RESUMO
Effect of the antiserotonin drug cyproheptadine on the erythropoiesis has been studied under conditions of the administration of cytostatics (fluoropyrimidine antimetabolite 5-fluorouracil (5-FU), alkylating agent cyclophosphane) with different mechanisms of action. It is established that the antiserotonin drug significantly accelerates regeneration of the erythroid hemopoietic branch, especially in the case of 5-FU. The depression of erythron under the conditions of cyclophosphane injections was retained. The erythropoiesis-stimulating effect of cyproheptadine is based on the restoration of the structural and functional organization of the bone marrow (formation of erythroid hemopoietic islets).
Assuntos
Antimetabólitos Antineoplásicos/toxicidade , Antineoplásicos Alquilantes/toxicidade , Ciproeptadina/farmacologia , Eritropoese/efeitos dos fármacos , Antagonistas da Serotonina/farmacologia , Animais , Medula Óssea/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Ciclofosfamida/toxicidade , Células Precursoras Eritroides/citologia , Células Precursoras Eritroides/efeitos dos fármacos , Fluoruracila/toxicidade , Masculino , Camundongos , Camundongos Endogâmicos CBARESUMO
Immune reactions of the progeny of female Wistar rats injected with paclitaxel a single MPD of 1 and 3 months before mating with intact males were studied. Thymic hyperplasia was detected in the progeny of female rats mated 1 month after treatment. Disorders in the antibody-specific and antibody-nonspecific mechanisms of the immune response were detected in the progeny of females mated with intact males 3 months after cytostatic treatment.
Assuntos
Imunidade/efeitos dos fármacos , Paclitaxel/toxicidade , Animais , Animais Recém-Nascidos , Citostáticos/toxicidade , Feminino , Hiperplasia/induzido quimicamente , Imunidade/imunologia , Masculino , Gravidez , Efeitos Tardios da Exposição Pré-Natal , Ratos , Ratos Wistar , Timo/efeitos dos fármacos , Timo/patologia , Fatores de TempoRESUMO
Mice of different strains can be classified by the intensity of humoral immune reaction to thymus-dependent antigen as high, moderate, and low responders. High and moderate responders (CBA/CaLac, DBA/1, BALB/c) are characterized by high sensitivity of the productive phase of humoral immune response and phagocytic activity of macrophages to immobilization stress. In low responders (C57BL/6, CC57W) stress only slightly affected the productive phase of the humoral immune response, but activity of peritoneal macrophages decreased. These differences in the reactions of the immune system of inbred mice after immobilization stress reflect different reactions of the immune system to extreme factors.
Assuntos
Imobilização , Animais , Catecolaminas/metabolismo , Sistema Imunitário , Macrófagos/metabolismo , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Camundongos Endogâmicos DBA , Camundongos Endogâmicos , Fagocitose , Especificidade da Espécie , Estresse Fisiológico , Timo/patologia , Fatores de TempoRESUMO
T cells were most sensitive to cyclophosphamide in DBA/2 mice, while in C57Bl/6 mice both T and B cells were sensitive. The formation of antibody-producing cells and the production of specific antibodies were delayed in DBA/2 mice immunized after pretreatment with antitumor drug. Accumulation of antibody-producing cells in the spleen was more active in immunized C57Bl/6 mice treated with cyclophosphamide compared to animals not treated with cyclophosphamide.