Assuntos
Humanos , Masculino , Pré-Escolar , Síndrome de Resposta Inflamatória Sistêmica/diagnóstico , Síndrome de Resposta Inflamatória Sistêmica/terapia , COVID-19/complicações , COVID-19/diagnóstico , Pulmão/diagnóstico por imagem , Radiografia , Tomografia Computadorizada por Raios X , Cuidados CríticosRESUMO
The oleoresin of several Copaifera species is used widely in the Amazonian Region mainly as a topical antiinflammatory and healing agent. The topical analgesic and antiinflammatory activities of Copaifera duckei oleoresin, whose terpenoidal chemical composition has been characterized, are now examined. Antiinflammatory activity was evaluated in rats using the carrageenin-induced paw edema and the granuloma tests, and in mice by the croton oil-induced dermatitis test. Analgesic activity was determined in mice using the writhing test method. In the carrageenin-induced edema and granuloma tests the oleoresin in a dose of 1,802 mg/kg inhibited the edema by 18% and granuloma by 42% (p < 0.05), this last result similar to that observed with dexamethasone. Topical doses of 517 mg/kg, 1,035 mg/kg and 1,802 mg/kg produced 52%, 58% and 62% (p < 0.05) reduction of the edema induced by croton oil, respectively, and 48%, 56% and 65% inhibition of the writhing process (p < 0.05). These results suggest that the Copaifera duckei oleoresin has topical antiinflammatory and analgesic activities.
Assuntos
Analgésicos/farmacologia , Anti-Inflamatórios/farmacologia , Fabaceae , Extratos Vegetais/farmacologia , Administração Cutânea , Análise de Variância , Animais , Óleo de Cróton , Dermatite/tratamento farmacológico , Edema/tratamento farmacológico , Granuloma de Corpo Estranho/tratamento farmacológico , Masculino , Camundongos , Fitoterapia , Extratos Vegetais/química , Extratos Vegetais/uso terapêutico , Ratos , Ratos Wistar , Terpenos/análiseRESUMO
Oleoresins from different species of Copaifera are used in popular medicine and in the cosmetics industry without giving due consideration to the differences between them. Comparison of the compositions of oleoresins from Copaifera guianensis Desf. and Copaifera duckei Dwyer, species now examined, and of the better known Copaifera multijuga Hayne, all of common occurrence in Brazilian Amaz nia, shows that significant chemical variation occurs not only between species but also within a given species and in an individual tree source.