RESUMO
Two new phenolic acid compounds, asparoffin C (1) and asparoffin D (2), together with four known compounds, asparenyol (3), gobicusin B (4), 1-methoxy-2-hydroxy-4-[5-(4-hydroxyphenoxy)-3-penten-1-ynyl] phenol (5), and asparinin A (6), have been isolated from the stems of Asparagus officinalis. The structures were established by extensive spectroscopic methods (MS and 1D and 2D NMR). Compound 6 has obvious antitumor activities both in vitro and in vivo.
Assuntos
Alcinos/isolamento & purificação , Alcinos/farmacologia , Asparagus/química , Fenóis/isolamento & purificação , Fenóis/farmacologia , Alcinos/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Fenóis/químicaRESUMO
Phellinus rhabarbarinus soaked in wine has folk usages by local residents of Ailao mountain of Yunnan province, China, which were to daub the wound to prevent infection and to drink to enhance immunity and treat other diseases such as cough, gastritis, and cancer. Systemic investigation on the chemical constituents of fruiting bodies of P. rhabarbarinus resulted in the isolation of 11 lanostane triterpenoids (1-10) including three new ones, namely, phellibarins A-C (1-3), together with five ergosterols (11-15). This is the first time reporting secondary metabolites of P. rhabarbarinus. Compounds 2, 3, 7, and 8 showed inhibitory activities against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages, whereas compounds 2-4, 6, 7, and 10 exhibited cytotoxicities against human cancer cell lines. The results of this assessment suggested that the lanostane triterpenoids in fruiting bodies of P. rhabarbarinus played key roles in its folk usages.
Assuntos
Basidiomycota/química , Carpóforos/química , Triterpenos/farmacologia , Animais , Antineoplásicos/farmacologia , Linhagem Celular Tumoral , China , Ergosterol/química , Ergosterol/isolamento & purificação , Ergosterol/farmacologia , Humanos , Macrófagos/efeitos dos fármacos , Macrófagos/metabolismo , Medicina Tradicional Chinesa , Camundongos , Estrutura Molecular , Óxido Nítrico/biossíntese , Células RAW 264.7 , Triterpenos/química , Triterpenos/isolamento & purificaçãoRESUMO
Two new acetylenic compounds, asparoffins A (1) and B (2), together with two known compounds, nyasol (3) and 3â³-methoxynyasol (4), were isolated from stems of Asparagus officinalis. The structures of two new compounds were elucidated on the basis of detailed spectroscopic analyses (UV, IR, MS, 1D, and 2D NMR). All compounds were evaluated for their cytotoxicities against three human cancer cell lines.