RESUMO
Microvasculature failure is expected in sepsis and at higher amine concentrations. Therefore, special attention focused individually on microcirculation is needed. Here, we present that methylene blue can prevent leukocytes from adhering to the endothelium in a rat model of lipopolysaccharide-induced endotoxemia. As hypothesis evidence, an intravital microscopy image is presented.
Assuntos
Sepse , Vasoplegia , Ratos , Animais , Azul de Metileno/farmacologia , Azul de Metileno/uso terapêutico , Vasoconstritores , Vasoplegia/tratamento farmacológico , Sepse/tratamento farmacológico , Microscopia IntravitalRESUMO
ABSTRACT Microvasculature failure is expected in sepsis and at higher amine concentrations. Therefore, special attention focused individually on microcirculation is needed. Here, we present that methylene blue can prevent leukocytes from adhering to the endothelium in a rat model of lipopolysaccharide-induced endotoxemia. As hypothesis evidence, an intravital microscopy image is presented.