estimated 247). Carotid stenting, vertebroplasty, and EVAR were performed at 40%, 59%, and 46% of respondents' centres respectively. Wait times, from referral to consultation, and from consultation to procedure, were both typically between 2 to 4 weeks, longer for EVAR. Of respondents currently not performing these procedures, 26%, 28%, and 16% anticipated beginning to perform carotid stenting, vertebroplasty, and EVAR, respectively, in the proceeding year from time of survey. Of respondents who wished to perform the procedure, the greatest impediments were a lack of training, lack of a referral base, and lack of support from their radiology department and (or) colleagues. CONCLUSIONS: Although carotid stenting, vertebroplasty, and EVAR were being performed at about one-half of respondent's centres, and there will likely be greater adoption of the procedures in the near future, there remain substantial impediments. The greatest impediments to additional radiologists performing these procedures were a lack of training, lack of referral base, and lack of support from their radiology department and (or) colleagues. The former impediment suggested an unmet need for additional training courses.
Assuntos
Aneurisma/cirurgia , Estenose das Carótidas/cirurgia , Radiologia Intervencionista/estatística & dados numéricos , Stents/estatística & dados numéricos , Procedimentos Cirúrgicos Vasculares/estatística & dados numéricos , Vertebroplastia , Angioplastia , Atitude do Pessoal de Saúde , Canadá , Coleta de Dados , Previsões , Humanos , Padrões de Prática Médica , Serviço Hospitalar de Radiologia , Radiologia Intervencionista/educação , Encaminhamento e Consulta , Inquéritos e Questionários , Fatores de Tempo , Vertebroplastia/estatística & dados numéricos , Listas de EsperaRESUMO
OBJECTIVE: To review evidence supporting the use of uterine fibroid embolization (UFE) as an alternative to hysterectomy and myomectomy for managing uterine fibroids. QUALITY OF EVIDENCE: MEDLINE was searched using the MeSH terms embolization, therapeutic; leiomyoma; treatment outcome; pregnancy; and clinical trials. Most published studies on use of UFE for management of uterine fibroids provide level II evidence. MAIN MESSAGE: For 71% to 92% of patients, UFE is effective at alleviating fibroid-related symptoms. After UFE, fibroids are reduced in size by 42% to 83%. Patients' satisfaction with the procedure is high (>90%), and UFE is safe and has a low rate of major complications (1.25%). When compared with hysterectomy, UFE is associated with fewer major complications, shorter hospital stays, and faster recovery. Although successful pregnancy following UFE is possible, there is insufficient evidence to advocate use of UFE over myomectomy for management of uterine fibroids in women wishing to preserve fertility. CONCLUSION: For treatment of symptomatic uterine fibroids, UFE is a safe and effective nonsurgical alternative to hysterectomy and myomectomy.
Assuntos
Embolização Terapêutica/métodos , Leiomioma/terapia , Neoplasias Uterinas/terapia , Adulto , Canadá , Educação Médica Continuada , Medicina de Família e Comunidade/educação , Feminino , Humanos , Histerectomia/métodos , Leiomioma/diagnóstico , Prognóstico , Medição de Risco , Resultado do Tratamento , Neoplasias Uterinas/diagnósticoRESUMO
OBJECTIVE: To review the evidence supporting use of percutaneous vertebroplasty for relief of pain and mechanical stability in patients with vertebral compression fractures unrelieved by conventional measures. QUALITY OF EVIDENCE: Ovid MEDLINE was searched from January 1966 to December2006 for all English-language papers on vertebroplasty. The quality of evidence in these papers was graded according to the 4-point classification system of evidence-based medicine. Level II evidence currently supports use of vertebroplasty. MAIN MESSAGE: Vertebroplasty alleviates pain from vertebral compression fractures that result from osteoporosis, hemangiomas, malignancies, and vertebral osteonecrosis. Vertebroplasty has provided substantial pain relief in 60% to 100% of patients; has decreasedanalgesic use in 34% to 91% of patients; and has improved physical mobility in 29% to 100% of patients. Contraindications to vertebroplasty include asymptomatic compression fractures of the vertebral body, vertebra plana, retropulsed bone fragments or tumours, active infection, uncorrectable coagulopathy, allergy to the bone cement or opacification agent, severe cardiopulmonary disease, pregnancy, and pre-existing radiculopathy. The short-term complication rate was found to be 0.5% to 54%. Rare but serious complications include compression of the spinal cord or nerve root, infection, cement embolization causing pulmonary infarct and clinical symptoms, paradoxical embolization of the cerebral artery, and severe hematomas. CONCLUSION: Vertebroplasty is a safe and effective treatment for vertebral fractures that cannot be treated using conservative measures.
Assuntos
Dor nas Costas/terapia , Vértebras Lombares/efeitos dos fármacos , Dor Intratável/terapia , Polimetil Metacrilato/farmacologia , Dor nas Costas/diagnóstico , Cimentos Ósseos , Feminino , Seguimentos , Humanos , Injeções Espinhais , Masculino , Medição da Dor , Dor Intratável/diagnóstico , Seleção de Pacientes , Polimetil Metacrilato/uso terapêutico , Medição de Risco , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
PURPOSE: To quantify the level of knowledge about interventional radiology (IR) among patients referred for an IR procedure and to develop recommendations on how to increase public awareness of IR. MATERIALS AND METHODS: Paper surveys were prospectively administered to consecutive patients scheduled to undergo an IR procedure at a community hospital. The study was terminated at the accrual of 100 completed surveys. RESULTS: Totals of 28% and 6% knew generally the job of a diagnostic radiologist and interventional radiologist, respectively, and 6% had heard of the field of IR before their referral (despite 21% having undergone a procedure previously). Before their arrival in the IR department, 87% had not received any information about IR. Three percent, 0%, 4%, 82%, and 82% had heard about uterine artery embolization, radiofrequency ablation, vertebroplasty, biopsy (any type), and angioplasty, respectively. After the procedures, 84% had a clearer view of what interventional radiologists do, but 98% believed that most others did not know what IR was. When asked how best to educate the public about IR, the responses were: unsure (39%), other (19%), pamphlets (12%), information from physicians (9%), television (8%), and Internet (7%). Overall, the mean satisfaction rate was 8.8 (with 0 representing the minimum and 10 representing the maximum), and 97% would choose IR over surgery for future treatments. CONCLUSIONS: These data quantify and strongly support the views that (1) even among patients specifically referred to IR for a procedure, the majority of people are unaware of what the field is or may offer; and (2) most patients were satisfied with their IR experience. Six results-based recommendations are made to increase public awareness about IR.
Assuntos
Educação em Saúde , Radiologia Intervencionista , Conscientização , Canadá , Pesquisas sobre Atenção à Saúde , Hospitais Comunitários , Humanos , Estudos Prospectivos , Encaminhamento e ConsultaRESUMO
PURPOSE: To describe the current state and limitations to interventional radiology (IR) in Canada through a large, national survey of Canadian interventional radiologists. METHODS: An anonymous online survey was offered to members of the Canadian Interventional Radiology Association (CIRA). Only staff radiologists were invited to participate. RESULTS: Seventy-five (75) responses were received from a total of 247, giving a response rate of 30%. Respondents were split approximately equally between academic centers (47%) and community practice (53%), and the majority of interventional radiologists worked in hospitals with either 200-500 (49%) or 500-1,000 (39%) beds. Procedures listed by respondents as most commonly performed in their practice included PICC line insertion (83%), angiography and stenting (65%), and percutaneous biopsy (37%). Procedures listed as not currently performed but which interventional radiologists believed would benefit their patient population included radiofrequency ablation (36%), carotid stenting (34%), and aortic stenting (21%); the majority of respondents noted that a lack of support from referring services was the main reason for not performing these procedures (56%). Impediments to increasing scope and volume of practice in Canadian IR were most commonly related to room or equipment shortage (35%), radiologist shortage (33%), and a lack of funding or administrative support (28%). CONCLUSION: Interventional radiology in Canada is limited by a number of factors including funding, manpower, and referral support. A concerted effort should be undertaken by individual interventional radiologists and IR organizations to increase training capacity, funding, remuneration, and public exposure to IR in order to help advance the subspecialty.
Assuntos
Radiografia Intervencionista/estatística & dados numéricos , Atitude do Pessoal de Saúde , Canadá/epidemiologia , Custos de Cuidados de Saúde/estatística & dados numéricos , Pesquisas sobre Atenção à Saúde , Mão de Obra em Saúde/estatística & dados numéricos , Humanos , Internet , Admissão e Escalonamento de Pessoal/estatística & dados numéricos , Guias de Prática Clínica como Assunto , Radiografia Intervencionista/economia , Encaminhamento e Consulta/estatística & dados numéricos , Projetos de Pesquisa , Alocação de Recursos/estatística & dados numéricos , Sociedades Médicas/estatística & dados numéricos , Carga de Trabalho/estatística & dados numéricosAssuntos
Adenocarcinoma/diagnóstico , Obstrução Intestinal/terapia , Invasividade Neoplásica/patologia , Neoplasias Ovarianas/diagnóstico , Cuidados Paliativos/métodos , Radiologia Intervencionista/métodos , Dor Abdominal/diagnóstico , Dor Abdominal/etiologia , Adenocarcinoma/cirurgia , Adulto , Apendicite/diagnóstico , Apendicite/cirurgia , Diagnóstico Diferencial , Progressão da Doença , Serviço Hospitalar de Emergência , Evolução Fatal , Feminino , Humanos , Obstrução Intestinal/patologia , Neoplasias Ovarianas/cirurgia , Medição de Risco , StentsRESUMO
Four patients with symptomatic uterine fibroids measuring less than 6 cm underwent laparoscopic ultrasound-guided radiofrequency ablation (RFA) using multiprobe-array electrodes. Follow-up of the treated fibroids was performed with gadolinium-enhanced magnetic resonance imaging (MRI) and patients' symptoms were assessed by telephone interviews. The procedure was initially technically successful in 3 of the 4 patients and MRI studies at 1 month demonstrated complete fibroid ablation. Symptom improvement, including a decrease in menstrual bleeding and pain, was achieved in 2 patients at 3 months. At 7 months, 1 of these 2 patients experienced symptom worsening which correlated with recurrent fibroid on MRI. The third, initially technically successfully treated patient did not experience any symptom relief after the procedure and was ultimately diagnosed with adenomyosis. Our preliminary results suggest that RFA is a technically feasible treatment for symptomatic uterine fibroids in appropriately selected patients.
Assuntos
Ablação por Cateter/métodos , Leiomioma/terapia , Neoplasias Uterinas/terapia , Adulto , Feminino , Humanos , Laparoscopia , Leiomioma/diagnóstico por imagem , Leiomioma/cirurgia , Pessoa de Meia-Idade , Ultrassonografia , Neoplasias Uterinas/diagnóstico por imagem , Neoplasias Uterinas/cirurgiaRESUMO
Transabdominal and transvaginal ultrasonography (US) are commonly used to assess the uterus and pelvis prior to and following uterine artery embolization (UAE) for symptomatic leiomyomas (fibroids). Preprocedural US may help identify relative contraindications for UAE, whereas postprocedural US can help determine the quality and quantity of fibroid involution and help identify any complications associated with the procedure. The consulting radiologist should be familiar with certain typical postprocedural US findings, which might otherwise be improperly interpreted, leading to unnecessary intervention. Magnetic resonance (MR) imaging or computed tomography will frequently provide the most accurate information in UAE patients with certain pathologic conditions, and early study results suggest that MR imaging may be helpful in predicting treatment response. Nevertheless, US is a readily available first-line imaging modality and a well-accepted method for both pre- and postprocedural evaluation of patients who undergo UAE. A proper understanding of the US findings in this patient population allows objective determination of treatment response and detection of most of the commonly recognized complications that are associated with UAE.
Assuntos
Embolização Terapêutica , Leiomioma/diagnóstico por imagem , Leiomioma/terapia , Neoplasias Uterinas/diagnóstico por imagem , Neoplasias Uterinas/terapia , Útero/irrigação sanguínea , Adulto , Feminino , Humanos , Leiomioma/irrigação sanguínea , Pessoa de Meia-Idade , Ultrassonografia , Neoplasias Uterinas/irrigação sanguíneaRESUMO
PURPOSE: To determine the incidence and risk factors associated with needle tract seeding after radiofrequency ablation (RFA) of liver tumors. MATERIALS AND METHODS: A prospective data base of patients with hepatic tumors treated by RFA from December 1999 until August 2003 was reviewed to identify patients with needle tract seeding. During this period, 200 patients (148 men, 52 women) with 299 lesions underwent 298 treatment sessions. Patients with both primary (153 hepatocellular carcinoma, two cholangiocarcinoma) and a variety of secondary tumors (35 colorectal, 10 other) were treated. RFA was performed percutaneously with computed tomography (CT) and/or ultrasound (US) guidance, or with US guidance at laparoscopy or laparotomy. All procedures were performed with a LeVeen needle electrode. The needle tract was not routinely coagulated or embolized. RESULTS: Eight patients out of 200 (4%) were identified with needle tract seeding, based on imaging findings or surgical reintervention. This corresponds to a rate of eight of 298 (2.7%) per treatment session and eight of 299 (2.7%) per lesion. Statistically significant risk factors for neoplastic seeding included treatment of a subcapsular lesion (OR = 11.57, P = .007), multiple treatment sessions (OR = 2.0, P = .037), and multiple electrode placements (OR = 1.4, P = .006). CONCLUSIONS: Neoplastic seeding may occur after RFA of liver tumors. The results show that the frequency of this complication is not insignificant, and are at the upper end of rates reported in the literature of 0.5% to 2.8%. Specific risk factors identified in this study include treatment of subcapsular lesions, patients treated in multiple sessions, and lesions requiring more than one electrode placement.
Assuntos
Ablação por Cateter/efeitos adversos , Neoplasias Hepáticas/cirurgia , Inoculação de Neoplasia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma Hepatocelular/secundário , Carcinoma Hepatocelular/cirurgia , Ablação por Cateter/instrumentação , Colangiocarcinoma/secundário , Colangiocarcinoma/cirurgia , Eletrodos/efeitos adversos , Feminino , Seguimentos , Humanos , Laparoscopia , Laparotomia , Neoplasias Hepáticas/patologia , Masculino , Pessoa de Meia-Idade , Agulhas/efeitos adversos , Estudos Prospectivos , Radiografia Intervencionista , Fatores de Risco , Tomografia Computadorizada por Raios X , Ultrassonografia de IntervençãoRESUMO
PURPOSE: To identify risk factors for the development of intrauterine infection following uterine artery embolization. MATERIALS AND METHODS: A retrospective review of uterine artery embolizations (UAE) performed for the treatment of symptomatic fibroids from January 2000 to July 2003 was conducted. With logistic regression and the Fisher exact test, multiple variables were analyzed as predictors for intrauterine infectious complications requiring medical and/or surgical therapy, including the use of preprocedural antibiotics, embolic agent used, quantity of embolic material, location of fibroids (submucosal, nonsubmucosal), and size and location of the dominant fibroid. RESULTS: A total of 414 UAE procedures were performed in 410 patients with a technical success rate of 99%. Average age of the patient cohort was 42.8 years (SD, 5.8 years). One hundred forty-eight patients (36.1%) had submucosal fibroids or fibroids projecting submucosally, 262 patients (63.9%) had nonsubmucosal fibroids. Intrauterine infectious complications requiring intravenous antibiotic therapy and/or surgery occurred in five patients (1.2%). A total of five infectious complications requiring therapy occurred in the submucosal group (3.4%) and none in the nonsubmucosal group. Patients within the submucosal group were more likely to develop intrauterine infectious complications than patients with nonsubmucosal fibroids based on univariate analysis (P = .006) but with logistic regression, the association was not significant (P = .079). No significant difference with embolic agent, quantity of embolic particles, use of preprocedure antibiotics, or size of or location of the dominant fibroid was found. CONCLUSION: No specific risk factor for intrauterine infection following UAE was identified in this study. Infection after UAE is rare and appears to be a sporadic occurrence. Nevertheless, close surveillance is warranted in all women following UAE given the potential morbidity of this complication.
Assuntos
Embolização Terapêutica/efeitos adversos , Leiomioma/terapia , Doenças Uterinas/etiologia , Doenças Uterinas/microbiologia , Neoplasias Uterinas/terapia , Útero/irrigação sanguínea , Adulto , Feminino , Humanos , Leiomioma/irrigação sanguínea , Leiomioma/diagnóstico por imagem , Modelos Logísticos , Valor Preditivo dos Testes , Estudos Retrospectivos , Fatores de Risco , Ultrassonografia , Doenças Uterinas/diagnóstico por imagem , Neoplasias Uterinas/irrigação sanguínea , Neoplasias Uterinas/diagnóstico por imagem , Útero/microbiologiaAssuntos
Ablação por Cateter , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/cirurgia , Neurofibrossarcoma/diagnóstico por imagem , Neurofibrossarcoma/cirurgia , Tomografia Computadorizada por Raios X , Adulto , Ablação por Cateter/métodos , Meios de Contraste , Seguimentos , Humanos , Neoplasias Pulmonares/secundário , Masculino , Recidiva Local de Neoplasia , Neurofibrossarcoma/secundário , Fatores de Tempo , Tomografia Computadorizada por Raios X/métodosRESUMO
PURPOSE: To evaluate the efficacy of embolotherapy in patients with bleeding traumatic uterine arteriovenous malformations (AVMs). MATERIALS AND METHODS: A retrospective review of all patients who underwent pelvic arterial embolization at our institution between July 1992 and September 2002 was performed. Fifteen patients were diagnosed with a uterine vascular malformation on duplex ultrasonography and correlative MR imaging. Serial beta-human chorionic gonadotropin levels were measured to exclude gestational trophoblastic neoplasia. All patients underwent transcatheter embolization of the uterine arteries. Embolizations were performed with use of standard 4-5-F catheters and microcatheters when necessary. Embolic agents in the 25 procedures included glue only (n = 13), polyvinyl alcohol (PVA) particles and glue (n = 4), PVA particles (n = 2), Gelfoam (n = 2), coils (n = 1), PVA particles and coils (n = 1), glue and Gelfoam (n = 1), and glue and coils (n = 1). PVA particle size ranged from 350 to 1,000 micro m. Outcomes assessed were cessation of bleeding, persistence or resolution of the AVM, complications, and pregnancy after embolization. These were assessed by chart, laboratory, and imaging reviews. RESULTS: A total of 25 embolization procedures were performed in 15 patients. Six patients required repeat embolization (one patient underwent embolization on six occasions; five patients had two embolization procedures each) for recurrence of bleeding. Sixteen procedures were performed on an elective basis and nine were performed on an emergent basis. The technical success rate of embolization was 100%. The clinical success rate was 93%: bleeding was controlled in 14 of 15 patients and one patient underwent a hysterectomy. Four of the 15 patients subsequently had a total of five uneventful intrauterine pregnancies carried to term. The 14 patients who underwent successful embolization had no recurrence of bleeding at a median follow-up of 53 months (range, 3-124 months) after treatment. Three patients were eventually lost to follow-up. One minor complication (0.4%) of non-flow-limiting dissection of the internal iliac artery occurred. CONCLUSION: Percutaneous embolotherapy is a safe and effective treatment for traumatic AVMs. This procedure allows for preservation of uterine function with the possibility of future pregnancy and should be considered as a primary treatment option.
Assuntos
Fístula Arteriovenosa/terapia , Embolização Terapêutica , Útero/irrigação sanguínea , Adulto , Fístula Arteriovenosa/complicações , Fístula Arteriovenosa/diagnóstico , Fístula Arteriovenosa/etiologia , Embolização Terapêutica/métodos , Feminino , Esponja de Gelatina Absorvível/uso terapêutico , Humanos , Álcool de Polivinil/uso terapêutico , Gravidez , Recidiva , Estudos Retrospectivos , Resultado do TratamentoRESUMO
The objectives of this study were to identify the presence/absence and location of any embolic material and to describe the morphologic appearance of the leiomyoma and adjacent tissues of cases undergoing surgical intervention following uterine artery embolization (UAE) for leiomyomas. A total of 555 women underwent UAE using polyvinyl alcohol particles (PVA) in a multicenter clinical trial. The histopathologic slides from 17 of 18 women who subsequently underwent myomectomy or hysterectomy in the follow-up period (median 8.2 months) were reviewed without knowledge of the indication for surgery or time elapsed since UAE. The presence/absence and distribution of PVA emboli, associated inflammatory response, and necrosis were noted. Necrosis of leiomyoma(s) was classified as hyaline-type, coagulative tumor cell necrosis, and/or acute suppurative necrosis. In all cases PVA emboli were identified within smooth muscle tumors of the uterine body, its periphery, cervix, uterine body, myometrium, and/or the adnexa. A florid foreign body giant cell type of chronic inflammatory reaction was seen within 1 week of UAE and persisted with visible PVA for up to 14 months post-UAE. Typically, post-UAE leiomyomas showed hyaline-type, but rarely coagulative tumor cell necrosis and acute suppurative necrosis could be seen as well. Five of eight cases coming to surgery for complications showed necrotizing endomyometritis with tissue infarction. PVA particles are recognizable in post-UAE specimens. Leiomyoma necrosis is typically of the hyaline type; coagulative tumor cell necrosis was rarely seen. In some cases with complications, uterine and/or cervical necrosis occurred. The applicability of these findings for UAE patients who have been successfully treated and not resected is uncertain.