Maintaining professional activity during breast cancer treatment.

The question of returning to work and pursuing professional activity during cancer treatment is an increasingly important consideration. The present work focuses on factors affecting the feasibility of maintaining professional activity during treatment for breast cancer, for women who wished to do so. Written questionnaires were collected from 216 patients between March and November 2012. Since the onset of their treatment, 31.4% of the women (68/216) had not been on sick-leave. The main factors associated with the pursuit of professional activity were: considering the availability of their physician to answer questions as unimportant [OR = 18.83 (3.60-98.53); P ≤ 0.05]; considering the diagnosis of cancer as likely to have a weak impact on career perspectives [OR = 4.07 (2.49-6.64); P ≤ 0.05]; not having any children in the household [OR = 3.87 (2.38-6.28); P ≤ 0.05]; being in a managerial position [OR = 3.13 (1.88-5.21); P ≤ 0.05]. Negative predictive factors were: physician mentioning adverse effects of the treatment [OR = 0.31 (0.16-0.58); P ≤ 0.05], and patient rating workload as high [OR = 0.26 (0.15-0.46); P ≤ 0.05]. As a result of advances in therapeutic strategies, more patients will expect healthcare professionals, as well as employers and occupational health societies, to prioritise issues pertaining to the maintenance of professional activities during cancer treatment.

[Granuloma annulare of the eyelid in a child: an atypical localization]. / Granulome annulaire des paupières: une localisation atypique.

BACKGROUND: Granuloma annulare is a common form of dermatosis in children and young adults. Lesions are typically found on the hands, the feet and the extensor surfaces of the limbs, and occasionally on the trunk. We report a case original in terms of its palpebral localization. CASE-REPORT: A 5 year-old girl consulted for papular lesions on the eyelids. The clinical examination revealed papules on the right lower eyelid measuring 8 mm, on the left lower eyelid measuring 5 mm and on the right upper eyelid measuring 3 mm. Laboratory tests including serum glucose, lipids and calcium as well as a complete blood count proved normal. Biopsy showed granulomatous lesions: a region of central necrosis surrounded by a palisade of inflammatory cells confirmed the diagnosis of granuloma annulare. The lesions disappeared in a few weeks without treatment. DISCUSSION: To our knowledge, 44 cases of granuloma annulare of the periorbital area have been reported, of which 19 concerned children. This presentation represents an atypical localization of granuloma annulare which must not be confused with many other palpebral disorders. Biopsy is necessary to confirm the diagnosis.

Infestation of rural houses by Triatoma infestans in the region of Los Llanos (La Rioja, Argentina)

Vectorial transmission of Chagas disease has been strongly reduced in most parts of the Southern Cone countries of South America, except in the Gran Chaco region of Argentina, Bolivia, and Paraguay. Given periodical interruptions of the vector control programmes in the endemic region of the Gran Chaco of Argentina, the vectorial transmission of the disease has been increasing during the last years. From the beginning of 2004, the provincial Ministry of Health of La Rioja, Argentina, started a vector control programme to cover the rural houses of the Los Llanos area in the southwestern area of the Gran Chaco region. This article reports the result of a standardized entomological survey and insecticide application against Chagas disease vectors in the intra and peridomestic structures of the rural houses of Los Llanos. A total of 4062 houses were inspected, of which 46.8 percent were found to be infested by Triatoma infestans. Infestation by vector species other than T. infestans was less than 0.5 percent(T. eratyrusiformis and T. platensis). Intradomestic infestation was found in 27.2 percent, whereas peridomestic infestation was found in 39.3 percent of the houses. The lowest figure of intradomestic infestation was 6.6 percent (Department F Varela), and the highest value of intradomestic infestation was 45.1 percent (Department Independencia). In spite of the demonstrated success of vector control elsewhere, this study shows that the vector populations are susceptible to pyrethroid insecticides in the southern area of the Gran Chaco of Argentina, that there still are regions where rural houses show heavy infestation by T. infestans associated with big peridomestic structures and that the vectorial transmission of the Chagas disease will continue, unless a sustained and well organized vector control effort is installed in the region.

Patterns of antenal sensilla of Panstrongylus megistus from three Brazilian states

The objective of the present study was to analyze and describe the phenotype of the antennal sensilla of Panstrongylus megistus, one of the epidemiologically most important species of triatomines in Brazil. Specimens from the Brazilian states of Goiás (GO), Minas Gerais (MG), and Rio Grande do Sul (RS) were compared, based on studies of four types of sensilla on three antennal segments: thick-walled trichoid (TK), thin-walled trichoid (TH), bristles (BR), and basiconica (BA). Discriminant analysis allowed the separation of the RS specimens from those of GO and MG. Multivariate discriminant analysis demonstrated that the sensilla of males differed from those of females, the variables with greatest weight being the BA of all three segments and the TK of flagellum 1. The basiconica sensilla were significantly more abundant in females, on all three segments. Antennal sensilla patterns also demonstrated significant differences among P. megistus specimens.

Entomological aspects of Chagas' disease transmission in the domestic habitat, Argentina

OBJETIVO: Estudiar el riesgo doméstico de transmisión de Trypanosoma cruzi por medio de un indicador entomológico y analizar su relación con características culturales y de las viviendas. MÉTODOS: Se estudiaron 158 casas en el área endémica argentina. Cada vivienda infestada se clasificó de acuerdo con un indicador entomológico de riesgo (número de picadas riesgosas/ humano). Mediante encuestas se evaluaron factores de riesgo asociados a la vivienda y habitos de los moradores. RESULTADOS: Las casas infestadas mostraron un rango amplio de valores de riesgo (0 a 5 picadas riesgosas/ humano). Se observó un gran número de viviendas con bajos valores de riesgo y pocas viviendas con valores elevados. El 44 por ciento de las Triatoma infestans colectadas estaban alimentadas sobre ser humano y el 27 por ciento sobre perro o gallina. Las viviendas donde perros y/o gallinas compartían la habitación humana, tuvieron valores de riesgo más elevados. Las viviendas ordenadas y limpias exhibieron bajos valores, debido a un escaso número de T. infestans. Se comprobó un 24.3 por ciento de correlación entre el tiempo transcurrido luego de aplicar insecticidas y el número de vectores en la vivienda. Sin embargo, no hubo correlación entre el tiempo post-rociado y la infectividad de T. infestans. Se observó correlación entre los valores del indicador entomológico y la seroprevalencia en niños. CONCLUSIONES: El riesgo de transmisión de T. cruzi en cada vivienda, medido a través de un indicador entomológico, se correlaciona positivamente con la prevalencia de seropositividad en niños y con hábitos de los moradores.

Changes associated with laboratory rearing in antennal sensilla patterns of Triatoma infestans, Rhodnius prolixus, and Rhodnius pallescens (Hemiptera, Reduviidae, Triatominae)

We examined changes in the array of antennal sensilla of three species of Triatominae (Triatoma infestans, Rhodnius prolixus, and R. pallescens) following their establishment for different periods in laboratory culture. In each case, the laboratory colonies were compared with conspecific samples taken directly from the field, by quantitative analysis of the sensilla arrays on the three distal segments of the antenna in terms of the densities of three types of chemoreceptors (basiconics and thick and thin walled trichoids) and one type of mechanoreceptor (bristles). Sensilla densities were compared by ANOVA or non-parametric tests, and by multivariate discriminant analysis. Strains of the same species reared in different laboratories showed significant differences in their sensilla arrays, especially when compared to field-collected material from the same geographic origin. A Bolivian strain of T. infestans reared in the laboratory for 15 years and fed at monthly intervals, showed greatest differences from its conspecific wild forms, especially in terms of reductions in the number of chemoreceptors. By contrast, an Argentine strain of T. infestans reared for 25 years in the laboratory and fed weekly, showed a relative increase in the density of mechanoreceptors. A Colombian strain of R. prolixus reared for 20 years and fed weekly or fortnightly, showed only modest differences in the sensilla array when compared to its wild populations from the same area. However, a Colombian strain of R. pallescens reared for 12 years and fed fortnightly, did show highly significant reductions in one form of chemoreceptor compared to its conspecific wild populations. For all populations, multivariate analysis clearly discriminated between laboratory and field collected specimens, suggesting that artificial rearing can lead to modifications in the sensory array. This not only supports the idea of morphological plasticity in these species, but also suggests caution in the use of long-established laboratory material for experimental studies designed to extrapolate the natural behaviour and physiology of these species.

Relationship between antennal sensilla pattern and habitat in six species of Triatominae

In order to determine if habitat similarity is correlated with a similarity of sensilla pattern, we analyzed six species of Triatominae present in two biogeographic regions of Brazil: the "caatinga" and the "cerrado". In broad terms Triatoma infestans (cerrado) and T. brasiliensis (caatinga) are found in human domiciles, T. sordida (cerrado) and T. pseudomaculata (caatinga) colonize peridomestic habitats, and Rhodnius neglectus (cerrado) and R. nasutus (caatinga) inhabit palm tree crowns. The number and distribution of four sensilla types (bristles, thin and thick walled trichoidea, and basiconica) were compared in these species. Sexual dimorphism of sensilla patterns was noted in T. sordida, T. brasiliensis and T. pseudomaculata. A principal component analysis showed three main groups: (i) species that live in the palms, (ii) domiciliated species and (iii) those living in the peridomestic habitat. T. infestans almost exclusively domestic, was placed at the centre of the canonical map and some individuals of other species overlapped there. These results support the idea that the patterns of antennal sensilla are sensitive indicators of adaptive process in Triatominae. We propose that those species that inhabit less stable habitats possess more types of sensilla on the pedicel, and higher number of antennal sensilla

Inter-specific and developmental differences on the array of antennal chemoreceptors in four species of triatominae (Hemiptera: Reduviidae)

The aim of the work was to investigate the pattern of chemoreceptor sensilla in adults and fifth stage nymphs of Rhodnius prolixus, R. neglectus, Triatoma infestans and T. sordida in order to study differences and similarities between genera and species. Three types of sensilla were analyzed by light microscopy: thin-walled trichoidea, thick-walled trichoidea and basiconica. The number of sensilla of each three types were counted. The length of the antennal segments were also used as a variable for the analysis. The statistical analysis showed that the number of these antennal chemoreceptors had significant differences between species and between adults and nymphs of each species. Discriminant analysis separates incompletely the fifth stage nymphs of the four species and showed similarity between them. Discriminant analysis performed with 12 variables of the antennae, allowed a complete separation of the adults of the four species.

Feeding and defaecation patterns in Triatoma sordida

Triatoma sordida is a peridomestic Triatominae that could play an important role in the transmission of Trypanosoma cruzi, although its vectorial competence is not well known. The aim of this work was to evaluate two aspects of the vectorial competence: the feeding behaviour and defaecation patterns, and to compare them with T. infestans. The feeding and defaecation patterns were studied in adults and fifth instar nymphys of T. sordida fed ad libitum on a restrained pigeon. The results showed how the blood meal size control excretion behaviour. Blood intake and time to first defaecation showed a significant negative correlation. Adults and nymphs frequently defaecated during the blood meal, reaching the maximum frequency within the first 10 minutes.

Are dead Triatoma infestans a competent vector of Trypanosoma cruzi?

After Triatoma infestans death, Trypanosoma cruzi survived several days, maintaining the ability to infect a vertebrate host. Dead bugs from an endemic area collected during an official spraying comapign showed mobile rectal tripanosomes up to 14 days after vector death. Two days after vector death2, 760 tripomastigotes were found alive in its rectal material. However, the number of mobile tripomastigotes decreased significantly from the 5th day after death. Laboratory proofs with third and fifth nymphal stage showed similar results. Living tripanosomes were found in their rectal material at 10 days in third stage and even at 30 days in fifth nymphal stage. The mean number of tripomastigotes had no changes up to 10 days in third nymphal stage and increased significantly from 1 to 10 days in the fifth stage. Conjuctival instillation as well as intraperitoneal innoculation to mice, of metacyclic forms from dead T. infestans produced infection in the vertebrate host. Present results show that human contact with dead vector highly probable in summer and living and infective T. cruzi are available for transmision in the vector

[Sensory stimuli in the reproductive function]. / Estímulos sensoriales en la función reproductiva.

There is very ancient evidence that sensory systems and specific stimuli affect reproductive functions. Studies of the reproductive cycles and behavior led to the concept that simuli acting through the nervous system could affect the endocrine system. The event which normally induces the milk ejection reflex is stimulation of the teat; however under certain conditions the reflex can be provoked by other sensory stimuli as the sound of other rats nursing their litters. The endocrine mechanisms involved in the termination of pregnancy in rats seem to be essential for the occurrence of parturition, the expression of maternal behavior and lactation. Ovariectomy performed on day 20 of pregnancy impaired parturition, maternal behavior and lactation. Treatment with estrogen permitted normal delivery, maternal response and lactation only when the hormone was injected immediately after ovariectomy. Estrogen administered the day after was not effective. The administration of progesterone to ovariectomized pregnant rats prevented parturition. Maternal behavior did not occur in ovariectomized-progesterone treated rats when delivery was induced by Caesarean section on day 22 of pregnancy. The association of a progesterone decrease and a simultaneous estrogen secretion is an important step for normal parturition, maternal behavior appearance and normal lactation. After parturition a progressive increase in circulating progesterone seems to "adapt" the C.N.S. to the steroid which may modulate the release of prolactin induced by suckling. An acute increase of the progesterone level by s.c. silastic implant or injection during the first 3 or 6 days following parturition impairs the normal growth of the litter probably by impairing milk secretion and milk ejection. Prolactin release was significantly diminished by the progesterone treatment. Pretreatment with an antiestrogen potentiates the inhibitory effect of progesterone on litter growth.(ABSTRACT TRUNCATED AT 250 WORDS)