RESUMO
A 69-year-old patient with no personal or family history of ichthyosis consulted our dermatology department for diffused cutaneous xerosis with intense pruritus evolving for 3 weeks. Physical examination revealed diffused ichthyosis of large polygonal fine scales on the skin without erythema (Figure 1). The lesions spared the face. Examination of the mucous membranes, hair, and nails revealed no abnormalities. There was no fever or adenomegaly. A skin biopsy revealed an orthokeratotic hyperkeratosis with thinning of granular layer (Figure 2). The initial diagnosis of acquired ichthyosis was maintained. The patient also reported a change in bowel habits since 2 weeks with watery, non-bloody diarrhea and mild steatorrhea. His laboratory investigations presented low serum vitamin B12 level, mild anemia, hypoalbuminemia, and fecal leukocytes; however, antinuclear antibodies, perinuclear anti-neutrophil cytoplasmic antibodies (pANCA), rheumatoid factor, and complement components C3 and C4 were normal. A colonoscopy performed was also normal without any abnormalities. Colon biopsies revealed histologic aspects of lymphocytic colitis with more than 20% increase in lymphocytes in the surface epithelium of colorectal mucosa. Laboratory investigations excluded neoplasia, hemopathies, or autoimmune-associated diseases. The patient was treated with salazopyrin with a remarkable lessening of diarrhea and cutaneous manifestations within 4 weeks (Figure 3).
Assuntos
Colite Linfocítica , Ictiose , Humanos , Idoso , Colite Linfocítica/diagnóstico , Ictiose/diagnóstico , Ictiose/etiologia , Pele , Diarreia/etiologiaRESUMO
A 61-year-old woman presented with a 3-year history of painless soft-tissue mass on the right sole. The patient reported gradual growth, with a rapid increase in size over the past few months, leading to difficulty in walking. She had no history of past trauma. Examination revealed a 4-cm ovoid mass located over the ball of the foot. It was firm in consistency, with well-defined margins, a smooth surface, and an overlying normal skin (Figure 1). An ultrasound image revealed an eccentric, hypoechoic, nonvascular subcutaneous lobular mass. A magnetic resonance imaging (MRI) of the foot revealed a well-defined mass arising from the flexor tendon sheath of the right foot. The lesion was heterogeneously hyperin-tense on T1- and T2-weighted images with an avid contrast enhancement. All of the surrounding soft tissues indicated normal signal intensity patterns. There was no associated bony destruction. Histopathologic examination after complete excision of the mass established a well-circumscribed lesion composed of osteoclast-like giant cells and mononuclear cells in a hyalinized stroma, consistent with a giant cell tumor of the tendon sheath (GCT-TS) (Figure 2). There was no recurrence during a 6-month follow-up period (Figure 3).
Assuntos
Tumor de Células Gigantes de Bainha Tendinosa , Tumores de Células Gigantes , Feminino , Humanos , Pessoa de Meia-Idade , Tendões/diagnóstico por imagem , Tendões/patologia , Tumores de Células Gigantes/diagnóstico , Tumores de Células Gigantes/cirurgia , Tumores de Células Gigantes/patologia , Tumor de Células Gigantes de Bainha Tendinosa/diagnóstico , Tumor de Células Gigantes de Bainha Tendinosa/cirurgia , Tumor de Células Gigantes de Bainha Tendinosa/patologia , Imageamento por Ressonância Magnética , Pé/patologiaRESUMO
Annular elastolytic giant cell granuloma (AEGCG) is a benign skin disorder, with, unknown cause. It appears as erythematous papules or annular plaques. Few challenging cases of AEGCG have been reported in the literature. We describe a rare clinical presentation of AEGCG mimicking cutaneous sarcoidosis.
RESUMO
Sweet syndrome is a rare inflammatory dermatosis that can be associated with various diseases, including leukemias. Physicians should be aware that a photodistributed clinical presentation of a pustular SS may reveal underlying malignancies, particularly hemopathies. If the hemopathy is known, recurrence lesions should be suspected of a relapse.
RESUMO
We report a 36-year-old male with an atypical variant of lipoma occurring on an atypical site.
RESUMO
Mycoplasma pneumoniae is a well-known cause of community-acquired pneumonia, mostly associated with dermatological manifestations especially with mucosal involvement and targetoid cutaneous lesions. For many years, it was considered among the spectrum of erythema multiforme. Recently, some authors have recommended the creation of a new syndrome called "mycoplasma-induced rash and mucositis." This new syndrome has distinct epidemiological, clinical and histological features making it different from drug-induced Stevens-Johnson syndrome, toxic epidermal necrosis and erythema multiforme. Herein, we report two patients with acute Mycoplasma pneumoniae respiratory tract infection presenting severe mucocutaneous lesions in accordance with this new syndrome.
Assuntos
Eritema Multiforme , Exantema , Mucosite , Pneumonia por Mycoplasma , Síndrome de Stevens-Johnson , Eritema Multiforme/complicações , Eritema Multiforme/diagnóstico , Exantema/etiologia , Humanos , Mucosite/induzido quimicamente , Mucosite/complicações , Mucosite/diagnóstico , Mycoplasma pneumoniae , Pneumonia por Mycoplasma/complicações , Pneumonia por Mycoplasma/diagnóstico , Síndrome de Stevens-Johnson/diagnósticoAssuntos
Infecções Oportunistas Relacionadas com a AIDS/complicações , Dermatite/diagnóstico , Granuloma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Infecções Oportunistas Relacionadas com a AIDS/patologia , Dermatite/patologia , Diagnóstico Diferencial , Granuloma/patologia , Humanos , Neoplasias Cutâneas/patologiaAssuntos
Granuloma Inguinal/diagnóstico , Dermoscopia , Humanos , Masculino , Tunísia , Adulto JovemRESUMO
Bullous morphea is a rare variant of localized scleroderma characterized by occasional intermittent blisters. Lichen sclerosus is a chronic inflammatory disease. The coexistence of morphea and lichen sclerosus has been reported in different sites in the same patient and more rarely in the same lesion. We report the case of a 54-year-old woman with an atypical presentation of bullous morphea and some histological features of lichen sclerosus. She presented with a 5-year history of an ulcerated plaque, with a sclerotic and atrophic center and indurated budding margins, localized on the lumbar back. Initially the diagnosis of a squamous cell carcinoma was suggested. A skin biopsy confirmed the diagnosis of bullous morphea and showed some histological features of lichen sclerosus. Topical betamethasone and silicone gel ointment were prescribed leading to complete healing of the ulceration within five months. Our case is unusual because of the atypical clinical presentation, the histological aspect combining signs of bullous morphea and lichen sclerosus, and the favorable results with the use of local corticotherapy and silicone gel.
Assuntos
Esclerodermia Localizada/patologia , Géis de Silicone/administração & dosagem , Administração Tópica , Corticosteroides/administração & dosagem , Feminino , Humanos , Pessoa de Meia-Idade , Esclerodermia Localizada/tratamento farmacológicoRESUMO
Lichen planus pigmentosus is uncommon in childhood and its treatment is often challenging. We report a case of cutaneous lichen planus pigmentosus in a 10-year-old boy, without oral mucosal involvement, two months after an amalgam dental restoration. The diagnosis was based on the histopathological examination of a skin biopsy, the positive patch test to mercury, and the improvement after amalgam removal. Our case report suggests that metal allergy may play a role, and amalgam replacement may be followed by clinical improvement.
Assuntos
Amálgama Dentário/efeitos adversos , Hiperpigmentação/etiologia , Hiperpigmentação/patologia , Hipersensibilidade Tardia/complicações , Líquen Plano/etiologia , Líquen Plano/patologia , Criança , Humanos , Hipersensibilidade Tardia/diagnóstico , Masculino , Testes do EmplastroAssuntos
Neoplasias de Cabeça e Pescoço/diagnóstico , Couro Cabeludo/patologia , Neoplasias das Glândulas Sebáceas/diagnóstico , Neoplasias Cutâneas/diagnóstico , Idoso de 80 Anos ou mais , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Masculino , Neoplasias das Glândulas Sebáceas/patologia , Neoplasias Cutâneas/patologiaAssuntos
Leucemia Linfocítica Crônica de Células B/diagnóstico , Metotrexato/administração & dosagem , Micose Fungoide/diagnóstico , Psoríase/diagnóstico , Neoplasias Cutâneas/diagnóstico , Idoso , Fármacos Dermatológicos/administração & dosagem , Esquema de Medicação , Humanos , Leucemia Linfocítica Crônica de Células B/complicações , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Masculino , Micose Fungoide/complicações , Micose Fungoide/tratamento farmacológico , Psoríase/complicações , Psoríase/tratamento farmacológico , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/tratamento farmacológicoAssuntos
Imunossupressores/efeitos adversos , Sarcoma de Kaposi/induzido quimicamente , Sarcoma de Kaposi/patologia , Neoplasias Cutâneas/induzido quimicamente , Neoplasias Cutâneas/patologia , Tacrolimo/efeitos adversos , Adulto , Humanos , Hospedeiro Imunocomprometido , Transplante de Rim , Masculino , Sarcoma de Kaposi/diagnóstico , Neoplasias Cutâneas/diagnósticoRESUMO
Multiple myeloma (MM) is a rare cancer. Cutaneous involvement is uncommon with fewer than 100 cases described in the literature. We report herein a patient with MM, subtype IgA kappa, with unusual clinical presentation including the lower lip.