RESUMO
BACKGROUND: We present our surgical experience with cardiac myxomas in the setting of Carney Complex (CNC). METHODS: We searched our institutional data explorers to identify patients diagnosed with CNC. We gathered clinical, surgical, and recurrence data from electronic medical records. In total, 38 patients with Carney Complex were documented from 1970 through 2023. RESULTS: There were 24 (63.1%) patients who developed cardiac myxomas in the setting of Carney Complex. The median age of onset for cardiac myxoma occurrence was 39.0 years (interquartile range[IQR], 25.0-56.0). The majority were females (62.5%), and all underwent surgery. A total of 42 (52.7%) myxomas were extracted from the left atrium, 12 (15.0%) from the right ventricle, 11 (13.7%) from the right atrium, and 6 (7.5%) from the left ventricle. Among the 24 myxoma patients, 54.1%(n=13) experienced at least one myxoma recurrence. The median time for the first myxoma recurrence was 7.5 years (IQR,3.8-10.0). There were 27 (52.9%) recurrences from the same chamber, 11 (29.4%) from different chambers, and 9 (17.6%) had undocumented localizations. The freedom from tumor recurrence was 100% (95%CI;100.0-100.0), 66.7% (95%CI; 44.7%-99.5%) and 16.7% (95%CI; 4.7%-59.1%) at 1, 5 and 10 years respectively. The long-term survival was 100.0% at 10 and 15 years. CONCLUSIONS: Nearly two-thirds of CNC patients in this study (63.1%) developed cardiac myxomas, and more than half (54.1%) experienced recurring instances. Consistent monitoring through echocardiograms is essential for detecting asymptomatic first-time occurrences or recurrences. Surgical removal remains the key treatment method for managing cardiac myxomas associated with CNC.