Morphologic Variations in the Circle of Willis as a Risk Factor for Aneurysm Rupture in the Anterior and Posterior Communicating Arteries.

BACKGROUND: Intracranial aneurysms are acquired abnormal vascular dilations. The most dangerous complication of a cerebral aneurysm is its rupture, with a high rate of mortality. This study aimed to determine whether there is an association between anatomic variations in the circle of Willis and ruptured aneurysms in the anterior and posterior communicating arteries. METHODS: A cross-sectional study of adult patients with a diagnosis of intracranial aneurysm was carried out between March 2015 and March 2019. The patients were divided into groups of ruptured or unruptured aneurysm in the anterior and posterior communicating arteries. RESULTS: A total of 132 patients with anterior and posterior communicating artery aneurysms were included. The presence of anatomic variation in the circle of Willis presented a statistically significant association with ruptured aneurysms (odds ratio [OR], 2.28; 95% confidence interval [CI], 1.11-4.65; P = 0.024). There was a statistically significant difference between the presence of nonspherical aneurysm and rupture (OR, 6.9; 95% CI, 3.12-15.48; P < 0.0001). Multivariate logistic regression observed smoking (OR, 2.4; 95% CI, 1.01-5.9; P = 0.4), anterior complex variations (OR, 2.68; 95% CI, 1.01-7.18; P < 0.04), and nonspherical morphology (OR, 4.7; 95% CI, 1.93-11.45; P = 0.001) presented a statistically significant association with the rupture. CONCLUSIONS: Our results suggest that the studied variations of the circle of Willis and nonspherical morphology, in addition to playing a role in the development of cerebral aneurysms, may contribute to their rupture.

Edema perianeurismático cerebral. Reporte de dos casos / Cerebral perianeurysmal edema. Report of two cases

La hemorragia subaracnoidea (HSA) secundaria a ruptura aneurismática es una causa importante de morbimortalidad. Hay muchos factores que aumentan la probabilidad de ruptura, como el tamaño, forma, localización, exclusión endovascular incompleta del aneurisma, entre otros. Existen reportes sobre el edema cerebral perianeurismático como factor de riesgo de ruptura aneurismática. Se presentan en el siguiente artículo dos casos, ambos con aneurisma silviano del lado derecho, asociado a edema "perianeurismático".

Subarachnoid hemorrhage (SAH) secondary to aneurysmal rupture is an important cause of morbidity and mortality. There are many factors that increase the probability of rupture, the size, shape, location, incomplete endovascular exclusion of the aneurysm, among others. There are reports on perianeurysmal cerebral edema as a risk factor for aneurysmal rupture. Two cases are presented in the following article, both with right-sided sylvian aneurysm, associated with "perianeursmatic" edema.

Surgical Indication Optimization of Brain Metastases Based on the Evolutionary Analysis of Karnofsky Performance Status.

BACKGROUND AND OBJECTIVE: Surgical resection of brain metastases (BM) offers the highest rates of local control and survival; however, it is reserved for patients with good functional status. In particular, the presence of BM tends to oversize the detriment of the overall functional status, causing neurologic deterioration, potentially reversible following symptomatic pharmacological treatment. Thus, a timely indication of surgical resection may be dismissed. We propose to identify and quantify these variations in the functional status of patients with symptomatic BM to optimize the indication of surgical resection. PATIENTS AND METHODS: Historic, retrospective cohort analysis of adult patients undergoing BM microsurgical resection, consecutively from January 2012 to May 2016, was conducted. The Karnofsky performance status (KPS) variation was recorded according to the symptomatic evolution of each patient at specific moments of the diagnostic-therapeutic algorithm. Finally, survival curves were delineated for the main identified factors. RESULTS: One hundred and nineteen resection surgeries were performed. The median overall survival was 243 days, while on average it was 305.7 (95% confidence interval [CI]: 250.6-360.9) days. The indication of surgical resection of 10% of the symptomatic patients in our series (7.5% of overall) could have been initially rejected due to pharmacologically reversible neurologic impairment. Survival curves showed statistically significant differences when KPS was stratified following pharmacological symptomatic treatment (p < 0.0001), unlike when they were estimated at the time of BM diagnosis (p = 0.1128). CONCLUSION: The preoperative determination of the functional status by KPS as an evolutive parameter after the nononcologic symptomatic pharmacological treatment allowed us to optimize the surgical indication of patients with symptomatic BM.

Application of Fibrin Rich in Leukocytes and Platelets in the Reconstruction of Endoscopic Approaches to the Skull Base.

BACKGROUND: The objective of this work is to report the feasibility and results of an institutional protocol for the application of an innovative biologically active hemoderivative autologous material, denominated leukocyte- and platelet-rich fibrin (L-PRF), in the reconstruction of endoscopic approaches to the sellar region. METHODS: L-PRF membranes were produced from centrifuged autologous venous blood. They were used for the reconstruction of transsphenoidal endoscopic approaches to the sellar region in 12 patients. The trophism of the mucosa was monitored during the first 30 days by means of fiberoptic endoscopic controls on the second and seventh postoperative days. Follow-up was performed to rule out complications up to 30 postoperatively days. RESULTS: The product obtained bore the characteristics of the original descriptions of L-PRF. Standardized preparation of L-PRF membranes promoted early regeneration of the sphenoid sinus mucosa to close endoscopic approaches to the sellar region. No complications within the first 30 postsurgical days were reported. CONCLUSIONS: L-PRF membranes offer characteristics that are superior to other techniques and products, mainly because of their role as biological promoters of tissue regeneration, their low economic cost, and immediate availability. However, it would be necessary to confirm these results in studies involving more patients.

[Relevance of Simpson's grades in the resection of grade I meningiomas]. / Relevancia de los grados de Simpson en la resección de meningiomas grado I.

OBJECTIVE: Compare the number of recurrences in patients with WHO Grade I meningiomas that underwent microsurgical resection. INTRODUCTION: In 1957 Simpson established five grades for surgical resection for intracranial meningiomas and recurrence rate. He thought that an aggressive removal of these tumors with dura and bone was necessary to cure them. Development of new diagnostic methods, advances in anatomopathology and microsurgical technique lead us to question if this scale has a value nowadays. METHODS: A retrospective analysis was performed. All patients operated from grade I meningiomas between February 2006 to December 2015 were included. Pre and postoperative MRI as well as histology were analyzed. A multivariate analysis was performed, a P < 0.05 was considered statistically significant. RESULTS: There was no statistical significant difference between patients undergoing Simpson Grade I, II, III or IV resection (P = 0,3117). This could be best stated for Simpson Grade I and II resection, where the number of patients included in the study was higher. When we analyze tumor location there was not significant difference in recurrence between groups (P = 0,2203). CONCLUSION: For grade I meningiomas there is no significant difference in the recurrence between patients with a Simpson Grade I or II resection, thus increasing morbidity of the surgery is not justified. A new resection scale should be designed taking into account the WHO classification.

[Pachymeningitis associated with IgG4 disease]. / Paquimeningitis asociada a enfermedad por IgG4.

Hypertrophic pachymeningitis is an infrequent disorder. It can be idiopathic or secondary to infectious, autoimmune or neoplastic disease. The recently described 〈IgG4-related disease〉 could be the origin of many cases considered cryptogenic. We present the case of a 60-year-old man, with a history of headache and episcleritis in both eyes, with partial response to corticoid therapy. The brain MR study with gadolinium showed enhancement and thickening of the dura mater, extending from lateral wall of left temporal and occipital lobes to ipsilateral tentorium. Meningeal biopsy showed fibrosis and lymphoplasmacytic infiltrate, with more than 10 IgG4+ plasma cells per high power field. After treatment with rituximab there was clinical improvement accompanied by the virtual disappearance of the alterations detected in neuroimaging. Hypertrophic pachymeningitis as a manifestation of IgG4-related disease can be based on MRI findings if plasma IgG4 are elevated.

Paquimeningitis asociada a enfermedad por IgG4 / Pachymeningitis associated with IgG4 disease

La paquimeningitis hipertrófica es una enfermedad infrecuente. Puede ser idiopática, secundaria a infección o enfermedad oncológica. Recientemente se la describió asociada a la enfermedad por IgG4, pudiendo ser esta la causa de muchas clasificadas como idiopáticas. Se presenta el caso de un hombre de 60 años de edad con historia de cefalea y epiescleritis, con respuesta parcial a corticoides. La resonancia magnética con contraste evidenciaba refuerzo meníngeo a nivel temporal y occipital izquierdo con extensión a la tienda del cerebelo. La biopsia meníngea demostró fibrosis e infiltrado linfoplasmocitario con más de 10 células plasmáticas IgG4 positivas por campo de gran aumento. El tratamiento con rituximab provocó mejoría clínica y radiológica. La paquimeningitis hipertrófica es una manifestación de la enfermedad por IgG4 y debe ser sospechada con la resonancia magnética y niveles plasmáticos altos de IgG4.

Hypertrophic pachymeningitis is an infrequent disorder. It can be idiopathic or secondary to infectious, autoimmune or neoplastic disease. The recently described ‹IgG4-related disease› could be the origin of many cases considered cryptogenic. We present the case of a 60-year-old man, with a history of headache and episcleritis in both eyes, with partial response to corticoid therapy. The brain MR study with gadolinium showed enhancement and thickening of the dura mater, extending from lateral wall of left temporal and occipital lobes to ipsilateral tentorium. Meningeal biopsy showed fibrosis and lymphoplasmacytic infiltrate, with more than 10 IgG4+ plasma cells per high power field. After treatment with rituximab there was clinical improvement accompanied by the virtual disappearance of the alterations detected in neuroimaging. Hypertrophic pachymeningitis as a manifestation of IgG4-related disease can be based on MRI findings if plasma IgG4 are elevated.

La internacionalización de la educación superior: cómo el instituto universitario gestiona esta nueva función estratégica / The internationalization of higher education: how the instituto universitario manages this new strategic role

La Educación Superior persigue entre sus objetivos la promoción, la difusión y la preservación de la cultura, la investigación científica y tecnológica y la creación artística.Cumple las funciones de docencia, investigación y extensión universitaria.En la actualidad es imposible concebir cualquier emprendimiento humano en soledad, sin que existan la colaboración y la cooperación solidaria entre las personas.Las instituciones universitarias han tomado conciencia de esta realidad en la que el intercambio académico y estudiantil se encuentra en permanente crecimiento, y las vinculaciones institucionales aportan calidad institucional.Hoy la internacionalización de la educación es una realidad, y consecuentemente surgen actividades que emanan de esta nueva función universitaria.El Instituto Universitario del Hospital Italiano ha asumido esta realidad y ha sumado las acciones que de ella se derivan a su gestión educativa.En el contexto del Departamento de Relaciones Interinstitucionales (DRI) se reflexiona sobre las diferentes instancias de cooperación académica y se vehiculiza el intercambio de alumnos y docentes y la formalización de convenios y acuerdos.El presente trabajo desarrolla el concepto de Internacionalización de la Educación Superior y relata la metodología específica que emprende el DRI para el cumplimiento de esta nueva función universitaria.

A new classification of complications in neurosurgery.

OBJECTIVE: To define and grade neurosurgical and spinal postoperative complications based on their need for treatment. METHODS: Complications were defined as any deviation from the normal postoperative course occurring within 30 days of surgery. A four-grade scale was proposed based on the therapy used to treat the complications: grade I, any non-life-threatening complications treated without invasive procedures; grade II, complications requiring invasive management such as surgical, endoscopic, and endovascular procedures; grade III, life-threatening adverse events requiring treatment in an intensive care unit (ICU); and grade IV, deaths as a result of complications. Each grade was classified as a surgical or medical complication. An observational test of this system was conducted between January 2008 and December 2009 in a cohort of 1190 patients at the Hospital Italiano de Buenos Aires. RESULTS: Of 167 complications, 129 (10.84%) were classified as surgical, and 38 (3.19%) were classified as medical complications. Grade I (mild) complications accounted for 31.73%, grade II (moderate) complications accounted for 25.74%, and grade III (severe) complications accounted for 34.13%. The overall mortality rate was 1.17%; 0.84% of deaths were directly related to surgical procedures. CONCLUSIONS: The authors present a simple, practical, and easy to reproduce way to report negative outcomes based on the therapy administered to treat a complication. The main advantages of this classification are the ability to compare surgical results among different centers and times, the ability to compare medical and surgical complications, and the ability to perform future meta-analyses.

Factors related to surgical complications and their impact on the functional status in 236 open surgeries for malignant tumors in a Latino-American hospital.

BACKGROUND: There are not many studies that address the selection of patients harboring malignant brain tumors for open surgery. It is necessary, especially in developing countries, to establish the standards because of their impact not only on the efficacy but also on the cost-effectiveness of surgery. With the concern to add information that may help in future studies about the decision making, we proposed to analyze factors associated with surgical complications and evaluate their influence on the functional status at 30 days after surgery. METHODS: A consecutive series of 236 surgeries performed between June 1999 and June 2005 were retrospectively analyzed (168 gliomas, 65 metastases, 3 others). Variables evaluated were age, sex, pre- and postoperative KPS, ASA status, anatomic localization, extent of tumor resection, tumor histology, and number of surgeries. RESULTS: The incidence of complicated craniotomies was 15.68% and mortality was 2.97%. Postoperatively, 92% of the patients improved or maintained the functional status, whereas 8% worsened. In multivariate analysis, only preoperative KPS (P = .009), ASA status (P = .02), and histology type (P = .03) showed significant association with postoperative complications. CONCLUSIONS: We found that the neurologic and clinical preoperative condition and grade III gliomas were factors related to postoperative complications, whereas age, extent of resection, and number of surgeries were not risk factors. We believe that these conclusions provide an additional benchmark for future multicentric studies that focus on the selection criteria for resection of malignant brain tumors.

Linfoma no Hodgkin primario del sistema nervioso central en pacientes inmunocompetentes: nuestra experiencia / Primary non-Hodgkin lymphoma of the central nervous system in immunocompetent patients

Objetivo: Presentar 5 casos de linfomas primarios del sistema nervioso central. (LPS) en pacientes inmunocompetentes. Metodo: se consideraron estas variables: presentacion clinica, Karnofsky preoperatorio, topografia y multiplicidad lesional confirmacion histopatologica (cirugia versus biopsia) y sobrevida. Resultados: Cuatro pacientes presentaron un foco neurologico y uno un sindrome depresivo: todos presentaron Karnofsky > de 70. Las imagenes mostraron cuatro lesiones supratentoriales y una cerebelosa, todas bien delimitadas y captando homogeneamente el contraste: tres se resecaron, dos se biopsiaron estereotacticamente. El tratamiento se realizo con metotrexate aplicando radioterapia conformada en loas recaidas. A largo plazo un paciente vive libre de enfermedad, tres con enfermedad y uno fallecio al cuarto mes. CONCLUSION: Los LPS no presentan caracteristicas clinicoimagenologicas particulares para diferenciarlos de otros tumores pero su incidencia en aumento y el peor pronostico asociado a la reseccion parcial versus biopsia estereotactica, hace importante considerarlos como diagnostico diferencial al evaluar pacientes con masa expansiva intracerebral