RESUMO
There is currently interest regarding CRSsNP patients with refractory symptomatology following functional endoscopic sinus surgery, and which of these patients can derive benefit from low-dose macrolide therapy. In the present study, we analyze a cohort of over fifty CRSsNP patients on macrolide therapy; structured histopathological findings at the time of surgery were analyzed against the success of macrolide treatment. Independently, fibrosis, absence of squamous metaplasia, absence of eosinophilia, presence of neutrophilic infiltrate, and lymphoplasmocytic predominance were all associated with objective success of macrolide treatment; these findings may allow clinicians to more appropriately select patients for this therapy.
Assuntos
Eosinofilia , Pólipos Nasais , Rinite , Sinusite , Humanos , Sinusite/cirurgia , Rinite/cirurgia , Macrolídeos/uso terapêutico , Doença Crônica , Eosinofilia/complicações , Antibacterianos/uso terapêutico , Pólipos Nasais/complicaçõesRESUMO
PURPOSE OF REVIEW: Patients with an immunodeficiency may present to their Rhinologist with a history of recurrent, severe, and chronic infections. Therefore, it is essential for the Rhinologist to have a basic understanding of clinically relevant immune deficiencies. RECENT FINDINGS: After describing different types of immunodeficiencies, their presentations, and management strategies, an evaluation algorithm is described. SUMMARY: Through a collaborative approach, Rhinologists and Clinical Immunologists can provide comprehensive medical care to patients with immunodeficiencies.