RESUMO
Fascioliasis is a rarely encountered parasitic infection in Turkey that mainly affects the liver and bile ducts. Other defined localizations of the parasite are the lungs, gastrointestinal system, and subcutaneous fatty tissue. Two cases of female patients who presented to the hospital with abdominal pain and whose physical examination and laboratory findings were normal except peripheral eosinophilia, were detected to have liver masses with necrotic areas. Segmental hepatectomies were performed in both cases with the preliminary diagnosis of liver tumors. Upon microscopic examinations of the resection materials, necrotic granulomatous inflammation with eosinophilic reaction at the periphery and the parasite (Fasciola hepatica) were seen. Both cases were reported to be fascioliasis according to these findings. Two cases of fascioliasis mimicking malignancy in the liver are presented here together with literature findings.
Assuntos
Fasciolíase/diagnóstico , Adulto , Colecistectomia , Diagnóstico Diferencial , Fasciolíase/diagnóstico por imagem , Fasciolíase/patologia , Fasciolíase/cirurgia , Feminino , Granuloma/patologia , Humanos , Fígado/diagnóstico por imagem , Fígado/patologia , Fígado/cirurgia , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/cirurgia , Pessoa de Meia-Idade , Necrose , Tomografia por Emissão de Pósitrons , Tomografia Computadorizada por Raios XRESUMO
We report a case of thrombotic thrombocytopenic purpura refractory to plasma exchange treatment. In bone marrow examination non hematopoetic cell groups have seen. But the primary tumor could neither be located endoscopically nor in imaging examinations. Upon the bone marrow biopsy confirm the adenocarcinoma metastasis an objective improvement have achived in the blood picture after polychemotherapy.
Assuntos
Adenocarcinoma/patologia , Neoplasias da Medula Óssea/patologia , Neoplasias da Medula Óssea/secundário , Púrpura Trombocitopênica Trombótica/patologia , Adenocarcinoma/tratamento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Neoplasias da Medula Óssea/tratamento farmacológico , Feminino , Humanos , Pessoa de Meia-Idade , Metástase Neoplásica , Púrpura Trombocitopênica Trombótica/tratamento farmacológicoRESUMO
Tufted angiomas may occur in the head and neck region, but the external auditory canal is a previously undefined localization. There are only 19 cases of hemangiomas reported in this unique localization. However, this case is the first capillary hemangioma of the tufted variant being reported with a recurrence after 7 years after surgical excision in a 47-year-old male patient.
Assuntos
Meato Acústico Externo/patologia , Neoplasias da Orelha/diagnóstico , Hemangioma Capilar/diagnóstico , Hemangioma/diagnóstico , Recidiva Local de Neoplasia/diagnóstico , Neoplasias Cutâneas/diagnóstico , Diagnóstico Diferencial , Seguimentos , Perda Auditiva Condutiva/diagnóstico , Hemangioma Capilar/patologia , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Inflammatory myofibroblastic tumor is composed of myofibroblast and inflammatory cell infiltration of the tissue. Malign transformation and recurrence rate of this tumor is rare and accepted as benign fibroinflammatory disease. The main etiology is unclear, but infection, trauma, and immunologic event are accused. In this study, we presented a 75-year-old man with a mass on his tongue, which was diagnosed as "inflammatory myofibroblastic tumor." This type of tumor is rarely seen in the tongue and might be difficult to diagnose. Complete mass excision was provided for an adaquete treatment.
RESUMO
We aimed to investigate whether the surgical removal of endometrioma alters the nuclear factor-kappa B1 (NF-kB1; p50/105) and NF-kB p65 (Rel A) expression in the eutopic endometrium of infertile women with endometrioma before and after laparoscopic removal of the ovarian endometrioma during the mid-secretory phase. Infertile women with endometrioma (n = 15) were enrolled. Infertile patients with nonendometriotic ovarian cyst (n = 10) and healthy fertile women (n = 10) were recruited as controls. Endometrial samples were obtained before and 3 months after the laparoscopic cystectomy. The NF-kB1 (p50/105) levels were analyzed by enzyme-linked immunosorbent assay (ELISA) in the endometrium of all groups before and after laparoscopic ovarian cystectomy during implantation window. Expression of NF-kB1 (p50/105) in eutopic endometrium was significantly higher in infertile women with endometrioma compared to nonendometriotic cyst and fertile controls (P < .05). Laparoscopic cystectomy resulted in a significant decrease in NF-kB1 expression in women with endometrioma. The NF-kB p65 (Rel A) immunoreactivity of eutopic endometrium decreased significantly subsequent to the surgical removal of the endometrioma. In conclusion, increased endometrial NF-kB expression may contribute to endometriosis-associated infertility.
Assuntos
Implantação do Embrião/fisiologia , Endometriose/metabolismo , Endometriose/cirurgia , Endométrio/metabolismo , Subunidade p50 de NF-kappa B/antagonistas & inibidores , Fator de Transcrição RelA/antagonistas & inibidores , Adulto , Endometriose/patologia , Endométrio/patologia , Feminino , Regulação da Expressão Gênica , Humanos , Infertilidade Feminina/diagnóstico , Infertilidade Feminina/metabolismo , Infertilidade Feminina/cirurgia , Subunidade p50 de NF-kappa B/biossíntese , Fatores de Tempo , Fator de Transcrição RelA/biossínteseRESUMO
Most malignant rectal tumors are histopathologically characterized as adenocarcinoma and generally metastasize to distant organs such as the lungs or the liver. Metastasis of rectal carcinomas to the skull is extremely rare. This study reports the initial diagnosis of rectal adenocarcinoma recurrence in a 65-year-old female with scalp metastasis. The patient's history indicated a colorectal adenocarcinoma that was resected five years earlier. A skull metastasis from a rectal adenocarcinoma has not yet been reported in the literature as an initial symptom for recurrence. This paper suggests that skull metastasis from any part of the body must be considered in the differential diagnosis of soft tissue tumors in the skull even in the absence of intestinal symptoms.
RESUMO
PURPOSE: The current study investigated the potential therapeutic efficiency of atosiban, an oxytocin receptor antagonist, in an experimental endometriosis model. METHODS: Endometriosis was surgically induced in 35 female rats during estrus. Four weeks after this procedure, relaparotomy was performed. The viability and dimensions of the endometriosis foci were recorded. Rats were then randomly divided into three groups. In the first group (n = 8), a daily dose of 0.2 ml 0.9 % NaCl was injected intraperitoneally (i.p.) (control cases). In the second and third groups (n = 8 and n = 8), 0.5 mg/kg/day i.p. atosiban and 1 mg/day i.p. diltiazem were given, respectively. At the end of the treatment, laparotomy was performed, and the dimensions of the endometriosis foci were recorded. The endometrial implants were processed for histological and immunohistochemical studies. The volumes of endometriotic implants were measured, and immunohistochemical analyses were performed, and compared between the groups. RESULTS: After the treatment with atosiban, volumes of endometriotic implants decreased significantly. Proliferating cell nuclear antigen expression levels were significantly reduced in the atosiban and diltiazem groups compared with the control group. CONCLUSIONS: In a rat endometriosis model, atosiban, an agent used for the first time for the medical treatment of endometriosis, has shown significant therapeutic efficiency.
Assuntos
Endometriose/tratamento farmacológico , Antagonistas de Hormônios/uso terapêutico , Receptores de Ocitocina/antagonistas & inibidores , Vasotocina/análogos & derivados , Animais , Bloqueadores dos Canais de Cálcio , Diltiazem , Modelos Animais de Doenças , Feminino , Humanos , Ratos , Ratos Wistar , Vasotocina/farmacologia , Vasotocina/uso terapêuticoRESUMO
PURPOSE: To evaluate the expression of c-kit (CD117) in endometrial hyperplasia and endometrial cancer. METHODS: Expression of c-kit in 10 normal endometrium, 18 simple endometrial hyperplasia, 16 complex endometrial hyperplasia (10 cases with atypia and 6 cases without atypia), and 6 endometrial cancer were investigated by immunohistochemistry. RESULTS: c-Kit expression decreased as the lesion progressed to endometrial cancer. Immunostaining was mostly focal and weak in the normal endometrium and was mostly diffuse and strong in the simple and complex endometrial hyperplasia. CONCLUSIONS: Simple and complex hyperplastic endometrial tissues express diffuse cytoplasmic staining for c-kit and the expression decreases with the progression of the lesion.
Assuntos
Neoplasias do Endométrio/metabolismo , Endométrio/metabolismo , Endométrio/patologia , Proteínas Proto-Oncogênicas c-kit/metabolismo , Análise de Variância , Transformação Celular Neoplásica/metabolismo , Feminino , Humanos , Hiperplasia/metabolismo , Imuno-Histoquímica , Proto-Oncogene MasRESUMO
The viability of cartilage grafts, in many forms, has been researched since the using of cartilage grafts in surgical procedures. Cryopreservation period and viability of cartilage grafts have remained unclear. This study was performed to investigate the durability, viability, and behavior of fresh or cryopreserved cartilage grafts when used as autografts or allografts in various forms.Six cartilage grafts (1 of each preparation type; 3 blocks and 3 diced) were prepared by wrapping with Surgicel or autogenous fascia, or they were left bare. After the graft preparation stage, the cartilage grafts were inserted into pockets prepared on the dorsum of each rabbit. Groups 1, 2, 3, and 4 (6 rabbits in each group) received autogenous fresh grafts, allogenous fresh grafts, autogenous cryopreserved grafts, and allogenous cryopreserved grafts, respectively. All cartilage grafts were implanted for 2 months.At the end of the second month, specimens were harvested and analyzed. The bare grafts provided the most viable specimens. There was no significant difference between the frozen or fresh and allograft or autograft groups with respect to viability and resorption ratios. The bare block graft, in all groups, survived significantly more than the other graft types.Allografts (homografts), similar autografts, did not create major problems, and they had excellent host tolerance and low antigenicity, especially when the perichondrium was removed. Viability and durability of the bare grafts (diced and block) were better than fascia or Surgicel-wrapped cartilage graft forms.
Assuntos
Cartilagem da Orelha/transplante , Animais , Materiais Biocompatíveis , Celulose Oxidada , Criopreservação , Fáscia/transplante , Sobrevivência de Enxerto , Coelhos , Estatísticas não Paramétricas , Transplante Autólogo , Transplante HomólogoRESUMO
Hairy polyps are rare benign tumors that are derived from 2 germ layers: ectoderm and mesoderm. Although location in the head and neck area is rare, the soft palate as the site of origin is even more unusual. The clinical presentation depends on the polyp's location and size. These masses can commonly cause respiratory and feeding difficulties. We present a case of a soft palate hairy polyp causing respiratory and feeding difficulties in a 6-month-old female infant and review the literature.
Assuntos
Obstrução das Vias Respiratórias/etiologia , Palato Mole/patologia , Pólipos/complicações , Diagnóstico Diferencial , Feminino , Cabelo , Humanos , Lactente , Nasofaringe , Palato Mole/cirurgia , Pólipos/diagnóstico , Pólipos/embriologia , Pólipos/patologia , Pólipos/cirurgia , Tomografia Computadorizada por Raios XRESUMO
Cystic echinococcocis (CE) is a zoonotic infection caused by metacestod form of Echinococcus granulosus. In this study, 91 patients with CE were revealed according to their gender, age, symptoms, cyst localization and size, and also to their preoperative serologic analysis results. These patients were recruited in Pathology Department of Inonu University, School of Medicine, Turgut Ozal Medical Center between January 2002 and December 2005. They had already undergone surgery following the preliminary diagnosis of CE and were diagnosed definitively after histopathological analysis. Thirty-seven of them were female (41%) and the rest were male (n=54, 59%). Mean age was 36.24 ± 20.35 (range: 4-80 years). Lung and liver were the most common localizations for CE cysts (n=67, 73.63%). Fifty patients' preoperative serological analysis (IHA) were already available (55%) and 46 of them (92%) were positive. Since histopathological definitive diagnosis was CE, false negative result rate was assessed as 8%. Intraabdominal CE cyst localization was found related with bigger cyst size and multiple organ involvement. Symptom duration was correlated with cyst size (p < 0.05; r < sup > 2 < /sup > =0.09). IHA results were failed to be found related with clinical features of the cysts.
Assuntos
Equinococose/epidemiologia , Equinococose/cirurgia , Echinococcus granulosus/isolamento & purificação , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Animais , Anticorpos Anti-Helmínticos/sangue , Criança , Pré-Escolar , Equinococose/diagnóstico , Echinococcus granulosus/imunologia , Feminino , Humanos , Fígado/parasitologia , Pulmão/parasitologia , Masculino , Pessoa de Meia-Idade , Distribuição por Sexo , Turquia/epidemiologia , Adulto JovemRESUMO
Hyperlipidemia is a major risk factor for coronary heart disease. The most commonly used antihyperlipidemic drugs are 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins), of which atorvastatin is one of the most widely used. Little is known about the relationship between tendinopathy and HMG CoA reductase inhibitors (statins) or the effects of atorvastatin use on tendon healing following surgical repair of tendon rupture. We hypothesized that atorvastatin negatively affects this healing process. The Achilles tendons of 16 New Zealand rabbits were ruptured surgically and repaired with sutures. Eight of the rabbits were given oral atorvastatin. The other 8 served as a surgical control group. Six weeks postoperatively, all the rabbits were sacrificed, and the repaired tendons were removed. After standard histological preparation, fibroblastic activity, re-vascularization, collagenization, collagen construction, and inflammatory-cell infiltration were evaluated. On comparing the atorvastatin and surgical control groups, we observed no difference in fibroblastic activity. Although it did not reach statistical significance in our study, a difference was noted in revascularization, collagenization, and inflammatory cell infiltration; and a statistical difference was observed in collagen construction. Doubt remains about the adverse effect of atorvastatin use during tendon healing. Further investigations in animal and human models are needed on the effects of tendon healing when atorvastatin is administered for a longer time frame prior to the injury.
Assuntos
Tendão do Calcâneo/lesões , Ácidos Heptanoicos/uso terapêutico , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Pirróis/uso terapêutico , Traumatismos dos Tendões/terapia , Cicatrização/efeitos dos fármacos , Tendão do Calcâneo/efeitos dos fármacos , Tendão do Calcâneo/patologia , Administração Oral , Animais , Atorvastatina , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Ácidos Heptanoicos/administração & dosagem , Inibidores de Hidroximetilglutaril-CoA Redutases/administração & dosagem , Masculino , Procedimentos Ortopédicos/métodos , Pirróis/administração & dosagem , Coelhos , Traumatismos dos Tendões/patologia , Resultado do TratamentoRESUMO
The adult form of Taenia taeniaeformis is found in the intestine of the cat and cheetah. The larva form is called Strobilocercus fasciolaris and is found in rodents such as mice and rats. Our objective was to draw attention to that rare zoonosis, since it has already been reported in the literature as strobilocercosis in humans. During an experimental animal study conducted at Inonu University, some unexpected cystic formations were found in the livers of nine 6-8-month-old healthy white mice, which affected the conducted study negatively. These cystic formations were examined histopathologically. Prepared sections were stained with haemotoxylin eosin, periodic acid-Schiff and Masson trichrome stains, and examined by light microscopy. Strobilocercus fasciolaris larvae that curled towards cyst cavity and their hooks were seen. Plasma cells, macrophage, focus of eosinophilic infiltration and fibroblastic connective tissue were simultaneous found. In this paper, histopathological changes in intermediate hosts caused by Strobilocercus fasciolaris and other cestod larvae have been discussed.
Assuntos
Fígado/patologia , Camundongos/parasitologia , Doenças dos Roedores/transmissão , Taenia/patogenicidade , Teníase/transmissão , Zoonoses/parasitologia , Acinonyx , Animais , Gatos , Humanos , Larva/patogenicidade , Fígado/parasitologia , Ratos , Doenças dos Roedores/parasitologia , Doenças dos Roedores/patologia , Taenia/isolamento & purificação , Teníase/parasitologia , Teníase/patologia , Zoonoses/transmissãoRESUMO
In this experimental study on endometriosis, the majority of the implants were successfully detected with technetium-(99mTc) labeled red blood cell scintigraphy.
Assuntos
Endometriose/diagnóstico por imagem , Endométrio/diagnóstico por imagem , Animais , Modelos Animais de Doenças , Endometriose/patologia , Endométrio/patologia , Endométrio/transplante , Eritrócitos/diagnóstico por imagem , Feminino , Radioisótopos do Iodo , Peritônio/cirurgia , Cintilografia , Compostos Radiofarmacêuticos , Ratos , Ratos Wistar , Pertecnetato Tc 99m de Sódio , Tamoxifeno/análogos & derivadosRESUMO
OBJECTIVE: To investigate the effects of follitropin alfa and beta on the myoelectrical activity of rat myometrium using signal-processing techniques. DESIGN: Prospective, placebo-controlled study. SETTING: Animal and pharmacology laboratory at Inonu University. ANIMAL(S): Forty-five female Wistar albino rats. INTERVENTION(S): Thirty of 45 animals involved in the experiment were registered as the superovulation group. After two successive normal estrous cycles, these animals were put into three equal subgroups. Group 1 was the control; animals were given 0.9% saline. Groups 2 and 3 were treated with follitropin alfa (Gonal-f) and follitropin beta (Puregon), respectively. The other 15 animals were ovariectomized (OVX) and subjected to the same protocol. The uterine myoelectrical signals were recorded and analyzed using a Matlab environment. MAIN OUTCOME MEASURE(S): Power/second, variance, and the effects of recombinant human follicle-stimulating hormone (FSH) on myoelectrical signals were assessed through temporal, spectral, and joint time-frequency analysis. The uterine endometrium and ovarian morphology were also assessed concerning primary follicles, antral follicles, and corpora lutea. RESULT(S): The power and some characteristic spectral components of myoelectrical signal were reduced with the administration of follitropin alfa and beta. No statistically significant difference was detected between endometrial and ovarian histology of the rats treated with these follitropins. CONCLUSION(S): Uterine myoelectrical signals change with administration of recombinant human FSH preparations. Follitropin beta and, more precisely, follitropin alfa suppress the spectral components and power of the myoelectrical signals, which provides uterine quiescence.
Assuntos
Fenômenos Eletrofisiológicos , Subunidade beta do Hormônio Folículoestimulante/metabolismo , Subunidade alfa de Hormônios Glicoproteicos/metabolismo , Miométrio/fisiologia , Animais , Feminino , Subunidade beta do Hormônio Folículoestimulante/genética , Subunidade alfa de Hormônios Glicoproteicos/genética , Humanos , Ratos , Ratos Wistar , Proteínas Recombinantes/genética , Proteínas Recombinantes/metabolismo , SuperovulaçãoRESUMO
We report a case of amyloidosis cutis dyschromica with diffuse postinflammatory-type hypo- and hyperpigmentation all over the body. The diagnosis was confirmed with routine light microscopic and immunohistochemical staining methods. The patient was treated with acitretin with a good response.
Assuntos
Acitretina/administração & dosagem , Amiloidose/tratamento farmacológico , Amiloidose/patologia , Hipopigmentação/patologia , Dermatopatias/tratamento farmacológico , Dermatopatias/patologia , Adulto , Biópsia por Agulha , Relação Dose-Resposta a Droga , Esquema de Medicação , Seguimentos , Humanos , Hipopigmentação/tratamento farmacológico , Hipopigmentação/etiologia , Imuno-Histoquímica , Masculino , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Mycobacterium tuberculosis (H(37)R(v))-infected guinea-pig model was used to investigate the effect of water extract of propolis (WEP). After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n=9), isoniazid (n=5) or saline (n=6) as placebo and were sacrificed 30 days later. Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (P>0.05). The granuloma formation in the same group was more prominent than the placebo and isoniazid groups; however, this finding failed to reach statistical significance by the Kruskal-Wallis test (P>0.05). These findings suggest that Turkish WEP may have a limited effect on the development of tuberculosis infection in this guinea-pig model.
Assuntos
Antituberculosos/isolamento & purificação , Antituberculosos/uso terapêutico , Própole/isolamento & purificação , Própole/uso terapêutico , Tuberculose/tratamento farmacológico , Animais , Antituberculosos/farmacologia , Cobaias , Masculino , Mycobacterium tuberculosis/efeitos dos fármacos , Própole/farmacologia , Tuberculose/patologia , TurquiaRESUMO
OBJECTIVE AND IMPORTANCE: Intracranial solitary fibrous tumors have been described previously, but intraventricular solitary fibrous tumors are extremely rare. We present what is, to our knowledge, the first reported case of solitary fibrous tumor in the third ventricle. CLINICAL PRESENTATION: A 63-year-old man presented with weakness of his lower extremities and headaches. Computed tomography and magnetic resonance imaging of the brain revealed an enhancing mass in the posterior part of the third ventricle. INTERVENTION: The tumor originated from the wall of the left internal cerebral vein and extended to the posterior part of the third ventricle. Nearly total excision was performed via an infratentorial-supracerebellar approach. CONCLUSION: The differential diagnosis of intracranial solitary fibrous tumors includes fibroblastic meningioma, meningeal hemangiopericytoma, neurofibroma, and schwannoma. The differential diagnosis in the present case was greatly helped by the immunohistochemical and ultrastructural findings, along with a disease-free 3.5-year follow-up. These findings are presented with reference to previous reports.
Assuntos
Neoplasias do Ventrículo Cerebral/diagnóstico por imagem , Neoplasias do Ventrículo Cerebral/ultraestrutura , Fibroma/diagnóstico por imagem , Fibroma/ultraestrutura , Neoplasias do Ventrículo Cerebral/metabolismo , Fibroma/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , RadiografiaRESUMO
Calciphylaxis is a poorly understood and highly morbid syndrome of vascular calcification and skin necrosis. Hypercalcemia, hyperphosphatemia, and secondary hyperparathyroidism are the factors implicated in the pathogenesis of calciphylaxis, which is generally identified in patients with hyperparathyroidism secondary to end-stage renal disease. It has also been observed in primary hyperparathyroidism, end-stage liver disease, and rheumatoid arthritis, in the absence of renal disease. There are few case reports of calciphylaxis occurring in hypercalcemia of malignancy. An unusual case is reported of calciphylaxis associated with malignant melanoma of the soft parts in the absence of renal or parathyroid disease. This is the first reported case of this soft tissue sarcoma showing calciphylactic changes.