Knowledge and attitudes of health professionals in Chile towards people living with human immunodeficiency virus: A cross-national survey.

Introduction: People living with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) often experience discrimination from both other individuals and the health personnel who care for them. Chile has experienced a marked increase in the number of new HIV cases.Methods: Prospective cross-sectional study. The HIV/AIDS questionnaire for providers and health personnel was obtained from the International Planned Parenthood Federation, initially carrying out a pilot test and evaluating its validity.Results: A total of 784 health professionals answered the questionnaire correctly. Among them, 68.4% (n = 536) were women, and 36.2% (n = 284) were physicians. The study revealed that more than 90% of respondents had a positive attitude towards caring for people living with HIV, and more than 75% did not mind buying food from them or sharing services with them. Furthermore, more than 99% rejected the religiously endorsed labeling of people living with HIV/AIDS as immoral. Additionally, 95.5% (n = 749) mentioned that they did not feel anxious about knowing whether the next patient on their care list was living with HIV, and 76.9% (n = 603) of the respondents felt safe taking blood samples.Conclusions: Chilean health professionals have good knowledge about HIV infection and its mode transmission. Their attitudes towards people living with HIV are also generally positive.

CEA-delta could be a biomarker of tumor phenotype, clinical stage, and chemotherapeutic response in rectal cancer with OCT4-positive cancer stem cells.

Background: There is very limited evidence on biomarkers for evaluating the clinical behavior and therapeutic response in rectal cancer (RC) with positive expression of cancer stem cells (CSCs). Methods: An exploratory prospective study was conducted, which included fresh samples of tumor tissue from 109 patients diagnosed with primary RC. Sociodemographic, pathological and clinical characteristics were collected from medical records and survey. The OCT4 protein was isolated using the Western Blot technique. It was calculated the ΔCEA, ΔOCT4, and ΔOCT4/GUSB values by assessing the changes before and after chemotherapy, aiming to evaluate the therapeutic response. Results: Patients had an average age of 69.9 years, with 55% (n=60) being male. Approximately 63.3% of the tumors were undifferentiated, and the most frequent staging classification was pathological stage III (n=64; 58.7%). Initial positive expression was observed in 77.1% of the patients (n=84), and the median ΔCEA was -1.03 (-3.82 - 0.84) ng/ml, with elevated levels (< -0.94 ng/ml) found in 51.4% of the subjects (n=56). Being OCT4 positive and having an elevated ΔCEA value were significantly associated with undifferentiated tumor phenotype (p=0.002), advanced tumor progression stage (p <0.001), and negative values of ΔOCT4 (p <0.001) (suggestive of poor therapeutic response) compared to those without this status. Conclusion: This study identified a significant and directly proportional association among the values of ΔCEA, ΔOCT4, and ΔOCT4/GUSB. These findings suggest that ΔCEA holds potential as a clinical biomarker for determining the undifferentiated tumor phenotype, advanced clinical stage, and poor therapeutic response in RC with CSCs positive expression.

Eutanasia y suicidio asistido: revisión y análisis de marcos legales internacionales comparados con Colombia

El avance en materia de derechos humanos es indispensable durante el desarrollo de políticas públicas en salud y marcos legales que garanticen el cuidado integro de la salud; la eutanasia y suicidio asistido siguen siendo conceptos ampliamente discutidos desde la medicina, y especialmente en la bioética por el peso que poseen en la toma de decisiones del paciente terminal y cuidados paliativos. Estos términos, su uso, aprobación y regulación legal dependen de la influencia de diversos determinantes como la investigación biomédica, las creencias religiosas, los aspectos socioculturales, entre otros. Sin embargo, lo que permite la interpretación y observación de resultados son las practicas soportadas por las legislaciones de cada país; Colombia es el único país que ha despenalizado la eutanasia en la región y que progresa activamente en temas relacionados. En este orden de ideas, el objetivo de esta revisión consiste en analizar los marcos legales internacionales sobre la definición y uso de la eutanasia y el suicidio asistido, que permitan comprender la evolución de la normatividad sobre el cuidado al final de la vida.

Advances in human rights are indispensable during the development of public policies in health and legal frameworks that guarantee integral health care; euthanasia and assisted suicide continue to be concepts widely discussed in medicine, and especially in bioethics due to the weight they have in the decision-making process of the terminal patient and palliative care. These terms, their use, approval, and legal regulation depend on the influence of various determinants such as biomedical research, religious beliefs, and sociocultural aspects. However, what allows the interpretation and observation of results are the practices supported by the legislation of each country; Colombia is the only country that has decriminalized euthanasia in the region and is actively progressing in related issues. In this order of ideas, the objective of this review is to analyze the international legal frameworks on the definition and use of euthanasia and assisted suicide to understand the evolution of regulations on end-of-life care.

Os avanços nos direitos humanos são indispensáveis para o desenvolvimento de políticas públicas de saúde e marcos legais que garantam a atenção integral à saúde. A eutanásia e o suicídio assistido continuam sendo conceitos amplamente discutidos na medicina e, principalmente, na bioética, devido ao peso que têm no processo de tomada de decisão de pacientes terminais e nos cuidados paliativos. Esses termos, seu uso, aprovação e regulamentação legal dependem da influência de vários determinantes, como pesquisas biomédicas, crenças religiosas, aspectos socioculturais, entre outros. No entanto, o que permite a interpretação e a observação dos resultados são as práticas apoiadas pela legislação de cada país; a Colômbia é o único país que descriminalizou a eutanásia na região e está avançando ativamente em questões relacionadas. O objetivo desta revisão é analisar as estruturas jurídicas internacionais sobre a definição e o uso da eutanásia e do suicídio assistido a fim de compreender a evolução das regulamentações de cuidados no fim da vida.

Euthanasia and assisted suicide: An in-depth review of relevant historical aspects.

End-of-life care is an increasingly relevant topic due to advances in biomedical research and the establishment of new disciplines in evidence-based medicine and bioethics. Euthanasia and assisted suicide are two terms widely discussed in medicine, which cause displeasure on many occasions and cause relief on others. The evolution of these terms and the events associated with their study have allowed the evaluation of cases that have established useful definitions for the legal regulation of palliative care and public policies in the different health systems. However, there are still many aspects to be elucidated and defined. Based on the above, this review aimed to compile relevant historical aspects on the evolution of euthanasia and assisted suicide, which will allow understanding the use and research of these terms.

Cursos en línea masivos y abiertos para educación continua: una herramienta que debe ser aprovechada por el estudiante y el profesional de la salud / Massive open online courses for continuing education: a tool for health students and professionals

Los cursos en línea masivos y abiertos han surgido como una estrategia pedagógica con un crecimiento exponencial en la última década. Han sido catalogados como la próxima evolución del aprendizaje a través de las redes, con la capacidad de romper las barreras hacia la formación académica y de promover habilidades, tanto teóricas como prácticas, en todas las áreas del conocimiento. El objetivo de este estudio consiste en exponer evidencia respecto a la utilidad de los cursos en línea en el desarrollo integral del estudiante y profesional de la salud. Se realizó una búsqueda no sistemática de la literatura, sin límite de fecha y hasta octubre del año 2020; se utilizaron términos como health personnel, health occupations students, distance education y massive open online courses, además de sinónimos combinados con los operadores AND y OR, en las bases PubMed, Science Direct y EBSCO. Los cursos en línea masivos y abiertos enfocados en el área de la salud, pueden ser una estrategia fuerte y efectiva para estimular un cambio educativo a nivel global, con el fin de mitigar las necesidades que actualmente azotan al mundo; además, la educación es la herramienta primordial para garantizar el crecimiento social, por lo tanto, si se refuerza el acceso al conocimiento para las poblaciones más vulnerables y grupos de cualquier edad, se puede esperar que el autocuidado y los estilos de vida saludable se conviertan en la prioridad de cada ser humano, y contribuyan a disminuir tasas de morbilidad, mortalidad y costos en salud(AU)

Massive open online courses have become an exponentially growing pedagogical strategy in the last decade. They have been categorized as the next evolution of network learning, with the capacity of breaking the barriers toward academic training, fostering theoretical and practical skills in all areas of knowledge. The purpose of this study is to present evidence of the usefulness of online courses for the comprehensive development of medical students and health professionals. A non-systematic search was conducted of the literature on the topic published in the databases PubMed, Science Direct and EBSCO on any date until October 2020, using search terms such as health personnel, health occupations students, distance education and massive open online courses, as well as their synonyms, combined with the operators AND and OR. Massive open online courses on health topics may be a strong, effective strategy to encourage a massive worldwide educational change aimed at mitigating the needs currently posed to the world. Education being the main tool to achieve social growth, if access to knowledge is reinforced among the most vulnerable populations of all age groups, it may be expected that self-care and healthy lifestyles will become a priority for all human beings, thus contributing to improve morbidity and mortality rates and reduce health care costs(AU)

Diferencias entre los modelos de riesgo Framingham y DAD en la evaluación del riesgo cardiovascular en pacientes con VIH bajo terapia antirretroviral: experiencia en una población del caribe colombiano / Differences between the Framingham and D:A:D risk models for cardiovascular risk assessment in HIV-positive patients on antiretroviral therapy: an experience in a Colombian Caribbean population

RESUMEN Objetivo: Evaluar el riesgo de enfermedad cardiovascular a cinco y a diez años en pacientes con infección por VIH en terapia antirretroviral, por medio de las escalas Framingham y Data collection on Adverse Effects of Anti-HIV Drugs Study. Materiales y métodos: Estudio observacional de corte transversal y prospectivo. Se incluyeron pacientes con infección por el VIH en tratamiento antirretroviral de un centro de referencia para pacientes con VIH, entre el 1 de enero y el 30 de abril de 2019. Se realizó evaluación del riesgo cardiovascular a cinco y a diez años a través de los modelos de predicción de Framingham y la escala Data collection on Adverse Effects of Anti-HIV Drugs Study (DAD), y una comparación entre ellos a través de modelos estadísticos. Resultados: Se incluyeron 159 pacientes, con un promedio de edad de 48,90 años ± 9,90. La media de valoración del riesgo cardiovascular por escala de Framingham a 5 años fue de 2,70 % ± 2,80; Framingham a 10 años fue 6,10 % ± 5,70; DAD a 5 años, 3,50 % ± 4,10; DAD a 10 años, de 6,90 % ± 7,70; y el riesgo escala de Framingham a 10 años recalculado para Colombia (multiplicado por 0,75) fue de 4,50 ± 4,20. A través de un modelo de regresión logística, se determinó que la puntuación con mayor número de variables significativamente relacionadas con el resultado de riesgo cardiovascular alto es el modelo DAD a 10 años. Conclusiones: El estudio evidenció una diferencia significativa, con mayor riesgo estimado de enfermedad cardiovascular al utilizar el modelo DAD en comparación con el Framingham, tanto para la estimación a cinco años como a diez.

ABSTRACT Objective: To assess the five- and ten-year cardiovascular disease risk in HIV-positive patients on antiretroviral therapy, using the Framingham risk score and the Data collection on adverse effects of anti-HIV drugs (D:A:D) study. Materials and methods: An observational prospective cross-sectional study. HIV-positive patients on antiretroviral treatment from a referral center for HIV patients were included in the study between January 1 and April 30, 2019. A five- and ten-year cardiovascular risk assessment was performed using the Framingham risk score and the D:A:D study. Additionally, both risk models were compared through statistical models. Results: The study population consisted of 159 patients with a mean age of 48.90 years ± 9.90. The mean cardiovascular risk according to the five-year Framingham risk score was 2.70 % ± 2.80, the ten-year Framingham risk score was 6.10 % ± 5.70, the five-year D:A:D study was 3.50 % ± 4.10, the ten-year D:A:D study was 6.90 % ± 7.70, and the ten-year Framingham risk score recalculated for Colombia (multiplied by 0.75) was 4.50 % ± 4.20. Using a logistic regression model, it was determined that the ten-year D:A:D study provided the greatest number of variables significantly related to a high cardiovascular risk. Conclusions: The study showed a significant difference between the risk models. Both the five- and ten-year D:A:D study provided a better cardiovascular disease risk estimation than the five- and ten-year Framingham model.

A step-by-step guide to creating an academic surgery interest group: Review article.

An academic interest group in medicine is defined as a collective that can be made up of undergraduate students, residents, and/or teachers, who share as an object of interest the advancement and growth of a specific area of medicine. It is organized to carry out extracurricular academic and research activities. It is essential to stimulate participation in these interest groups, which allow the personal and professional growth of their members, being a tool that promotes and provides better opportunities for entry as candidates for graduate studies. The American College of Surgeons is one of the largest medical scientific societies with the participation of undergraduate students with an interest in surgery. This society mentions the benefits of participating in interest groups in surgery, specifically, it highlights the importance of contributing to these when looking for a surgical specialty, because they address issues such as: what is the mentioned specialty itself?, what are the details about the application process for each surgical specialty?, these groups can provide information on different residency programs, lifestyle benefits, and/or cons; in addition to improving practical skills through surgical technique workshops or various organized activities. Based on the above, the objective of this manuscript is to design a Step-by-step guide for the creation of a surgical interest group, in order to encourage participation by medical students, residents, and teachers in the research and academic field.

Hidradenitis suppurativa: Basic considerations for its approach: A narrative review.

Hidradenitis suppurativa is a chronic and debilitating skin disease, whose lesions can range from inflammatory nodules to abscesses and fistulas in the armpits, groin, perineum, inframammary region. Diagnosis can be confused with a large number of clinical pictures, and although studies on hidradenitis suppurativa are not so scarce in the literature, doctors are often unaware of this disease and therefore its diagnosis is often late. Pharmacological treatment ranges from retinoids to immunosuppression and radiation therapy, and surgical treatment ranges from incision and drainage to more complete excisions and laser therapies. Hidradenitis suppurativa is a disease seen and treated mainly by dermatologists and general surgeons, however, it is necessary for general practitioners to have basic knowledge about this entity, as they are the first line of care in the health system.

Correlación clínico-radiológica como primera ruta en el diagnóstico de síndrome de Gorham-Stout / Clinical-radiological correlation as the first route in the diagnosis of Gorham-Stout syndrome

Resumen El síndrome de Gorham-Stout constituye una rara enfermedad ósea cuya etiología sigue siendo desconocida, que se caracteriza por presentar osteólisis y proliferación anormal de canales vasculares. Se describe el caso de un paciente masculino de 47 años quien consultó por un cuadro de aproximadamente 15 días de evolución consistente en edema, dolor, eritema y secreción sero-hemática por herida quirúrgica en hombro derecho, con diagnóstico reciente de artritis séptica. Refería antecedente de síndrome de Gorham-Stout, evidenciándose al examen físico y radiografía comparativa de hombros. La presentación clínica de estos pacientes depende del área afectada y la extensión de la enfermedad, convirtiéndose su diagnóstico en un desafío en caso de que el deterioro se presente en zonas no expuestas. El principal síntoma consiste en dolor localizado, acompañado de hinchazón, debilidad y deterioro funcional de las extremidades afectadas. Estos pacientes pueden permanecer asintomáticos hasta sufrir una fractura ósea espontáneamente o después de un trauma menor

Abstract Gorham-Stout syndrome is a rare bone disease whose etiology remains unknown, characterized by osteolysis and abnormal proliferation of vascular channels. We describe the case of a 47-year-old male patient who consulted for 15 days of evolution of edema, pain, erythema and seroma expulsion from surgical wound in the right shoulder, with a recent diagnosis of septic arthritis. He referred a history of Gorham-Stout syndrome, evidenced with physical examination and comparative radiography of the shoulders. The clinical presentation of these patients depends on the affected area and the extent of the disease, making their diagnosis a challenge in case the deterioration occurs in unexposed areas. The main symptom is localized pain, accompanied by swelling, weakness and functional impairment of the affected limbs. These patients may remain asymptomatic until suffering a bone fracture spontaneously or after minor trauma

Hernia inguinoescrotal reincidente con megauréter: presentación de caso / Recurrent inguinoscrotal hernia with megaureter: a case report

RESUMEN La frecuencia de la enfermedad herniaria es una de las más altas dentro de los cuadros quirúrgicos. Sin embargo, su asociación al megauréter en el saco herniario o contenido es extremadamente rara y existen pocos reportes en la literatura internacional. El diagnóstico es incidental, ya sea por hallazgo transoperatorio o por estudios contrastados de imagen. Se presenta el caso clínico de un paciente con antecedente de hernia inguinal que fue sometido a una herniorrafia hace veinte años y que se presenta a un servicio de urgencias con un aparente defecto herniario. Además, padece diabetes mellitus que está mal controlada. Durante la estancia hospitalaria se confirma la reaparición de la hernia con un saco que contiene megauréter y adherencias visceroparietales con ciego en posición subhepática.

ABSTRACT Herniation is one of the most frequent surgical conditions. However, the presence of a megaureter in the hernia sac or content is extremely rare. Little has been reported on this topic in the world literature, and its diagnosis has been incidentally reached either as an intraoperative finding or during different contrast imaging studies. This is the clinical case of a patient with a history of inguinal hernia who underwent a herniorrhaphy 20 years ago and presented to the emergency department with a diagnostic impression of a relapsed hernial defect. He also had poorly-controlled diabetes mellitus. During his hospital stay, a diagnosis of relapsed hernia sac containing a megaureter was confirmed, and visceral-parietal adhesions and a subhepatic cecum were found.

Consideraciones clínicas de la abetalipoproteinemia: revisión de la literatura / Clinical considerations of abetalipoproteinemia: literature review

La abetalipoproteinemia es una enfermedad rara que se suele presentarse en la primera década de la vida; sus principales manifestaciones son esteatorrea, alteración en el desarrollo y niveles plasmáticos lipídicos onsiderablemente disminuidos. Sin embargo, este cuadro suele ser confuso, puesto que existe un grupo de desórdenes genéticos que conllevan a mala absorción lipídica, que requieren un exhaustivo diagnóstico diferencial desde el punto de vista clínico, bioquímico y molecular. Este artículo expone una revisión actualizada sobre la abetalipoproteinemia, enfocándose en su fisiopatología, manifestaciones sistémicas, diagnóstico y abordaje en general, para facilitar su comprensión integral. La estrategia de búsqueda y los métodos de selección de estudios se realizó con base en elementos de la declaración prisma y guías Cochrane, utilizando términos de búsqueda tales como "abetalipoproteinemia" ,"bioquímica" y sinónimos, los cuales fueron combinados con los operadores "and" y "or", en las bases de datos PubMed, Science Direct, Clinical Key y Ebsco. No existe mucha literatura específica sobre esta condición, lo cual explica que sea una entidad subvalorada y poco conocida. Es fundamental realizar más investigaciones en torno al tema, pues en caso de no establecerse un diagnóstico y manejo adecuado, las complicaciones serán muchas y severas..Au

Abetalipoproteinemia is a rare disease that occurs predominantly in the first decade of life, having as main manifestations, steatorrhea, alteration in development and considerably decreased lipid plasma levels. However, this clinical presentation is often confusing, since there is a group of genetic disorders that lead to poor lipid absorption, requiring the need to make a comprehensive differential diagnosis from a clinical, biochemical and molecular point of view. This article will provide an updated review on Abetalipoproteinemia, focusing on its pathophysiology, systemic manifestations, diagnosis and general approach, allowing easy access to an integral knowledge. The search strategy and study selection methods were based on elements of the prisma statement and Cochrane guidelines, using search terms such as "Abetalipoproteinemia" and "Biochemistry", in addition to synonyms, which were combined with "and" and "or" operators, in the PubMed, Science Direct, Clinical Key and Ebsco databases. It is necessary to highlight that there is not much specific literature on this condition, which would support the fact that it is an undervalued and little-known entity, it is essential to carry out more research on the subject, taking into account that if a diagnosis is not established proper management, the complications are many and severe..Au

Perforación de íleon distal por espina de pescado: reporte de caso / Distal ileum perforation caused by a fish bone: a case report

Se presenta un caso de perforación de íleon distal, posterior a la ingesta de una espina de pescado. Se realiza la presentación del caso, en relación a la sintomatología clínica, estudios realizados para el diagnóstico conciso, ecografía abdominal. Se describe técnica operatoria y se realiza una discusión del asunto y de la información obtenida en la bibliografía.

Distal ileum perforation caused by a fish bone: a case reportABSTRACT We present a case of distal ileum perforation after the ingestion of a fish bone. This case report includes the symptomatology, studies conducted for reaching a concise diagnosis, abdominal ultrasound results, and description of the operative technique. In addition, a discussion of the topic and information gathered from the literature is carried out.