[Catatonic dilemma in a schizoaffective patient with combined lithium-risperidone administration]. / Katatones Dilemma unter Kombinationsbehandlung mit Lithium und Risperidon.

OBJECTIVE: The case of a schizoaffective patient suffering from a malignant catatonic syndrome following combined lithium-risperidone therapy is explored. METHOD: A case report and relevant deliberations regarding pathophysiology of the catatonic dilemma are discussed. CONCLUSIONS: There are two critical transitions in the development of a malignant catatonic syndrome. Dopaminergic system and psychopharmacological factors are supposed to play a key role. However, other neurotransmitter systems and the individual predisposition must be considered.

[Neurotoxicity related to lithium-risperidon combination treatment in a patient with schizoaffective disorder]. / Neurotoxische Enzephalopathie unter Kombinationsbehandlung mit Lithium und Risperidon bei einer Patientin mit schizoaffektiver Störung.

OBJECTIVE: The case of a schizoaffective patient with a neurotoxic encephalopathy related to lithium-risperidon combination treatment is explored. METHOD: A case report and the relevant theoretical and clinical deliberations are described. CONCLUSIONS: Neurotoxicity related to lithium-risperidon combination treatment is the result of an interaction of different ethiopathogenetic mechanisms. The EEG is the most important diagnostic parameter.