Biochemical phenotyping of paroxysmal nocturnal hemoglobinuria reveals solute carriers and ß-oxidation deficiencies.

INTRODUCTION: Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disease of hematopoietic cells with a variable clinical spectrum characterized by intravascular hemolysis, high risk of thrombosis, and cytopenias. To understand the biochemical shifts underlying PNH, this study aimed to search for the dysfunctional pathways involved in PNH physiopathology by comparing the systemic metabolic profiles of affected patients to healthy controls and the metabolomic profiles before and after the administration of eculizumab in PNH patients undergoing treatment. METHODS: Plasma metabolic profiles, comprising 186 specific annotated metabolites, were quantified using targeted quantitative electrospray ionization tandem mass spectrometry in 23 PNH patients and 166 population-based controls. In addition, samples from 12 PNH patients on regular eculizumab maintenance therapy collected before and 24 hours after eculizumab infusion were also analyzed. RESULTS: In the PNH group, levels of the long-chain acylcarnitines metabolites were significantly higher as compared to the controls, while levels of histidine, taurine, glutamate, glutamine, aspartate and phosphatidylcholines were significantly lower in the PNH group. These differences suggest altered acylcarnitine balance, reduction in the amino acids participating in the glycogenesis pathway and impaired glutaminolysis. In 12 PNH patients who were receiving regular eculizumab therapy, the concentrations of acylcarnitine C6:1, the C14:1/C6 ratio (reflecting the impaired action of the medium-chain acyl-Co A dehydrogenase), and the C4/C6 ratio (reflecting the impaired action of short-chain acyl-Co A dehydrogenase) were significantly reduced immediately before eculizumab infusion, revealing impairments in the Acyl CoA metabolism, and reached levels similar to those in the healthy controls 24 hours after infusion. CONCLUSIONS: We demonstrated significant differences in the metabolomes of the PNH patients compared to healthy controls. Eculizumab infusion seemed to improve deficiencies in the acyl CoA metabolism and may have a role in the mitochondrial oxidative process of long and medium-chain fatty acids, reducing oxidative stress, and inflammation.

Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial / Uso de probióticos em pacientes com doença renal crônica em hemodiálise: um ensaio clínico randomizado

ABSTRACT Introduction: Supplementation with probiotics for patients with chronic kidney disease (CKD) may be associated with decreased systemic inflammation. Objective: To assess the impact of oral supplementation with probiotics for patients with CKD on hemodialysis. Method: This double-blind randomized clinical trial included 70 patients on hemodialysis; 32 were given oral supplementation with probiotics and 38 were in the placebo group. Blood samples were collected at the start of the study and patients were given oral supplementation with probiotics or placebo for three months. The probiotic supplement comprised four strains of encapsulated Gram-positive bacteria: Lactobacillus Plantarum A87, Lactobacillus rhamnosus, Bifidobacterium bifidum A218 and Bifidobacterium longum A101. Patients were given one capsule per day for 3 months. Blood samples were taken throughout the study to check for inflammatory biomarkers. Non-traditional biomarkers Syndecan-1, IFN-y, NGAL, and cystatin C were measured using an ELISA kit, along with biochemical parameters CRP, calcium, phosphorus, potassium, PTH, GPT, hematocrit, hemoglobin, glucose, and urea. Results: Patients given supplementation with probiotics had significant decreases in serum levels of syndecan-1 (239 ± 113 to 184 ± 106 ng/mL, p = 0.005); blood glucose levels also decreased significantly (162 ± 112 to 146 ± 74 mg/dL, p = 0.02). Conclusion: Administration of probiotics to patients with advanced CKD was associated with decreases in syndecan-1 and blood glucose levels, indicating potential improvements in metabolism and decreased systemic inflammation.

Resumo Introdução: A suplementação com probióticos na doença renal crônica (DRC) pode estar associada à redução do processo inflamatório sistêmico. Objetivo: Avaliar a suplementação oral com probióticos em pacientes com DRC em hemodiálise. Método: Ensaio clínico, duplo cego, randomizado com 70 pacientes em hemodiálise, sendo 32 do grupo que recebeu o suplemento de probióticos e 38 do grupo placebo. Inicialmente ocorreu a coleta de sangue e suplementação oral com probióticos ou placebo durante três meses. O suplemento probiótico foi composto pela combinação de 4 cepas de bactérias Gram-positivas encapsuladas: Lactobacillus Plantarum A87, Lactobacillus rhamnosus, Bifidobacterium bifidum A218 e Bifidobacterium longum A101, sendo 1 cápsula do suplemento ao dia, durante 3 meses. Após esse período foram feitas novas coletas de sangue para dosagem dos biomarcadores inflamatórios. Foram analisados os biomarcadores não tradicionais: Syndecan-1, IFN-y, NGAL e cistatina C pelo método ELISA, e os seguintes parâmetros bioquímicos: PCR, cálcio, fósforo, potássio, PTH, TGP, hematócrito, hemoglobina, glicose e ureia. Resultados: Os pacientes que receberam suplemento tiveram diminuição significativa dos níveis séricos de syndecan-1 (de 239 ± 113 para 184 ± 106 ng/mL, p = 0,005). Outro parâmetro que diminuiu significativamente nos pacientes que receberam suplemento foi a glicemia (de 162 ± 112 para 146 ± 74 mg/dL, p = 0,02). Conclusão: O uso de probióticos na DRC avançada esteve associado à redução dos níveis de syndecan-1 e glicemia, sinalizando possível melhora no metabolismo e redução do processo inflamatório sistêmico.

Marcadores do consumo alimentar do Sisvan: tendência temporal da cobertura e integração com o e-SUS APS, 2015-2019 / Food intake markers in Sisvan: temporal trends in coverage and integration with e-SUS APS, Brazil 2015-2019

Resumo O objetivo deste estudo foi estimar a cobertura populacional e a taxa de incremento anual (TIA) média, em âmbito nacional, do registro de marcadores do consumo alimentar do Sistema de Vigilância Alimentar e Nutricional (Sisvan), entre 2015 e 2019, considerando a entrada dos dados via Estratégia e-SUS APS e Sisvan Web. Trata-se de estudo ecológico de séries temporais, com estratificação por macrorregiões e faixas etárias. A TIA da cobertura foi calculada utilizando regressão de Prais-Winsten e a correlação com IDH, PIB per capita e cobertura da APS foi avaliada por teste de Spearman. A cobertura populacional do registro de marcadores de consumo alimentar no país foi de 0,92% em 2019, com TIA significante de 45,63% desde 2015. As maiores coberturas foram observadas na região Nordeste (4,08%; TIA=45,76%, p<0,01) e em crianças entre 2 e 4 anos (3,03%; TIA=34,62%, p<0,01). Houve tendência crescente para a entrada dos dados via e-SUS APS, em detrimento do Sisvan Web. A TIA da cobertura dos registros via e-SUS APS exibiu correlação positiva com IDH e PIB per capita em alguns recortes etários. A cobertura populacional do registro de marcadores de consumo alimentar do Sisvan ainda se mostra incipiente no país e o e-SUS APS parece ser uma estratégia relevante para sua expansão.

Abstract The aim of the present study was to estimate the population coverage of recording food intake markers in Brazil's Food and Nutrition Surveillance System (Sisvan) and mean annual percent change (APC) in coverage according to the system used for data entry (e-SUS APS and Sisvan Web). We conducted an ecological time series study of the period 2015-2019. The data were stratified into region and age group. APC in coverage was calculated using Prais-Winsten regression and the correlation between APC and HDI, GDP per capita and primary healthcare coverage was assessed using Spearman's correlation coefficient. Population coverage of recording food intake markers at national level was 0.92% in 2019. Mean APC in coverage throughout the period was 45.63%. The region and age group with the highest coverage rate were the Northeast (4.08%; APC=45.76%, p<0.01) and children aged 2-4 years (3.03%; APC=34.62%, p<0.01), respectively. There was an upward trend in data entry using e-SUS APS, to the detriment of Sisvan Web. There was a positive correlation between APC in coverage using e-SUS APS and HDI and GDP per capita in some age groups. Population coverage of recording Sisvan food intake markers remains low across the country. The e-SUS APS has the potential to be an important strategy for expanding food and nutrition surveillance.

Association of coffee intake and its polyphenols with mammographic findings in women who visited the Brazilian Public Health Service.

Introduction: Objective: this study aimed to evaluate if there is an association of intake of coffee and its polyphenols with mammographic findings in women treated at a breast care service unit of the Unified Health System (SUS), Brazil. Research methods and procedures: this was a cross-sectional study with 532 women treated at a health service. The participants were divided according to their mammographic reports into two groups: without and with altered findings. Two 24-h dietary recalls were applied and coffee consumption was categorized into three groups (less than 1 cup, 1 to 3 cups, and more than 3 cups). Phenolic acids were determined using the Phenol Explorer program. The intake of polyphenols was calculated by adding the values obtained from the total amount of coffee consumed during the day. The Multiple Source Method (MSM) was applied to analyze the usual intake. Results: of the 532 women, 178 (33.5 %) had altered mammographic findings. The participants' average daily coffee intake was 193.4 mL. No significant association was found between coffee consumption and mammographic findings. However, it was found that the second tertile of polyphenols was a protective factor for breast changes. Conclusion: Coffee polyphenols are protective against breast changes in the group evaluated and, thus, can help prevent breast cancer.

Introducción: Objetivo: este estudio tuvo como objetivo evaluar si existe una asociación de la ingesta de café y sus polifenoles con los hallazgos mamográficos de mujeres tratadas en una unidad de patología mamaria del Sistema Unificado de Salud (SUS), Brasil. Métodos y procedimientos de investigación: este fue un estudio transversal con 532 mujeres tratadas en un servicio de salud. Las participantes se dividieron de acuerdo con sus informes mamográficos en dos grupos: sin y con hallazgos alterados. Se aplicaron dos registros dietéticos de 24 horas y el consumo de café se clasificó en tres grupos (menos de 1 taza, 1 a 3 tazas y más de 3 tazas). Los ácidos fenólicos se determinaron utilizando el programa Phenol Explorer. La ingesta de polifenoles se calculó sumando los valores obtenidos de la cantidad total de café consumido durante el día. Se aplicó el método de fuentes múltiples (MSM) para analizar la ingesta habitual. Resultados: de las 532 mujeres, 178 (33,5 %) tenían hallazgos mamográficos alterados. La ingesta diaria promedio de café de los participantes fue de 193,4 ml. No se encontró una asociación significativa entre el consumo de café y los hallazgos mamográficos. Sin embargo, se encontró que el segundo tercil de polifenoles era un factor protector para los cambios mamarios. Conclusión: los polifenoles del café son protectores contra los cambios mamarios en el grupo evaluado y, por lo tanto, podrían ayudar a prevenir el cáncer de mama.

Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial.

INTRODUCTION: Supplementation with probiotics for patients with chronic kidney disease (CKD) may be associated with decreased systemic inflammation. OBJECTIVE: To assess the impact of oral supplementation with probiotics for patients with CKD on hemodialysis. METHOD: This double-blind randomized clinical trial included 70 patients on hemodialysis; 32 were given oral supplementation with probiotics and 38 were in the placebo group. Blood samples were collected at the start of the study and patients were given oral supplementation with probiotics or placebo for three months. The probiotic supplement comprised four strains of encapsulated Gram-positive bacteria: Lactobacillus Plantarum A87, Lactobacillus rhamnosus, Bifidobacterium bifidum A218 and Bifidobacterium longum A101. Patients were given one capsule per day for 3 months. Blood samples were taken throughout the study to check for inflammatory biomarkers. Non-traditional biomarkers Syndecan-1, IFN-y, NGAL, and cystatin C were measured using an ELISA kit, along with biochemical parameters CRP, calcium, phosphorus, potassium, PTH, GPT, hematocrit, hemoglobin, glucose, and urea. RESULTS: Patients given supplementation with probiotics had significant decreases in serum levels of syndecan-1 (239 ± 113 to 184 ± 106 ng/mL, p = 0.005); blood glucose levels also decreased significantly (162 ± 112 to 146 ± 74 mg/dL, p = 0.02). CONCLUSION: Administration of probiotics to patients with advanced CKD was associated with decreases in syndecan-1 and blood glucose levels, indicating potential improvements in metabolism and decreased systemic inflammation.

Nutritional status and temporal trend of coverage of Brazilian adolescents monitored in the Food and Nutritional Surveillance System, 2008 to 2019 / Estado nutricional e tendência temporal da cobertura de adolescentes brasileiros acompanhados no Sistema de Vigilância Alimentar e Nutricional, 2008 a 2019

Abstract Objectives: to analyze the nutritional status and temporal trend of the coverage of Brazilian adolescents monitored in the Food and Nutritional Surveillance System in the period 2008-2019. Methods: ecological study of temporal series with SISVAN data collected from 2008 to 2019 with 45,869.266 registration. Body mass index data were collected and the registration coverage of adolescents monitored by the system was calculated. The percentage of annual variation in coverage and nutritional status was estimated using Prais-Winsten regression, with a significance level of 5%. Results: an increase in the prevalence of obesity was observed between 2008 and 2019, during this period thinness remained stable in Brazil. National coverage evolved from 9.3% in 2008 to 19.6% in 2019, with an annual variation of 9% and a statistically significant increase trend. In Brazil, obesity in this age group increased between 2008 and 2019, with an annual variation of 8.7% (CI95% = 7.8-9.6). Conclusion: modifications were observed in nutritional status suggest the occurrence of nutritional transition in the adolescents' population. The percentage of coverage available in the system has growth potential, however, the current scenario impacts on a possible insufficient analysis to support the elaboration and reorientation of public policies.

Resumo Objetivos: analisar o estado nutricional e a tendência temporal da cobertura de adolescentes brasileiros acompanhados no Sistema de Vigilância Alimentar e Nutricional no período de 2008-2019. Métodos: estudo ecológico de séries temporais com dados do SISVAN coletados no período de 2008 a 2019 com 45.869.266 de registos. Foram coletados dados de índice de massa corporal e calculadas as coberturas dos registros dos adolescentes acompanhados pelo sistema. Estimou-se a percentagem da variação anual da cobertura e estado nutricional pela regressão de Prais-Winsten, com nível de significância de 5%. Resultados: observa-se crescimento da prevalência de obesidade entre 2008 a 2019, nesse período a magreza manteve-se estável no Brasil. A cobertura nacional evoluiu de 9,3% em 2008 para 19,6% em 2019, com variação anual de 9% e tendência de aumento estatisticamente significativa. No Brasil, a obesidade nessa faixa etária apresentou um aumento entre os anos de 2008 e 2019, com uma variação anual de 8,7% (IC95%= 7,8-9,6). Conclusão: modificações observadas no estado nutricional sugerem a ocorrência da transição nutricional na população de adolescentes. O percentual de cobertura disponível no sistema tem potencial de crescimento, entretanto, o atual cenário impacta em possível análise insuficiente para subsidiar a elaboração e reorientação de políticas públicas.

Anthropometric indicators in traditional peoples and communities in Brazil: analysis of individual records from the Food and Nutrition Surveillance System, 2019 / Indicadores antropométricos en pueblos y comunidades tradicionales en Brasil: análisis de registros individuales del Sistema de Vigilancia Alimentaria y Nutricional, 2019 / Indicadores antropométricos em povos e comunidades tradicionais do Brasil: análise de registros individuais do Sistema de Vigilância Alimentar e Nutricional, 2019

Abstract Objective: To describe the prevalence of underweight and obesity indicators among individuals registered as traditional peoples and communities in the Food and Nutrition Surveillance System, across Brazil, in 2019. Methods: This was a descriptive study using individual secondary data from participants receiving care in the Primary Health Care within the Brazilian National Health System. Results: In the study population (N = 13,944), there was a higher prevalence of short stature among male children and adolescents (14.2%), when compared to their female counterparts (11.8%); in the adult female population, there was a higher prevalence of obesity (23.0%), when compared to the male population (11.3%); the prevalence of low height-for-age in riverine communities (18.5%) and obesity in the adult faxinalense population (75.1%) stood out. Conclusion: Anthropometric disparities between different communities require tailored responses, emphasizing targeted primary health care and programs to ensure food and nutrition security.

Resumen Objetivo: Describir la prevalencia de indicadores de bajo peso y obesidad entre individuos registrados como pueblos y comunidades tradicionales en el Sistema de Vigilancia Alimentaria y Nutricional, en todo Brasil, en 2019. Métodos: Estudio descriptivo, con datos secundarios individuales de participantes atendidos en atención primaria de Salud del Sistema Único de Salud. Resultados: En la población estudiada (N = 13.944), hubo mayor prevalencia de talla baja en niños y adolescentes en el sexo masculino (14,2%), cuando se compara con el femenino (11,8%); en la población adulta femenina hubo mayor prevalencia de obesidad (23,0%), en comparación con la masculina (11,3%); se destacó la prevalencia de baja talla para la edad en comunidades ribereñas (18,5%), y obesidad en la población adulta faxinalense (75,1%). Conclusiones: Las heterogeneidades antropométricas entre comunidades requieren respuestas adaptadas, con énfasis en la atención primaria de salud y en garantizar la seguridad alimentaria y nutricional.

Resumo Objetivo: Descrever a prevalência de indicadores de baixo peso e de obesidade entre os indivíduos registrados como povos e comunidades tradicionais no Sistema de Vigilância Alimentar e Nutricional, de todo o Brasil, em 2019. Métodos: Estudo descritivo, com dados individualizados secundários de participantes atendidos na Atenção Básica do Sistema Único de Saúde. Resultados: Na população estudada (N = 13.944), houve maior prevalência de altura baixa entre crianças e adolescentes do sexo masculino (14,2%), quando comparados aos do sexo feminino (11,8%); na população adulta do sexo feminino, observou-se maior prevalência de obesidade (23,0%), quando comparada à do sexo masculino (11,3%); destacou-se a prevalência de altura baixa para a idade nas comunidades ribeirinhas (18,5%), e de obesidade na população adulta faxinalense (75,1%). Conclusões: As heterogeneidades antropométricas entre as comunidades exigem respostas adaptadas, com ênfase na atenção primária à saúde e na garantia da segurança alimentar e nutricional.

Prejudice associated with weight images in health communication in the social networks / Preconceito relacionado ao peso em imagens para a comunicação em saúde nas redes sociais

ABSTRACT Objective The aim of this study was to evaluate whether the depiction of a fat body for health communication on the Instagram social network by the national societies governing obesity management present elements that enhance weight-related prejudice, with the slim body as a reference. Methods We investigated the last publication quintile, totaling 2,155 publications. A total of 72 images were included and 99 bodies were decoded. The bodies were classified according to positive and negative characteristics into four categories (body presentation, clothing, food and moving behavior) in which the negative characteristics have the potential to enhance the prejudice. The chi-square test was applied to test the difference in the proportion of bias elements associated with body weight between the fat body and the thin body. Results The fat body was more represented (p≤0.05 for all) headless (32.3% vs 9.2%), with bare abdomen (17.6% vs 0%), with a focus on the abdomen (11% vs 0% ), with tight clothes (32.3% vs 0%), sad expression (23.5% vs 6.1%), involved with food of low nutritional value (14.7% vs 0%) and in sedentary behavior ( 11% vs 0%) compared to the thin body. Conclusion National societies that govern management of obesity presented the fat body with more negative elements that enhance the prejudice associated with excess weight, which is an important public health problem.

RESUMO Objetivo O objetivo do presente estudo foi avaliar se a representação do corpo gordo nas imagens para a comunicação em saúde em perfis de sociedades nacionais diretivas orientadas ao manejo da obesidade na rede social Instagram apresentam elementos que potencializam o preconceito relacionado ao peso, tendo como referência o corpo magro. Métodos Foi analisado o último quintil de postagens, totalizando 2.155 publicações. Setenta e duas imagens foram incluídas e 99 corpos foram decodificados. Os corpos foram classificados em quatro categorias (apresentação do corpo, vestimenta, alimentação e comportamento de movimento) de acordo com características positivas e negativas, sendo que as negativas possuem potencial para reforçar o preconceito. O teste qui-quadrado foi aplicado para testar a diferença na proporção de elementos de preconceito relacionados ao peso entre o corpo gordo e o corpo magro. Resultados O corpo gordo foi mais representado (p≤0,05 para tudo) sem cabeça (32,3% vs 9,2%), com abdomen nu (17,6% vs 0%), com foco no abdomen (11% vs 0%), com roupa apertada (32,3% vs 0%), expressão triste (23,5% vs 6,1%), envolvido com alimento de baixo valor nutricional (14,7% vs 0%) e relacionado a um comportamento sedentário (11% vs 0%) em comparação ao corpo magro. Conclusão Sociedades nacionais diretivas ao manejo da obesidade apresentaram o corpo gordo com mais elementos negativos que reforçam o preconceito relacionado ao peso, sendo importante problema de saúde pública.

Cobertura do Sistema de Vigilância Alimentar e Nutricional (SISVAN), estado nutricional de idosos e sua relação com desigualdades sociais no Brasil, 2008-2019: estudo ecológico de série temporal / Cobertura del Sistema de Vigilancia Alimentaria y Nutricional (SISVAN), estado nutricional de los ancianos y su relación con las desigualdades sociales en Brasil, 2008-2019: un estudio de serie temporal ecológica / Food and Nutrition Surveillance System (SISVAN) coverage, nutritional status of older adults and its relationship with social inequalities in Brazil, 2008-2019: an ecological time-series study

Objective: to analyze the temporal trend of Food and Nutrition Surveillance System (Sistema de Vigilância Alimentar e Nutricional - SISVAN) coverage and the nutritional status of older adults, and its correlation with indicators of social inequality in Brazil between 2008-2019. Methods: this was an ecological study using records from SISVAN, related to the population aged 60 years and older; the temporal trend of coverage and the correlation between indicators of social inequality and increment rate of nutritional status were analyzed; slope index of inequality and concentration index were used to measure absolute and relative inequalities. Results: 11,587,933 records were identified; national coverage increased from 0.1% (2008) to 2.9% (2019), with a statistically significant upward trend; a moderate inverse correlation with an annual increment rate of overweight between human development index and gross domestic product per capita, was found. Conclusion: there was an increasing trend in SISVAN coverage; the increase in overweight was associated with social inequality.

Objetivo: analizar la tendencia temporal de cobertura del Sistema de Vigilancia Alimentaria y Nutricional (SISVAN), y el estado nutricional de adultos mayores, correlacionándolos con indicadores de desigualdad social, en el período 2008-2019. Métodos: estudio ecológico mediante registros del SISVAN sobre la población ≥60 años. Se realizaron análisis de correlación entre indicadores de desigualdad social y la tasa de incremento del estado nutricional y análisis de desigualdades absolutas y relativas para obtener el índice de desigualdad angular y el índice de concentración. Resultados: se identificaron 11.587.933 registros. La cobertura nacional evolucionó del 0,1% en 2008 al 2,9% en 2019, con una tendencia ascendente estadísticamente significativa. Se encontró una correlación inversa moderada con la tasa de incremento anual de sobrepeso para IDH y PIB per cápita. Conclusión: hubo una tendencia de crecimiento en la cobertura del SISVAN. El aumento del sobrepeso se asoció con la desigualdad social.

Objetivo: analisar a tendência temporal da cobertura do Sistema de Vigilância Alimentar e Nutricional (SISVAN) e do estado nutricional de idosos, e sua correlação com indicadores de desigualdade social no Brasil, no período 2008-2019. Métodos: estudo ecológico, sobre registros do SISVAN relativos à população na idade de 60 anos ou mais; analisaram-se a tendência temporal da cobertura e a correlação entre indicadores de desigualdade social e taxa de incremento do estado nutricional; os índices angular e de concentração foram utilizados para medir desigualdades absolutas e relativas. Resultados: foram identificados 11.587.933 registros de idosos; a cobertura nacional evoluiu de 0,1% (2008) para 2,9% (2019), com tendência de aumento estatisticamente significativa; foi encontrada correlação inversa moderada com taxa de incremento anual de sobrepeso, para índice de desenvolvimento humano e produto interno bruto per capita. Conclusão: houve tendência de crescimento da cobertura do SISVAN; o aumento de sobrepeso esteve associado à desigualdade social.

Enteral nutritional support for patients hospitalized with COVID-19: Results from the first wave in a public hospital.

OBJECTIVES: Nutrition has become an important component in treating individuals during the coronavirus disease of 2019 (COVID-19) pandemic, which is increasingly affecting the world population and causing a collapse in health services. Prolonged hospitalization, including immobilization and catabolism, induces a decrease in body weight and muscle mass that may result in sarcopenia, a condition that impairs respiratory and cardiac function and worsens the prognosis. The present study aimed to analyze enteral nutritional support and the clinical evolution of patients admitted with COVID-19 in Brazil. METHODS: This was a retrospective study, conducted from March to May 2020, of patients admitted to a referral hospital in cardiology and pulmonology in Fortaleza-Ce/Brazil. Two hundred patients infected with COVID-19 were selected for the study. Sociodemographic, clinical, and nutritional data were collected from electronic medical records, and associations between outcomes and the use of the prone body position with nutritional variables were analyzed by linear regression. Odds ratio and 95% confidence interval estimates for the death outcome were analyzed by logistic regression. RESULTS: Of the 112 patients who were fed by enterally, the majority were male (n = 61; 54.5%), elderly (n = 88; 78.6%), and with no current smoking habit (n = 81; 72.3%). The median hospital stay was 14 d, mostly in intensive care units (median: 9 d). Prone body positioning impacted the nutritional therapy. In general, patients who maintained a prone body position tested lower for kcal/kg of body weight, protein/kg of body weight, percentage of diet adequacy, and total caloric value. In addition, patients who died had a lower mean maximum kcal/kg body weight, protein/kg body weight, percentage of diet adequacy, and total caloric value compared with surviving patients. CONCLUSIONS: An association between inadequacies in protein and energy supply with mortality was confirmed, suggesting that nutritional support optimization should be prescribed in such situations.

Food environment of the economic capital of the Northeast: social and territorial disparities in the availability of food stores / Ambiente alimentar da capital econômica do Nordeste: disparidades sociais e territoriais da disponibilidade dos comércios de alimentos

ABSTRACT Objective Characterize the community food environment through the different types of food outlets in the city of Fortaleza and associate their distribution according to sociodemographic indicators. Methods This is an ecological study carried out in the city of Fortaleza in which data from the Health Surveillance Service were used with the location of all licensed food stores in the city in the years 2018 and 2019. Georeferenced maps were set up to illustrate the spatial distribution of the establishments. Correlation analyses were performed to verify the association between food outlets and socioeconomic data. Values of p≤0.005 were considered significant. Results We identified a greater concentration of food stores in the neighborhoods with better socioeconomic levels. Snack bars (n=2051; 27.7%) and restaurants (n=1945; 26.3%), were in greater quantity and exhibited a positive correlation with the Human Development Index and average income. Supermarkets and hypermarkets (n=288; 3.9%) and street markets (n=81; 1.1%) were in a smaller number and had the worst spatial distribution. Conclusion We observed socioeconomic inequalities in the distribution of different types of food outlets. The little diversity and the limited number of establishments in peripheral neighborhoods, besides the centralization of outlets that sell food that is harmful to health, constitute obstacles for the population to make healthy food choices.

RESUMO Objetivo Caracterizar o ambiente alimentar comunitário por meio dos diferentes tipos de estabelecimentos de venda de alimentos existentes na cidade de Fortaleza e relacionar sua distribuição de acordo com indicadores sociodemográficos. Métodos Trata-se de um estudo ecológico realizado na cidade de Fortaleza em que foram utilizados dados da Vigilância Sanitária com a localização de todos os comércios de alimentos licenciados para funcionamento no município nos anos de 2018 e 2019. Foram construídos mapas georreferenciados para ilustrar a distribuição espacial dos estabelecimentos. Análises de correlação foram realizadas para verificar associação entre os estabelecimentos de venda de alimentos e dados socioeconômicos. Consideraram-se significativos valores de p≤0,005. Resultados Foi possível identificar maior concentração de comércios de alimentos nos bairros com melhores níveis socioeconômicos. Lanchonetes (n=2051; 27,7%) e restaurantes (n=1945; 26,3%) apresentaram-se em maior quantidade e obtiveram correlação positiva com o Índice de Desenvolvimento Humano e a renda média. Supermercados e hipermercados (n = 288; 3,9%) e feiras livres (n=81; 1,1%) existiam em menor proporção e apresentaram a pior distribuição espacial. Conclusão Desigualdades socioeconômicas foram observadas na distribuição dos diferentes tipos de pontos de venda de alimentos. A pouca diversidade e a limitada quantidade de estabelecimentos em bairros periféricos, além da centralização da oferta de comércios que vendem alimentos prejudiciais à saúde, constituem-se obstáculos para que a população faça escolhas alimentares saudáveis.

Sistema de Vigilância Alimentar e Nutricional: tendência temporal da cobertura e estado nutricional de adultos registrados, 2008-2019 / Sistema de Vigilancia Alimentaria y Nutricional: tendencia temporal de la cobertura y estado nutricional de los adultos registrados, Brasil, 2008-2019 / Food and Nutrition Surveillance System: temporal trend of coverage and nutritional status of adults registered on the system, Brazil, 2008-2019

Objetivo: Analisar a tendência temporal da cobertura do Sistema de Vigilância Alimentar e Nutricional (Sisvan) e do estado nutricional, entre adultos acompanhados na Atenção Primária à Saúde do Brasil, 2008-2019. Métodos: Estudo ecológico de séries temporais, sobre dados das macrorregiões brasileiras. A variação percentual anual da classificação do estado nutricional e da cobertura total foi estimada pela regressão de Prais-Winsten. Resultados: Foram identificados 115.034.534 registros no período. A cobertura passou de 5,0% em 2008 para 10,6% em 2019, com variação anual de 8,4%, intervalo de confiança de 95% (IC95% 6,7;10,0) A obesidade apresentou tendência crescente entre 2008 e 2019, com variação anual de 6,4% (IC95% 5,3;7,3), assim como o sobrepeso (1,8%; IC95% 1,2;2,5). Já o baixo peso (-7,0%; IC95% -8,0;-6,1) e a eutrofia (-3,8%; IC95% -4,1;-3,4) decresceram no período. Conclusão: Identificou-se melhora na cobertura do Sisvan, tendo-se observado aumento de excesso de peso e obesidade na população estudada.

Objetivo: Analizar la tendencia temporal de la cobertura del Sistema de Vigilancia Alimentaria y Nutricional (Sisvan) y del estado nutricional de los adultos acompañados en la Atención Primaria de Brasil, 2008-2019. Métodos: Estudio ecológico de series emporales con datos de las macrorregiones brasileñas. La variación porcentual anual del estado nutricional y la cobertura total se estimaron mediante regresión de Prais-Winsten. Resultados: Fueran 115.034.534 registros en el periodo. La cobertura pasó del 5,0% en 2008 al 10,6% en 2019, con una variación anual del 8,4%, intervalo de confianza del 95% (IC95% 6,7;10,0). La obesidad mostró tendencia creciente entre 2008 y 2019, con variación anual del 6,4% (IC95% 5,3;7,3), al igual que el sobrepeso (1,8%; IC95% 1,2;2,5). El bajo peso (-7,0%; IC95% -8,0; -6,1) y la eutrofia (-3,8%; IC95% -4,1; -3,4) disminuyeron en el periodo. Conclusión: Se identificó mejora en la cobertura del Sisvan, pero acompañada de un aumento del sobrepeso y de obesidad.

Objective: To analyze the temporal trend of Food and Nutrition Surveillance System (SISVAN) coverage and nutritional status of adults undergoing follow-up in the Brazilian Primary Health Care, 2008-2019. Methods: This was an ecological time series study using data on Brazilian macro-regions. The annual percent change in the classification of nutritional status and total coverage was estimated using the Prais-Winsten regression model. Results: A total of 115,034,534 records were identified in the period. Coverage increased from 5.0% in 2008 to 10.6% in 2019, with an annual change of 8.4%, 95% confidence interval (95%CI 6.7;10.0). Obesity and overweight showed a rising trend between 2008 and 2019, with an annual change of 6.4% (95%CI 5.3;7.3) and (1.8%; 95%CI 1.2;2.5) respectively, while underweight (-7.0%; 95%CI -8.0;-6.1) and eutrophy (-3.8%; 95%CI -4.1;-3.4) decreased in the period. Conclusion: There was an improvement in SISVAN coverage, with an increase in overweight and obesity among the population studied.

Comportamento alimentar e imagem corporal em universitários da área de saúde / Eating behavior and body image in health sciences university students

OBJETIVO: Avaliar a associação da imagem corporal e o comportamento alimentar de universitários de uma capital do Nordeste do Brasil. MÉTODOS: Participaram da pesquisa universitários (n = 1570) da área da saúde de ambos os sexos, de quatro instituições de ensino superior. As dimensões da imagem corporal (i.e., perceptiva e atitudinal) foram avaliadas por meio da Escala de Silhuetas para adultos brasileiros; e o comportamento alimentar por meio da versão brasileira do Dutch Eating Behavior Questionnaire (DEBQ). Para a avaliação do estado nutricional, foram coletados peso corporal e estatura de modo autorreportado. A análise de associação foi feita pela regressão linear múltipla, após estratificação por sexo. RESULTADOS: Notou-se maior prevalência de universitárias do sexo feminino (72,9%), com idade média de 21,8 (DP = 4,1) anos. Foi encontrada associação entre percepção e (in)satisfação corporal com o comportamento alimentar em ambos os sexos. As mulheres que superestimaram o tamanho corporal obtiveram associação inversa com a dimensão alimentar restritiva (p = 0,001); e as insatisfeitas por magreza, associação direta entre alimentação restritiva; e inversa com o comportamento emocional (p < 0,001). Os homens que superestimaram seu tamanho corporal evidenciaram associação direta com a alimentação emocional; e entre os insatisfeitos por excesso de peso houve associação direta com a dimensão emocional (p = 0,032) e global (p = 0,046) do comportamento alimentar. CONCLUSÕES: O presente estudo demonstra que a imagem corporal negativa, considerando as duas dimensões avaliadas (i.e., perceptiva e atitudinal), foi associada ao comportamento alimentar entre universitários de ambos os sexos.

OBJECTIVE: To analyze an association of image and eating behavior of university students from a capital city in Northeast Brazil. METHODS: Participated in university research (n = 1570) in the health area of both sexes, from four higher education institutions. The dimensions of body image (that is, perceptual and attitudinal) were assessed using the Brazilian Adult Silhouettes Scale; and eating behavior using the Brazilian version of the Dutch eating behavior questionnaire (DEBQ). For an assessment of nutritional status, body weight and height were collected automatically reported. An association analysis was performed using the selected linear regression, after stratification by sex. RESULTS: There is no higher prevalence of women (72.9%), with a mean age of 21.8 (SD = 4.1) years. An association was found between perception and (in) body satisfaction with eating behavior in both sexes. Women who overestimated body size had an inverse association with the restrictive dietary dimension (p = 0.001); and as dissatisfied by law, direct association between restrictive eating; and inverse with emotional behavior (p < 0.001). Men who overestimate their body size, showed an association with emotional nutrition; among those dissatisfied with excess weight, there was an association with emotional (p = 0.032) and global (p = 0.046) dimensions of eating behavior. CONCLUSIONS: The present study demonstrates that a negative body image, considering two dimensions evaluated (that is, perceptual and attitudinal), was associated with eating behavior among university students of both sexes.

Conhecimento de recomendações nutricionais por outros profissionais da Estratégia Saúde da Família / Knowledge on nutritional recommendations by doctors and nurses of the Family Health Strategy / Conocimiento de recomendaciones nutricionales de otros profesionales de la Estrategia Salud de la Familia

Objetivo: Analisar o conhecimento de médicos e enfermeiros da Estratégia Saúde da Família sobre as orientações nutricionais para diabetes mellitus tipo 2 (DM2) e hipertensão arterial sistêmica (HAS). Métodos: Estudo transversal e descritivo realizado com 67 médicos e enfermeiros de 11 Unidades de Atenção Primária à Saúde da Regional II do município de Fortaleza, Ceará, entre dezembro de 2019 e janeiro de 2020. Foram incluídos profissionais contratados, concursados ou participantes de programas de educação em serviço, aplicando-se um questionário fechado do tipo Likert, elaborado pelos pesquisadores, contendo 29 questões relacionadas às recomendações nutricionais das sociedades de referência em DM2 e HAS, e do Guia Alimentar para a População Brasileira. A análise dos dados ocorreu de forma descritiva, utilizando frequências absolutas e relativas e teste qui-quadrado. Resultados: A concordância com as diretrizes nutricionais das sociedades de referência de DM2 e HAS pelos profissionais foi de 17,9% (n=12) para a proporção de carboidratos na dieta do paciente diabético; 22,4% (n=15) para o consumo de café e controle da pressão arterial; 34,3% (n=23) para o consumo de açúcar pelo diabético e 37,3% (n=25) para o consumo de leite e controle da pressão arterial. Em relação às orientações do guia alimentar, a totalidade (n=67) dos entrevistados concordou que os alimentos ultraprocessados devem ser evitados, e que deve haver regularidade e atenção no consumo das refeições. Conclusão: Os profissionais apresentaram conhecimento insuficiente a respeito das recomendações nutricionais estabelecidas pelas principais sociedades nacionais e internacionais de DM2 e HAS.

Objective: To analyze the knowledge of doctors and nurses from the Family Health Strategy on nutritional guidelines for type 2 diabetes mellitus (DM2) and systemic arterial hypertension (SAH). Methods: Cross-sectional and descriptive study was carried out with 67 physicians and nurses from 11 Primary Health Care Units in Regional II in the city of Fortaleza, Ceará, between December 2019 and January 2020. service, applying a closed Likert-type questionnaire, prepared by the researchers, containing 29 questions related to the nutritional recommendations of reference societies in DM2 and SAH, and the Food Guide for the Brazilian Population. Data analysis was descriptive, using absolute and relative frequencies and the chi-square test. Results: The agreement of the nutritional guidelines of the reference societies of DM2 and SAH by the professionals was 17.9% (n=12) for the proportion of carbohydrates in the diabetic patient's diet; 22.4% (n=15) for coffee consumption and blood pressure control; 34.3% (n=23) for the consumption of sugar by the diabetic and 37.3% (n=25) for the consumption of milk and blood pressure control. Regarding the guidelines of the Food Guide, all (n=67) of the interviewees agreed that ultra-processed foods should be avoided and that there should be regularity and attention in the consumption of meals. Conclusion: The professionals showed a lack of knowledge about the nutritional recommendations established by the main national and international societies of DM2 and SAH.

Objetivo: Analizar el conocimiento de médicos y enfermeros de la Estrategia Salud de la Familia sobre las orientaciones nutricionales de la Diabetes Mellitus del tipo 2 (DM2) y la Hipertensión Arterial Sistémica (HAS). Métodos: Estudio transversal y descriptivo realizado con 67 médicos y enfermeros de 11 Unidades de Atención Primaria de Salud de la Regional II del municipio de Fortaleza, Ceará, Brasil, entre diciembre de 2019 y enero de 2020. Se ha incluido los profesionales contratados, los concursantes o los participantes de programas de educación en servicio aplicándose un cuestionario cerrado del tipo Likert elaborado por los investigadores con 29 preguntas relacionadas con las recomendaciones nutricionales de las sociedades de referencia en DM2 y HAS, y del Guía Alimentario para la Población Brasileña. El análisis de los datos se dio de modo descriptivo utilizándose las frecuencias absolutas y relativas y la prueba de chi-cuadrado. Resultados: La concordancia con las directrices nutricionales de las sociedades de referencia de DM2 y HAS por los profesionales ha sido del 17,9% (n=12) para la proporción de carbohidratos de la dieta del paciente diabético; el 22,4% (n=15) para el consumo de café y el control de la presión arterial; el 34,3% (n=23) para el consumo de azúcar por el diabético y el 37,3% (n=25) para el consumo de la leche y el control de la presión arterial. Respecto las orientaciones de la guía alimentaria, la totalidad (n=67) de los entrevistados estuvo de acuerdo de que se debe evitar a los alimentos ultra procesados y tener regularidad y atención con el consumo de las comidas. Conclusión: Los profesionales presentaron conocimiento insuficiente respecto las recomendaciones nutricionales establecidas por las principales sociedades nacionales e internacionales de DM2 y HAS.

Envelhecimento e dependência no Brasil: características sociodemográficas e assistenciais de idosos e cuidadores / Aging and dependence in Brazil: sociodemographic and care characteristics of older adults and caregivers

Resumo O artigo tem como objetivo identificar características sociodemográficas e assistenciais de idosos dependentes, cuidadores formais e familiares em municípios de diferentes regiões brasileiras. Realizou-se um estudo transversal com amostra de 175 pessoas, sendo 64 idosos, 27 cuidadores formais e 84 cuidadores familiares. Foram realizadas entrevistas semiestruturadas, com questões específicas para cada grupo sobre a temática do cuidado e dependência. A maioria dos idosos era do sexo feminino, com idade igual ou maior a 80 anos, com baixa escolaridade e dependente há quatro anos ou mais. Os idosos relataram sentimentos de solidão, apontaram dificuldades na assistência médica e 29% tinham acesso apenas a ações da Atenção Primária à Saúde. Entre os cuidadores familiares, encontrou-se desigualdades, sobrecargas, adoecimentos e problemas sociais. Entre os formais predominou o sexo feminino, a raça negra, sem vínculo legal de trabalho, pouca ou nenhuma formação para a função e baixa remuneração; o cuidado associou-se aos afazeres domésticos. Conclui-se que perduram as desigualdades de gênero e raça no cuidado às pessoas idosas em situação de dependência. Observou-se também que a rigidez dos papeis sociais atribuídos a homens e mulheres no Brasil persistem nas dinâmicas familiares e laborais no cuidado ao idoso dependente.

Abstract This paper aims to identify sociodemographic and care characteristics of dependent older adults, formal and family caregivers in municipalities from different Brazilian regions. A cross-sectional study was carried out with a sample of 175 people, of whom 64 were older adults, 27 formal caregivers, and 84 family caregivers. Semi-structured interviews were conducted with specific questions for each group on the theme of care and dependence. Most older adults were female, aged 80 years or older, with low education and have been dependent for four years or more. Older adults reported feelings of loneliness, pointed out difficulties in medical care, and 29% had only access to Primary Health Care actions. Inequalities, burden, illnesses, and social problems were found among family caregivers. Black females with no formal employment, little or no training for the function, and low remuneration predominated among formal caregivers, and care was associated with domestic chores. We can conclude that gender and race inequalities persist in the care of dependent older adults, and we observed that the rigid social roles assigned to men and women in Brazil persist in the family and work dynamics in caring for the dependent older adults.

Plasma metabolomics are associated with metabolic syndrome: A targeted approach.

OBJECTIVES: Advances in metabolomic tools have allowed us to gain a more comprehensive understanding of metabolic syndrome (MetS). The aim of this study was to evaluate the association between plasma metabolomic profiles and MetS. METHODS: For this study, adults without diabetes, chronic kidney disease, stroke, heart disease, or cancer and with full metabolomics, biochemical, and dietetic data available, representing a subsample of the Health Survey of Sao Paulo study (ISA-Capital; N = 130), were included. The joint interim statement consensus criteria were used for diagnosing MetS. Absolute quantification (µmol/L) of blood metabolites was achieved by targeted quantitative profiling of annotated metabolites by electrospray ionization tandem mass spectrometry in plasma samples. Mean differences in the compounds for MetS were evaluated by linear regression adjusted for confounding factors. RESULTS: Serine was inversely associated with MetS (ß = -15.04; P = 0.014). In glycerophospholipids with acyl-alkyl bonds, there was an inverse association with MetS, including phosphatidylcholine (PC) ae C42:5 (ß = -0.15; P = 0.040), PC ae C44:5 (ß = -0.15; P = 0.046), PC ae C40:4 (ß = -0.21; P = 0.014) and PC ae C44:4 (ß = -0.04; P = 0.032). CONCLUSION: Plasma metabolomic profiles were associated with MetS, especially the amino acid serine and some acyl-alkyl PCs.

Biochemical phenotyping of multiple myeloma patients at diagnosis reveals a disorder of mitochondrial complexes I and II and a Hartnup-like disturbance as underlying conditions, also influencing different stages of the disease.

The aim of this study was to identify novel plasma metabolic signatures with possible relevance during multiple myeloma (MM) development and progression. A biochemical quantitative phenotyping platform based on targeted electrospray ionization tandem mass spectrometry technology was used to aid in the identification of any eventual perturbed biochemical pathway in peripheral blood plasma from 36 MM patients and 73 healthy controls. Our results showed that MM cases present an increase in short and medium/long-chain species of acylcarnitines resembling Multiple AcylCoA Dehydrogenase Deficiency (MADD), particularly, associated with MM advanced International Staging System (ISS). Lipids profile showed lower concentrations of phosphatidylcholine (PC), lysophosphatidylcholine (LPC) and sphingomyelins (SM) in the MM patients and its respective ISS groups. MM cases were accompanied by a drop in the concentration of essential amino acids, especially tryptophan, with a significant inverse correlation between the progressive drop in tryptophan with the elevation of ß2-microglobulin, with the increase in systemic methylation levels (Symmetric Arginine Dimethylation, SDMA) and with the accumulation of esterified carnitines in relation to free carnitine (AcylC/C0). Serotonin was significantly elevated in cases of MM, without a clear association with ISS. Kynurenine/tryptophan ratio demonstrates that the activity of dioxigenases is even higher in the cases classified as ISS 3. In conclusion, our study showed that MM patients at diagnosis showed metabolic disorders resembling both mitochondrial complexes I and II and Hartnup-like disturbances as underlying conditions, also influencing different stages of the disease.

Adaptação transcultural e avaliação de propriedades psicométricas do Emotional Appetite Questionnaire em mulheres de língua portuguesa / Cross-cultural adaptation and evaluation of the psychometric properties of the Emotional Appetite Questionnaire among Portuguese-speaking women

Resumo A obesidade e seus determinantes são foco de amplas pesquisas, dentre tais determinantes, encontra-se o apetite emocional, definido como a tendência a comer em excesso em reposta às emoções negativas. Alguns instrumentos foram criados para mensurar esse constructo, dentre eles o "Emotional Appetite Questionnaire" (EMAQ). O objetivo deste estudo foi realizar adaptação transcultural e avaliação de propriedades psicométricas do EMAQ em mulheres de língua portuguesa. Realizou-se uma pesquisa com 450 mulheres, mediante a adaptação transcultural e avaliação de propriedades psicométricas do instrumento (validade e confiabilidade). A consistência interna do instrumento foi medida pelo Alfa de Cronbach e a estabilidade foi feita por meio do teste-reteste. O instrumento demonstrou boa consistência interna e correlação intraclasse. As entrevistadas não referiram alteração do consumo alimentar frente às emoções e situações positivas. Houve tendência a redução do apetite emocional quando submetidas a emoções e situações negativas. O Questionário de Apetite Emocional (QUEAPEM) apresentou-se como um instrumento confiável, de fácil aplicação e administração, para avaliação do apetite emocional na língua portuguesa.

Abstract Obesity and its determinants have been the topic of broad research. Emotional appetite, defined as the tendency to overeat in response to negative emotions, is among these determinants. Some instruments were created to measure this construct, the Emotional Appetite Questionnaire (EMAQ) being one of them. The objective of this study was to perform cross-cultural adaptation and evaluation of psychometric properties of EMAQ among Portuguese-speaking women. Methodological research was carried out by translation, back-translation and cross-cultural adaptation of the instrument. A study was conducted with 450 women, through cross-cultural adaptation and evaluation of the instrument's psychometric properties (validity and reliability). The internal consistency of the instrument was measured using Cronbach's Alpha and stability was checked by means of test-retest. The instrument showed good internal consistency and intraclass correlation. The interviewees did not mention changes in food consumption linked to positive emotions and situations. There was a tendency towards reduction in emotional appetite when subjected to negative emotions and situations. The Portuguese EMAQ (QUEAPEM) was considered a reliable instrument, easy to apply and administer, to assess emotional appetite in the Portuguese language.

Condições de ambiência em restaurantes comerciais / Ambience conditions in commercial restaurants

Introdução: Ambiência é a organização que um espaço físico recebe, envolvendo questões técnicas e estruturais do ambiente. Além do espaço físico, é também levado em consideração que, nesse espaço, haverá relações sociais e interpessoais e que, portanto, o local deve ser acolhedor e confortável em todos os sentidos. Objetivo: Avaliar as condições de ambiência em restaurantes comerciais de Fortaleza-CE. Métodos: O estudo foi do tipo observacional, transversal, descritivo e analítico, desenvolvido no período de dezembro de 2018 a fevereiro de 2019, quando foi avaliada a ambiência de 20 restaurantes comerciais da cidade de Fortaleza-CE. Nesses restaurantes, foram avaliados os setores de recebimento, pré-preparo e preparo, cocção, higienização, distribuição, inspeção de matérias-primas, salão de refeição e setores administrativos. A avaliação das unidades de alimentação e nutrição (UAN) foi realizada por um instrumento estruturado que possuía um cabeçalho com a identificação da empresa, e no qual foram registrados dados de temperatura, ruído, iluminação, umidade e cor do piso, parede e teto. Os dados foram tabulados no software Excel® 2013 e apresentados em frequência absoluta e relativa, e em média e desvio padrão. Resultados: Os resultados mostraram inadequações em umidade, temperatura, iluminação e cores em vários setores dos restaurantes avaliados, confirmando a hipótese do trabalho. Conclusões: Conclui-se que há inadequações de ambiência primária em restaurantes comerciais de Fortaleza-CE, podendo-se levar em consideração que a maioria das UANs foi construída sem o planejamento adequado à saúde dos colaboradores. (AU)

Introduction: Ambience is the organization acquired by a physical space, involving technical and structural issues of the environment. Besides the physical space, it is also taken into consideration that in this space social and interpersonal relations will take place and that, therefore, the place must be welcoming and comfortable in every sense. Objective: Evaluate the ambience conditions in commercial restaurants in Fortaleza-CE. Methods: The study was of the observational, cross-sectional, descriptive, and analytical type, developed from December 2018 to February 2019, when the ambience of 20 commercial restaurants in the city of Fortaleza-CE was evaluated. In these restaurants, the reception, pre-preparation and preparation, cooking, sanitation, distribution, inspection of raw materials, meal room, and administrative sectors were evaluated. The evaluation of the food and nutrition units (FNU) was performed by a structured instrument, with a header to identify the company, and in which temperature, noise, lighting, humidity, and floor, wall and ceiling color data were recorded. The data were recorded in Excel® 2013 software and presented in absolute and relative frequency and mean and standard deviations. Results: The results showed inadequacies in humidity, temperature, lighting and colors in several sectors of the restaurants evaluated, confirming the hypothesis of this study. Conclusions: It is concluded that there are inadequacies of primary ambience in commercial restaurants in Fortaleza-CE, and it can be taken into account that most of the FNUs were built without adequate planning for the health of the employees. (AU)

The effects of the Paleolithic Diet on obesity anthropometric measurements / Efeito da Dieta Paleolítica em medidas antropométricas de obesos

Abstract Comparing the effects of Paleolithic Diet (PD) and of a Guidelines Substantiated Diet (GSD) on anthropometric indicators of obese individuals. Randomized clinical trial. Obese patients were divided into two groups based on dietary prescription: PD and GSD. These diets encompassed 82 and 73 patients, respectively, who were followed-up for 60 days. Anthropometric measurements were taken before the beginning of the trial, at the 30th day of it and at the end of the experimental period. At the 60th experimental day, there was 26.8% treatment abandonment by individuals in group PD and 19.2% by the ones in group GSD; there was not difference between groups (p = 0.684). Weight and height measurements were taken in order to determine body mass index (BMI), waist circumference (WC) and hip circumference (HC), which allowed determining the waist/hip ratio (WHR). There was no initial difference between groups in demographic, socioeconomic, exercising and anthropometric variables (p > 0.05). Group PD recorded the highest weight (p = 0.003), BMI (p = 0.002) and WC (p = 0.033) values at the 30th experimental day. Group PD kept the highest weight loss at the 60th day (p < 0,001), as well as the highest BMI (p < 0.001), WC (p = 0.002) and WHR (p = 0.002) reduction. PD is a feasible option to treat obesity, it led to reduced anthropometric markers. Other studies are necessary to assure the safety of its use for longer periods of time.

Resumo Comparação do efeito da Dieta Paleolítica (DP) e da Dieta baseada em Diretrizes (DBD) em indicadores antropométricos de indivíduos obesos. Ensaio clínico randomizado. Pacientes obesos foram divididos em 2 grupos baseados na prescrição dietética: DP e DBD. Estas dietas abrageram 82 e 73 pacientes, respectivamente que foram acompanhados durante 60 dias. Medidas antropométricas foram aferidas anteriormente ao início da intervenção, no 30º dia e no fim da intervenção. No 60º dia de acompanhamento, houve 26,8% de desistência no grupo DP e 19,2% no grupo DBD , não havendo diferença entre os grupos (p= 0.684). Peso e estatura foram aferidas para determinar o Índice de Massa Corporal (IMC), circunferência da cintura (CC), circunferência do quadril (CQ), com os quais foi determinado a relação cintura-quadril (RCQ). Não houve diferença estatística inicial entre os grupos nas variáveis demográficas, socioeconômicas, atividade física e antropométricas (p > 0.05). O grupo DP registrou maior redução de peso (p = 0.003), IMC (p = 0.002) e CC (p = 0.033) no 30º dia de experimento. Grupo DP manteve maior redução de peso no 60º dia (p < 0,001), bem como maior redução de IMC (p < 0.001), CC (p = 0.002) e RCQ (p = 0.002). DP é uma possível opção de tratamento para a obesidade, a qual resultou na redução de marcadores antropométricos. Outros estudos são necessários para verificar seu uso por maiores períodos de tempo.