Cervical cancer in Mozambique: Clinical characteristics, treatment and survival of incident cases admitted to the Oncology Service of Maputo Central Hospital in 2016-2018.

In Mozambique, cervical cancer is the most frequent cancer in women. However, studies about cervical cancer treatment and prognosis are scarce. We describe the clinical characteristics, treatment and survival of patients with cervical cancer admitted to Maputo Central Hospital (MCH) in 2016 to 2018. Sociodemographic, clinical and cancer-related data were retrieved from clinical records of patients admitted to the Oncology Service of the MCH with an incident cervical cancer in 2016 to 2018 (n = 407). The Pathology Service database was used to obtain information regarding pathological diagnosis. Survival data was obtained through the MCH Cancer Registry and clinical records. Odds ratios for the association between patients' characteristics and the diagnosis of advanced stage cancer were computed using logistic regression. Survival analyses were performed using the Kaplan-Meier estimator. A total of 91.2% of the patients were diagnosed with advanced disease (stage IIB-IV) and squamous cell carcinoma was the predominant histological subtype. Most of the patients underwent chemotherapy (93.1%) but <7% were submitted to surgery, radiotherapy or brachytherapy. Those living with HIV had 3.4-fold higher odds of advanced disease. Overall survival was 72.7% (95% confidence interval [CI]: 67.9-77.0) at 1-year and 51.0% (95%CI: 45.3-56.3) at 2-years. Those with early stage (IA-IIA) and asymptomatic at diagnosis had a significantly higher 2-year overall survival. In Mozambique, cervical cancer is diagnosed mostly in advanced stages, resulting in poor prognosis. This highlights the importance of HPV vaccination and screening, to decrease the burden of cervical cancer in this context.

Surgery of the primary tumor in patients with de novo metastatic breast cancer: a nationwide population-based retrospective cohort study in Belgium.

PURPOSE: We aimed to assess the impact of surgery of primary tumor in overall survival (OS) of women with de novo metastatic breast cancer. METHODS: Nationwide, population-based retrospective cohort study of women diagnosed with de novo metastatic breast cancer in Belgium, between Jan/2010-Dec/2014. Data was obtained from the Belgian Cancer Registry and administrative databases. "Surgery" group was defined by surgery of primary tumor up to nine months after diagnosis. We excluded women who did not receive systemic treatment or did not complete nine months follow-up after diagnosis. All the subsequent analyses reporting on overall survival and the stratified outcome analyses were performed based on this nine-month landmark cohort. OS was estimated using Kaplan-Meier method and compared using adjusted Cox proportional hazards models controlling for confounders with 95% confidence intervals (CI). We performed a stratified analysis according to surgery timing and a propensity score matching analysis. RESULTS: 1985 patients, 534 (26.9%) in the "Surgery" and 1451 (73.1%) in the "No Surgery" group. Patients undergoing surgery were younger (p < 0.001), had better performance status (PS) (p < 0.001), and higher proportion of HER2-positive and triple-negative breast cancer (p = 0.012). Median follow-up was 86.0 months (82.6-88.5). Median OS was 60.1 months (57.1-68.2) in the "Surgery" vs. 41.9 months (39.8-44.2) in the "No Surgery" group (adjusted HR 0.56; 0.49-0.64). OS was similar when surgery was performed upfront or after systemic treatment. Propensity score matching analysis confirmed the same findings. CONCLUSION: Among patients receiving systemic treatment for de novo metastatic breast cancer and surviving nine months or more, those who received surgery of the primary tumor within nine months of diagnosis have longer subsequent survival than those who did not.

Immunotherapy and Targeted Therapies Efficacy in Thymic Epithelial Tumors: A Systematic Review.

BACKGROUND: Thymic epithelial tumors (TET) are rare neoplasms of the anterior mediastinum. Surgery is the mainstay treatment for resectable TET, whereas systemic treatments are reserved for unresectable and metastatic tumors. The development of new treatments, such as immune checkpoint inhibitors (ICI) and targeted therapies, with promising results in other types of solid tumors, has led to the investigation of their potential efficacy in TET. The study of tumor microenvironments (TME) is another field of investigation that has gained the interest of researchers. Taking into account the complex structure of the thymus and its function in the development of immunity, researchers have focused on TME elements that could predict ICI efficacy. MATERIALS AND METHODS: The primary objective of this systematic review was to investigate the efficacy of ICI in TET. Secondary objectives included the toxicity of ICI, the efficacy of targeted therapies in TET, and the evaluation of the elements of TME that may be predictive factors of ICI efficacy. A literature search was conducted in February 2023 using the Ovid Medline and SciVerse Scopus databases. RESULTS: 2944 abstracts were retrieved, of which 31 were retained for the systematic review. Five phase II and one retrospective study assessed ICI efficacy. The overall response rate (ORR) varied from 0% to 34%. Median progression-free survival (PFS) ranged from 3.8 to 8.6 months, being lower in thymic carcinoma (TC) (3.8-4.2 months). Median overall survival (OS) ranged from 14.1 to 35.4 months. Treatment-related adverse events occurred in 6.6% to 27.3% of patients. Sixteen studies assessed targeted therapies. The most active molecule was lenvatinib, with 38% ORR in patients with TC while no activity was detected for imatinib, erlotinib plus bevacizumab, and saracatinib. Ten studies assessed TME elements that could predict ICI efficacy. Four studies focused on the tumor-infiltrating immune cells suggesting improved outcomes in patients with TC and high tumor-infiltrating lymphocyte densities. Another study showed that CD8+, CD20+, and CD204+ tumor-infiltrating immune cells in cancer stroma might be prognostic biomarkers in TC. Another study identified the immune-related long non-coding RNAs as a predictor of response to ICI. Tumor mutational burden was identified as a predictive factor of ICI efficacy in one study. CONCLUSIONS: Despite study heterogeneity, this review shows that ICI could be a therapeutic option for selected patients with TET that are not amenable to curative radical treatment after first-line chemotherapy.

Impact of disease duration on proteomic bioprofile and prognosis in rheumatoid arthritis patients.

OBJECTIVES: Cardiovascular disease worsens the prognosis of rheumatoid arthritis (RA) and vice-versa. Inflammation may be a common pathway for both conditions. It is expected that a longer RA duration leads to a greater inflammatory cumulative exposure burden; however, studies on the association between RA disease duration and outcomes are scarce. Our aim is to compare the characteristics, biomarker expression and outcomes according to the duration of RA. METHODS: Prospective cohort study including 399 RA patients, with detailed clinical, echocardiographic, and proteomic phenotyping that were compared across tertiles of RA disease duration. Cox proportional models were used to study the association of disease duration with cardiovascular outcomes. RESULTS: RA duration tertiles were: tertile 1 with median of 3.2; tertile 2 with median of 8.8; and tertile 3 with median of 21.8 years. Compared to tertile 1, patients in tertile 3 were older, had more erosive disease, more frequent echocardiographic alterations, lower haemoglobin and walked a shorter distance on the 6MWT. Natriuretic peptides, cathepsin L1, galectin 9, matrix metalloproteinase-12, adrenomedullin and tumour necrosis factor receptor 11A were higher in patients with longer disease duration. Compared to patients in tertile 1, those in tertile 3 had higher risk of a subsequent cardiovascular hospitalisation or cardiovascular death (HR 2.71, 95%CI 1.06-6.92, p=0.04). CONCLUSIONS: RA patients with longer disease duration had more organ damage and worse outcomes than those with shorter disease duration. Biomarker expression suggested that patients with longer RA duration had activation of pathways related to inflammation, extracellular matrix organisation, fibrosis and congestion.

Evaluation of Antibiotic Prophylaxis Prescriptions for Infectious Endocarditis Before Oral Procedures Between Cardiologists and Dentists

Abstract Background Infective endocarditis (IE) is a serious disease with a high mortality rate. Antibiotic prophylaxis for bacterial endocarditis before invasive procedures has been recommended in patients with predisposing cardiac conditions since 1960, but contemporary guidelines worldwide have proposed changes. Objective To evaluate the knowledge and pattern of prescription by cardiologists and dentists regarding antibiotic prophylaxis for bacterial endocarditis before risky oral procedures. Methods This is an observational and cross-sectional study. Data were obtained from an online questionnaire, sent to cardiologists and dentists linked to specialty societies, in the first semester of 2021. Data analysis was performed using descriptive statistics, and comparisons between variables were done in an exploratory approach. The significance level adopted was 5%. Results From 613 responders, 82.5% of cardiologists and 79.5% of dentists reported prescribing antibiotic prophylaxis for patients at high and moderate risk for IE. Of dental procedures capable of generating bacteremia, all were correctly identified by more than 50.0% of the sample. As for the habits of daily living, flossing and toothbrushing had almost 50.0% of correct answers, chewing had only 17.3%, and 40.9% reported that none of the actions presented a risk of bacteremia. When comparing variables, the correct prescription of amoxicillin (2 g, 30-60 minutes before the procedure) was more prevalent among cardiologists and in responders with less than 20 years of graduation (p<0.01). Conclusion In the present study, the prescription of antibiotic prophylaxis for IE were frequent for high- and moderate-risk patients, before oral/dental procedures. Partial knowledge was found about endocarditis, which highlights the need for continuous medical/dental education.

Systemic treatment for neuroendocrine non-small cell lung carcinoma: A cases series and a systematic review of the literature.

INTRODUCTION: Neuroendocrine lung cancer constitutes a continuum from carcinoid tumours (CT) to large cell neuroendocrine (LCNEC) and small-cell carcinomas (SCLC). Except for SCLC, there is no consensual agreement on systemic therapy. The aim of this study is to review our clinical experience among patients with CT and LCNEC in the light of a systematic review of the literature. METHODS: A retrospective study of all patients with CT and LCNEC receiving a systemic therapy at Institut Jules Bordet and Erasme Hospital between 01/01/2000-31/12/2020. A systematic review of the literature was performed in Ovid Medline. RESULTS: 53 patients (21 CT and 32 LCNEC) were included. Despite limited response rates, patients with CT receiving a "carcinoid-like" 1st-line regimen (somatostatin analogues (SSA), everolimus, peptide receptor radionuclide therapy (PRRT)) had a numerically longer survival compared to those receiving other type of regimens (median 51.4 vs 18.6 months, respectively; p = 0.17). We observed a similar survival between 1st line "SCLC-like" vs "non-small cell lung cancer (NSCLC)-like" schemes in LCNEC (median 11.2 vs 12.6 months, respectively; p = 0.46). The systematic review identified 23 studies (12 prospective, 15 and 8 for CT and LCNEC respectively). For CT, everolimus and SSA led to prolonged disease control with an acceptable toxicity profile, while higher response rates but lower tolerance were associated with PRRT and chemotherapy regimens including oxaliplatine and dacarbazine. For LCNEC, no difference emerged when comparing "SCLC-like" and "NSCLC-like" regimens considering response rate, progression-free or overall survival. CONCLUSIONS: SSA, everolimus and PRRT present a good therapeutic index for CT, while the role of chemotherapy remains limited to aggressive and rapidly evolving CT. The best type of chemotherapy regimen remains an open question in LCNEC.

Oncology in Mozambique: Overview of the Diagnostic, Treatment, and Research Capacity.

Mozambique is one of the poorest countries worldwide, with nearly two thirds of the population living below the poverty line. Similarly to other less developed countries, there is a weak provision of health care for non-communicable diseases due to competing priorities with infectious diseases. Although the leading causes of death in Mozambique in 2019 were Acquired Immune Deficiency Syndrome/Human Immunodeficiency Virus and other sexually transmitted diseases and respiratory infections and tuberculosis, with increasing urbanization and westernization of lifestyles, deaths attributed to cancer are also on the rise. This review summarizes cancer burden, cancer prevention and screening, cancer care resources, and trends in cancer training and research in Mozambique, providing a background for the development of cancer care policies in the country.

Systemic treatment and radiotherapy for patients with non-small cell lung cancer (NSCLC) and HIV infection - A systematic review.

Lung cancer is the most common non-AIDS defining cancer among people living with HIV (PLWH), but there is a paucity of data regarding the efficacy and toxicity of radiotherapy and systemic regimens, including immunotherapy, in the treatment of these patients. In order to answer this question, we have performed a systematic search of the literature in Ovid Medline until March 17, 2022. We included 21 publications, enrolling 513 PLWH with non-small cell lung cancer (NSCLC), mostly male (75-100%), (ex-)smokers (75-100%) and with stage III-IV at diagnosis (65-100%). The overall response rate (ORR) to chemotherapy (n = 186 patients, mostly receiving platinum-based regimens) was highly variable (17 %-83 %), with a substantial hematological toxicity. ORR varied between 13 % and 50 % with single-agent immunotherapy (n = 68), with median overall survival between 9 and 11 months and a very acceptable toxicity profile, in line with studies in the HIV non-infected population. All five patients receiving tyrosine kinase inhibitors (TKIs; gefitinib or erlotinib) showed a partial response and long overall survival. Yet, combination of TKIs with antiretroviral therapy using pharmacological boosters, such as ritonavir, should be avoided. Radiotherapy was evaluated among 42 patients, showing high ORR (55 %-100 %), but 18 % of patients had a pneumonitis. This systematic review shows that radiotherapy and systemic therapy are effective and safe among PLWH with controlled infection diagnosed with NSCLC. Nonetheless, most reports were small and heterogeneous and larger studies are needed to confirm these encouraging findings. Moreover, clinical trials should not restrict the inclusion of PLWH, as more data is needed regarding the long-term efficacy and safety of treatments among this underserved population, especially of immunotherapy.

Immune response to anti-SARS-CoV-2 prime-vaccination in patients with cancer: a systematic review and meta-analysis.

PURPOSE: This systematic review and meta-analysis aimed to evaluate the immune response to anti-SARS-CoV-2 prime-vaccination in patients with cancer. METHODS: We performed a systematic literature search using PubMed, Embase, and Cochrane Library until 28/09/2021, and conference proceedings from ASCO and ESMO 2021 annual meetings. We screened for observational or interventional studies including subjects ≥ 16 years old with cancer diagnosis who were vaccinated against SARS-CoV-2. Prime-vaccination was defined as one dose of Ad26.COV2-S vaccine or two doses of BNT162b2, mRNA-1273, ChAdOx1-S or inactivated SARS-CoV-2 vaccine. The outcomes were humoral and adaptive immune responses (proportion of subjects with positive titers of antibody anti-SARS-CoV-2 spike protein and anti-SARS-CoV-2 cellular responses, respectively). RESULTS: We included 89 records reporting data from 30,183 subjects. The overall seropositive rate within the first month after complete anti-SARS-CoV-2 prime-vaccination was 80% [95% confidence interval (CI), 72-86%], 60% (95%CI, 53-67%) in patients with hematological malignancies (HM) versus 94% (95%CI, 88-97%) in patients with solid malignancies (SM). The diagnosis of HM was significantly associated with a lower seropositive rate on multivariate meta-regression (odds ratio 0.35, 95% CI 0.18-0.69, HM versus both, p = 0.002). The overall humoral response was 49% (95% CI, 42-56%) after incomplete prime-vaccination and 79% (95% CI, 70-86%) at 2 months after complete prime-vaccination. These responses were also lower in patients with HM at these time points. The overall cellular response rate at any time after vaccination was 61% (95% CI, 44-76%). CONCLUSION: This meta-analysis provides compelling evidence of humoral and adaptive immune responses against SARS-CoV-2 in patients with cancer, which last for at least 2 months following complete prime-vaccination.

Características socioeconômicas, demográficas e nutricionais de crianças com transtorno do espectro autista / Socioeconomic, demographic and nutritional characteristics of children with autism spectrum disorder

Introdução: O transtorno do espectro autista (TEA) é um grupo de desordens neurocomportamentais de grande complexidade. Ao longo dos anos, um número crescente de pessoas vem apresentando o diagnóstico. No Brasil, ainda há poucos estudos sobre o perfil nutricional desse grupo populacional. Objetivo: Traçar o perfil socioeconômico, demográfico, antropométrico e consumo alimentar de crianças com TEA de um movimento social de Macaé, Rio de Janeiro. Métodos: Realizou-se um estudo do tipo exploratório, descritivo, quantitativo, de base primária, no período entre março e junho de 2020, com 92 crianças entre 2 e 9 anos e suas respectivas mães vinculadas ao movimento social de Macaé. Utilizaram-se dois questionários, o primeiro semiestruturado contendo variáveis socioeconômicas, demográficas, clínicas e antropométricas; e o segundo estruturado sobre consumo alimentar. As variáveis contínuas foram descritas por média, desvio-padrão, e as variáveis categóricas como proporção (%). Para verificar a significância das diferenças encontradas nas respostas por grupos e categorias, foi utilizado o teste estatístico qui-quadrado. Utilizou-se o pvalor <0,05 para significância estatística. Resultados: A maioria das crianças era do sexo masculino (81,5%) e não estava alfabetizada (75,0%). Detectaram-se 53,5% crianças com excesso de peso para a idade, segundo IMC por idade, e 91,1% com estatura adequada, segundo estatura por idade. Das 59 crianças avaliadas quanto ao consumo alimentar, 78,0% consumiram feijão no dia anterior; 57,6% frutas frescas e 54,2% vegetais e/ou legumes; 59,3% bebidas adoçadas e 37,3% doces. Conclusão: O excesso de peso e o consumo de marcadores de alimentos não saudáveis foram elevados no grupo avaliado.

Introduction: Autism spectrum disorder (ADS) is a group of highly complex disorders. Over the years, there has been a growing number of ADS-diagnosed persons. In Brazil, there are few studies on the nutritional profile of this population. Objective: To describe the socioeconomic, demographic, anthropometric characteristics and food consumption of children with ADS from a social movement in Macaé, Rio de Janeiro. Methods: An exploratory, descriptive, quantitative, primary research was carried out between March and June 2020, with 92 children aged 2 to 9 years and their respective mothers, members of the social movement in Macaé. Two questionnaires were used: the first was semi-structured containing socioeconomic, demographic clinical and anthropometric variables; the second, a structured questionnaire about foods consumption. The continuous variables were described as means, standard deviation, and the categorical variables as proportion (%). To determine the significance of the differences found in the responses by groups and categories, the chi-square test was used. P-value <0.05 was used for statistical significance. Results: Most children were male (81.5%) and illiterate (75.0%). It was found that 53.5% of the children were overweight, according to the BMI for age, and 91.1% had adequate height for age. Out of 59 children assessed for foods intake, 78.0% ate beans the day before the interview; 57.6% ate fresh fruits, and 54.2% vegetables; 59.3% consumed sweetened drinks and 37.3%, sweets. Conclusion: Overweight and markers of unhealthy eating habits were high for he assessed group.

Association between time of exposure to screens and food consumption of children aged 2 to 9 years during the COVID-19 pandemic / Associação entre tempo de exposição às telas e consumo alimentar de crianças de dois a nove anos durante a pandemia de COVID-19

Abstract Objective: To identify and map families' time of exposure to screens during the COVID-19 pandemic and to associate it with the frequency of children's food consumption. Methods: This is a cross-sectional study carried out with parents or guardians of children aged between 2 and 9 years through an online questionnaire. The participants answered questions about socioeconomic data, family's screen habits, and children's food consumption. Results: A total of 517 parents or guardians participated in the research. Children's median age when first exposed to screens was 6 months (interquartile range: 1-12 months). The average number of hours that children and guardians/parents were exposed to electronic devices was 3.9±2.3 and 9.0±2.9 respectively. As for food consumption, 60.9% of the guardians/parents and 54.3% of the children had the habit of having meals in front of screens. In addition, the consumption of snacks outside mealtimes, while using screens, was frequent in both groups. Conclusions: Children aged 2 to 9 years are excessively exposed to screens and the consumption of meals or snacks while using the devices is frequent. Considering the current demands of the pandemic, the necessity of using electronic devices is understandable. However, the authors emphasize the importance to educate families regarding limiting the use of screens, especially during meals, and monitoring the content of activities with electronic devices, as this exposure can influence food consumption and affect children's nutritional status and health.

RESUMO Objetivo: Identificar e mapear o tempo de exposição das famílias às telas durante a pandemia de COVID-19 e associá-lo com a frequência de consumo alimentar das crianças. Métodos: Trata-se de um estudo transversal, realizado com pais ou responsáveis de crianças de dois a nove anos de idade por meio de um questionário online. Participantes responderam a perguntas sobre dados socioeconômicos, hábitos familiares de uso de telas e consumo alimentar das crianças. Resultados: Participaram da pesquisa 517 pais ou responsáveis. A mediana de idade em que as crianças foram expostas pela primeira vez às telas foi de seis meses (intervalo interquartil: 1-12 meses). A média de horas durante as quais as crianças e os responsáveis ficavam expostos aos aparelhos eletrônicos foi de 3,9±2,3 e 9,0±2,9, respectivamente. Sobre o consumo de alimentos, 60,9% dos responsáveis e 54,3% das crianças tinham o hábito de realizar refeições em frente às telas. Além disso, o consumo de petiscos fora do horário das refeições, durante o uso de telas, foi frequente em ambos os grupos. Conclusões: Crianças de dois a nove anos estão expostas excessivamente às telas e o consumo de refeições ou petiscos durante o uso dos aparelhos é frequente. Diante das demandas atuais da pandemia, entende-se a importância do uso dos eletrônicos, porém reforça-se a necessidade de educar as famílias em relação à importância de limitar o uso de telas, especialmente durante as refeições, e de monitorar o conteúdo das atividades com telas, pois essa exposição pode influenciar a alimentação e repercutir no estado nutricional e na saúde das crianças.

Aspectos sociais e clínicos de crianças com transtorno do espectro autista de um movimento social de um município litorâneo da região do norte fluminense / Social and clinical aspects of children with autistic spectrum disorder (asd) from a social movement in a coastal municipality of the northern fluminense region / Aspectos sociales y clínicos de los niños con trastorno del espectro autista (tea) de un movimiento social de un municipio del litoral del norte fluminense

Objetivo: Identificar os aspectos sociais e clínicos de crianças com transtorno do espectro autista (TEA) de um movimento social de Macaé, Rio de Janeiro, Brasil. Métodos: Estudo do tipo exploratório, quantitativo, de corte seccional, de base primária, desenvolvido no período entre março e junho de 2020, com crianças (2 a 9 anos 11 meses e 29 dias) com TEA (n=97) e suas respectivas mães de um movimento social do município de Macaé, Rio de Janeiro. A coleta de dados foi realizada com a aplicação de um questionário virtual semiestruturado, elaborado para o estudo, contendo os dados socioeconômicos, demográficos, características clínicas e aspectos marcantes da criança respondido pelos pais ou responsáveis dela. O estudo foi aprovado pelo Comité de Ética em Pesquisa. Resultados: O estudo revelou crianças com idade média±DP de 5,4±1,8 anos, a maioria do sexo masculino (81,5%); sem alfabetização (75,0%); pardas (48,0%) e brancas (44,0%); sem doenças associadas (72,8%) e sem doenças adquiridas (75,0%); em uso de medicamentos (60,9%), dos quais 38,0% eram antipsicóticos atípicos. Verificou-se que 72,8% apresentavam déficits na comunicação e interação social; 71,7% dificuldade ou ausência de fala; 68,5% atividades repetitivas e comportamentos estereotipados; 44,6% redução do contato visual, e 31,5% restrição em mostrar, pegar ou utilizar objetos. Conclusão: A maior parte das crianças analisadas não apresentou doenças associadas, doenças adquiridas e seletividade alimentar; usa medicamentos, principalmente, a risperidona; possui déficits na comunicação e interação social, dificuldade ou ausência de fala, atividades repetitivas e comportamentos estereotipados, como descritos na literatura.

Objective: To identify the social and clinical aspects of children with autistic spectrum disorder (ASD) from a social movement in Macaé, Rio de Janeiro, Brazil. Methods: Exploratory, quantitative, sectional, primary-based study, developed between March and June 2020, with children (2 to 9 years 11 months and 29 days) with ASD (n=97) and their mothers from a social movement in the municipality of Macaé, Rio de Janeiro. Data collection was performed with the application of a semi-structured virtual questionnaire, prepared for the study, containing socioeconomic, demographic data, clinical characteristics and striking aspects of the child answered by his parents or guardians. The study was approved by the Research Ethics Committee. Results: The study revealed children with mean±DP age of 5.4±1.8 years, mostly male (81.5%); non-literate (75.0%); brown (48.0%) and white (44.0%); no associated diseases (72.8%) and no acquired diseases (75.0%); on medication use (60.9%), of which 38.0% were atypical antipsychotics. It was found that 72.8% had deficits in communication and social interaction; 71.7% difficulty or absence of speech; 68.5% repetitive activities and stereotyped behaviors; 44.6% reduced eye contact, and 31.5% restricted showing, picking up or using objects. Conclusion: Most of the children analyzed had no associated diseases, acquired diseases, and food selectivity; they use medication, mainly risperidone; have deficits in communication and social interaction, difficulty or absence of speech, repetitive activities, and stereotyped behaviors, as described in the literature.

Objetivo: Identificar los aspectos sociales y clínicos de los niños con trastorno del espectro autista (TEA) de un movimiento social de Macaé, Río de Janeiro, Brasil. Método: Estudio exploratorio, cuantitativo, seccional, de base primaria, desarrollado entre marzo y junio de 2020, con niños (2 a 9 años 11 meses y 29 días) con TEA (n=97) y sus madres de un movimiento social del municipio de Macaé, Río de Janeiro. La recogida de datos se realizó con la aplicación de un cuestionario virtual semiestructurado, elaborado para el estudio, que contenía datos socioeconómicos, demográficos, características clínicas y aspectos llamativos del niño respondidos por sus padres o tutores. El estudio fue aprobado por el Comité de Ética en Investigación. Resultados: El estudio reveló niños con edad media±DP de 5,4±1,8 años, en su mayoría de sexo masculino (81,5%); analfabetos (75,0%); morenos (48,0%) y blancos (44,0%); sin enfermedades asociadas (72,8%) y sin enfermedades adquiridas (75,0%); en uso de medicamentos (60,9%), de los cuales 38,0% eran antipsicóticos atípicos. Se observó que el 72,8% presentaba déficit de comunicación e interacción social; el 71,7% dificultad o ausencia de habla; el 68,5% actividades repetitivas y conductas estereotipadas; el 44,6% disminución del contacto visual, y el 31,5% restricción para mostrar, coger o usar objetos. Conclusiones: La mayoría de los niños analizados no presentaban enfermedades asociadas, enfermedades adquiridas y selectividad alimentaria; utilizan medicación, principalmente risperidona; presentan déficits en la comunicación e interacción social, dificultad o ausencia de habla, actividades repetitivas y conductas estereotipadas, según lo descrito en la literatura.

Optic neuritis in lung adenocarcinoma: A challenging diagnosis.

Optic neuritis with CRMP-5 IgG is a paraneoplastic inflammation of the optic nerve associated with lung cancer, mostly small-cell lung cancer. We present the case of a patient with lung adenocarcinoma who developed progressive bilateral visual loss a few months after immune-chemotherapy with pembrolizumab and after Covid-19 vaccination. Positive CRMP-5 IgG were detected in blood sample and complete work-up - including brain MRI - did not show any progression. High dose systemic corticoids were administered with transient improving, followed by intravenous immunoglobulins, methotrexate and rituximab but despite negativization of CRMP-5 IgG, the patient had a progressive visual loss.

Screening, Diagnosis and Management of Atrial Fibrillation in Cancer Patients: Current Evidence and Future Perspectives. / Rastreamento, Diagnóstico e Manejo da Fibrilação Atrial em Pacientes com Câncer: Evidências Atuais e Perspectivas Futuras.

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the general population, carrying a high morbimortality burden, and this also holds true in cancer patients. The association between AF and cancer goes even further, with some studies suggesting that AF can be a marker of occult cancer. There is, however, a remarkable paucity of data concerning specific challenges of AF management in cancer patients. AF prompt recognition and management in this special population can lessen the arrhythmia-related morbidity and have an important prognostic benefit. This review will focus on current AF diagnosis and management challenges in cancer patients, with special emphasis on AF screening strategies and devices, and anticoagulation therapy with non-vitamin K antagonist oral anti-coagulants (NOACs) for thromboembolic prevention in these patients. Some insights concerning future perspectives for AF prevention, diagnosis, and treatment in this special population will also be addressed.

A fibrilação atrial (FA) é a arritmia cardíaca sustentada mais comum na população geral, tendo uma alta carga de morbimortalidade, e isso também é válido para pacientes com câncer. A associação entre FA e câncer vai ainda mais longe, com alguns estudos sugerindo que a FA pode ser um marcador de câncer oculto. Há, no entanto, uma notável escassez de dados sobre os desafios específicos do manejo da FA em pacientes com câncer. O reconhecimento e o manejo imediatos da FA nesta população especial podem diminuir a morbidade relacionada à arritmia e ter um importante benefício prognóstico. Esta revisão se concentrará nos desafios atuais de diagnóstico e manejo da FA em pacientes com câncer, com ênfase especial nas estratégias e dispositivos de rastreamento da FA e na terapia de anticoagulação com anticoagulantes orais não antagonistas da vitamina K (NOACs) para prevenção tromboembólica nesses pacientes. Alguns insights sobre as perspectivas futuras para a prevenção, diagnóstico e tratamento da FA nesta população especial também serão abordados.

Rastreamento, Diagnóstico e Manejo da Fibrilação Atrial em Pacientes com Câncer: Evidências Atuais e Perspectivas Futuras / Screening, Diagnosis and Management of Atrial Fibrillation in Cancer Patients: Current Evidence and Future Perspectives

Resumo A fibrilação atrial (FA) é a arritmia cardíaca sustentada mais comum na população geral, tendo uma alta carga de morbimortalidade, e isso também é válido para pacientes com câncer. A associação entre FA e câncer vai ainda mais longe, com alguns estudos sugerindo que a FA pode ser um marcador de câncer oculto. Há, no entanto, uma notável escassez de dados sobre os desafios específicos do manejo da FA em pacientes com câncer. O reconhecimento e o manejo imediatos da FA nesta população especial podem diminuir a morbidade relacionada à arritmia e ter um importante benefício prognóstico. Esta revisão se concentrará nos desafios atuais de diagnóstico e manejo da FA em pacientes com câncer, com ênfase especial nas estratégias e dispositivos de rastreamento da FA e na terapia de anticoagulação com anticoagulantes orais não antagonistas da vitamina K (NOACs) para prevenção tromboembólica nesses pacientes. Alguns insights sobre as perspectivas futuras para a prevenção, diagnóstico e tratamento da FA nesta população especial também serão abordados.

Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the general population, carrying a high morbimortality burden, and this also holds true in cancer patients. The association between AF and cancer goes even further, with some studies suggesting that AF can be a marker of occult cancer. There is, however, a remarkable paucity of data concerning specific challenges of AF management in cancer patients. AF prompt recognition and management in this special population can lessen the arrhythmia-related morbidity and have an important prognostic benefit. This review will focus on current AF diagnosis and management challenges in cancer patients, with special emphasis on AF screening strategies and devices, and anticoagulation therapy with non-vitamin K antagonist oral anti-coagulants (NOACs) for thromboembolic prevention in these patients. Some insights concerning future perspectives for AF prevention, diagnosis, and treatment in this special population will also be addressed.

Prevalence of Primary Biliary Cholangitis in a Cohort of Primary Sjögren's Syndrome Patients.

Objective To analyze the prevalence and clinical progression of primary biliary cholangitis (PBC) in patients with primary Sjögren's syndrome (pSS) and possible associations between biochemical and immunological features and the development of PBC. Methods We retrospectively reviewed a cohort of 115 pSS patients followed up in an outpatient clinic from 1987 to 2020, without a history of liver disease, and looked for the presence of PBC through analysis of several biochemical, immunological, and histologic characteristics. Results Twenty patients (17.4%) had chronic cholestatic liver biochemistry. After exclusion of extrahepatic liver disease by abdominal ultrasound, 13 of them were tested for antimitochondrial autoantibodies (AMA) detected by indirect immunofluorescence (IF), of which five tested positive, fulfilling the diagnostic criteria for PBC. Three of the five PBC patients and three of the eight chronic cholestasis AMA-negative patients were further investigated with liver biopsy, which showed features of PBC in all three PBC patients and in one of the chronic cholestasis AMA-negative patients, allowing for the diagnosis of AMA-negative PBC in the latter. The remaining two AMA-negative patients had liver histology compatible with autoimmune hepatitis and unspecific findings, respectively. Overall, six (5.2%) patients with pSS had AMA-positive PBC (n=5) or AMA-negative PBC (n=1). Comparing immunological characteristics between PBC and non-PBC patients, we found that PBC patients had a higher mean maximum erythrocyte sedimentation rate (ESR) during follow-up than patients without PBC. All PBC patients were treated with ursodeoxycholic acid (UDCA) and after treatment with UDCA, only one patient showed biochemical and clinical progression of PBC, with increasing alkaline phosphatase and total bilirubin levels, eventually progressing to cirrhosis. Conclusions Among patients with pSS, PBC had an overall prevalence of six of 115 (5.2%). Higher ESR was a feature associated with PBC patients. In our cohort, after initiation of UDCA treatment, PBC showed predominantly slow progress, with only one patient progressing to cirrhosis during follow-up.

Exercise in lung Cancer, the healthcare providers opinion (E.C.H.O.): Results of the EORTC lung cancer Group (LCG) survey.

OBJECTIVES: Exercise has been reported to alleviate disease as well as treatment impact in patients with lung cancer. Nevertheless, there is limited information available regarding the perception of lung cancer dedicated healthcare professionals' and their advice on exercise. MATERIALS AND METHODS: An online survey exploring healthcare professionals' practice patterns, perceptions, barriers, and facilitators of exercise in patients with lung cancer was conducted within members of the EORTC Lung Cancer Group (LCG). RESULTS: One hundred forty-one healthcare providers completed the survey, mainly medical and radiation oncologists. Overall, 63% of the study participants declared that they frequently assessed exercise level in their patients, and 43% of them reinforced the importance of exercise. However, only 10% referred patients to an exercise program or specialist. Although the majority of the respondents had a positive perception regarding the benefits and safety of exercise (even in patients with advanced disease and/or bone metastasis), two-thirds of clinicians reported not having adequate training about exercise counselling. Moreover, 53% reported to lack of knowledge of guidelines referring to exercise in patients with cancer. Several obstacles and facilitators to improve exercise promotion in lung cancer care were identified. CONCLUSION: Healthcare providers recognize the relevance and feasibility of exercise as part of cancer treatment intervention, but specific pathways to do the referral are frequently missing. Future structured and well-designed strategies and initiatives are needed to support an effective referral in order to implement exercise interventions routinely in clinical practice.