Hylan g-f 20 versus triamcinolone in the treatment of primary shoulder osteoarthritis. randomized trial / Hilano g-f 20 versus triancinolona no tratamento da osteoartrite primária do ombro. estudo randomizado

ABSTRACT Introduction The aim of this study was to evaluate the effect of using an intra-articular injection of hylan G-F 20 (HA group) on primary shoulder osteoarthritis compared with an intra-articular triamcinolone injection (T group). Materials and Methods The patients were randomized into 2 groups: in the HA group a single dose of intra-articular hylan G-F 20 was administered and in the T control group a dose of triamcinolone 20 mg was administered. The participants were evaluated at 1 week, 1, 3, and 6 months after the procedure. The patients were evaluated for pain, range of motion, Constant score, modified UCLA score, and SPADI. Results Seventy patients met the inclusion criteria and were randomized to the HA (38) and T (32) groups. Improvements in range of motion were significant (p > 0.05). We observed decreases in the general visual analog scale (VAS) for pain in both groups, especially in the cases of mild and moderate arthritis that received hyaluronic acid (mean values from 8.1 initially to 4.9 after 6 months) (p = 0). Conclusions Both injections led to a decrease in pain and an increase in patient satisfaction. The results tend to be better and longer lasting in patients receiving hyaluronic acid. Level of evidence II b; Cohort study.

RESUMO Introdução O objetivo deste estudo foi avaliar o efeito do uso de uma injeção intra-articular de Hilano G-F 20 (Grupo HA) na osteoartrite primária do ombro em comparação com injeção intra-articular de triancinolona (Grupo T). Material e Método Os pacientes foram randomizados em dois grupos: no Grupo HA foi administrada uma dose única de Hilano G-F 20 intra-articular e no Grupo controle T foi administrada uma dose de 20 mg de triancinolona. Os participantes foram avaliados 1 semana, 1, 3 e 6 meses depois do procedimento. Os pacientes foram avaliados quanto à dor, amplitude de movimento, escore de Constant, escore UCLA modificado e índice SPADI. Resultados Setenta pacientes satisfizeram os critérios de inclusão e foram randomizados para os Grupos HA (38) e T (32). As melhoras da amplitude de movimento foram significativas (p > 0,05). Observamos diminuições na escala visual analógica (EVA) geral para dor em ambos os grupos, principalmente nos casos de artrite leve e moderada que receberam ácido hialurônico (valores médios de 8,1 inicialmente a 4,9 depois de 6 meses) (p = 0). Conclusões Ambas as injeções reduziram a dor e aumentaram a satisfação do paciente. Os resultados tendem a ser melhores e mais duradouros em pacientes que recebem ácido hialurônico. Nível de evidência II b; Estudo de Coorte.

Genetic Aspects in Shoulder Disorders / Aspectos genéticos nas afecções do ombro

Abstract The influence of genetic inheritance has been increasingly investigated in shoulder disorders, such as rotator cuff injury, instability and frozen shoulder. Although the initial findings are enlightening, it is necessary to progressively build a database of genetic markers to catalog genomic profiles that, later, may contribute for predicting the risk of the disease, as well as to the development of better diagnostic and treatment tools. The present article seeks to update what is evidence of genetic studies in the literature for these diseases, from polymorphism analyses, expression of candidate genes in tissues and broad genomic association studies (GWAS). However, it is necessary to point out that there is great difficulty in replicating and using the findings, mainly due to the lack of statistical power, the high rate of false-positive results and the large number of variables involved.

Resumo A influência da herança genética tem sido cada vez mais investigada nas afecções do ombro, como a lesão do manguito rotador, instabilidade e ombro congelado. Ainda que os achados iniciais sejam pouco esclarecedores, é necessário construir progressivamente um banco de marcadores genéticos para catalogar perfis genômicos que, mais adiante, poderão contribuir para a previsão do risco da doença, desenvolvimento de melhores ferramentas de diagnóstico e tratamento. O presente artigo busca atualizar o que há de evidências de estudos genéticos na literatura para essas doenças, desde análises de polimorfismos, expressão de genes candidatos em tecidos e estudos de associação genômica ampla (GWAS, na sigla em inglês). Porém, é necessário apontar que existe grande dificuldade na replicação e utilização dos achados, principalmente em razão da falta de poder estatístico, da alta taxa de resultados falso-positivos e da grande quantidade de variáveis envolvidas.

Association between Frozen Shoulder and Thyroid Diseases: Strengthening the Evidences.

Objective To clarify the association of thyroid disorders and primary frozen shoulder by comparing this group with controls without shoulder disease and with patients with rotator cuff tears. Methods We evaluated 166 patients who presented frozen shoulder with treatment in progress or already treated, which were compared with 129 patients with diagnosis of rotator cuff tears and 251 control subjects. All of the participants answered the questionnaire on the following variables: age, gender, body mass index (BMI), occupation, physical activity, presence of thyroid disorders and other comorbidities, smoking and use of alcohol. Results When comparing the frozen shoulder group with the control and rotator cuff groups, there is a specific association between the presence of thyroid disorders and frozen shoulder. By calculating relative risk, it is possible to state that an individual with thyropathy has 2.69 more chance of developing frozen shoulder. Also, there was an association with gender, since women with frozen shoulder exceeded significantly the risk. Conclusions Thyroid disorders, especially hypothyroidism and the presence of benign thyroid nodules, are risk factors significantly associated with frozen shoulder, rising the chances to 2.69 times of developing frozen shoulder. This is the first study that uses, in addition to the control group, a second group with rotator cuff tears, so it was shown that there is a specific association of thyroid disorders and frozen shoulder, but not with shoulder disorders in general.

Association between Frozen Shoulder and Thyroid Diseases: Strengthening the Evidences / Associação entre ombro congelado e tireopatias: Reforçando as evidências

Abstract Objective To clarify the association of thyroid disorders and primary frozen shoulder by comparing this group with controls without shoulder disease and with patients with rotator cuff tears. Methods We evaluated 166 patients who presented frozen shoulder with treatment in progress or already treated, which were compared with 129 patients with diagnosis of rotator cuff tears and 251 control subjects. All of the participants answered the questionnaire on the following variables: age, gender, body mass index (BMI), occupation, physical activity, presence of thyroid disorders and other comorbidities, smoking and use of alcohol. Results When comparing the frozen shoulder group with the control and rotator cuff groups, there is a specific association between the presence of thyroid disorders and frozen shoulder. By calculating relative risk, it is possible to state that an individual with thyropathy has 2.69 more chance of developing frozen shoulder. Also, there was an association with gender, since women with frozen shoulder exceeded significantly the risk. Conclusions Thyroid disorders, especially hypothyroidism and the presence of benign thyroid nodules, are risk factors significantly associated with frozen shoulder, rising the chances to 2.69 times of developing frozen shoulder. This is the first study that uses, in addition to the control group, a second group with rotator cuff tears, so it was shown that there is a specific association of thyroid disorders and frozen shoulder, but not with shoulder disorders in general.

Resumo Objetivo Verificar a asssociação entre tireopatias e ombro congelado primário, comparando com grupo controle e com grupo de pacientes com lesão no manguito rotador. Métodos Foram avaliados 166 pacientes com diagnóstico de ombro congelado primário com tratamento em andamento ou já tratados. Este grupo foi comparado com 129 pacientes com diagnóstico de lesão de manguito rotador e com um terceiro grupo controle formado por 251 indivíduos sem acometimento dos ombros. Todos os participantes responderam questionário sobre as seguintes variáveis: idade, gênero, índice de massa corpórea (IMC), profissão, atividade física, presença de tireopatia e de outras comorbidades, hábito tabagista e etilismo. Resultados Quando comparamos o grupo de ombro congelado com os grupos controle e lesão de manguito rotador, percebemos que existe uma associação específica entre presença de doenças da tireoide (tireoidite, hipotireoidismo, hipertireoidismo, nódulos e câncer) e ombro congelado. Através do cálculo do risco relativo, é possível afirmar que um indivíduo com tireopatia tem probabilidade 2.69 maior de desenvolver ombro congelado. Também houve associação com gênero, já que as mulheres com ombro congelado elevam significativamente esse risco. Conclusão Os distúrbios da tireoide, especialmente o hipotireoidismo e a presença de nódulos tireoidianos benignos, são fatores de risco significativamente associados ao ombro congelado, aumentando as chances em 2,69 vezes de desenvolver a doença. Este é o primeiro estudo que utiliza, além do grupo controle, um segundo grupo com lesões do manguito rotador, de modo que foi demonstrada uma associação específica de distúrbios da tireoide e ombro congelado.

Supraspinatus Muscle Tendon Lesion and Its Relationship with Long Head of the Biceps Lesion / Lesão do tendão do músculo supraespinal e sua relação com a lesão do tendão da cabeça longa do bíceps

Abstract Objective To identify the clinical, radiological, and arthroscopic correlation of long head of the biceps tendon injuries and their influence on pain when associated with rotator cuff injuries. Methods Between April and December 2013, 50 patients were evaluated, including 38 (76%) women and 12 (24%) men, with a mean age of 65.1 years old. The patients were operated by the Shoulder and Elbow Group, Discipline of Sports Medicine, Orthopedics and Traumatology Department, Universidade Federal de São Paulo. The subjects underwent repair of the rotator cuff lesion with clinical, radiological and/or arthroscopic evidence of involvement of the long head of the biceps tendon. Results An association between pain at palpation of the intertubercular groove of the humerus and high-grade partial lesions (partial rupture of the tendon affecting more than 50% of its structure) was observed at the arthroscopy (p = 0.003). There was also an association between the high-grade lesion of the long head of the biceps and injury to the supraspinatus muscle tendon (p < 0.05). For each centimeter of the supraspinatus muscle tendon injury, the patient presented a 1.7 higher probability of having a high-grade lesion at the long head of the biceps. Conclusion Pain at the anterior shoulder region during palpation of the intertubercular groove of the humerus may be related to high-grade lesions to the long head of the biceps. Rotator cuff injury and its size are risk factors for high-grade injuries to the long head of the biceps tendon.

Resumo Objetivo Identificar a correlação clínica, radiológica, e artroscópica das lesões do tendão da cabeça longa do bíceps e sua influência na dor do paciente quando associada às lesões do manguito rotador. Métodos Entre abril e dezembro de 2013, foram avaliados 50 pacientes, sendo 38 (76%) do sexo feminino e 12 (24%) do sexo masculino, com idade média de 65,1 anos. Os pacientes foram operados pelo Grupo de Ombro e Cotovelo da Disciplina de Medicina Esportiva do Departamento de Ortopedia e Traumatologia da Universidade Federal de São Paulo. Os indivíduos foram submetidos a reparo da lesão do manguito rotador com evidência clínica, radiológica e/ou artroscópica de acometimento do tendão da cabeça longa do bíceps. Resultados Observou-se associação entre dor à palpação do sulco intertubercular do úmero com lesão parcial de alto grau (ruptura parcial acometendo mais de 50% do tendão) na artroscopia (p = 0,003). Encontramos ainda uma associação entre a lesão de alto grau da cabeça longa do bíceps e a lesão do tendão do músculo supraespinal (p < 0,05), sendo que, para cada centímetro de lesão do tendão do músculo supraespinal, o paciente apresenta probabilidade 1,7 maior de ter uma lesão de alto grau da cabeça longa do bíceps. Conclusão A dor na região anterior do ombro à palpação do sulco intertubercular do úmero pode estar relacionada às lesões de alto grau da cabeça longa do bíceps. A lesão do manguito rotador e o seu tamanho são fatores de risco para lesão de alto grau do tendão da cabeça longa do bíceps.

Rotator Cuff Tear Susceptibility Is Associated With Variants in Genes Involved in Tendon Extracellular Matrix Homeostasis.

Rotator cuff tears (RCT) is a multifactorial disease with genetic factors contributing for the disease etiology. We hypothesized that genetic variants in genes involved in extracellular matrix (ECM) homeostasis may alter susceptibility to RCT. We evaluated 20 polymorphisms of genes involved in ECM homeostasis in 211 cases of full-thickness tears of the supraspinatus (Nfemales = 130; Nmales = 81) and 567 age-matched controls (Nfemales = 317; Nmales = 250). Multivariate logistic regressions were carried out with age, gender, genetic ancestry (based on the analysis of 61 biallelic short insertion/deletion polymorphisms), and common co-morbidities (diabetes, dyslipidemia, and smoking habits) as covariates. We observed that carriers of the rare allele of both studied variants of TGFB1, as well as their G/A (rs1800470/rs1800469) haplotype, were less susceptible to RCT (p < 0.05). In contrast, carriers of the G allele of MMP9 rs17576 (p = 0.014) or G/G haplotype (rs17576/rs17577; p < 0.001) had an increased risk for tendon tears. The presence of the T allele of MMP2 rs2285053 (p = 0.033), the T allele of MMP3 rs679620 (p = 0.024), and the TT-genotype of TIMP2 rs2277698 (p = 0.01) was associated with susceptibility to tears, especially in females. In males, the A allele of COL5A1 rs3196378 (p = 0.032) and the G allele of TGFBR1 rs1590 (p = 0.039) were independent risk factors for RCT. The C/T COL5A1 (rs3196378/rs11103544) haplotype was associated with a reduced risk of tears in males (p = 0.03). In conclusion, we identified the genetic variants associated with RCT susceptibility, thereby reinforcing the role of genes involved in the structure and homeostasis of the ECM of tendons in disease development. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:192-201, 2020.

Changes in the expression of matrix extracellular genes and TGFB family members in rotator cuff tears.

Lack of synthesis of extracellular matrix compounds may contribute to degeneration of the tendons. Thus, we aimed to evaluate the expression of extracellular matrix and TGFB family members in ruptured and non-ruptured tendons of the rotator cuff, as well as the effect of clinical factors on gene expression in tendon samples, and the relationship between histological findings and altered gene expression. Injured and non-injured supraspinatus tendon samples and subscapular non-injured tendon samples were collected from 38 patients with rotator cuff tears. Non-injured supraspinatus tendons were obtained from eight controls. Specimens were used for histological evaluation, quantification of collagen fibers, and mRNA and protein expression analyses. Increased COL1A1, COL1A2, COL3A1, COL5A1, FN1, TNC, and TGFBR1 mRNA expression was observed in the tear samples (p < 0.05). Duration of symptoms was correlated with the levels of collagen type I/III fibers (p = 0.032; ρ = 0.0447) and FN1 immunostaining (p = 0.031; ρ = 0.417). Smoking was associated with increased frequency of microcysts, myxoid degeneration, and COL5A1, FN1, TNC, and TGFB1 mRNA expression (p < 0.05). FN1 immunostaining was correlated with the number of years of smoking (p = 0.048; ρ = 0.384). Lower levels of collagen type I/III fibers were detected in samples with fissures (0 = 0.046). High frequency of microcysts was associated with increased COL5A1, FN1, and TNC expression (p < 0.05, for all comparisons). Neovascularization was associated with reduced FN1 (p = 0.035) and TGFBR1 expression (p = 0.034). Our findings show differential expression of matrix extracellular genes and TGFB family members in the degeneration process involved in rotator cuff tears. These molecular alterations are influenced by clinical factors. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2542-2553, 2018.

Epigenetic regulation of metalloproteinases and their inhibitors in rotator cuff tears.

Rotator cuff tear is a common orthopedic condition. Metalloproteinases (MMP) and their inhibitors (TIMP) seem to play a role in the development of joint injuries and in the failure of tissue healing. However, the mechanisms of regulation of gene expression in tendons are still unknown. Epigenetic mechanisms, such as DNA methylation and microRNAs regulation, are involved in the dynamic control of gene expression. Here, the mRNA expression and DNA methylation status of MMPs (MMP1, MMP2, MMP3, MMP9, MMP13, and MMP14) and TIMPs (TIMP1-3) and the expression of miR-29 family members in ruptured supraspinatus tendons were compared with non-injured tendons of individuals without this lesion. Additionally, the gene expression and methylation status at the edge of the ruptured tendon were compared with macroscopically non-injured rotator cuff tendon samples from the anterior and posterior regions of patients with tendon tears. Moreover, the possible associations between the molecular alterations and the clinical and histologic characteristics were investigated. Dysregulated expression and DNA methylation of MMP and TIMP genes were found across the rotator cuff tendon samples of patients with supraspinatus tears. These alterations were influenced at least in part by age at surgery, sex, smoking habit, tear size, and duration of symptoms. Alterations in the studied MMP and TIMP genes may contribute to the presence of microcysts, fissures, necrosis, and neovascularization in tendons and may thus be involved in the tendon healing process. In conclusion, MMPs and their inhibitors are regulated by epigenetic modifications and may play a role in rotator cuff tears.

The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis: a pilot gene expression study.

OBJECTIVES: We evaluated mRNA expression levels of genes that encode TGF-ß1; the TGF-ß1 receptor; the collagen-modifying enzymes LOX, PLOD1, and PLOD2; and the extracellular matrix proteins COMP, FN1, TNC and TNXB in synovial/capsule specimens from patients with idiopathic adhesive capsulitis. Possible associations between the measured mRNA levels and clinical parameters were also investigated. METHODS: We obtained glenohumeral joint synovium/capsule specimens from 9 patients with idiopathic adhesive capsulitis who had not shown improvement in symptoms after 5 months of physiotherapy. Adhesive capsulitis was confirmed in all patients by magnetic resonance imaging. We also obtained specimens from 8 control patients who had underwent surgery for acute acromioclavicular joint dislocation and who had radiological indication of glenohumeral capsule alteration based on arthroscopic evaluation. mRNA expression in the synovium/capsule specimens was analyzed by quantitative reverse transcription PCR. The B2M and HPRT1 genes were used as references to normalize target gene expression in the shoulder tissue samples. RESULTS: The synovium/capsule samples from the patients with adhesive capsulitis had significantly higher TNC and FN1 expression than those from the controls. Additionally, symptom duration directly correlated with expression of TGFß1 receptor I. CONCLUSION: Elevated levels of TNC and FN1 expression may be a marker of capsule injury. Upregulation of TGFß1 receptor I seems to be dependent on symptom duration; therefore, TGFß signaling may be involved in adhesive capsulitis. As such, TNC, FN1 and TGFß1 receptor I may also play roles in adhesive capsulitis by contributing to capsule inflammation and fibrosis.

The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis: a pilot gene expression study

OBJECTIVES: We evaluated mRNA expression levels of genes that encode TGF-β1; the TGF-β1 receptor; the collagen-modifying enzymes LOX, PLOD1, and PLOD2; and the extracellular matrix proteins COMP, FN1, TNC and TNXB in synovial/capsule specimens from patients with idiopathic adhesive capsulitis. Possible associations between the measured mRNA levels and clinical parameters were also investigated. METHODS: We obtained glenohumeral joint synovium/capsule specimens from 9 patients with idiopathic adhesive capsulitis who had not shown improvement in symptoms after 5 months of physiotherapy. Adhesive capsulitis was confirmed in all patients by magnetic resonance imaging. We also obtained specimens from 8 control patients who had underwent surgery for acute acromioclavicular joint dislocation and who had radiological indication of glenohumeral capsule alteration based on arthroscopic evaluation. mRNA expression in the synovium/capsule specimens was analyzed by quantitative reverse transcription PCR. The B2M and HPRT1 genes were used as references to normalize target gene expression in the shoulder tissue samples. RESULTS: The synovium/capsule samples from the patients with adhesive capsulitis had significantly higher TNC and FN1 expression than those from the controls. Additionally, symptom duration directly correlated with expression of TGFβ1 receptor I. CONCLUSION: Elevated levels of TNC and FN1 expression may be a marker of capsule injury. Upregulation of TGFβ1 receptor I seems to be dependent on symptom duration; therefore, TGFβ signaling may be involved in adhesive capsulitis. As such, TNC, FN1 and TGFβ1 receptor I may also play roles in adhesive capsulitis by contributing to capsule inflammation and fibrosis.

Rodeo athletes: management of shoulder instability.

BACKGROUND: The aim of this study was to describe epidemiological data and evaluate the clinical results of traumatic anterior glenohumeral instability in rodeo athletes. METHODS: Thirteen patients, all male, with a mean age of 23.2 (18-31) years old, with anterior glenohumeral instability were include in this study. In 9 patients, the right side was affected. The mean time elapsed between injury and undergoing surgery was 56 months (24-120 months). The surgical technique used (arthroscopic or open bone block procedure) was chosen based on the ISIS (Instability Severity Index Score). Only professional athletes who had been in the sport for at least 60 months were included. Functional evaluation was conducted using the UCLA scale, after a 24-month follow-up period. RESULTS: The number of dislocation episodes varied from 10 to 100 (mean 27 episodes). All of the patients were submitted a surgical treatment open bone block procedure, due to their degree of sport participation, type of sport (forced overhead and collision) and the presence of associated bone defect lesions. According to UCLA criteria, the results were excellent in 12 patients and good in one. The mean time elapsed before returning to the sport was five months, varying between two and ten months. Complications included one patient developing axillary neuropraxia, which was completely resolved six months after the operation, and another patient developed a superficial skin infection. CONCLUSIONS: The rodeo athletes with anterior shoulder instability had serious associated bony lesions and has good outcome after bone block procedure.

Evaluation of the results from arthroscopic surgical treatment of rotator cuff injuries in patients aged 65 years and over.

OBJECTIVES: To evaluate the results from arthroscopic surgical treatment of rotator cuff injuries in patients aged 65 years and over. METHODS: Between 1998 and 2009, 168 patients underwent operations. Five cases were excluded. The remaining 163 patients were stratified according to their age group: 65-69 years (49.1%), 70-74 (26.4%) and 75 years and over (24.5%). Their mean age was 71 years (range: 65-83). There were 63 male patients (38.7%). The mean length of time with pain, from the onset of symptoms to the surgery, was 23 months (range: 2 days to 240 months). Sixty-two patients (38%) reported histories of trauma and 26 (16%) reported that their pain worsened through exertion. RESULTS: From the UCLA criteria, 80.4% of the results were excellent, 16% good, 1.8% fair and 1.8% poor. Complications occurred in 11%. The final clinical result did not show any correlation with age progression, injury size or tendons affected. However, there was a significant association (p < 0.001) between the presence of trauma and larger injuries. The length of time between the onset of symptoms and the surgical procedure had a significant relationship (p < 0.027) with the postoperative results: the longer this time was, the worse the results were. CONCLUSION: Arthroscopic treatment of rotator cuff injuries in patients aged 65 years and over presented excellent and good results in 96.4% of the cases, according to the UCLA assessment, with a low complication rate. Advanced age did not show any influence on the postoperative clinical evolution, but the earlier the surgical treatment was instituted, the better the results were.

OBJETIVOS: Avaliar os resultados do tratamento cirúrgico por via artroscópica nas lesões do manguito rotador (LMR) de pacientes com 65 anos ou mais. MÉTODOS: Entre 1998 e 2009 foram operados 168 pacientes. Cinco casos foram excluídos. Os 163 pacientes foram estratificados de acordo com a faixa etária de 65 a 69 (49,1%), 70 a 74 (26,4%) e acima de 75 (24,5%). A média foi de 71 anos (65 a 83). Eram do sexo masculino 63 pacientes (38,7%). A média de tempo de dor (início dos sintomas) até a cirurgia foi de 23 meses (2d­240 m). Referiram história de trauma 62 pacientes (38%) e 26 (16%) algum esforço com pioria da dor. RESULTADOS: Pelos critérios da Universidade da Califórnia em Los Angeles (UCLA) tivemos 80,4% de excelentes resultados, 16% bons, 1,8% regular e 1,8% ruim. Tivemos 11% de complicações. O resultado clínico final não mostrou correlação com a progressão da idade, o tamanho da lesão ou os tendões acometidos. Mas existe uma associação significativa (p < 0,001) entre a presença de trauma e lesões maiores. O tempo entre o início dos sintomas e o procedimento cirúrgico mostra uma relação significativa (p < 0,027) com os resultados pós-operatórios: quanto maior, piores os resultados. CONCLUSÃO: O tratamento artroscópico da LMR em pacientes com 65 anos ou mais apresentou resultados excelentes e bons em 96,4% quando avaliados pelo UCLA, com baixa taxa de complicações. A idade avançada não demonstrou influência na evolução clínica pós-operatória. Entretanto, quanto mais precocemente o tratamento cirúrgico for instituído, melhores os resultados.

Lesão parcial do manguito rotador no atleta - bursal ou articular? / Partial rotator cuff injury in athletes: bursal or articular?

O ombro doloroso é uma queixa muito comum entre os atletas, especialmente no caso dos arremessadores. As lesões parciais do manguito rotador podem ser muito dolorosas e causar limitação funcional importante na pratica esportiva do atleta. A incidência das lesões parciais do manguito é variável (13% a 37%). O diagnóstico clínico e radiológico é difícil e deve ser considerado em todo atleta que apresente sintomatologia da síndrome do manguito rotador, inclusive nos pacientes diagnosticados apenas com tendinopatia. OBJETIVO: Avaliar o comportamento epidemiológico das lesões parciais do manguito rotador nos atletas tanto amadores como profissionais de diferentes modalidades esportivas. MÉTODOS: Avaliamos 720 prontuários de atletas atendidos no serviço de ombro da disciplina de medicina esportiva no Centro de Traumatologia do Esporte da Universidade Federal de São Paulo, a maioria (65%) homens. Dentre todos, 83 pacientes foram diagnosticados com lesão parcial do manguito rotador por meio da ultrassonografia ou ressonância magnética e em alguns casos por ambas. Aplicamos o teste binomial para comparar as proporções encontradas. RESULTADO: Verificou-se um predomínio das lesões intra-articulares (67,6%) e que essas ocorreram com maior frequência nos arremessadores (66%). Já com relação às lesões bursais, essas ocorreram em 32,4% dos atletas e predominam nos de musculação (75%). CONCLUSÃO: As lesões intra-articulares são mais frequentes em relações às bursais e predominam nos atletas arremessadores, enquanto que as lesões bursais foram mais prevalentes nos atletas de musculação.

A painful shoulder is a very common complaint among athletes, especially in the case of those in sports involving throwing. Partial lesions of the rotator cuff may be very painful and cause significant functional limitation to athletes' sports practice. The incidence of partial lesions of the cuff is variable (13-37%). It is difficult to make the clinical and radiological diagnosis, and this condition should be borne in mind in the cases of all athletes who present symptoms of rotator cuff syndrome, including in patients who are diagnosed only with tendinopathy. OBJECTIVE: To evaluate the epidemiological behavior of partial lesions of the rotator cuff in both amateur and professional athletes in different types of sports. METHODS: We evaluated 720 medical files on athletes attended at the shoulder service of the Discipline of Sports Medicine at the Sports Traumatology Center, Federal University of São Paulo. The majority of them were men (65%). Among all the patients, 83 of them were diagnosed with partial lesions of the rotator cuff, by means of ultrasonography or magnetic resonance, or in some cases using both. We applied the binomial test to compare the proportions found. RESULT: It was observed that intra-articular lesions predominated (67.6%) and that these occurred more frequently in athletes in sports involving throwing (66%). Bursal lesions occurred in 32.4% of the athletes, predominantly in those who did muscle building (75%). CONCLUSION: Intra-articular lesions are more frequent than bursal lesions and they occur predominantly in athletes in sports involving throwing, while bursal lesions were more prevalent in athletes who did muscle building.

Avaliação dos resultados do tratamento cirúrgico artroscópico das lesões do manguito rotador em pacientes com 65 anos ou mais / Evaluation of the results from arthroscopic surgical treatment of rotator cuff injuries in patients aged 65 years and over

OBJETIVOS:Avaliar os resultados do tratamento cirúrgico por via artroscópica nas lesões do manguito rotador (LMR) de pacientes com 65 anos ou mais.MÉTODOS:Entre 1998 e 2009 foram operados 168 pacientes. Cinco casos foram excluídos. Os 163 pacientes foram estratificados de acordo com a faixa etária de 65 a 69 (49,1%), 70 a 74 (26,4%) e acima de 75 (24,5%). A média foi de 71 anos (65 a 83). Eram do sexo masculino 63 pacientes (38,7%). A média de tempo de dor (início dos sintomas) até a cirurgia foi de 23 meses (2d-240m). Referiram história de trauma 62 pacientes (38%) e 26 (16%) algum esforço com pioria da dor.RESULTADOS:Pelos critérios da Universidade da Califórnia em Los Angeles (UCLA) tivemos 80,4% de excelentes resultados, 16% bons, 1,8% regular e 1,8% ruim. Tivemos 11% de complicações. O resultado clínico final não mostrou correlação com a progressão da idade, o tamanho da lesão ou os tendões acometidos. Mas existe uma associação significativa (p < 0,001) entre a presença de trauma e lesões maiores. O tempo entre o início dos sintomas e o procedimento cirúrgico mostra uma relação significativa (p < 0,027) com os resultados pós-operatórios: quanto maior, piores os resultados.CONCLUSÃO:O tratamento artroscópico da LMR em pacientes com 65 anos ou mais apresentou resultados excelentes e bons em 96,4% quando avaliados pelo UCLA, com baixa taxa de complicações. A idade avançada não demonstrou influência na evolução clínica pós-operatória. Entretanto, quanto mais precocemente o tratamento cirúrgico for instituído, melhores os resultados.

OBJECTIVES: To evaluate the results from arthroscopic surgical treatment of rotator cuff injuries in patients aged 65 years and over. METHODS: Between 1998 and 2009, 168 patients underwent operations. Five cases were excluded. The remaining 163 patients were stratified according to their age group: 65-69 years (49.1%), 70-74 (26.4%) and 75 years and over (24.5%). Their mean age was 71 years (range: 65-83). There were 63 male patients (38.7%). The mean length of time with pain, from the onset of symptoms to the surgery, was 23 months (range: 2 days to 240 months). Sixty-two patients (38%) reported histories of trauma and 26 (16%) reported that their pain worsened through exertion. RESULTS: From the UCLA criteria, 80.4% of the results were excellent, 16% good, 1.8% fair and 1.8% poor. Complications occurred in 11%. The final clinical result did not show any correlation with age progression, injury size or tendons affected. However, there was a significant association (p < 0.001) between the presence of trauma and larger injuries. The length of time between the onset of symptoms and the surgical procedure had a significant relationship (p < 0.027) with the postoperative results: the longer this time was, the worse the results were. CONCLUSION: Arthroscopic treatment of rotator cuff injuries in patients aged 65 years and over presented excellent and good results in 96.4% of the cases, according to the UCLA assessment, with a low complication rate. Advanced age did not show any influence on the postoperative clinical evolution, but the earlier the surgical treatment was instituted, the better the results were.

The pectoralis major footprint: An anatomical study / Footprint do tendão do peitoral maior: estudo anatômico

Objective: To study the insertion of the pectoralis major tendon to the humerus, through knowledge of its dimensions in the coronal and sagittal planes. Methods: Twenty shoulders from 10 cadavers were dissected and the pectoralis major tendon insertion on the humerus was identified and isolated. The dimensions of its "footprint" (proximal to distal and medial to lateral borders) and the distance from the top edge of the pectoralis major tendon to apex of the humeral head structures were measured. Results: The average proximal to distal border length was 80.8 mm (range: 70 -90) and the medial-to-lateral border length was 6.1 mm (5 -7). The average distance (and range) from the apex of the pectoralis major tendon to the humeral head was 59.3 mm. Conclusions: We demonstrate that the insertion of the pectoralis major tendon is laminar, and the pectoralis major tendon has an average footprint height and width of 80.8 mm and 6.1 mm, respectively. .

Objetivo: Estudar a inserção do tendão do peitoral maior no úmero, por meio do conhecimento de suas dimensões nos planos coronal e sagital. Métodos: Foram dissecados 20 ombros de dez cadáveres frescos (cinco homens e cinco mulheres). Todos os cadáveres encontravam-se em bom estado, sem cicatrizes ou sinais de trauma prévios. Fez-se o estudo por meio da via deltopeitoral estendida e foi identificada e isolada a inserção do tendão do peitoral maior no úmero. Mensuraram-se as dimensões do footprint por meio das aferições com um paquímetro milimetrado, de seus limites de proximal para distal e medial para lateral. Foi aferida a distância da borda superior do tendão do peitoral maior ao ápice da cabeça umeral. Resultados: Em todos os cadáveres o peitoral maior apresentou uma inserção única. O comprimento médio de proximal para distal foi de 80,8 mm (70-90) e de lateral para medial de 6,1mm (5-7). Já a distância média do ápice do tendão do peitoral maior ao ápice da cabeça umeral foi de 59,3 mm (55-64). Conclusões: O tendão do músculo peitoral maior apresenta inserção laminar. O footprint tem a altura e a largura média de 80,8 mm e 6,1 mm, respectivamente. .

Anatomic study of the coracoid process: safety margin and practical implications.

PURPOSE: The aim of this study was to define a safety margin for coracoid process osteotomy that does not compromise the coracoclavicular ligaments and that can be used in the coracoid transfer procedures. METHODS: Thirty shoulders from 15 cadavers were dissected, exposing the coracoid process and attached anatomic structures. The distance of the insertion of these structures to the coracoid process apex was measured. RESULTS: The average length of the coracoid process was 4.26 ± 0.26 cm. The average width and height at the tip were 2.11 ± 0.2 and 1.49 ± 0.12 cm, respectively. The average distance from the tip to the anterior and posterior margin of the pectoralis minor was 0.1 ± 1.17 and 1.59 ± 0.27 cm, respectively. The average distance from the tip to the posterior margin of the coracoacromial ligament was 2.79 ± 0.33 cm. The average distance from the apex to the most anterior part of the trapezoid ligament was 3.33 ± 0.38 cm. We obtained a constant value of 0.85 cm for this measure, and the value increased with each 1.0-cm increase in the distance from the tip to the posterior margin of the pectoralis minor. The safety margin for osteotomy (i.e., available bone distance for the coracoid process transfer) was 2.64 cm. CONCLUSIONS: This study established a safety margin of 2.64 cm for the osteotomy of the coracoid process and its relation with the posterior margin of the pectoralis minor. The anatomic descriptions of bone and soft tissue, as well as a measure of correlation for the safety margin of the coracoid, provide tools for surgeons performing anatomic surgical procedures to correct glenohumeral instability with significant bone loss. CLINICAL RELEVANCE: Knowing the safety margin allows the surgeon to perform a safe osteotomy without direct visualization of the coracoclavicular ligaments attachments, thereby making procedures more anatomic.

The pectoralis major footprint: An anatomical study.

OBJECTIVE: To study the insertion of the pectoralis major tendon to the humerus, through knowledge of its dimensions in the coronal and sagittal planes. METHODS: Twenty shoulders from 10 cadavers were dissected and the pectoralis major tendon insertion on the humerus was identified and isolated. The dimensions of its "footprint" (proximal to distal and medial to lateral borders) and the distance from the top edge of the pectoralis major tendon to apex of the humeral head structures were measured. RESULTS: The average proximal to distal border length was 80.8 mm (range: 70-90) and the medial-to-lateral border length was 6.1 mm (5-7). The average distance (and range) from the apex of the pectoralis major tendon to the humeral head was 59.3 mm. CONCLUSIONS: We demonstrate that the insertion of the pectoralis major tendon is laminar, and the pectoralis major tendon has an average footprint height and width of 80.8 mm and 6.1 mm, respectively.

OBJETIVO: Estudar a inserção do tendão do peitoral maior no úmero, por meio do conhecimento de suas dimensões nos planos coronal e sagital. MÉTODOS: Foram dissecados 20 ombros de dez cadáveres frescos (cinco homens e cinco mulheres). Todos os cadáveres encontravam-se em bom estado, sem cicatrizes ou sinais de trauma prévios. Fez-se o estudo por meio da via deltopeitoral estendida e foi identificada e isolada a inserção do tendão do peitoral maior no úmero. Mensuraram-se as dimensões do footprint por meio das aferições com um paquímetro milimetrado, de seus limites de proximal para distal e medial para lateral. Foi aferida a distância da borda superior do tendão do peitoral maior ao ápice da cabeça umeral. RESULTADOS: Em todos os cadáveres o peitoral maior apresentou uma inserção única. O comprimento médio de proximal para distal foi de 80,8 mm (70-90) e de lateral para medial de 6,1 mm (5-7). Já a distância média do ápice do tendão do peitoral maior ao ápice da cabeça umeral foi de 59,3 mm (55-64). CONCLUSÕES: O tendão do músculo peitoral maior apresenta inserção laminar. O footprint tem a altura e a largura média de 80,8 mm e 6,1 mm, respectivamente.

Effect of Ginkgo biloba extract (GbE-761) on the survival of fasciocutaneous flaps in rats.

Cutaneous and fasciocutaneous flaps are used widely in the surgical reconstruction of various body segments, especially to cover exposed vital tissues. Partial or total necrosis of these flaps, secondary to insufficient tissue irrigation, is one possible complication. Therefore, investigations into antiplatelet aggregation, vasodilation and antioxidant properties are highly significant. The aim of the present study was to analyse the effect of GbE 761 on the survival of fasciocutaneous flaps in rats. For that purpose, GbE 761 was administered to 30 rats after the creation of 10 × 3 cm dorsal flaps on each animal. The rats were divided into three equal groups. GbE 761 was administered to Group A, starting immediately after surgery; Group B received it 24 h after the flap was cut; and Group C (controls) received 0.9% NaCl solution. The average area of necrosis was 29.53% in Group A, 26.25% in Group B and 46.12% in Group C. The difference between Groups B and C was statistically significant (p = 0.026). These initial findings suggest that GbE 761 administered on day 1 after surgery reduces the percentage of necrosis in fasciocutaneous flaps, relative to not giving GbE at all.

CALCIFYING TENDINOPATHY: A LOCAL OR A SYSTEMIC CONDITION?

OBJECTIVE: To evaluate the relationship between cases of calcifying tendinopathy of the shoulder and symptomatic metabolic diseases such as kidney stones, gallstones and gout. METHODS: Calcifying tendinopathy of the shoulder was diagnosed in 63 patients between May 2007 and September 2011. All the patients were treated by the same orthopedic surgeon and were interviewed to gather the following data: age at diagnosis, sex, affected side, dominant side, body mass index (BMI), smoking status and previous histories of kidney stones, gallstones or gout. For statistical analysis, a control group of 63 patients with similar demographic characteristics was used. RESULTS: Among the 63 patients with calcifying tendinopathy of the shoulder, 35 (56%) were male. The right side was affected in 38 patients (60%) and the average age was 48.2 years. Thirty-one patients (49%) had histories involving some of the metabolic diseases investigated: 20 patients (32%) reported kidney stones, six (9.5%) gallstones, four (6.3%) gout and one (2%) concurrent diagnoses of kidney stones and gout. In the control group, eleven patients (17%) had histories involving some of the metabolic diseases investigated: six patients (9.5%) reported kidney stones, four (6.3%) gallstones and one (1.6 %) gout. CONCLUSIONS: The high frequency of nephrolithiasis in patients with calcifying tendinopathy of the shoulder in our study suggests that there are common mechanisms in the pathophysiology of these disorders. Better understanding of these diseases may enable improvement of diagnostics and treatments.

Análise da variação dos valores da rotação medial conforme a posição da diáfise do úmero / Analysis on the variation of medial rotation values according to the position of the humeral diaphysis

OBJETIVO: Analisar a validade da medida de rotação medial (RM) do ombro pelos níveis vertebrais conforme a variação da posição da diáfise do úmero, testando o bigoniômetro como novo instrumental de aferição. MÉTODOS: Foram avaliados, prospectivamente, 140 ombros (70 pacientes) que tinham limitação da RM do ombro unilateral. Avaliou-se, por meio da escala visual, o nível vertebral e correlacionou-se com o ângulo obtido conforme a posição da diáfise do úmero utilizando o bigoniômetro desenvolvido com a Engenharia Mecânica do Mackenzie. RESULTADOS: O nível vertebral máximo alcançado na RM do lado não acometido variou de T3 a T12, e para o lado acometido variou de T6 a trocânter. Já quando o membro acometido foi reposicionado em RM de acordo com os valores angulares do lado normal, 57,13% dos pacientes alcançaram níveis mais baixos entre sacro, glúteo e trocânter. Analisando o nível vertebral máximo alcançado e a variação entre o ângulo x (plano frontal: abdução e RM do ombro) acometido e o ângulo x não acometido em RM, verificamos que quanto maior a angulação do eixo da diáfise menor a variação do nível vertebral alcançado. Avaliando a correlação linear entre as variáveis diferença do nível vertebral máximo alcançado e a variação do ângulo y (extensão e adução do ombro) acometido e ângulo y não acometido em RM, verificamos que não há uma relação linear bem estabelecida entre estas variáveis. CONCLUSÃO: A medida da RM pelos níveis vertebrais não corresponde aos valores reais, pois varia conforme o posicionamento da diáfise do úmero.

OBJECTIVE: To analyze the validity of measurements of shoulder medial rotation (MR) of the shoulder, using vertebral levels, according to the variation in the position of the humeral diaphysis, and to test the bi-goniometer as a new measuring instrument. METHODS: 140 shoulders (70 patients) were prospectively evaluated in cases presenting unilateral shoulder MR limitation. The vertebral level was evaluated by means of a visual scale and was correlated with the angle obtained according to the position of the humeral diaphysis, using the bi-goniometer developed with the Department of Mechanical Engineering of Mackenzie University. RESULTS: The maximum vertebral level reached through MR on the unaffected side ranged from T3 to T12, and on the affected side, from T6 to the trochanter. Repositioning of the affected limb in MR according to the angular values on the normal side showed that 57.13% of the patients reached lower levels, between the sacrum, gluteus and trochanter. From analysis on the maximum vertebral level attained and the variation between the affected angle x (frontal plane: abduction and MR of the shoulder) and the unaffected angle x in MR, we observed that the greater the angle of the diaphyseal axis was, the lower the variation in the vertebral level attained was. From evaluating the linear correlation between the variables of difference in maximum vertebral level reached and variation in the affected angle y (extension and abduction of the shoulder) and the unaffected angle y in MR, we observed that there was no well-established linear relationship between these variables. CONCLUSION: Measurement of MR using vertebral levels does not correspond to the real values, since it varies according to the positioning of the humeral diaphysis.