RECURRENT ACUTE RETINAL NECROSIS.

PURPOSE: To describe a patient with recurrent acute retinal necrosis (ARN), her treatment, and propose a possible pathophysiologic mechanism. METHOD: Case report. RESULTS: A 4-year-old girl presented elsewhere with bilateral ARN, was treated, but developed a retinal detachment in the left eye that failed vitrectomy surgery. She was referred 10 years later with recurrent ARN. The infection was difficult to get under control, but eventually responded to intravenous acyclovir and foscarnet. She was given laser photocoagulation. She was placed on oral valacyclovir prophylaxis and was disease-free for 10 years at which point she decided to go to South America on vacation and stop her valacyclovir. Within a few days she developed a recurrence of ARN and flew back for treatment. She had discrete areas of retinal necrosis, vasculitis, and the laser photocoagulation lesions seemed to be ringed by a retinal change suggestive of retinitis. She responded to antiviral treatment, but developed a retinal detachment that was successfully treated. Her visual acuity was 20/20 six years later, and she was using antiviral prophylaxis. CONCLUSION: Recurrent ARN can respond to aggressive treatment. Chorioretinal scars, such as from photocoagulation, may be potential sites of viral invasion during recurrences. Antiviral prophylaxis may be indicated for at-risk patients.

Associations of weight cycling with cardiovascular health using American Heart Association's Life's Simple 7 in a diverse sample of women.

Prior research shows that weight cycling is associated with poorer cardiovascular health (CVH). Women experience unique life events (e.g. pregnancy, menopause) which may make them more prone to weight cycling. Examining the influence of weight cycling history (HWC) on CVH, quantified using the American Heart Association's Life's Simple 7 (LS7), may provide novel targets to improve CVH. A cross-sectional sample of 485 women at Columbia University Irving Medical Center (2016-2018) were scored on each LS7 metric (BMI, blood pressure, fasting cholesterol and glucose, physical activity, diet, and smoking): 0 (low), 1 (moderate) or 2 (high). Metric points were summed into a composite LS7 score as a measure of CVH: 0-8 (low), 9-10 (moderate), 11-14 (high). Multivariable-adjusted logistic and linear regression models were used for the associations between HWC and CVH. Most women (73%) reported HWC (range: 0-20); 26% had low CVH and 74% moderate/high CVH. Logistic models showed HWC was associated with higher odds of having poor CVH [OR (95%CI): 2.39 (1.36-4.20)]. Linear models showed each additional weight cycling episode was associated with lower LS7 scores [ß(SE): -0.37 (0.07); p < 0.01]. Associations between HWC and odds of having poor CVH were stronger among pre-menopausal women and those with no pregnancy history (p-interaction = 0.009, 0.004, respectively). In conclusion, HWC was associated with higher odds of poorer CVH with stronger associations seen in pre-menopausal and women with no pregnancy history. These findings suggest that in addition to having a healthy weight, maintaining a consistent weight may be important for achieving optimal CVH, but warrant prospective confirmation.