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2.
Surg Infect (Larchmt) ; 25(1): 56-62, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38285892

RESUMO

Background: Trials have shown non-inferiority of non-operative management (NOM) for appendicitis, although critically ill patients have been often excluded. The purpose of this study is to evaluate surgical versus NOM outcomes in critically ill patients with appendicitis by measuring mortality and hospital length of stay (LOS). Patients and Methods: The Healthcare Cost and Utilization Project's (HCUP) Database was utilized to analyze data from 10 states between 2008 and 2015. All patients with acute appendicitis by International Classification of Diseases, Ninth Revision (ICD-9) codes over the age of 18 were included. Negative binomial and logistic regression were used to determine the association of acute renal failure (ARF), cardiovascular failure (CVF), pulmonary failure (PF), and sepsis by treatment strategy (laparoscopic, open, both, or no surgery) on mortality and hospital LOS. Results: Among 464,123 patients, 67.5%, 23.3%, 8.2%, and 0.8% underwent laparoscopic, open, NOM, or both laparoscopic and open surgery, respectively. Patients who underwent surgery had 58% lower odds of mortality and 34% shorter hospital LOS compared with NOM patients. Patients with ARF, CVF, PF, and sepsis had 102%, 383%, 475%, and 666% higher odds of mortality and a 47%, 46%, 71%, and 163% longer hospital LOS, respectively, compared with patients without these diagnoses on admission. Conclusions: Critical illness on admission increases mortality and hospital LOS. Patients who underwent laparoscopic, and to a lesser extent, open appendectomy had improved mortality compared with those who did not undergo surgery regardless of critical illness status.


Assuntos
Apendicite , Laparoscopia , Sepse , Humanos , Adulto , Pessoa de Meia-Idade , Estado Terminal , Apendicite/cirurgia , Apendicite/diagnóstico , Tempo de Internação , Doença Aguda , Apendicectomia/efeitos adversos , Sepse/etiologia , Estudos Retrospectivos , Resultado do Tratamento
3.
J Infect Dis ; 229(5): 1256-1265, 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38207119

RESUMO

BACKGROUND: Natural killer (NK) cells are dysfunctional in chronic human immunodeficiency virus (HIV) infection as they are not able to clear virus. We hypothesized that an infusion of NK cells, supported by interleukin 2 (IL-2) or IL-15, could decrease virus-producing cells in the lymphatic tissues. METHODS: We conducted a phase 1 pilot study in 6 persons with HIV (PWH), where a single infusion of haploidentical related donor NK cells was given plus either IL-2 or N-803 (an IL-15 superagonist). RESULTS: The approach was well tolerated with no unexpected adverse events. We did not pretreat recipients with cyclophosphamide or fludarabine to "make immunologic space," reasoning that PWH on stable antiretroviral treatment remain T-cell depleted in lymphatic tissues. We found donor cells remained detectable in blood for up to 8 days (similar to what is seen in cancer pretreatment with lymphodepleting chemotherapy) and in the lymph nodes and rectum up to 28 days. There was a moderate decrease in the frequency of viral RNA-positive cells in lymph nodes. CONCLUSIONS: There was a moderate decrease in HIV-producing cells in lymph nodes. Further studies are warranted to determine the impact of healthy NK cells on HIV reservoirs and if restoring NK-cell function could be part of an HIV cure strategy. Clinical Trials Registration. NCT03346499 and NCT03899480.


Assuntos
Infecções por HIV , Interleucina-15 , Interleucina-2 , Células Matadoras Naturais , Humanos , Células Matadoras Naturais/imunologia , Infecções por HIV/imunologia , Infecções por HIV/virologia , Infecções por HIV/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Adulto , Projetos Piloto , Feminino , Carga Viral , Linfonodos/imunologia , HIV-1/imunologia
4.
JAMA Netw Open ; 5(3): e222735, 2022 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-35294537

RESUMO

Importance: SARS-CoV-2 viral entry may disrupt angiotensin II (AII) homeostasis, contributing to COVID-19 induced lung injury. AII type 1 receptor blockade mitigates lung injury in preclinical models, although data in humans with COVID-19 remain mixed. Objective: To test the efficacy of losartan to reduce lung injury in hospitalized patients with COVID-19. Design, Setting, and Participants: This blinded, placebo-controlled randomized clinical trial was conducted in 13 hospitals in the United States from April 2020 to February 2021. Hospitalized patients with COVID-19 and a respiratory sequential organ failure assessment score of at least 1 and not already using a renin-angiotensin-aldosterone system (RAAS) inhibitor were eligible for participation. Data were analyzed from April 19 to August 24, 2021. Interventions: Losartan 50 mg orally twice daily vs equivalent placebo for 10 days or until hospital discharge. Main Outcomes and Measures: The primary outcome was the imputed arterial partial pressure of oxygen to fraction of inspired oxygen (Pao2:Fio2) ratio at 7 days. Secondary outcomes included ordinal COVID-19 severity; days without supplemental o2, ventilation, or vasopressors; and mortality. Losartan pharmacokinetics and RAAS components (AII, angiotensin-[1-7] and angiotensin-converting enzymes 1 and 2)] were measured in a subgroup of participants. Results: A total of 205 participants (mean [SD] age, 55.2 [15.7] years; 123 [60.0%] men) were randomized, with 101 participants assigned to losartan and 104 participants assigned to placebo. Compared with placebo, losartan did not significantly affect Pao2:Fio2 ratio at 7 days (difference, -24.8 [95%, -55.6 to 6.1]; P = .12). Compared with placebo, losartan did not improve any secondary clinical outcomes and led to fewer vasopressor-free days than placebo (median [IQR], 9.4 [9.1-9.8] vasopressor-free days vs 8.7 [8.2-9.3] vasopressor-free days). Conclusions and Relevance: This randomized clinical trial found that initiation of orally administered losartan to hospitalized patients with COVID-19 and acute lung injury did not improve Pao2:Fio2 ratio at 7 days. These data may have implications for ongoing clinical trials. Trial Registration: ClinicalTrials.gov Identifier: NCT04312009.


Assuntos
Bloqueadores do Receptor Tipo 1 de Angiotensina II/uso terapêutico , Tratamento Farmacológico da COVID-19 , COVID-19/complicações , Losartan/uso terapêutico , Lesão Pulmonar/prevenção & controle , Lesão Pulmonar/virologia , Adulto , Idoso , COVID-19/diagnóstico , Método Duplo-Cego , Feminino , Hospitalização , Humanos , Lesão Pulmonar/diagnóstico , Masculino , Pessoa de Meia-Idade , Escores de Disfunção Orgânica , Testes de Função Respiratória , Estados Unidos
5.
Surg Infect (Larchmt) ; 22(10): 1021-1030, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34129395

RESUMO

Background: Pancreatitis accounts for more than $2.5 billion of healthcare costs and remains the most common gastrointestinal (GI) admission. Few contemporary studies have assessed temporal trends of incidence, complications, management, and outcomes for acute pancreatitis in hospitalized patients at the national level. Methods: We used data from one of the largest hospital-based databases available in the United States, the Healthcare Cost and Utilization Project's (HCUP) State Inpatient Database, from 10 states between 2008 and 2015. We included patients with a diagnosis of acute pancreatitis (ICD-9 CM 577.0). Patient- and hospital-level data were used to estimate incidence and inpatient mortality rates. Results: From 80,736,256 hospitalizations, 929,914 (1.15%) cases of acute pancreatitis were identified, 186,226 (20.2%) of which were caused by gallbladder disease). The median age was 53 years (interquartile range [IQR], 41-67) and 50.8% were men. In-hospital mortality was 2.5% and crude mortality rates declined from 2.9% to 2.0% over the study period. Admission year remained significant after adjusting for patient demographics and comorbidities (odds ratio [OR], 0.90; 95% confidence interval [CI], 0.89-0.90; p < 0.001). Gallbladder disease was associated with decreased odds of mortality (OR, 0.60; 95% CI, 0.57-0.62). Median length of stay was four days (IQR, 2-7) and decreased over time. The rates of surgical and endoscopic interventions were highest in 2011 (peak incidence of 16.1% and 9.5%, respectively) and have been decreasing since. Surgical providers were, on average, more likely than medical providers to perform surgery in both those with and without gallbladder disease etiology (gallbladder disease OR, 7.11; 95% CI, 5.46-9.25; non-gallbladder disease OR, 20.50; 95% CI, 16.81-25.01), endoscopy (gallbladder disease OR, 1.22; 95% CI, 0.87-1.72; non-gallbladder disease OR, 1.60; 95% CI, 1.18-2.16), or both (gallbladder disease OR, 7.00; 95% CI, 5.22-9.37; non-gallbladder disease OR, 8.85; 95% CI, 5.61-13.96). Conclusions: The incidence of pancreatitis, from 2008 to 2015, has increased whereas inpatient mortality (i.e., case fatality) has decreased. Understanding temporal trends in outcomes and management along with provider, hospital, and regional variation can better identify areas for future research and collaboration in managing these patients.


Assuntos
Pancreatite , Doença Aguda , Mortalidade Hospitalar , Hospitalização , Humanos , Incidência , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Pancreatite/epidemiologia , Estados Unidos/epidemiologia
6.
J Surg Res ; 266: 44-53, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-33984730

RESUMO

BACKGROUND: Preoperative optimization is increasingly emphasized for high-risk surgical patients. One critical component of this includes preoperative advanced care planning to promote goal-concordant care. We aimed to define a subset of patients that might benefit from preoperative palliative care consult for advanced care planning. MATERIALS AND METHODS: We examined adult patients admitted from January 2016 to December 2018 to a university health system for elective surgery. Multivariate logistic regression was used to identify variables associated with death within 1 y, and presence of palliative care consults preoperatively. Chi-square analysis evaluated the impact of a palliative care consult on advanced care planning variables. RESULTS: Of the 29,132 inpatient elective procedures performed, there was a 2.0% mortality rate at 6 mo and 3.5% at 1 y. Those who died were more likely to be older, male, underweight (BMI <18), or have undergone an otolaryngology, neurosurgery or thoracic procedure type (all P-values < 0.05). At the time of admission, 29% had an advance directive, 90% had a documented code status, and 0.3% had a preoperative palliative care consult. Patients were more likely to have an advanced directive, a power of attorney, a documented code status, and have a do not resuscitate order if they had a palliative care consult (all P-values <0.05). The mortality rates and preoperative palliative care rates per procedure type did not follow similar trends. CONCLUSIONS: Preoperative palliative care consultation before elective admissions for surgery had a significant impact on advanced care planning.


Assuntos
Planejamento Antecipado de Cuidados , Procedimentos Cirúrgicos Eletivos/mortalidade , Cuidados Paliativos/métodos , Cuidados Pré-Operatórios/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
7.
Am J Surg ; 221(2): 394-400, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33303187

RESUMO

BACKGROUND: Surgical intensive care units (SICU) require complex care from a multi-disciplinary team. Frequent changes in team members can lead to shifting expectations for junior general surgical trainees, which creates a challenging working and learning environment. We aim to identify expectations of junior surgery trainee's medical knowledge and technical/non-technical skills at the start of their SICU rotation. We hypothesize that expectations will not be consistent across SICU stakeholder groups. METHODS: Twenty-eight individual semi-structured interviews were conducted with six SICU stakeholder groups at a medium-sized academic hospital. Expectations were identified from interview transcripts. Frequency counts were analyzed. RESULTS: Forty-one expectations were identified. 4 expectations were identified by a majority of interviewees. Most expectations were identified by 7 or fewer interviewees. 23 (53%) expectations were shared by at least one stakeholder group. 2 (8%) expectations were shared by all groups. CONCLUSIONS: SICU stakeholder groups identified ten medical knowledge, ten technical skill, and three non-technical skill expectations. Yet, few expectations were shared among the groups. Thus, SICU stakeholder groups have disparate expectations for surgery trainees in our SICU.


Assuntos
Cirurgia Geral/educação , Unidades de Terapia Intensiva/estatística & dados numéricos , Internato e Residência/normas , Avaliação das Necessidades/estatística & dados numéricos , Equipe de Assistência ao Paciente/estatística & dados numéricos , Competência Clínica/normas , Competência Clínica/estatística & dados numéricos , Cuidados Críticos/normas , Cuidados Críticos/estatística & dados numéricos , Cirurgia Geral/normas , Cirurgia Geral/estatística & dados numéricos , Humanos , Unidades de Terapia Intensiva/normas , Comunicação Interdisciplinar , Práticas Interdisciplinares , Internato e Residência/métodos , Internato e Residência/estatística & dados numéricos , Aprendizagem , Motivação , Equipe de Assistência ao Paciente/normas , Participação dos Interessados , Cirurgiões/educação , Cirurgiões/normas , Inquéritos e Questionários/estatística & dados numéricos
8.
Hellenic J Cardiol ; 62(1): 38-45, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32387591

RESUMO

OBJECTIVES: To investigate the baseline risk of patients treated with Extracorporeal Cardiopulmonary Membrane Oxygenation (ECMO) in relation to cannulation strategy and indication for ECMO as well as the relation of cannulation strategy with survival and secondary hospitalization outcomes. METHODS: Severity of illness and predicted mortality risk were assessed in 317 patients. Central cannulation was used in 52 patients unable to wean off cardiopulmonary bypass after cardiac surgery. Peripheral cannulation was used in 179 patients for extracorporeal cardiopulmonary resuscitation (eCPR) and in 86 patients who received ECMO for refractory cardiogenic shock (RCS). RESULTS: Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were significantly worse (P < 0.01) for peripheral ECMO eCPR (23.2) vs central ECMO (14.6) and vs peripheral ECMO for RCS (18.9). Survival After Venoarterial ECMO (SAVE) scores were significantly worse for peripheral ECMO for eCPR (-7.85) and RCS (-10.38) vs central ECMO (-3.97), and P < 0.01. Peripherally cannulated patients had significantly worse renal function. No significant difference existed for survival to discharge (peripheral ECMO for eCPR, 31%; central ECMO, 44%; peripheral ECMO for refractory cardiac shock, 39.5%; and P = 0.176), although centrally cannulated patients had significantly longer treatment durations compared with peripheral ECMO for eCPR. CONCLUSIONS: Peripherally cannulated patients with eCPR had significantly worse APACHE II and SAVE scores compared to peripherally cannulated RCS or patients with central ECMO, despite having similar mortality.


Assuntos
Reanimação Cardiopulmonar , Oxigenação por Membrana Extracorpórea , Parada Cardíaca , Cateterismo , Humanos , Estudos Retrospectivos , Choque Cardiogênico/terapia
9.
J Trauma Acute Care Surg ; 89(2): 279-288, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32384370

RESUMO

BACKGROUND: Epidemiologic assessment of surgical admissions into intensive care units (ICUs) provides a framework to evaluate health care system efficiency and project future health care needs. METHODS: We performed a 9-year (2008-2016), retrospective, cohort analysis of all adult admissions to 88 surgical ICUs using the prospectively and manually abstracted Cerner Acute Physiology and Chronic Health Evaluation Outcomes database. We stratified patients into 13 surgical cohorts and modeled temporal trends in admission, mortality, surgical ICU length of stay (LOS), and change in functional status (FS) using generalized mixed-effects and Quasi-Poisson models to obtain risk-adjusted outcomes. RESULTS: We evaluated 78,053 ICU admissions and observed a significant decrease in admissions after transplant and thoracic surgery, with a concomitant increase in admissions after otolaryngological and facial reconstructive procedures (all p < 0.05). While overall risk-adjusted mortality remained stable over the study period; mortality significantly declined in orthopedic, cardiac, urologic, and neurosurgical patients (all p < 0.05). Cardiac, urologic, gastrointestinal, neurosurgical, and orthopedic admissions showed significant reductions in LOS (all p < 0.05). The overall rate of FS deterioration increased per year, suggesting ICU-related disability increased over the study period. CONCLUSION: Temporal analysis demonstrates a significant change in the type of surgical patients admitted to the ICU over the last decade, with decreasing mortality and LOS in selected cohorts, but an increasing rate of FS deterioration. Improvement in ICU outcomes may highlight the success of health care advancements within certain surgical cohorts, while simultaneously identifying cohorts that may benefit from future intervention. Our findings have significant implications in health care systems planning, including resource and personnel allocation, education, and surgical training. LEVEL OF EVIDENCE: Economic/decision, level IV.Epidemiologic, level IV.


Assuntos
Unidades de Terapia Intensiva/estatística & dados numéricos , Unidades de Terapia Intensiva/tendências , Procedimentos Cirúrgicos Operatórios/estatística & dados numéricos , Procedimentos Cirúrgicos Operatórios/tendências , APACHE , Adulto , Utilização de Instalações e Serviços , Feminino , Mortalidade Hospitalar/tendências , Humanos , Unidades de Terapia Intensiva/normas , Tempo de Internação/estatística & dados numéricos , Tempo de Internação/tendências , Masculino , Avaliação de Resultados em Cuidados de Saúde , Estudos Retrospectivos , Procedimentos Cirúrgicos Operatórios/normas , Fatores de Tempo , Estados Unidos/epidemiologia
10.
J Surg Educ ; 77(3): 627-634, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32201143

RESUMO

OBJECTIVE: We examined the impact of video editing and rater expertise in surgical resident evaluation on operative performance ratings of surgical trainees. DESIGN: Randomized independent review of intraoperative video. SETTING: Operative video was captured at a single, tertiary hospital in Boston, MA. PARTICIPANTS: Six common general surgery procedures were video recorded of 6 attending-trainee dyads. Full-length and condensed versions (n = 12 videos) were then reviewed by 13 independent surgeon raters (5 evaluation experts, 8 nonexperts) using a crossed design. Trainee performance was rated using the Operative Performance Rating Scale, System for Improving and Measuring Procedural Learning (SIMPL) Performance scale, the Zwisch scale, and ten Cate scale. These ratings were then standardized before being compared using Bayesian mixed models with raters and videos treated as random effects. RESULTS: Editing had no effect on the Operative Performance Rating Scale Overall Performance (-0.10, p = 0.30), SIMPL Performance (0.13, p = 0.71), Zwisch (-0.12, p = 0.27), and ten Cate scale (-0.13, p = 0.29). Additionally, rater expertise (evaluation expert vs. nonexpert) had no effect on the same scales (-0.16 (p = 0.32), 0.18 (p = 0.74), 0.25 (p = 0.81), and 0.25 (p = 0.17). CONCLUSIONS: There is little difference in operative performance assessment scores when raters use condensed videos or when raters who are not experts in surgical resident evaluation are used. Future validation studies of operative performance assessment scales may be facilitated by using nonexpert surgeon raters viewing videos condensed using a standardized protocol.


Assuntos
Competência Clínica , Internato e Residência , Teorema de Bayes , Boston , Humanos , Gravação em Vídeo
11.
Am J Surg ; 219(2): 355-358, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31898943

RESUMO

BACKGROUND: A shortage of general surgeons is predicted in the future, with particular impact on rural surgery. This is an exploratory analysis on a rural-focused longitudinal integrated clerkship to determine if such clerkships can be used to increase interest and recruitment in rural general surgery. METHODS: An institutional database was reviewed to identify students who became general surgeons after completing a rural-focused longitudinal integrated clerkship. Telephone interviews were conducted on a portion of these surgeons. RESULTS: Fifty-seven students (3.6%) completing the rural-focused longitudinal integrated clerkship became general surgeons. Of those participating in phone interviews, most (90%) decided to become surgeons during their experience while all stated that preclinical years did not influence their specialty decision. CONCLUSIONS: A substantial portion of these surgeons went on to practice in rural communities. Pre-existing rural and primary care-focused education could help to address the future projected shortage of rural general surgeons.


Assuntos
Escolha da Profissão , Estágio Clínico/organização & administração , Educação de Graduação em Medicina/organização & administração , Cirurgia Geral/educação , Avaliação de Resultados em Cuidados de Saúde , Bases de Dados Factuais , Feminino , Hospitais Rurais/organização & administração , Humanos , Entrevistas como Assunto , Masculino , Atenção Primária à Saúde/organização & administração , Atenção Primária à Saúde/estatística & dados numéricos , Estudos Retrospectivos , Serviços de Saúde Rural/organização & administração , Estudantes de Medicina/estatística & dados numéricos , Cirurgiões/provisão & distribuição , Estados Unidos , Adulto Jovem
12.
J Trauma Acute Care Surg ; 88(3): 416-424, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31895331

RESUMO

INTRODUCTION: Elderly trauma patients are at high risk for mortality, even when presenting with minor injuries. Previous prognostic models are poorly used because of their reliance on elements unavailable during the index hospitalization. The purpose of this study was to develop a predictive algorithm to accurately estimate in-hospital mortality using easily available metrics. METHODS: The National Trauma Databank was used to identify patients 65 years and older. Data were split into derivation (2007-2013) and validation (2014-2015) data sets. There was no overlap between data sets. Factors included age, comorbidities, physiologic parameters, and injury types. A two-tiered scoring system to predict in-hospital mortality was developed: a quick elderly mortality after trauma (qEMAT) score for use at initial patient presentation and a full EMAT (fEMAT) score for use after radiologic evaluation. The final model (stepwise forward selection, p < 0.05) was chosen based on calibration and discrimination analysis. Calibration (Brier score) and discrimination (area under the receiving operating characteristic curve [AuROC]) were evaluated. Because National Trauma Databank did not include blood product transfusion, an element of the Geriatric Trauma Outcome Score (GTOS), a regional trauma registry was used to compare qEMAT versus GTOS. A mobile-based application is currently available for cost-free utilization. RESULTS: A total of 840,294 patients were included in the derivation data set and 427,358 patients in the validation data set. The fEMAT score (median, 91; S.D., 82-102) included 26 factors, and the qEMAT score included eight factors. The AuROC was 0.86 for fEMAT (Brier, 0.04) and 0.84 for qEMAT. The fEMAT outperformed other trauma mortality prediction models (e.g., Trauma and Injury Severity Score-Penetrating and Trauma and Injury Severity Score-Blunt, age + Injury Severity Score). The qEMAT outperformed the GTOS (AuROC, 0.87 vs. 0.83). CONCLUSION: The qEMAT and fEMAT accurately estimate the probability of in-hospital mortality and can be easily calculated on admission. This information could aid in deciding transfer to tertiary referral center, patient/family counseling, and palliative care utilization. LEVEL OF EVIDENCE: Epidemiological Study, level IV.


Assuntos
Mortalidade Hospitalar , Escala de Gravidade do Ferimento , Ferimentos e Lesões/mortalidade , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Causas de Morte , Tomada de Decisão Compartilhada , Humanos , Aplicativos Móveis , Fatores de Risco , Estados Unidos/epidemiologia
13.
J Surg Educ ; 77(2): 485-490, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31882238

RESUMO

OBJECTIVES: The primary objective of this study is to investigate whether undergraduate, nonmedical students could pass the FLS Manual Skills Exam with minimal practice. The secondary objective is to examine ACGME case log data from graduating chief residents over the past 18 years to examine how laparoscopic experience has evolved over that time period. DESIGN: Undergraduate, nonmedical students received training and unlimited practice time before being tested on each task of the FLS Manual Skills Exam. Each task was timed and scored using the MISTELS system. ACGME case log data from graduating chief residents over the past 18 years was obtained. SETTING: The setting is SimPortal, the simulation center associated with the University of Minnesota Medical School. PARTICIPANTS: The participants are 25 undergraduate, nonmedical students from the University of Minnesota. Participants were recruited on campus. RESULTS: Twenty-three out of 25 (92%) undergraduate, nonmedical students successfully completed one attempt for each task of the FLS Manual Skills Exam and 21 out of 25 (84%) completed both attempts. The average total practice time was 39 minutes. Over the past 18 years, the average number of laparoscopic cases completed by a graduating chief increased from 142 to 275 cases (93% increase). Additionally, the average number of cases of the top 5 most common laparoscopic operations increased from 25% to over 400%. CONCLUSIONS: Undergraduate, nonmedical students can pass the FLS Manual Skills Exam with minimal practice. Additionally, general surgery residents and medical students continue to gain more laparoscopic experience throughout medical training as laparoscopic surgery is utilized for more operations. The FLS Manual Skills Exam should be re-examined to determine its utility as a high-stakes exam.


Assuntos
Laparoscopia , Estudantes de Medicina , Competência Clínica , Simulação por Computador , Humanos
14.
Surg Infect (Larchmt) ; 21(3): 246-254, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31618109

RESUMO

Background: Chronic critical illness (CCI) is a new and increasing entity that accounts for substantial cost despite its low incidence. We hypothesized that patients with end-stage liver failure undergoing liver transplant would be at high risk for developing CCI. With limited liver donors it is essential to understand pre- and peritransplant predictors of CCI. Methods: To accomplish this we performed a retrospective cohort study at a large academic transplant center of all adult liver transplant patients from 2011 to 2017. We defined CCI as the need for mechanical ventilation for seven days or more post-transplant. Recipients who had re-transplantation during their index admission, acute rejection, or who died during transplant surgery were excluded. Logistic regression was performed using the Akaike information criterion (AIC) and the likelihood ratio test. Results: We identified 382 transplant recipients. Forty-five (11.8%) developed CCI. Univariable analysis identified 16 pre-transplant factors associated with post-transplant CCI. Subsequent multivariable logistic regression identified eight independent factors associated with CCI in liver transplant recipients including previous liver transplant, acute renal failure, frailty, lower albumin level, higher international normalized ratio, need for mechanical ventilation, and higher systolic pulmonary artery pressure. Pre-transplant factors associated with protection against CCI included higher Model for End-Stage Liver Disease (MELD) score. Conclusion: The incidence of CCI post-liver transplant is similar to the general population admitted to the intensive care unit. Pre-transplant factors associated with CCI can help identify at-risk patients, and furthermore, promote further research and interventions with the goal to decrease the incidence of CCI in the liver transplant recipients.


Assuntos
Doença Crônica/epidemiologia , Estado Terminal/epidemiologia , Doença Hepática Terminal/cirurgia , Transplante de Fígado , Complicações Pós-Operatórias/epidemiologia , Respiração Artificial/estatística & dados numéricos , Injúria Renal Aguda/epidemiologia , Adulto , Pressão Sanguínea , Doença Hepática Terminal/sangue , Feminino , Fragilidade/epidemiologia , Humanos , Hipoalbuminemia/epidemiologia , Incidência , Coeficiente Internacional Normatizado , Cirrose Hepática/sangue , Cirrose Hepática/cirurgia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Período Perioperatório , Hipertensão Arterial Pulmonar/epidemiologia , Artéria Pulmonar , Reoperação , Estudos Retrospectivos , Fatores de Risco , Albumina Sérica , Índice de Gravidade de Doença
15.
Surgery ; 166(5): 738-743, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31326184

RESUMO

BACKGROUND: Despite an increasing number of women in the field of surgery, bias regarding cognitive or technical ability may continue to affect the experience of female trainees differently than their male counterparts. This study examines the differences in the degree of operative autonomy given to female compared with male general surgery trainees. METHODS: A smartphone app was used to collect evaluations of operative autonomy measured using the 4-point Zwisch scale, which describes defined steps in the progression from novice ("show and tell") to autonomous surgeon ("supervision only"). Differences in autonomy between male and female residents were compared using hierarchical logistic regression analysis. RESULTS: A total of 412 residents and 524 faculty from 14 general surgery training programs evaluated 8,900 cases over a 9-month period. Female residents received less autonomy from faculty than did male residents overall (P < .001). Resident level of training and case complexity were the strongest predictors of autonomy. Even after controlling for potential confounding factors, including level of training, intrinsic procedural difficulty, patient-related case complexity, faculty sex, and training program environment, female residents still received less operative autonomy than their male counterparts. The greatest discrepancy was in the fourth year of training. CONCLUSION: There is a sex-based difference in the autonomy granted to general surgery trainees. This gender gap may affect female residents' experience in training and possibly their preparation for practice. Strategies need to be developed to help faculty and residents work together to overcome this gender gap.


Assuntos
Cirurgia Geral/educação , Internato e Residência/organização & administração , Salas Cirúrgicas/organização & administração , Autonomia Profissional , Cirurgiões/estatística & dados numéricos , Competência Clínica , Feminino , Identidade de Gênero , Cirurgia Geral/organização & administração , Cirurgia Geral/estatística & dados numéricos , Humanos , Internato e Residência/estatística & dados numéricos , Relações Interprofissionais , Masculino , Salas Cirúrgicas/estatística & dados numéricos , Fatores Sexuais , Cirurgiões/educação
16.
Afr Health Sci ; 19(1): 1778-1788, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31149008

RESUMO

BACKGROUND: Uganda's ageing population (age 50 years and older) will nearly double from 2015 to 2050. HIV/AIDS, diabetes, stroke among other disease processes have been studied in the elderly population. However, the burden of disease from surgically-treatable conditions is unknown. OBJECTIVES: To determine the proportion of adults above 50 years with unmet surgical need and deaths attributable to probable surgically-treatable conditions. METHODS: A cluster randomized sample representing the national population of Uganda was enumerated. The previously validated Surgeons Overseas assessment of surgical need instrument, a head-to-toe verbal interview, was used to determine any surgically-treatable conditions in two randomly-selected living household members. Deaths were detailed by heads of households. Weighted metrics are calculated taking sampling design into consideration and Taylor series linearization was used for sampling error estimation. RESULTS: The study enumerated 425 individuals above age 50 years. The prevalence proportion of unmet surgical need was 27.8% (95%CI, 22.1-34.3). This extrapolates to 694,722 (95%CI, 552,279-857,157) individuals living with one or more surgically treatable conditions. The North sub-region was observed to have the highest prevalence proportion. Nearly two out of five household deaths (37.9%) were attributed to probable surgically treatable causes. CONCLUSION: There is disproportionately high need for surgical care among the ageing population of Uganda with approximately 700,000 consultations needed.


Assuntos
Acessibilidade aos Serviços de Saúde/estatística & dados numéricos , Necessidades e Demandas de Serviços de Saúde/estatística & dados numéricos , Procedimentos Cirúrgicos Operatórios/estatística & dados numéricos , Adulto , Idoso , Envelhecimento , Estudos Transversais , Feminino , Pesquisas sobre Atenção à Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação das Necessidades , População Rural , Inquéritos e Questionários , Uganda , População Urbana
17.
Ann Glob Health ; 85(1)2019 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-30951271

RESUMO

BACKGROUND: Abdominal operations account for a majority of surgical volume in low-income countries, yet population-level prevalence data on surgically treatable abdominal conditions are scarce. OBJECTIVE: In this study, our objective was to quantify the burden of surgically treatable abdominal conditions in Uganda. METHODS: In 2014, we administered a two-stage cluster-randomized Surgeons OverSeas Assessment of Surgical Need survey to 4,248 individuals in 105 randomly selected clusters (representing the national population of Uganda). FINDINGS: Of the 4,248 respondents, 185 reported at least one surgically treatable abdominal condition in their lifetime, giving an estimated lifetime prevalence of 3.7% (95% CI: 3.0 to 4.6%). Of those 185 respondents, 76 reported an untreated condition, giving an untreated prevalence of 1.7% (95% CI: 1.3 to 2.3%). Obstructed labor (52.9%) accounted for most of the 238 abdominal conditions reported and was untreated in only 5.6% of reported conditions. In contrast, 73.3% of reported abdominal masses were untreated. CONCLUSIONS: Individuals in Uganda with nonobstetric abdominal surgical conditions are disproportionately undertreated. Major health system investments in obstetric surgical capacity have been beneficial, but our data suggest that further investments should aim at matching overall surgical care capacity with surgical need, rather than focusing on a single operation for obstructed labor.


Assuntos
Traumatismos Abdominais/epidemiologia , Dor Abdominal/epidemiologia , Cesárea/estatística & dados numéricos , Distocia/epidemiologia , Hérnia/epidemiologia , Aceitação pelo Paciente de Cuidados de Saúde , Procedimentos Cirúrgicos Operatórios/estatística & dados numéricos , Traumatismos Abdominais/cirurgia , Dor Abdominal/cirurgia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Estudos Transversais , Países em Desenvolvimento , Distocia/cirurgia , Status Econômico , Medo , Feminino , Acessibilidade aos Serviços de Saúde , Necessidades e Demandas de Serviços de Saúde , Herniorrafia , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Gravidez , Prevalência , Melhoria de Qualidade , Apoio Social , Meios de Transporte , Confiança , Uganda/epidemiologia , Adulto Jovem
18.
J Surg Educ ; 76(2): 459-468, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30279137

RESUMO

OBJECTIVE: The objective of this study was to present the process of developing a rural surgery training track within an established residency program and review the current rural surgery training programs in the nation. DESIGN: This study reviews current rural surgery training opportunities at Accreditation Council for Graduate Medical Education accredited surgical residencies in the United States and presents the process of creating the University of Minnesota's rural surgery training track. SETTING: This study was performed at the University of Minnesota, in Minneapolis, Minnesota, and at Essentia Health-Saint Mary's Medical Center, in Duluth, Minnesota. PARTICIPANTS: Accredited general surgery residencies were reviewed. The creation of a designated rural surgery training track added an additional rural-designated surgical resident during each postgraduation year and created a required postgraduation year 2 rural surgery rotation for all categorical surgical residents. RESULTS: Two hundred sixty-eight surgery residency programs were reviewed. Twenty-seven had required rural rotations, 10 offered only elective rural rotations, and 4 had dedicated National Resident Matching Program codes for rural training tracks. After review of national rural surgery training opportunities, the University of Minnesota's process of creating a designated rural surgery training program required attention to 5 main components: needs assessment and review of local opportunities, surgery residency review committee approval, funding, surgical education, and clinical/operative education. CONCLUSIONS: Increasing opportunities for surgical residents to train in rural settings may help with recruitment of medical students and retention of surgeons pursuing careers in rural surgery.


Assuntos
Cirurgia Geral/educação , Internato e Residência/organização & administração , Serviços de Saúde Rural , Estudos de Coortes , Minnesota
19.
J Surg Educ ; 76(1): 99-106, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30122638

RESUMO

OBJECTIVE: Impostor phenomenon (IP) characterizes feelings of self-doubt coupled with feelings that achievements were based on luck and a fear of being discovered as an intellectual fraud. Recently, studies have focused on IP in medical trainees and its association with burnout; however, this research has not yet been conducted on surgeons. This study addresses that gap by investigating the prevalence of IP and burnout in general surgeons and surgery residents. DESIGN: Participants completed two unlinked, blinded surveys. The first survey included demographics and scholarly activity, while the second included the Clance Impostor Phenomenon Scale (CIPS) and a validated, single-item burnout score. SETTING: Hennepin County Medical Center and University of Minnesota, Minneapolis, MN. PARTICIPANTS: General surgeons and general surgery residents at two teaching hospitals, one community-based (N = 46) and one university-based (N = 42). RESULTS: The majority of both surgeons and residents were male, Caucasian, and married. Residents scored significantly higher compared to faculty in nearly half of CIPS questions. The overall CIPS score was significantly higher in trainees as well (61 vs 51, p = 0.017). Burnout did not differ significantly between trainees (30%) and faculty (41%) (p = 0.545). We found no significant differences in gender or years of practice in those with clinical IP (CIPS >62), and logistic regression analysis showed burnout as the only significant association for clinical IP symptoms (OR 3.95, p = 0.017). CONCLUSIONS: Contrary to studies in other medical fields, female general surgery faculty and trainees were no more likely than males to display characteristics of IP. Residents did; however, score higher than faculty on overall CIPS score. While we cannot determine how burnout and IP directly impact each other, our study shows that both faculty and trainees experiencing burnout are more likely to report symptoms of IP.


Assuntos
Esgotamento Profissional/epidemiologia , Medo , Cirurgia Geral/educação , Internato e Residência , Cirurgiões/psicologia , Feminino , Fraude , Humanos , Masculino
20.
J Surg Educ ; 76(2): 387-392, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30245059

RESUMO

OBJECTIVE: To assess the medical student perception and experience of a 24-hour call requirement, and to learn if improvements can be made to improve the 24-hour call requirement. DESIGN: Medical students completing their required surgical clerkship over 1 academic year at our institution were surveyed prior to their clerkship and on the last week of clerkship regarding their perceptions and experience with 24-hour call. SETTING: This study was performed at the University of Minnesota, in Minneapolis, Minnesota, a medical school and tertiary medical center. PARTICIPANTS: Two hundred one medical students were given the option to complete an anonymous survey before and after their required surgical clerkship. RESULTS: Response rate for the preclerkship survey was 70% (n = 140) and 58% (n = 117) for the postclerkship survey. The mean age of respondents was 26 years, and the majority of students were in their third year of medical school. After completing the clerkship, students interested in surgery more often agreed the 24-hour call requirement should remain (51% versus 31%, p = 0.01). Students rotating at a Level I Trauma Center were also more likely to agree the call requirement should remain (59% versus 33%, p = 0.008). Medical students generally had less concerns (mental health, fatigue, mistakes, and grade performance) related to 24-hour call after completion of the clerkship. Concerns about the effect of 24-hour call on study schedule remained high in both pre and postclerkship groups. CONCLUSIONS: Medical students have concerns about the experience prior to the clerkship that diminished by its completion. To improve medical student perceptions and overall experience of 24-hour call, frequency of shifts could be limited and the 24-hour call requirement sites could be shifted to Level I Trauma Centers.


Assuntos
Atitude , Estudantes de Medicina/psicologia , Carga de Trabalho/estatística & dados numéricos , Adulto , Estágio Clínico , Humanos , Fatores de Tempo
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