Minimally invasive surgery and sphincter preservation in rectal cancer.

BACKGROUND: National adoption of sphincter-preserving surgery (SPS) and minimally invasive surgery (MIS) has not been well documented. We examined national trends in use of SPS and MIS. MATERIALS AND METHODS: The National Inpatient Sample was used to evaluate open, laparoscopic, and robotic low anterior resection (LAR) or abdominoperineal resection (APR) for patients undergoing rectal cancer surgery from 2009 to 2011. Trends in SPS and MIS were stratified by hospital volume. Propensity score matching was used. RESULTS: A total of 24,999 (62.0%) patients underwent LAR, and 15,288 (38.0%) underwent APR from 2009 to 2011. A total of 22,310 (89.2%) LARs were open and 2689 (10.8%) MIS. A total of 11,600 (75.9%) APRs were open and 3688 (24.1%) MIS. Most procedures were at high-volume centers. In propensity-matched analysis, length of stay for LAR was longer in open surgery (6 versus 5 d; P = 0.01); in APR, MIS patients were less likely to have wound, infectious, urinary, and gastrointestinal complications, and length of stay was shorter (6 versus 8 d; P < 0.01). CONCLUSIONS: SPS and MIS rates have increased nationally, especially in high-volume centers. In addition, the perioperative benefits seen in randomized clinical trials are maintained in a national database. Further studies should focus on understanding differences in survival and oncologic outcomes with MIS techniques.

Acute liver failure following cleft palate repair: a case of therapeutic acetaminophen toxicity.

Background : Acetaminophen is a widely used analgesic and antipyretic agent in the pediatric population. While the hepatotoxic effects of the drug have been well recognized in cases of acute overdose and chronic supratherapeutic doses, the toxic effects of acetaminophen are rarely documented in cases where therapeutic guidelines are followed. Case : An 8-month-old boy underwent cleft palate repair and placement of bilateral myringotomy tubes. His anesthetic course was uneventful, consisting of maintenance with desflurane and fentanyl. He received acetaminophen for routine postoperative pain management and was tolerating liquids and discharged home on postoperative day 1. On day 3, the child was profoundly lethargic with multiple episodes of emesis and was taken to the emergency department. He suffered a 45-second tonic-clonic seizure in transport to the regional children's medical center, and initial laboratory results demonstrated acute hepatitis with AST 24,424 U/L, ALT 12,885 U/L, total bilirubin 3.1 mg/dL, and a serum acetaminophen level of 83 µg/mL. Aggressive supportive measures including blood products and periprocedural fresh frozen plasma, piperacillin/tazobactam, and intravenous infusions of N-acetylcysteine, sodium phenylacetate and sodium benzoate, carnitine, and citrulline were administered. His metabolic acidosis and acute hepatitis began to correct by day 4, and he was discharged home without further surgical intervention on day 15. Conclusion : Although acetaminophen is an effective and commonly used analgesic in pediatric practice, hepatotoxicity is a potentially devastating complication. This report challenges the appropriateness of existing guidelines for acetaminophen administration and emphasizes the importance of close follow-up and hydration after even relatively minor surgery.

A systematic review and pooled analysis of peroneal artery perforators for fibula osteocutaneous and perforator flaps.

BACKGROUND: Despite the availability of cadaveric, anatomic, and clinical models to identify peroneal artery perforators in the lower leg, there is no consensus on the optimal fibula interval to reliably capture perforators for flap and skin paddle design. METHODS: A systematic review of the MEDLINE and Cochrane databases was performed to identify all anatomical, clinical, and radiographic reports of peroneal artery perforators in the lower leg. Locations were indexed along tenths of the total fibula length to incorporate a uniform format. RESULTS: Three clinical and six cadaveric reports identified 445 legs and 1710 perforators. The 0.6 interval had the greatest total perforator frequency at 19.1 ± 1 percent, with 310 perforators and a positive probability of 79.1 ± 2.1 percent. Chi-square analysis found a statistical difference in perforator frequency at the flanking intervals of 0.5 and 0.8 (p = 0.0058 and p = 0.0019) and beyond. Subgroup analysis of septocutaneous perforators was based on 345 legs and 608 perforators. The 0.6 interval was the densest, with 110 perforators and a frequency of 18.1 ± 1.6 percent. The musculocutaneous subgroup analysis found 292 legs and 831 perforators, and a densest interval at 0.4, based on 157 perforators and a frequency of 18.9 ± 1.4 percent. CONCLUSIONS: This systematic review and pooled analysis of all available and complete peroneal artery perforator data demonstrates clustering over the 0.6 interval of the lateral leg. This interval should be considered during flap design and elevation to reliably capture irrigating perforators for free and local flap applications.