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Transplantation ; 100(1): 233-8, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26154392

RESUMO

BACKGROUND: Patients with proximal forearm and arm transplantation have obtained and/or maintained function of the elbow joint and full active range of motion of the extrinsic muscles of the hand, but with diminished protective sensibility and a lack of good function of the intrinsic muscles. These patients have improved function, as measured by the Disabilities of the Arm, Shoulder and Hand questionnaire. METHODS: We report the case of a 52-year-old man who suffered a high-voltage electrical burn requiring amputation of his upper limbs. He underwent bilateral proximal forearm transplantation in Mexico City in May 2012. RESULTS: At 2-year follow-up, immunosuppressive treatment has not led to metabolic, oncologic, or infectious complications. Keloid scars developed at the graft-recipient interface. There have been 4 acute rejections: the fourth was treated with methylprednisolone, rituximab, and immunoglobulin. Chronic rejection has not been detected. The extrinsic muscles of the wrist and digits have good function. Although the intrinsic muscles demonstrated electrical activity 15 months postoperatively, clinically, they are nonuseful. After 2 years, hand function is sufficient to allow the patient to grasp lightweight and medium-sized objects. The patient's Disabilities of the Arm, Shoulder and Hand questionnaire score improved from 50.00 points to 30.83 points, and his Hand Transplantation Score System rating is good, at 69/73 (right/left) of 100. The patient and his family are very satisfied with the functional and aesthetic outcomes. CONCLUSIONS: Upper arm or proximal forearm transplantation is a reconstructive option for patients who have experienced amputation because of trauma.


Assuntos
Queimaduras por Corrente Elétrica/cirurgia , Traumatismos do Antebraço/cirurgia , Antebraço/cirurgia , Transplante de Órgãos/métodos , Doença Aguda , Amputação Cirúrgica , Fenômenos Biomecânicos , Biópsia , Queimaduras por Corrente Elétrica/diagnóstico , Queimaduras por Corrente Elétrica/fisiopatologia , Avaliação da Deficiência , Antebraço/inervação , Traumatismos do Antebraço/diagnóstico , Traumatismos do Antebraço/fisiopatologia , Rejeição de Enxerto/tratamento farmacológico , Rejeição de Enxerto/imunologia , Humanos , Imunossupressores/administração & dosagem , Masculino , México , Pessoa de Meia-Idade , Monitorização Imunológica , Transplante de Órgãos/reabilitação , Satisfação do Paciente , Recuperação de Função Fisiológica , Fatores de Tempo , Resultado do Tratamento
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