1.
Angew Chem Int Ed Engl
; 58(21): 6911-6915, 2019 05 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30924239
RESUMO
The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, inâ situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small-sized multi-colored fluorophores for real-time tracking of essential metabolites in live cells and inâ vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.