An overview of the efficacy of inhaled curcumin: a new mode of administration for an old molecule.

INTRODUCTION: Curcumin is a polyphenol with a variety of pharmacological actions. Despite its therapeutic effects and well-known safety profile, the utility of curcumin has been limited due to its deprived physical, chemical, and pharmacokinetic profile resulting from limited solubility, durability, prompt deterioration and pitiable systemic availability. Employment of an amalgamated framework integrating the potential advantages of a nanoscaffold alongside the beneficial traits of inhalational drug delivery system beautifully bringing down the restricting attributes of intended curative interventions and further assures its clinical success. AREAS COVERED: Current review discussed different application of inhalable nanocurcumin in different medical conditions. Lung diseases have been the prime field in which inhalable nanocurcumin had resulted in significant beneficial effects. Apart from this several lung protective potentials of the inhaled nanocurcumin have been discussed against severe pulmonary disorders such as pulmonary fibrosis, radiation pneumonitis and IUGR induced bronchopulmonary dysplasia. Also, application of the disclosed intervention in the clinical management of COVID-19 and Alzheimer's Disease has been discussed. EXPERT OPINION: In this portion, the potential of inhalable nanocurcumin in addressing various medical conditions along with ongoing advancements in nanoencapsulation techniques and the existing challenges in transitioning from pre-clinical models to clinical practice has been summarized.

Polychlorinated Biphenyls: A Review of Recent Updates on Food Safety and Environmental Monitoring, Health and Toxicological Implications, and Analysis.

A class of organic chemicals known as polychlorinated biphenyls (PCBs) consists of chlorine, hydrogen, and carbon atoms. High boiling points, chemical stability, non-flammability, and insulating properties have enabled them to be used in various industries. Because of their high toxicity, PCBs were one of the first industrial compounds to be banned from production. These compounds have high-fat solubility with bioaccumulation and biomagnification properties in the environment, food chain, and individuals. Hence, they may have an impact not only on individual organisms but ultimately on whole ecosystems. The main sources of PCB exposure are food and environmental pollutants. In the toxicology of PCBs, oxidative stress plays the most influential function. The induction of CYP1A1 due to the high affinity of PCBs for aryl hydrocarbon receptors is considered a trigger for oxidative stress. Production of reactive oxygen species and depletion of glutathione occur due to phase Ⅰ and Ⅱ metabolism, respectively. Thus, cellular redox balance may be disrupted in the presence of PCBs and their metabolites. Chronic and long-term exposure to these compounds can often lead to life-threatening diseases, like diabetes, obesity, cardiovascular and neurological diseases, cancer, and reproductive and endocrine disorders. We present the current knowledge of the routes of PCB exposure and bioaccumulation, the outlook regarding environmental and food safety, the potential role of PCBs in various diseases, the principal mechanisms responsible for PCB toxicity, and the main detection techniques used for PCBs.

Curcumin Nanofibers: A Novel Approach to Enhance the Anticancer Potential and Bioavailability of Curcuminoids.

Development of novel treatment methods for cancer is needed given the limitations of current treatment methods, including side effects and chemotherapeutic resistance, which may provide new hope to cancer patients. Cancer is the second leading cause of global mortality. Curcumin, the active ingredient of turmeric, has been used since ancient times for various therapeutic purposes. Several studies have identified its activity against cancer. Despite the established anticancer activity of curcumin, its low aqueous solubility and bioavailability are barriers to its effectiveness. In an attempt to solve this problem, many studies have formulated curcumin nanofiber preparations using a variety of methods. Electrospinning is a simple and affordable method for the production of nanofibers. Studies have shown increased curcumin bioavailability in nanofibers resulting from their high surface/volume ratio and porosity. We have undertaken a detailed review of studies on the anticancer effects of curcumin nanofibers. Curcumin acts by inhibiting various biological cancer pathways, including NF-κB, mTOR, complex I, cytokines, expression of p-p65, Ki67, and angiogenesis-associated genes. It also induces apoptosis through activation of caspase pathways and ROS production in cancer cells. Curcumin-loaded PLA50/PVP50/Cur15 nanofibers were investigated in breast cancer, one of the most studied cancers, and was shown to have significant effects on the widely used HeLa-cell line. Most of the studies undertaken have been performed in cell lines in vitro, while relatively few animal studies have been reported. More preclinical and clinical studies are needed to evaluate the anticancer activity of curcumin nanofibers. Amongst studies undertaken, a variety of curcumin nanofibers of various formulations have been shown to suppress a variety of cancer types. Overall, curcumin nanofibers have been found to be more efficient than free curcumin. Thus, curcumin nanofibers have been observed to improvise cancer treatment, offering great potential for effective cancer management. Further studies, both in vitro and in vivo, involving curcumin nanofibers have the potential to benefit cancer management.

A systematic review of mechanistic studies on the relationship between pesticide exposure and cancer induction.

INTRODUCTION: Pesticides are toxic and biological substances used for mitigating harmful pests. Their application in agricultural fields and homes increased environmental pollution. Studies showed their harmful effects on human health, specifically children, who are more vulnerable than adults. The International Agency for Research on Cancer (IARC) has introduced several pesticides as carcinogens. This study aims to systematically summarize and review all studies related to pesticides and cancer. METHODOLOGY: This systematic review is based on PRISMA rules. Three central databases were employed to find studies on pesticide exposure and cancer correlation published from 2017 to September 2022. RESULTS: After reviewing several studies, we found that most studies revealed a significant relationship between pesticide exposure and an increased cancer incidence rate. Among the most studied group of pesticides is organochlorine (OC) pesticides. OC pesticides and their residues could significantly increase cancer in children and adults. Mechanistic studies revealed that pesticides could increase the risk of different cancers by genetics, like an increased expression of some genes like p21, p53 or epigenetic impairments. Cell cycle impairments like expanding the G1 to S phase transition are another mechanism of causing cancer. DNA methylation and histone modifications increase the risk of numerous cancers. CONCLUSION: Based on epidemiological studies, pesticides are a significant concern to human health, specifically cancer development, and should be more restrained. Their most reported mechanism of action were genetic and epigenetic impairments which cause cancers.

Comparison of serum concentrations of essential and toxic elements between cigarette smokers and non-smokers.

The habit of smoking remains a severe public health problem. Heavy metals in cigarettes and mainstream smoke have been extensively investigated. This study has attempted to determine the essential and toxic elements in a biological sample of smokers and non-smokers. In this case-control study, 100 smokers were compared with 100 age- and gender-matched non-smoker healthy subjects. The smoker group was selected via the snowball sampling method. Serum concentrations of trace elements were determined using ICP-MS (Agilent 7900) for subsequent analysis. Data were analyzed by SPSS software using t test or Mann-Whitney U test along with chi-square test at the significant level of less than 0.05. The results of this study indicated that subjects in the smoker group compared with non-smokers had a significantly higher median of manganese (Mn) (11.5 [5.7-17.2] versus 6 [4-12.5] (µg/L), p = 0.003), copper (Cu) (40 [34-47.2] versus 34 [29-42] (µg/L), p = 0.005), arsenic (As) (39 [9-49.2] versus 12 [5-42] (µg/L), p = 0.007), thallium (Tl) (0.54 [0.27-0.68] versus 0.34 [0.11-0.66] (µg/L), p = 0.04), and lower iron (Fe) concentration (218 [156-508] versus 429 [192-573] (µg/L), p = 0.03). This study found that the concentrations of Mn, Cu, As, and TI in cigarette smokers were significantly higher than those obtained from the control group. These results can provide health policymakers with the necessary information to take public health measures towards preventive interventions in the community, though further studies are still warranted.