Prospective Study Assessing Impact of Ethylene Oxide Sterilization on Endoscopic Ultrasound Image Quality.

BACKGROUND & AIMS: Duodenoscope-associated transmission of infections has raised questions about efficacy of endoscope reprocessing using high-level disinfection (HLD). Although ethylene oxide (ETO) gas sterilization is effective in eradicating microbes, the impact of ETO on endoscopic ultrasound (EUS) imaging equipment remains unknown. In this study, we aimed to compare the changes in EUS image quality associated with HLD vs HLD followed by ETO sterilization. METHODS: Four new EUS instruments were assigned to 2 groups: Group 1 (HLD) and Group 2 (HLD + ETO). The echoendoscopes were assessed at baseline, monthly for 6 months, and once every 3 to 4 months thereafter, for a total of 12 time points. At each time point, review of EUS video and still image quality was performed by an expert panel of reviewers along with phantom-based objective testing. Linear mixed effects models were used to assess whether the modality of reprocessing impacted image and video quality. RESULTS: For clinical testing, mixed linear models showed minimal quantitative differences in linear analog score (P = .04; estimated change, 3.12; scale, 0-100) and overall image quality value (P = .007; estimated change, -0.12; scale, 1-5) favoring ETO but not for rank value (P = .06). On phantom testing, maximum depth of penetration was lower for ETO endoscopes (P < .001; change in depth, 0.49 cm). CONCLUSIONS: In this prospective study, expert review and phantom-based testing demonstrated minimal differences in image quality between echoendoscopes reprocessed using HLD vs ETO + HLD over 2 years of clinical use. Further studies are warranted to assess the long-term clinical impact of these findings. In the interim, these results support use of ETO sterilization of EUS instruments if deemed clinically necessary.

Oritavancin polymethylmethacrylate (PMMA)-compressive strength testing and in vitro elution.

BACKGROUND: Polymethylmethacrylate (PMMA) is used for local antimicrobial delivery in orthopedic infection. Oritavancin is a long half-life lipoglycopeptide with broad activity against Gram-positive bacteria. Herein, we addressed if 7.5% w/w oritavancin mixed into PMMA affects PMMA strength and whether it elutes from PMMA, compared to vancomycin. METHODS: Elution was assessed by placing an oritavancin- or vancomycin-loaded bead in a flow system with human plasma. Compressive strength of bland compared to oritavancin- or vancomycin-loaded PMMA was assessed after 0, 3, and 7 days of soaking in 1 ml of pooled normal human plasma at 37 °C, by testing to failure in axial compression using a servo-hydraulic testing machine. RESULTS: Median compressive strength on days 0, 3, and 7 for bland PMMA compared to oritavancin- or vancomycin-loaded PMMA was 80.1, 79.4, and 72.4 MPa, respectively; 93.3, 86.4, and 65.3 MPa, respectively; and 97.8, 82.7, and 65.9 MPa, respectively. Oritavancin reduced PMMA compressive strength after 3 and 7 days (P = 0.0250 and 0.0039, respectively), whereas vancomycin reduced the PMMA compressive strength after 0, 3, and 7 days (P = 0.0039, 0.0039, and 0.0062, respectively) as compared to bland PMMA. Oritavancin-loaded PMMA had higher compressive strength than vancomycin-loaded PMMA on days 3 and 7 (P = 0.0039 and 0.0062, respectively). Compressive elastic moduli were 1226, 1299, and 1394 MPa for bland PMMA; 1253, 1078, and 1245 MPa for oritavancin-loaded PMMA; and 986, 879, and 779 MPa for vancomycin-loaded PMMA on days 0, 3 and 7, respectively. Oritavancin-loaded PMMA had higher compressive elastic moduli than vancomycin-loaded PMMA on days 0 and 7 (P = 0.0250 and 0.0062, respectively). Following polymerization, 1.0% and 51.9% of the initial amount of oritavancin and vancomycin were detected, respectively. Cmax, Tmax, and AUC0-24 were 1.7 µg/ml, 2 h, and 11.4 µg/ml for oritavancin and 21.4 µg/ml, 2 h, and 163.9 µg/ml for vancomycin, respectively. CONCLUSIONS: Oritavancin-loaded PMMA had higher compressive strength than vancomycin-loaded PMMA on days 3 and 7 and higher compressive elastic moduli than vancomycin-loaded PMMA on days 0 and 7. However, proportionally less oritavancin than vancomycin eluted out of PMMA.

Effects of axial forearm instability on force transmission across the elbow.

BACKGROUND: The interosseous membrane (IOM) and distal radioulnar joint (DRUJ) provide axial stability to the forearm. Our hypothesis was that injury to these structures alters force transmission through the elbow. METHODS: A custom-designed apparatus that applies axial loads from the wrist to the elbow was used to test 10 cadaveric upper limbs under the following simulated conditions (1) intact, (2) DRUJ injury, (3) IOM injury, or (4) IOM + DRUJ injury. IOM injury was simulated by osteotomies of the IOM attachment to the radius, and DRUJ injury was simulated by distal ulnar oblique osteotomy. We applied 160 N of axial force during cyclic and functional range of forearm rotation (40o pronation/40o supination), and force, contact pressure, and contact area through the elbow joint were measured simultaneously. RESULTS: The force across the radiocapitellar joint was significantly higher in the IOM + DRUJ injury and the IOM injury groups than in the intact and DRUJ injury groups. The mean force across the radiocapitellar joint was not significantly different between the intact and DRUJ injury groups or between the IOM + DRUJ injury and the IOM injury groups. Forces across the ulnohumeral joint showed an inverse pattern to those in the radiocapitellar joint. CONCLUSIONS: These findings suggest that injury to the IOM contributes more to the disruption of the normal distribution of axial loads across the elbow than injury to the DRUJ.

Engineered tendon-fibrocartilage-bone composite and bone marrow-derived mesenchymal stem cell sheet augmentation promotes rotator cuff healing in a non-weight-bearing canine model.

Reducing rotator cuff failure after repair remains a challenge due to suboptimal tendon-to-bone healing. In this study we report a novel biomaterial with engineered tendon-fibrocartilage-bone composite (TFBC) and bone marrow-derived mesenchymal stem cell sheet (BMSCS); this construct was tested for augmentation of rotator cuff repair using a canine non-weight-bearing (NWB) model. A total of 42 mixed-breed dogs were randomly allocated to 3 groups (n = 14 each). Unilateral infraspinatus tendon underwent suture repair only (control); augmentation with engineered TFBC alone (TFBC), or augmentation with engineered TFBC and BMSCS (TFBC + BMSCS). Histomorphometric analysis and biomechanical testing were performed at 6 weeks after surgery. The TFBC + BMSCS augmented repairs demonstrated superior histological scores, greater new fibrocartilage formation and collagen fiber organization at the tendon-bone interface compared with the controls. The ultimate failure load and ultimate stress were 286.80 ± 45.02 N and 4.50 ± 1.11 MPa for TFBC + BMSCS group, 163.20 ± 61.21 N and 2.60 ± 0.97 MPa for control group (TFBC + BMSCS vs control, P = 1.12E-04 and 0.003, respectively), 206.10 ± 60.99 N and 3.20 ± 1.31 MPa for TFBC group (TFBC + BMSCS vs TFBC, P = 0.009 and 0.045, respectively). In conclusion, application of an engineered TFBC and BMSCS can enhance rotator cuff healing in terms of anatomic structure, collagen organization and biomechanical strength in a canine NWB model. Combined TFBC and BMSCS augmentation is a promising strategy for rotator cuff tears and has a high potential impact on clinical practice.

Articular Contact Area and Pressure in Posteromedial Rotatory Instability of the Elbow.

BACKGROUND: Joint incongruity in posteromedial rotatory instability (PMRI) has been theorized to determine early articular degenerative changes. Our hypothesis was that the articular contact area and contact pressure differ significantly between an intact elbow and an elbow affected by PMRI. METHODS: Seven cadaveric elbows were tested under gravity varus stress using a custom-made machine designed to simulate muscle loads and allow passive elbow flexion (0° to 90°). The mean contact area and contact pressure data were collected and processed using the Tekscan sensor and software. After testing the intact specimen (intact elbow), a PMRI injury was simulated (PMRI elbow) and the specimen was tested again. RESULTS: The PMRI elbows were characterized by initial joint subluxation and significantly elevated articular contact pressure. Both worsened, corresponding with a reduction in contact area, as the elbow was flexed from 0° until the joint subluxation and incongruity spontaneously reduced (at a mean [and standard error] of 60° ± 5° of flexion), at which point the mean contact pressure decreased from 870 ± 50 kPa (pre-reduction) to 440 ± 40 kPa (post-reduction) (p < 0.001) and the mean contact area increased from 80 ± 8 mm to 150 ± 58 mm (p < 0.001). This reduction of the subluxation was also followed by a shift of the contact area from the coronoid fracture edge toward the lower portion of the coronoid. At the flexion angle at which the PMRI elbows reduced, both the contact area and the contact pressure of the intact elbows differed significantly from those of the PMRI elbows, both before and after the elbow reduction (p < 0.001). CONCLUSIONS: The reduction in contact area and increased contact pressures due to joint subluxation and incongruity could explain the progressive arthritis seen in some elbows affected by PMRI. CLINICAL RELEVANCE: This biomechanical study suggests that the early degenerative changes associated with PMRI reported in the literature could be subsequent to joint incongruity and an increase in contact pressure between the coronoid fracture surface and the trochlea.

Axial load transmission through the elbow during forearm rotation.

BACKGROUND: Forearm rotation is closely associated with the axiorotational force transmission through the elbow joint. A technique has been developed to study the transmission of force across the radiocapitellar and ulnotrochlear joints during forearm rotation. METHODS: Ten human cadaveric upper limbs were prepared on a custom-designed apparatus that permits the application of extrinsic axial loads across an intact cadaveric elbow joint. A force-sensitive transducer was inserted into the elbow joint of each cadaver. A 160 N axial force was applied to the specimen during cyclic forearm rotation while the force, contact pressure, and contact area through the elbow joint were measured. RESULTS: The mean force across the radiocapitellar joint showed no significant difference between pronation and supination (P = .3547). The radiocapitellar joint showed significantly higher contact area (P = .0001) and lower contact pressure (P = .0001) in pronation than in supination. The mean values for contact pressure, area, and force across the ulnotrochlear joint were not significantly different between supination and pronation. CONCLUSION: The contact pressure and contact area of the radiocapitellar joint in the cadaveric model changed according to forearm rotation while the force remained constant. The mean contact pressure of the radiocapitellar joint in pronation was significantly lower than that in supination because the force across it did not change significantly and its contact area decreased significantly. These findings may suggest that the pronated elbow can play an important role in protecting the radiocapitellar joint in high-impact activities like delivering punch in martial arts or falling on an outstretched arm.

Coronoid reconstruction using osteochondral grafts: a biomechanical study.

HYPOTHESIS: The purposes of this study were to test the hypothesis that coronoid deficiency in the setting of posteromedial rotatory instability (PMRI) must be reconstructed to restore articular contact pressures to normal and to compare 3 different osteochondral grafts for this purpose. METHODS: After creation of a anteromedial fracture, six cadaveric elbows were tested under gravity varus stress using a custom-made machine designed to simulate muscle loads and to passively flex the elbow. Mean articular surface contact pressure data were collected and processed using TekScan sensors and software. After testing of the intact specimen (intact condition), a PMRI injury was created (PMRI condition). Testing was repeated after reconstruction of the lateral collateral ligament (LCL) (LCL-only condition), followed by reconstruction of the coronoid with 3 different osteochondral graft techniques (reconstructed conditions). RESULTS: Contact pressure was consistently significantly higher in the PMRI elbow compared with the intact, LCL-only, and reconstructed conditions (P < .006). The LCL-only elbow contact pressure was significantly higher than that of the intact and reconstructed conditions from 5° to 55° of flexion (P = .018). The contact pressure of the intact elbow was never significantly different from that of the reconstructed elbow, except at 5° of flexion (P ≤ .008). No significant difference was detected between each of the reconstructed techniques (P ≥ .15). However, the annular surface of the radial head was the only graft that yielded contact pressures not significantly different from normal at any flexion angle. CONCLUSION: Isolated reconstruction of the LCL did not restore native articular surface contact pressure, and reconstruction of the coronoid using osteochondral graft was necessary. There was no difference in contact pressures among the 3 coronoid reconstruction techniques.

Role of the lateral collateral ligament in posteromedial rotatory instability of the elbow.

BACKGROUND: Posteromedial rotatory instability (PMRI) of the elbow consists of an anteromedial coronoid fracture with lateral collateral ligament (LCL) and posterior bundle of the medial collateral ligament (PMCL) tears. We hypothesized that the LCL tear is required for elbow subluxation/joint incongruity and that an elbow affected by an anteromedial subtype 2 coronoid fracture and a PMCL tear exhibits contact pressures different from both an intact elbow and an elbow affected by PMRI. MATERIALS AND METHODS: Six cadaveric elbows were tested under gravity varus stress using a custom-made machine designed to simulate muscle loads and to passively flex the elbow from 0° to 90° and measure joint contact pressures. After testing of the intact specimen (INTACT-elbow), an anteromedial subtype 2 coronoid fracture with a PMCL tear (COR+PMCL-elbow) and a PMRI injury (PMRI-elbow), after adding an LCL tear, were tested. The highest values of mean contact pressure were used for the comparison among the 3 groups. RESULTS: Neither subluxation nor joint incongruity was observed in the COR+PMCL-elbow. The addition of an LCL detachment consistently caused subluxation and joint incongruity. Mean contact pressures were higher in the COR+PMCL-elbow compared with the INTACT-elbow (P < .03) but lower than in the PMRI-elbow (P < .001). CONCLUSIONS: The LCL lesion in PMRI is necessary for elbow subluxation and causes marked elevations in contact pressures. Even without subluxation, the COR+PMCL-elbow showed higher contact pressures compared with the INTACT-elbow. Treatment of PMRI should be directed toward prevention of joint incongruity, whether by surgical or nonsurgical means, to prevent high articular contact pressures.

Influence of radial head prosthetic design on radiocapitellar joint contact mechanics.

HYPOTHESIS: Our aim was to test whether anatomically designed metallic radial head implants could better reproduce native radiocapitellar contact pressure and areas than nonanatomic implants. METHODS: The distal humerus and proximal radius from 6 cadaveric upper extremities were serially tested in supination with 100 N of compression force at 4 angles of flexion (0°, 30°, 60°, and 90°). By use of a thin flexible pressure transducer, contact pressures and areas were measured for the native radial head, an anatomic implant, a nonanatomic circular monopolar implant, and a bipolar nonanatomic implant. The data (mean contact pressure and mean contact area) were modeled using a 2-factor repeated-measures analysis of variance with P ≤ .05 considered to be significant. RESULTS: The mean contact areas for the prosthetic radial heads were significantly less than those seen with the intact radial heads at every angle tested (P < .01). The mean contact pressures increased significantly with all prosthetic radial head types as compared with the native head. The mean contact pressures increased by 29% with the anatomic prosthesis, 230% with the monopolar prosthesis, and 220% with the bipolar prosthesis. Peak pressures of more than 5 MPa were more commonly observed with both the monopolar and bipolar prostheses than with the anatomic or native radial heads. CONCLUSIONS: The geometry of radial head implants strongly influences their contact characteristics. In a direct radius-to-capitellum axial loading experiment, an anatomically designed radial head prosthesis had lower and more evenly distributed contact pressures than the nonanatomic implants that were tested.

Biomechanical analysis of a novel locking plate with smooth pegs versus a conventional locking plate with threaded screws for proximal humerus fractures.

BACKGROUND: Repair of proximal humeral fractures with locking plates has greatly improved outcomes. However, an alarming rate of complications including screw cutout and impingement under the acromion has recently been reported. A novel locking plate with smooth pegs was developed to reduce these risks. The purpose of this study was to compare these 2 fixation methods with a cadaveric biomechanical study. MATERIALS AND METHODS: Fourteen pairs of cadaveric proximal humeri (mean age, 77 years) were harvested, and bone density was measured. Osteosynthesis was performed on each pair using either a locking plate with threaded screws (TS group) or smooth pegs (SP group) on the contralateral side. Seven pairs of humeri were tested for cyclic bending, and 7 pairs for cyclic torsional evaluation: TS bending, SP bending, TS torsion, and SP torsion. The bending protocol consisted of cyclically loading to a maximum of 7.5 Nm bending moment for 10,000 cycles. The torsion protocol consisted of ±2 Nm of axial torque for 10,000 cycles. Surgical neck fractures were simulated by excising a 10-mm wedge of bone. RESULTS: No implant failure or screw cutout was observed in any of the groups tested. Under bending loads, mean displacement of the distal fragment was significantly less for the SP group than that for the TS group over 5,000 cycles. In torsion tests, no significant differences were observed between the 2 fixation methods. DISCUSSION: The SP group demonstrated superior biomechanical characteristics to the TS group in regards to cyclic bending.

The stabilizing effect of the distal interosseous membrane on the distal radioulnar joint in an ulnar shortening procedure: a biomechanical study.

BACKGROUND: The importance of the stabilizing effect of the distal interosseous membrane on the distal radioulnar joint, especially in patients with a distal oblique bundle, has been described. The purpose of this study was to evaluate the stability of the distal radioulnar joint after an ulnar shortening osteotomy and to quantify longitudinal resistance to ulnar shortening when the osteotomy was proximal or distal to the ulnar attachment of the distal interosseous membrane. These relationships were characterized for forearms with or without a distal oblique bundle. METHODS: Ten fresh-frozen cadavers were used. A transverse osteotomy and ulnar shortening was performed proximal (proximal shortening) and distal (distal shortening) to the ulnar attachment of the distal interosseous membrane. Distal radioulnar joint laxity was evaluated as the volar and dorsal displacements of the radius relative to the fixed ulna with 20 N of applied force. Testing was performed under controlled 1-mm increments of ulnar shortening up to 4 mm, with the forearm in neutral alignment, 60° of pronation, and 60° of supination. Resistance to ulnar shortening was quantified as the slope of the load-displacement curve obtained by displacing the distal ulnar segment proximally. RESULTS: In proximal shortening, significantly greater stability of the distal radioulnar joint was obtained with even 1 mm of shortening compared with the control, whereas distal shortening demonstrated significant improvement in stability of the distal radioulnar joint only after shortening of ≥4 mm in all rotational positions. Significantly greater stability of the distal radioulnar joint was achieved with proximal shortening than with distal shortening and in specimens with a distal oblique bundle than in those without a distal oblique bundle. The longitudinal resistance to ulnar shortening was significantly greater in proximal shortening than in distal shortening. The stiffness in proximal shortening was not affected by the presence of a distal oblique bundle in the distal interosseous membrane. CONCLUSIONS: Ulnar shortening with the osteotomy carried out proximal to the attachment of the distal interosseous membrane had a more favorable effect on stability of the distal radioulnar joint compared with distal osteotomy, especially in the presence of a distal oblique bundle.

The biomechanical effect of the distal interosseous membrane on distal radioulnar joint stability: a preliminary anatomic study.

PURPOSE: The distal interosseous membrane (DIOM) is a secondary stabilizer of the distal radioulnar joint (DRUJ) and has a considerably variable morphology. The purpose of this study was to investigate whether innate DRUJ stability is influenced by the anatomic variation of the DIOM. METHODS: Ten fresh-frozen cadaver upper extremities were used in this study. The humerus and the ulna were affixed rigidly to a custom-made apparatus, with the elbow in 90° of flexion. Testing was performed by translating the radius in volar and dorsal directions relative to the ulna, with a 20-N applied force in neutral forearm alignment, 60° pronation, and 60° supination. Total translation of the radius was measured as DRUJ laxity. After the experiment, we investigated anatomic variation of the DIOM, especially regarding the existence of the distal oblique bundle (DOB), which is a notably thick fiber within the DIOM. We compared the DRUJ stability between the groups with and without the DOB. RESULTS: The DOB was found in 4 of 10 specimens. The group with a DOB demonstrated a significantly greater DRUJ stability in the neutral position than the group without a DOB. In pronated and supinated forearm positions, no significant difference in DRUJ stability was obtained between the groups with and without a DOB. CONCLUSIONS: Innate DRUJ stability in the neutral forearm position was greater in the group with a DOB than in those without a DOB. CLINICAL RELEVANCE: This study suggests that considerable variation exists in DRUJ laxity and that it partially depends on anatomical variations of the DIOM.

Radial head prosthesis micromotion characteristics: Partial versus fully grit-blasted stems.

BACKGROUND: Compared to fully textured prosthetic stems, partial texturing lessens bone loss due to stress shielding and makes removal easier. However, initial press-fit stability is necessary for bone ingrowth. HYPOTHESIS: There is no significant difference in the initial stability of radial head prostheses that are partially grit-blasted compared to those that are fully grit-blasted. MATERIALS AND METHODS: Cadaveric radii were implanted with partial or fully grit-blasted radial head prostheses. Micromotion of the stem at the isthmus of the canal and stem tip were measured under circumstances simulating eccentric loads. RESULTS: Micromotion was not significantly different in the fully grit-blasted stems (isthmus, 11 ± 1 µm; tip, 21 ± 2 µm) and partially grit-blasted stems (isthmus, 13 ± 2 µm; tip, 25 ± 2 µm) (P = 0.4). The direction of loading had no effect on micromotion characteristics in either the fully or partially grit-blasted stems (P = .07). DISCUSSION: Micromotion is comparable in partially and fully grit-blasted radial head prosthetic stems. For both stem surfaces, micromotion was well within the range that is conducive for bone ingrowth. A partially textured stem might have less bone loss due to stress shielding, making it easier to remove without destroying bone. CONCLUSION: The initial stability of a radial head stem that is partially grit-blasted only at the proximal end is comparable to that of a radial head stem that is grit-blasted along its entire length.

Biomechanical evaluation of the dynamic radioulnar convergence after ulnar head resection, two soft tissue stabilization methods of the distal ulna and ulnar head prosthesis implantation.

INTRODUCTION: The biomechanical performance of the Darrach procedure, its stabilizing methods and the effectiveness of an ulnar head prosthesis was evaluated in this experiment. PURPOSE: The purpose of this study was to: (1) analyze the dynamic effects of the resection of the distal ulna on radioulnar convergence; and (2) evaluate the mechanical performance of two soft tissue stabilizing procedures (pronator quadratus advancement flap and ECU/FCU tenodesis) for the unstable distal ulnar stump and the implantation of an ulnar head prosthesis (uHead) following a distal ulnar resection (Darrach procedure) on radioulnar convergence. METHOD: With a dynamic PC-controlled forearm simulator, cadaveric forearm rotation was actively and passively performed while simultaneously loading the relevant muscles. The resultant total forearm torque and the three-dimensional kinematics of the ulna, radius and third metacarpal were simultaneously recorded in seven fresh-frozen cadaver upper extremities. RESULTS: The resection of the distal ulna created an extreme instability of the forearm with movement of the radius toward the ulna (0.92-0.38 cm compared to the intact state) in each particular loading condition. The implantation of the ulnar head prosthesis effectively restored the stability of the DRUJ by simulating the geometry of the ulnar head. There were significantly better results after the implantation of the prosthesis compared with the Darrach and the soft tissue stabilization procedures. CONCLUSION: This study provides laboratory validity to the option of implanting an ulnar head endoprosthesis as an attempt to stabilize the distal forearm with instability after Darrach resection in lieu of performing soft tissue stabilization techniques.

Biomechanical evaluation of posterior lumbar dynamic stabilization: an in vitro comparison between Universal Clamp and Wallis systems.

Treatment of chronic low back pain due to degenerative lumbar spine conditions often involves fusion of the symptomatic level. A known risk of this procedure is accelerated adjacent level degeneration. Motion preservation devices have been designed to provide stabilization to the symptomatic motion segment while preserving some physiologic motion. The aim of this study was to compare the changes in relative range of motion caused as a result of application of two non-fusion, dynamic stabilization devices: the Universal Clamp (UC) and the Wallis device. Nine fresh, frozen human lumbar spines (L1-Sacrum) were tested in flexion-extension, lateral bending, and axial rotation with a custom spine simulator. Specimens were tested in four conditions: (1) intact, (2) the Universal Clamp implanted at L3-4 (UC), (3) the UC with a transverse rod added (UCTR), and (4) the Wallis device implanted at L3-4. Total range of motion at 7.5 N-m was determined for each device and compared to intact condition. The UC device (with or without a transverse rod) restricted motion in all planes more than the Wallis. The greatest restriction was observed in flexion. The neutral position of the L3-4 motion segment shifted toward extension with the UC and UCTR. Motion at the adjacent levels remained similar to that observed in the intact spine for all three constructs. These results suggest that the UC device may be an appropriate dynamic stabilization device for degenerative lumbar disorders.

Stem diameter and micromotion of press fit radial head prosthesis: a biomechanical study.

BACKGROUND: Aseptic loosening of the stem, ranging from mild periprosthetic lucency to symptomatic loosening leading to implant removal, has been reported in press fit radial head prostheses. HYPOTHESIS: The purpose of this study was to determine the effect of the stem diameter and insertion force on initial stability with a press fit radial head prosthesis designed for bone ingrowth. MATERIALS AND METHODS: Cadaveric radii were implanted with radial head prostheses of increasing stem diameter. The insertion forces for each rasp and stem were measured. Micromotion of the stem at the isthmus of the canal and stem tip were measured under circumstances simulating eccentric loads. RESULTS: Insertion forces for all submaximum-sized rasps were similar. However, the insertion force for the maximum-sized rasp was approximately twice as large, and the insertion force for the oversized rasp was twice as large again, potentially indicating that the insertion force may be useful as a guide for determining appropriate stem size. Micromotions of the maximum diameter stem (isthmus, 41 microm; tip, 64 microm) were near the threshold for bone ingrowth, whereas the micromotions of the submaximum stem (isthmus, 253 microm; tip, 394 microm) were above this threshold. DISCUSSION: The maximum diameter stem achieved greater stability (minimum micromotion) compared with the submaximum diameter stem. CONCLUSION: The best fixation strength in the press fit radial head prosthesis was achieved by maximum sizing in the neck canal.

Radiocapitellar joint stability with bipolar versus monopolar radial head prostheses.

BACKGROUND: Bipolar and monopolar designs are both available for replacement of the radial head. Few data exist comparing the biomechanical characteristics of these 2 quite different prostheses. This study evaluated the relative contribution to radiocapitellar stability by concavity compression with these 2 types of radial head prostheses. METHODS: The study used 12 fresh frozen elbow cadavers. The capitellum of the distal humerus and 3 different conditions of radial head (native, monopolar and bipolar) were tested for radiocapitellar joint stability. RESULTS: The monopolar metallic head and the native radial head behaved similarly regarding resistance to subluxation. The bipolar head behaved in an entirely opposite manner than the native and monopolar head and actually acted to facilitate subluxation. CONCLUSIONS: Mobility of radial head components, such as in the bipolar radial head, has a compromising effect on the concavity compression stability of the radiocapitellar joint. A monopolar implant is more effective in stabilizing the radiocapitellar joint than a bipolar radial head prosthesis.

Biomechanical evaluation of a new fixation device for the thoracic spine.

The technology used in surgery for spinal deformity has progressed rapidly in recent years. Commonly used fixation techniques may include monofilament wires, sublaminar wires and cables, and pedicle screws. Unfortunately, neurological complications can occur with all of these, compromising the patients' health and quality of life. Recently, an alternative fixation technique using a metal clamp and polyester belt was developed to replace hooks and sublaminar wiring in scoliosis surgery. The goal of this study was to compare the pull-out strength of this new construct with sublaminar wiring, laminar hooks and pedicle screws. Forty thoracic vertebrae from five fresh frozen human thoracic spines (T5-12) were divided into five groups (8 per group), such that BMD values, pedicle diameter, and vertebral levels were equally distributed. They were then potted in polymethylmethacrylate and anchored with metal screws and polyethylene bands. One of five fixation methods was applied to the right side of the vertebra in each group: Pedicle screw, sublaminar belt with clamp, figure-8 belt with clamp, sublaminar wire, or laminar hook. Pull-out strength was then assessed using a custom jig in a servohydraulic tester. The mean failure load of the pedicle screw group was significantly larger than that of the figure-8 clamp (P = 0.001), sublaminar belt (0.0172), and sublaminar wire groups (P = 0.04) with no significant difference in pull-out strength between the latter three constructs. The most common mode of failure was the fracture of the pedicle. BMD was significantly correlated with failure load only in the figure-8 clamp and pedicle screw constructs. Only the pedicle screw had a statistically significant higher failure load than the sublaminar clamp. The sublaminar method of applying the belt and clamp device was superior to the figure-8 method. The sublaminar belt and clamp construct compared favorably to the traditional methods of sublaminar wires and laminar hooks, and should be considered as an alternative fixation device in the thoracic spine.

The effect of glenoid component size on the stability of total shoulder arthroplasty.

Frequently, during the course of total shoulder arthroplasty, the measurement of the patient's native glenoid is between the available prosthetic glenoid sizes. Technically, it may be easier for the surgeon to implant a smaller glenoid component. Currently, there is no information regarding the difference in joint stability by use of glenoid components of different sizes. Stability ratio measurements were performed by use of a multiaxis testing machine with 3 different glenoid sizes (small, medium, and large) and compared by use of analysis of variance and the Tukey HSD test. Changes in the size of the glenoid component were found to have a significant effect on the stability ratio. At a load of 50 N, the stability ratio increased by 18% from the small to the medium glenoid component and by 15% from the medium to the large glenoid in the superoinferior axis. In the anteroposterior axis, the stability ratio increased by 17% from small to medium and by 10% from medium to large. The results from this study indicate a modest increase in stability when one chooses the larger of the 2 glenoid components.

An analysis of symmetry of torque strength of the forearm under resisted forearm rotation in normal subjects.

PURPOSE: To establish normative pronation and supination torque values in right-handed adults without evidence of upper-extremity dysfunction or impairment in the forearm positions of neutral, pronation, and supination. METHODS: Fifty-one normal right-handed participants ages 22 to 45 years were enrolled and tested in this study using a custom device that incorporated a torque cell and a grip system that produced a digital recording of the peak torque during maximal resisted pronation and supination in positions of neutral forearm rotation, 60 degrees pronation, and 60 degrees supination. RESULTS: The greatest peak torque strength for both male and female participants was found during resisted pronation in the supinated position. The peak torque values averaged 11.9 +/- 3.7 N.m on the right side and 10.4 +/- 3.3 N.m on the left side for men, and 6.0 +/- 1.4 N.m on the right side and 5.0 +/- 1.2 N.m on the left side for women. The weakest torque strengths were resisted pronation in the pronated position and resisted supination in the supinated position. CONCLUSIONS: Torque strength measurements are reliable and should be collected when treating patients with forearm dysfunction. Maximal torque follows the same pattern related to hand dominance as grip strength. Men generate average torque strengths that are approximately twice the magnitude of those generated by women.