RESUMO
Efim Osipovich Mukhin is an outstanding representative of Russian medical science who made an important contribution to the development of anatomo-physiological studies, establishment of surgery and traumatology as independent medical disciplines in this country, introduction of smallpox vaccination and aseptics into clinical practice as well as to the improvement of teaching medicine at universities.
Assuntos
Anatomia/história , Medicina Clínica/história , História do Século XVIII , História do Século XIX , Humanos , Federação RussaRESUMO
We studied the effect of antistress peptide Semax, an ACTH4-10 analogue, on the cellular composition of spleen lymphoid structures in Wistar rats with different stress tolerance in the course of post-stress recovery (days 1, 3, 14, and 30). Preliminary administration of Semax alleviates stress-induced proliferation of macrophages and destructive processes in functionally active zones of the rat spleen on days 1, 3, and 14 after the stress exposure, which attests to its capacity to reduce the adverse effects of 1-h stress load on proliferation of macrophages and destructive processes in functionally active zones of this organ.