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J Chromatogr B Biomed Sci Appl ; 700(1-2): 131-8, 1997 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-9390722

RESUMO

An assay was developed for the quantification of anastrozole [2,2'-[5-(1H-1,2,4-triazol-1-ymethyl)-1,3-phenylene]bis(2-++ +methylpropiononitrile)] in human plasma using liquid-liquid extraction. Anastrozole and an internal standard were chromatographed and detected by gas chromatography with electron capture detection, using a combination temperature-pressure program. The range of the assay is 3 to 100 ng/ml. Anastrozole was quantified by comparing its peak area to that of an internal standard. A cross-validation of this assay was also successfully performed between several laboratories.


Assuntos
Antineoplásicos Hormonais/sangue , Nitrilas/sangue , Triazóis/sangue , Anastrozol , Antineoplásicos Hormonais/farmacocinética , Cromatografia Gasosa/instrumentação , Estabilidade de Medicamentos , Feminino , Humanos , Nitrilas/farmacocinética , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Triazóis/farmacocinética
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