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Dis Esophagus ; 26(1): 22-6, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22332893

RESUMO

The ingestion of caustic substances may result in significant esophageal injury. There is no standard treatment protocol for esophageal injury and most patients are treated with a proton pump inhibitor or H2 antagonist. However, there is no clinical study evaluating the efficacy of omeprazole for caustic esophageal injury. A prospective study of 13 adult patients (>18 years of age) who were admitted to our hospital for caustic ingestion between May 2010 and June 2010 was conducted. Mucosal damage was graded using a modified endoscopic classification described by Zargar et al. Patients were treated with a proton pump inhibitor and maintained without oral intake until their condition was considered stable. Patients received omeprazole 80 mg in bolus IV, followed by continuous infusion of 8 mg/hour for 72 hours. A control endoscopy was performed 72 hours after admission. There was significant difference regarding endoscopic healing between the before and after omeprazole infusion (P = 0.004). There was no hospital mortality at the follow-up. Omeprazole may effectively be used in the acute phase treatment of caustic esophagus injuries.


Assuntos
Queimaduras Químicas/tratamento farmacológico , Cáusticos/intoxicação , Doenças do Esôfago/induzido quimicamente , Doenças do Esôfago/tratamento farmacológico , Omeprazol/administração & dosagem , Inibidores da Bomba de Prótons/administração & dosagem , Adulto , Queimaduras Químicas/patologia , Estudos de Coortes , Tratamento de Emergência/métodos , Esofagoscopia/métodos , Esôfago/efeitos dos fármacos , Esôfago/lesões , Feminino , Seguimentos , Humanos , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Mucosa/efeitos dos fármacos , Mucosa/patologia , Estudos Prospectivos , Medição de Risco , Resultado do Tratamento , Adulto Jovem
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