RESUMO
We investigated serum ghrelin levels (SGL) in 12 patients with schizophrenia over a 10-week period after initiation of clozapine treatment. In contrast to increments of body mass indices (BMI, kg/m2) and serum leptin levels (SLL), no significant change in SGL was detected. Inverse correlations between delta SGL and delta SLL did not reach statistical significance. Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain.
Assuntos
Antipsicóticos/efeitos adversos , Clozapina/efeitos adversos , Hormônios Peptídicos/sangue , Esquizofrenia/sangue , Esquizofrenia/tratamento farmacológico , Adulto , Antipsicóticos/administração & dosagem , Índice de Massa Corporal , Clozapina/administração & dosagem , Feminino , Grelina , Humanos , Leptina/sangue , Estudos Longitudinais , Masculino , Estudos Prospectivos , Esquizofrenia Catatônica/sangue , Esquizofrenia Catatônica/tratamento farmacológico , Esquizofrenia Hebefrênica/sangue , Esquizofrenia Hebefrênica/tratamento farmacológico , Esquizofrenia Paranoide/sangue , Esquizofrenia Paranoide/tratamento farmacológico , Aumento de Peso/efeitos dos fármacosRESUMO
The torsion of an ectopic (= wandering) spleen is a rare entity especially in children. Clinically it presents either with signs of an "acute abdomen" or as a fairly painful abdominal "tumor" of the chronic recurrent type. Ultrasonography, arteriography, and additional scintigraphy in special cases are of greatest value in the preoperative diagnostic management. Splenopexy, sometimes after resecting parts of a very enlarged organ, is the therapy of choice. The complete exstirpation of the ectopic spleen should be reserved only for exceptional cases. By presenting a case report, the etiologic factors, the clinical signs, the diagnostic steps, the differential diagnostic considerations as well as the mode of therapy for this rare disease are described and discussed.