Assuntos
Leiomioma/cirurgia , Sarcoma/epidemiologia , Neoplasias Uterinas/epidemiologia , Neoplasias Uterinas/cirurgia , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Incidência , Leiomioma/diagnóstico , Pessoa de Meia-Idade , Estudos Retrospectivos , Sarcoma/diagnóstico , Taxa de Sobrevida , Resultado do Tratamento , Neoplasias Uterinas/diagnósticoRESUMO
OBJECTIVE: To evaluate whether hyperemesis gravidarum (HG) affects first-trimester maternal serum PAPP-A and free ß-hCG levels. METHOD: An observational study was conducted in 115 cases of HG and 110 control pregnancies who attended the first-trimester prenatal screening program between January 2006 and July 2010. RESULTS: Maternal serum TSH levels were lower and free T4, and transaminases (ALT, AST) levels were higher in pregnancies complicated with HG compared with controls (p < 0.05 for all). In HG cases, median values of maternal serum PAPP-A were significantly higher with respect to normal pregnancies (1.2 vs 1.0 MoM; p = 0.009). Similarly, median values of free ß-hCG were 1.3 MoM in HG pregnancies and 1.0 MoM in controls (p = 0.006). Multivariate analysis revealed that PAPP-A and hCG were independently associated with HG after controlling for TSH, free T4, AST, and ALT. CONCLUSION: HG is associated with elevated levels of PAPP-A and free ß-hCG, and such changes are independent of serum indicators of thyroid and liver function.
Assuntos
Gonadotropina Coriônica Humana Subunidade beta/sangue , Hiperêmese Gravídica/sangue , Primeiro Trimestre da Gravidez/sangue , Proteína Plasmática A Associada à Gravidez/metabolismo , Adulto , Alanina Transaminase/sangue , Aspartato Aminotransferases/sangue , Feminino , Humanos , Hiperêmese Gravídica/diagnóstico , Gravidez , Tireotropina/sangue , Tiroxina/sangueRESUMO
PURPOSE: Ovarian hemangiomas are seen rarely. We present a case of an ovarian hemangioma occurring synchronously with contralateral mature cystic teratoma. CASE HISTORY: An 81-year-old woman presented with hypertension and hyponatremia. In ultrasonographic evaluation a pelvic mass was found located at the left ovary. Histologically, a mature cystic teratoma measuring 9.5 × 9 × 8 cm was seen in left ovary. In the right ovary an incidental vascular lesion measuring 3.5 × 1.5 × 1 cm was observed. Final histopathological examination of this lesion demonstrated a hemangioma of cavernous type. CONCLUSION: To the best of our knowledge, this is the first ovarian hemangioma case occurring synchronously with contralateral mature cystic teratoma.