RESUMO
Aluminum sulfate, potash alum, ammonium alum, purified and unpurified nephelinic coagulant are assigned to the 3rd jeopardy class (moderately dangerous chemicals), sodium alum--to the 4th jeopardy class (slightly dangerous chemicals) at the single exposure. Local irritation of rabbit's skin was not revealed, but instillation into the eye results in conjunctivitis and purulent ophthalmitis. Aluminum sulfate and coagulants afflict the nervous system, liver and heart. The recommended MAC in the air of workplace for aluminum sulfate, potash alum, sodium alum and coagulants based on them is equal to 0.5 mg/m3.
Assuntos
Poluentes Ocupacionais do Ar , Compostos de Alúmen , Coagulantes , Saúde Ocupacional , Animais , Olho/efeitos dos fármacos , Coração/efeitos dos fármacos , Dose Letal Mediana , Fígado/efeitos dos fármacos , Concentração Máxima Permitida , Camundongos , Sistema Nervoso/efeitos dos fármacos , Coelhos , Ratos , Pele/efeitos dos fármacos , Local de TrabalhoRESUMO
The study (experiments on animals and on culture of rats' peritoneal macrophages) covered fluorides of rare-earth metals (REM) assigned to yttrium group--yttrium, terbium, ytterbium, lutetium. Fluorides of REM have low toxicity and cumulativity, induce no local irritation of skin and eyes. Fluorides of yttrium, terbium and lutetium, if administered into stomach, result in specific intoxication (fluorosis). Fluoride of ytterbium did not cause such intoxication. According to short-term tests of cytotoxicity, the foreseeable fibrogenic danger for ytterbium fluoride is moderate, for fluorides of yttrium, terbium and lutetium is mild. The authors recommend to control the level of yttrium, terbium and lutetium fluorides in the air of workplace through the MACs for the fluorides at 2.5 mg/cu m (maximal single concentration) and 0.5 mg/cu m (average shift concentration), the level of ytterbium fluoride as moderate fibrogenic dust at 6 mg/cu m.