1.
Mol Pharm
; 15(3): 768-797, 2018 03 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29303588
RESUMO
Spatial and temporal control over DNA cleavage by photoactivated enediynes can be complemented by additional factors such as the release of internal strain, chelation, pH changes, intramolecular H-bonds, and substituent effects. This review presents design and reactivity of photoactivated enediynes/enynes and analyses the chemical, biological, and photophysical challenges in their applications.