Genomic landscapes of ovarian clear cell carcinoma from latin countries reveal aberrations linked to survival and progression.

BACKGROUND: Ovarian clear cell carcinomas (OCCCs) are rare, aggressive and chemoresistant tumors. Geographical and ethnic differences in the incidence of OCCC have been reported with a higher incidence in Asiatic countries. There is a paucity of information regarding OCCC in Latin America (LA) and other countries. METHODS: Here, we characterized two cohorts of 33 patients with OCCC from LA (24 from Brazil and 9 from Costa Rica) and a cohort of 27 patients from Spain. Genomic analysis was performed for 26 OCCC using the OncoScan platform. Tumors were classified according to their genomic landscapes into subgroups. Clinical parameters were related to the frequency of genomic aberrations. RESULTS: The median overall survival (OS) was not significantly different between the cohorts. Genomic landscapes were characterized by different homologous recombination deficiency (HRD) levels. No difference in the distribution of genomic landscapes profiles was detected between patients from the different cohorts. OCCCs with MYC-amplified tumors harboring a concomitant loss of a region in chromosome 13q12-q13 that includes the BRCA2 gene had the longest OS. In contrast, patients carrying a high number (> 30) of total copy number (CN) aberrations with no concomitant alterations in MYC and BRCA2 genes presented the shortest OS. Furthermore, amplification of the ASH1L gene was also associated with a shorter OS. Initial-stage OCCCs with early progression were characterized by gains in the JNK1 and MKL1 genes. CONCLUSIONS: Our results provide new data from understudied OCCC populations and reveal new potential markers for OCCCs.

Sintomas depressivos em acadêmicos de medicina da Universidade Federal de Goiás: um estudo de prevalência / Depressive symptoms in medical students of Universidade Federal de Goiás: a prevalence study

INTRODUÇÃO: O presente estudo teve como objetivo investigar a prevalência de sintomas depressivos em alunos de medicina da Universidade Federal de Goiás, comparando com a população em geral e verificando a possibilidade de determinado período do curso atuar como fator de risco. MÉTODO: Estudo transversal, descritivo, de amostra representativa de alunos regularmente matriculados na Faculdade de Medicina da Universidade Federal de Goiás. Foram selecionados 287 alunos do primeiro ao sexto ano através de sorteio aleatório simples. Utilizou-se, para avaliação, o Inventário de Depressão de Beck e um questionário de identificação. RESULTADOS: Na população entrevistada, 26,8 por cento apresentaram sintomas depressivos de acordo com escores do Inventário de Depressão de Beck estabelecidos para este estudo. A prevalência de sintomas depressivos moderados e graves entre os entrevistados foi de 6,9 por cento, enquanto 19,9 por cento apresentaram sintomas leves. Em relação ao sexo, encontrou-se 33,5 por cento de mulheres e 19 por cento de homens com sintomas depressivos. Em relação ao ano em curso, houve maior prevalência entre os alunos do terceiro e do quarto ano. Tristeza, anedonia, baixa auto-estima, perfeccionismo, irritabilidade, desinteresse por pessoas, redução da capacidade de trabalho e cansaço excessivo foram os itens do Inventário de Depressão de Beck mais pontuados. CONCLUSÃO: A prevalência de sintomas depressivos encontrada neste estudo é superior à média encontrada na população em geral, havendo indicativo de que a escola médica possa ser um fator predisponente para tais sintomas.

INTRODUCTION: The objective of the present study was to assess the prevalence of depressive symptoms among medical students of Universidade Federal de Goiás, Brazil, comparing them to the general population and investigating the possibility of a certain period throughout the course being a risk factor. METHOD: A cross-sectional descriptive study of a representative sample of students regularly enrolled at the Medical School of Universidade Federal de Goiás was performed. A total of 287 students from the first to sixth year were selected using simple random drawing. The Beck Depression Inventory and an identification questionnaire were used for evaluation. RESULTS: In the interviewed population, 26.8 percent had depressive symptoms according to the Beck Depression Inventory scores established for this study. The prevalence of moderate and severe depressive symptoms among the interviewees was 6.9 percent, while 19.9 percent had mild symptoms. As to gender, 33.5 percent of the women and 19 percent of the men had depressive symptoms. There was higher prevalence between third- and fourth-year students. Sadness, anhedonia, low self-esteem, perfectionism, irritability, lack of interest for people, reduced work capacity, and excessive tiredness were the most punctuated items of the Beck Depression Inventory. CONCLUSION: The prevalence of depressive symptoms found in this study is higher than the average found in the general population, and there is an indication that the medical school can be one of the predisposing factors for these symptoms.