Assuntos
Hematúria/etiologia , Neuroblastoma , Neoplasias da Bexiga Urinária , Humanos , Lactente , Metástase Linfática , Masculino , Neuroblastoma/complicações , Neuroblastoma/patologia , Neuroblastoma/terapia , Neoplasias da Bexiga Urinária/complicações , Neoplasias da Bexiga Urinária/patologia , Neoplasias da Bexiga Urinária/terapiaRESUMO
We report on a case of adult chronic granulomatous disease which first manifested as a pulmonary mass, and was histologically diagnosed as bronchocentric granulomatosis associated with aspergillosis in a patient with a deficiency of p67phox and a low oxidative response. Antifungal treatment was required for clinical resolution.
Assuntos
Aspergilose Broncopulmonar Alérgica/diagnóstico , Broncopatias/diagnóstico , Granuloma do Sistema Respiratório/diagnóstico , Fosfoproteínas/deficiência , Adulto , Aspergilose Broncopulmonar Alérgica/tratamento farmacológico , Biópsia por Agulha , Broncopatias/terapia , Feminino , Seguimentos , Granuloma do Sistema Respiratório/terapia , Humanos , Itraconazol/administração & dosagem , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Malign small cell tumors in the thoracopulmonary region is a tumor of neuroectodermic origins with polymorphous and infrequent presentation. It is mostly found among young people, developing an aggressive and severe course. It is a small cell tumor involving small quantities of cytoplasm without glucogen, round or oval nucleus with disperse chromatin, and little prominent nucleolus without tendency of manifesting pseudo red spots, being PAS negative. Two cases which initially resembled pleuropulmonary infection are presented. Case 1: Sixteen year old male. Presented with a high fever, pleuritic thoracic pain, and a cough with little expectoration. He was diagnosed with severe pulmonary infection and parapneumonic right pleural discharge. His condition improved with antibiotic treatment, but the cough persisted. Thoracoabdominal echography showed right pleural discharge and possible hepatic mass. Surgical intervention was performed. Askin's tumor was detected by biopsy. He began treatment with chemotherapy. Case 2: Thirty-four year old woman. Presented with non-productive cough, pleuritic thoracic pain, and high fever. In the thoracic TAC, there was right pleural discharge along with images suggesting hypodense mass. Given the patient's lack of response to antibiotics, a thoracotomy was performed. The anatomopathological diagnosis was Atkin's tumor. After beginning treatment, the patient died after ten days.
Assuntos
Neoplasias Pulmonares/diagnóstico , Sarcoma de Células Pequenas/diagnóstico , Adolescente , Adulto , Feminino , Humanos , MasculinoRESUMO
Inflammatory pseudotumor (IP) is a rare pathological entity. Although, the pulmonary affection is the most frequent, any other organ can be involved. Its etiopathology is unknown. The disease is considered as a reactive process constituted by chronic inflammatory elements and a benign behavior. The lack of a specific clinical setting and the low profitability of the bloodless techniques makes mandatory the thoracostomy for a definitive diagnosis. We report two cases of pulmonary IP. One of them with an endobronchial localization which is a infrequent variety, scantily reported in the medical literature. We discuss the clinical and etiopathologic aspects of this rare pathological entity.
Assuntos
Broncopatias , Granuloma de Células Plasmáticas Pulmonar , Adolescente , Broncopatias/diagnóstico por imagem , Broncopatias/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Granuloma de Células Plasmáticas Pulmonar/diagnóstico por imagem , Granuloma de Células Plasmáticas Pulmonar/cirurgia , Tomografia Computadorizada por Raios XAssuntos
Síndrome da Imunodeficiência Adquirida/complicações , HIV-1 , Doença de Hodgkin/complicações , Síndrome da Imunodeficiência Adquirida/diagnóstico , Síndrome da Imunodeficiência Adquirida/patologia , Adulto , Dependência de Heroína/complicações , Doença de Hodgkin/diagnóstico , Doença de Hodgkin/patologia , Homossexualidade , Humanos , MasculinoRESUMO
A 3-year-old child diagnosed as having acute lymphatic leukemia (ALL), developed meningeal leukemia 36 months after the onset of the disease. He was twice subjected to cranial irradiation plus intrathecal methotrexate (i.t. MTX). Skull radiology showed bilateral gyriform calcification of both cerebral hemispheres. Hematological relapse was first detected 5 years after diagnosis and the child died 5 months later. The most striking findings of a right frontal lobe biopsy and the postmortem examination were wide calcium deposits located in the cortex and in the adjacent white matter. Intense demyelination as well as areas of neuron poverty were apparent in the necropsy but in the biopsy specimen. The possible interrelationship between such deposition and cranial irradiation and/or i.t. MTX suggests a new iatrogenic disorder.