1.
Org Lett
; 3(7): 1001-4, 2001 Apr 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11277780
RESUMO
[structure: see text]. A small library of cyclic RGD pseudopentapeptides incorporating stereoisomeric 6,5- and 7,5-fused bicyclic lactams was synthesized with the aim of developing active and selective integrin antagonists. The solid-phase synthesis and activity of these RGD derivatives is described. The approach led to two of the most active known inhibitors of alpha(V)beta3 receptor.