Worker studies suggest unique liver carcinogenicity potential of polyvinyl chloride microplastics.

BACKGROUND: Plastic debris pervades our environment. Some breaks down into microplastics (MPs) that can enter and distribute in living organisms causing effects in multiple target organs. MPs have been demonstrated to harm animals through environmental exposure. Laboratory animal studies are still insufficient to evaluate human impact. And while MPs have been found in human tissues, the health effects at environmental exposure levels are unclear. AIM: We reviewed and summarized existing evidence on health effects from occupational exposure to MPs. Additionally, the diverse effects documented for workers were organized by MP type and associated co-contaminants. Evidence of the unique effects of polyvinyl chloride (PVC) on liver was then highlighted. METHODS: We conducted two stepwise online literature reviews of publications focused on the health risks associated with occupational MP exposures. This information was supplemented with findings from animal studies. RESULTS: Our analysis focused on 34 published studies on occupational health effects from MP exposure with half involving exposure to PVC and the other half a variety of other MPs to compare. Liver effects following PVC exposure were reported for workers. While PVC exposure causes liver toxicity and increases the risk of liver cancers, including angiosarcomas and hepatocellular carcinomas, the carcinogenic effects of work-related exposure to other MPs, such as polystyrene and polyethylene, are not well understood. CONCLUSION: The data supporting liver toxicity are strongest for PVC exposure. Overall, the evidence of liver toxicity from occupational exposure to MPs other than PVC is lacking. The PVC worker data summarized here can be useful in assisting clinicians evaluating exposure histories from PVC exposure and designing future cell, animal, and population exposure-effect research studies.

Effects of the Indian National Health Insurance Scheme (PM-JAY) on Hospitalizations, Out-of-pocket Expenditures and Catastrophic Expenditures.

India launched one of the world's largest health insurance programs, the Pradhan Mantri Jan Arogya Yojana (PM-JAY), targeting more than 500 million economically and socially disadvantaged Indians. PM-JAY is publicly funded and covers hospitalization costs in public and private facilities. We examine how PM-JAY has affected hospitalizations and out-of-pocket expenditures (OOPE), and given the high use of private health care in India, we compare these outcomes across public and private facilities. We conducted a household survey to collect data on socioeconomic and demographic information, health status and hospitalizations for more than 57,000 PM-JAY eligible individuals in six Indian states. Using multivariate regression models, we estimated whether PM-JAY was associated with any changes in hospitalizations, OOPE and catastrophic health expenditures (CHE) and whether these differed across public and private facilities. We found that PM-JAY was not associated with an increase in hospitalizations, but it increased the probability of visiting a private facility by 4.6% points (p < .05). PM-JAY was associated with a relative reduction of 13% in OOPE (p < .1) and 21% in CHE (p < .01). This was entirely driven by private facilities, where relative OOPE was reduced by 17% (p < .01) and CHE by 19% (p < .01). This implied that PM-JAY has shifted use from public to private hospitalizations. Given the complex healthcare system with the presence of parallel public and private systems in India, our study concludes that for economically and socially disadvantaged groups, PM-JAY contributes to improved access to secondary and tertiary care services from private providers.

Awareness of India's national health insurance scheme (PM-JAY): a cross-sectional study across six states.

The literature suggests that a first barrier towards accessing benefits of health insurance in low- and middle-income countries is lack of awareness of one's benefits. Yet, across settings and emerging schemes, limited scientific evidence is available on levels of awareness and their determinants. To fill this gap, we assessed socio-demographic and economic determinants of beneficiaries' awareness of the Pradhan Mantri Jan Arogya Yojana (PM-JAY), the national health insurance scheme launched in India in 2018, and their awareness of own eligibility. We relied on cross-sectional household (HH) survey data collected in six Indian states between 2019 and 2020. Representative data of HHs eligible for PM-JAY from 11 618 respondents (an adult representative from each surveyed HH) were used. We used descriptive statistics and multivariable logistic regression models to explore the association between awareness of PM-JAY and of one's own eligibility and socio-economic and demographic characteristics. About 62% of respondents were aware of PM-JAY, and among the aware, 78% knew that they were eligible for the scheme. Regression analysis confirmed that older respondents with a higher educational level and salaried jobs were more likely to know about PM-JAY. Awareness was lower among respondents from Meghalaya and Tamil Nadu. Respondents from Other Backward Classes, of wealthier socio-economic status or from Meghalaya or Gujarat were more likely to be aware of their eligibility status. Respondents from Chhattisgarh were less likely to know about their eligibility. Our study confirms that while more than half of the eligible population was aware of PM-JAY, considerable efforts are needed to achieve universal awareness. Socio-economic gradients confirm that the more marginalized are still less aware. We recommend implementing tailored, state-specific information dissemination approaches focusing on knowledge of specific scheme features to empower beneficiaries to demand their entitled services.

Health Academy Program and physical activity levels in Brazilian state capitals / Programa Academia da Saúde e níveis de atividade física nas capitais brasileiras

The objective of this study was to analyze the impact of a community-based physical activity program, the Health Academy Program (Academia da Saúde or PAS), on leisure-time physical activity (LTPA) among the population living at the Brazilian state capitals. We pooled individual data from the National Surveillance for Protective and Risk Factors for Chronic Diseases (VIGITEL) between 2006 and 2016 and estimated odds ratios according to levels of exposure by using a multilevel logistic regression. Total sample was composed of 572,437 individuals. In the initial model, chances of reaching sufficient LTPA was 1.20 (95%CI: 1.16-1.25) times higher among individuals exposed since 2011. In the analyses adjusted for year, sex, age and education, this probability was only 1.04 (95%CI: 1.00-1.08) times higher among exposed individuals. Odds of reaching recommended LTPA was 1.09 (95%CI: 1.04-1.15) times higher among women exposed since 2011 as compared to women in the control group with no exposure. No other statistically significant results were found. We conclude that the PAS cannot substantially affect whole populations. Yet it is possible to visualize a positive influence of the program on specific subgroups, pointing to its potential to reduce gender inequity in LTPA practice. We recommend more tailored interventions before indistinctively scaling up the program, as well as we suggest better monitoring for large scale evaluations

O objetivo deste estudo foi analisar o efeito de um programa de atividade física de base comunitária, o Programa Academia da Saúde (PAS), no nível de atividade física durante o lazer (AFDL) da população residente nas capitais brasileiras. Reunimos dados individuais do sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico ( VIGITEL) entre 2006 e 2016 e estimamos os odds ratios de acordo com níveis de exposição ao programa usando uma regressão logística multinível. A amostra total foi composta por 572.437 indivíduos. No modelo inicial, as chances de se atingir níveis suficientes de AFDL foram 1,20 (95%IC: 1,16-1,25) vezes maior entre os indivíduos expostos desde 2011. Nas análises ajustadas por ano, sexo, idade e escolaridade, essa probabilidade foi apenas 1,04 (95%IC: 1,00-1,08) vezes maior entre indivíduos expostos. As chances de se atingir níveis de AFDL suficiente foram 1,09 (95%IC: 1,04-1,15) vezes maior entre as mulheres expostas desde 2011 em comparação ao grupo controle de mulheres não expostas. Nenhum outro resultado estatisticamente significativo foi encontrado. Concluímos que o PAS não pode afetar substancialmente populações inteiras. No entanto, é possível visualizar influência positiva em subgrupos específicos, apontando para o seu potencial em reduzir a desigualdade de gênero em relação a prática de AFDL. Recomendamos intervenções mais personalizadas antes de escalonar indistintamente o programa, bem como sugerimos um melhor monitoramento para avaliações em larga escala