RESUMO
A study of the level of the sex steroid receptors in the endometrium of women with the syndrome of insufficiency of the luteal phase of the cycle (ILP-syndrome) has shown that disorders of receptor processes affect, first of all, progesterone receptors. An increase in a degree of a delay of endometrial development was accompanied by a rise of the level of progesterone in the endometrium which depended on the estradiol-progesterone ratio in the circulation, detectable on the 20th day of the menstrual cycle. The ILP-syndrome is characterized by the sufficient induction of progesterone receptors at the end of the proliferative--the beginning of the luteal phase of the cycle and by their insufficient inhibition with a low level of progesterone in the middle of the luteal phase. Insufficient synthesis of receptors as a result of sharp hypoestrogenemia is less frequent. The primary affection of the receptor apparatus as a cause of the ILP-syndrome against a normal hormonal background in the examinees was undetectable.
Assuntos
Endométrio/análise , Fase Luteal/fisiologia , Receptores de Estradiol/análise , Receptores de Progesterona/análise , Adulto , Biópsia , Doença Crônica , Endométrio/metabolismo , Endométrio/patologia , Estradiol/sangue , Feminino , Humanos , Infertilidade Feminina/fisiopatologia , Ooforite/fisiopatologia , Progesterona/sangue , Salpingite/fisiopatologia , Síndrome , Fatores de TempoRESUMO
Changes in uterine estradiol and progesterone receptor content in patients with luteal insufficiency (the insufficient luteal phase/ILP/ syndrome developing in the presence of tubal and uterine inflammations, hyperandrogenism or insignificantly increased prolactin level were described. The level of steroid receptors is correlated to blood levels of the respective hormones throughout the cycle. It is suggested that changes in sex steroid receptors are secondary to disorders of progesterone and estradiol secretion in cases of the ILP syndrome developing in the presence of uterine and tubal inflammations, and in patients with increased blood prolactin. In hyperandrogenic patients with the ILP syndrome, nuclear progesterone receptors night possibly be inadequate.