1.
Angew Chem Int Ed Engl
; 52(42): 11092-5, 2013 Oct 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24039048
RESUMO
Enzyme quartet: Isolation of the first sulfur-bearing intermediate of the gliotoxin pathway in Aspergillus fumigatus and successful inâ vitro conversion of the bisglutathione adduct into an intact epidithiodiketopiperazine by a four-enzyme cascade (including glutamyltransferase GliK and dipeptidase GliJ) revealed an outstanding adaptation of a primary metabolic pathway into natural product biosynthesis that is widespread in fungi.