1.
J Chemother
; 16 Suppl 5: 15-8, 2004 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15675469
RESUMO
The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: alpha particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.
Assuntos
Terapia por Captura de Nêutron de Boro , Boro/farmacocinética , Neoplasias Colorretais/patologia , Neoplasias Hepáticas/radioterapia , Neoplasias Hepáticas/secundário , Animais , Masculino , Ratos , Distribuição Tecidual
2.
Strahlenther Onkol
; 165(2-3): 170-2, 1989.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2928941