Fitness Levels and Gender Are Related With the Response of Plasma Adipokines and Inflammatory Cytokines in Prepubertal Children.

Background and Aim: Changes in adipokines have been related with the development of metabolic syndrome, frequently associated with obesity, and other risk factors. Fitness seems to promote a healthy cardiovascular status and could be a protector factor, just from childhood. Therefore, the present study aimed to evaluate the relationship between fitness levels with plasma adipokines and inflammatory biomarkers in prepubertal children. Methods: One hundred and thirty-seven healthy normal-weight prepubertal children were recruited from local schools and divided after performing the fitness tests, into two groups according to fitness level-low cardiovascular fitness group (LF) and equal or higher cardiovascular fitness group (HF). Anthropometric variables, blood pressure (BP) and plasma insulin, and leptin, resistin, adiponectin, tumor necrosis factor-alpha, hepatic growth factor, interleukin (IL)-8, monocyte chemoattractant protein-1, nerve growth factor (NGF), and plasminogen activator inhibitor-1 (PAI-1) were measured fasting in both groups to be compared. Univariate analysis of variance, comparative analysis, binary logistic regression, stepwise linear regression, and principal component analysis were conducted to evaluate the association between fitness, BMI, gender, and the biochemical parameters. Results: Girls and boys with HF presented lower waist circumference Z-score, BMI Z-score, systolic BP (only boys) as well as lower levels of leptin and NGF compared with their respective LF group. Regarding the association between variables, fitness showed an inverse relationship with BMI Z-score, leptin, PAI-1, HOMA-IR, resistin, IL-8, and NGF. Conclusion: An adequate level of fitness seems to protect against risk factors related to low-grade inflammation and altered adipokines that are related to the onset of obesity just from the prepubertal stage.

Prevention and educational intervention on bullying: physical education as an opportunity / Prevenção e intervenção educativa sobre o bullying: a educação física como uma oportunidade / Prevención e intervención educativa sobre el acoso escolar: la educación física como oportunidad

Bullying is a social problem characterized by intentional aggression over time, usually in school contexts and in cyberspace (cyberbullying). There has been growing interest in preventing that phenomenon to reduce its adverse effects. Different studies and reports suggest that Physical Education may be a setting of interest to promote attitudes and behaviors against bullying. This work examines the state of the debate in this area through scientific literature. Based on the analysis of the evidence, we conclude by making recommendations regarding strategies and skills that should be included in Physical Education curricula to prevent bullying and cyberbullying. Among those most widely used, we highlight cooperative methodologies, a teaching attitude that promotes a motivational climate focused on the task, and curricular integration of teaching resources that address skills and protective factors.

O bullying é um problema social caracterizado pela agressão intencional que ocorre ao longo do tempo, geralmente em contextos escolares e no ciberespaço (cyberbullying). Tem havido um interesse crescente na prevenção deste fenômeno, a fim de reduzir os efeitos adversos. Diferentes estudos e relatórios sugerem que o tema da Educação Física pode ser um cenário de interesse para promover atitudes e comportamentos contra o bullying. O objetivo deste trabalho é examinar o estado da questão nesta área através de uma revisão da literatura científica. Com base na análise das evidências, concluímos fazendo recomendações sobre estratégias e habilidades que devem ser incluídas nos currículos de Educação Física para prevenir o bullying e o cyberbullying. Dentre as mais utilizadas, destacamos as metodologias cooperativas, uma atitude de ensino que promove um clima motivacional focado na tarefa e a integração curricular de recursos didáticos que abordam habilidades e fatores de proteção.

El acoso escolar es un problema social caracterizado por la agresión intencional que se produce a lo largo del tiempo, generalmente en contextos escolares y en el ciberespacio (ciberacoso). Hay un creciente interés en la prevención de este fenómeno, con el fin de reducir sus efectos adversos. Diferentes estudios e informes sugieren que la Educación Física puede impulsar actitudes y comportamientos contra el acoso escolar. El objetivo de este trabajo es examinar, a través de una revisión de la literatura científica, el estado de este tema en el área. Con base en el análisis de las evidencias, concluimos con recomendaciones sobre estrategias y habilidades que deberían incluirse en los currículos de Educación Física para prevenir el acoso y el ciberacoso. Entre las más utilizadas, destacamos las metodologías cooperativas, una actitud docente que promueve un clima motivacional centrado en la tarea y la integración curricular de recursos didácticos que aborden habilidades y factores de protección.

Profile of oxidant and antioxidant activity in prepubertal children related to age, gender, exercise, and fitness.

Tissue damage resulting from oxidative stress induced by a pathological condition might have more serious consequences in children than in adults. Researchers have not yet identified particular markers - alone or in combination with others - of oxidative stress, or their role in pediatric diseases. The aim of this study was to identify gender-based biomarkers for measuring oxidative stress. Oxidative biomarkers were studied in 138 healthy Spanish children (85 boys, 53 girls) 7 to 12 years of age, at the prepubertal (Tanner I) stage, independent of body mass index (BMI), age, fitness (measured by 20-m shuttle run test), and physical activity (measured by participation in an after-school exercise program). The oxidative biomarkers measured were lipid peroxidation products, total nitrites, protein carbonyls, and oxidized glutathione (GSSG). The antioxidant biomarkers measured were total glutathione (TG), reduced glutathione (GSH), superoxide dismutase activity (SOD), and glutathione peroxidase activity. In the study population, height, weight, waist circumference, and BMI were lower in girls than in boys. For oxidative biomarkers, boys had higher levels of protein carbonyl than girls (p < 0.001). In spite of this, girls had higher levels of GSSG (p < 0.001) and TG (p = 0.001), and a lower GSH/GSSG ratio (p < 0.001) than boys. For the antioxidant response, girls had higher levels of SOD (p = 0.002) than boys. All analyses were adjusted for BMI, age, fitness, and physical activity. In conclusion, prepubertal girls had higher oxidative stress than boys, in addition to higher levels of SOD, independent of age, BMI, fitness, and physical activity.

Influence of intense exercise on saliva glutathione in prepubescent and pubescent boys.

Intense aerobic exercise has been found to prompt changes in oxidative stress, but in children remains almost unexplored. The aim was to investigate the effect of intense physical exercise on reduced glutathione (GSH as a biomarker of oxidative stress) and adrenocortical response (to verify a certain level of stress after exercise) in 38 prepubescent and 32 pubescent non-athlete boys. Four subgroups were established as puberty stage and physical fitness. Saliva samples were taken before and after incremental exercise testing to measure GSH, and cortisol levels. Saliva reduced glutathione levels were lower in all subgroups after exercise except in the prepubescent average fit group, significance being greater in the pubescent (P < 0.001) than in the prepubescent group (P < 0.01). Saliva cortisol increased after exercise in all except in the prepubescent "average fit" group. Physical exercise may give rise to oxidative stress and adrenocortical response in pubescent and prepubescent boys, depending on the duration and intensity of the test.