RESUMO
Background: the Cornelia de Lange Syndrome (CDLs) is a rare and complex syndrome characterized, basically, by psychomotor retardation associated with a number of congenital malformations. Aims: this paper reports the case of an 11-year-old female child diagnosed with Cornelia de Lange Syndrome (CdLS) and her successful dental management. Case report: the patient had severe mental retardation, definite negative behavior and the clinical findings included oral and physical changes. The patient's oral hygiene was deficient with the presence of calculus and gingivitis, besides several active caries lesions in permanent and deciduous dental elements. The treatment consisted in guidance for caregivers about oral hygiene and diet, and the dental procedures were performed under general anesthesia. Currently, the patient is accompanied by monthly follow-ups. Conclusions: the lack of knowledge about oral hygiene and cariogenic diets was identified as a one of the reasons for the oral diseases present. Due to the need to care for the other more serious and complex health problems, the oral diseases had evolved faster than usual and thus were difficult to treat and maintain thereafter. Under such conditions, the dentist plays a key role within a multidisciplinary team. From the guidance and knowledge provided in the dental clinic, there was a significant improvement in the life quality of the child and her family
Assuntos
Humanos , Feminino , Criança , Síndrome de Cornélia de Lange , Transtornos MentaisRESUMO
OBJECTIVES: To evaluate prevalence, distribution, and sexual dimorphism of dental anomalies (DA) among different skeletal malocclusions (SM) and growth patterns (GP) under the hypothesis that specific clinical patterns exist and may indicate common etiological roots. MATERIALS AND METHODS: A total of 1047 orthodontic records of patients older than 8 years were evaluated. The SN-GoGn angle was used to classify GP (hypodivergent, normal, and hyperdivergent), and the ANB angle was used to verify SM (Angle Classes I, II, and III). These assessments were done from lateral cephalometric radiographs. DA were diagnosed using panoramic radiographs by one calibrated investigator. Odds ratios, chi-square, and Student's t-tests were used. RESULTS: Of the subjects, 56.7% were female, with mean age of 16.41 (±10.61) years. The prevalence of DA was 15.7%. Impaction and tooth agenesis were the most prevalent DA, with relative frequencies of 14.4% and 9.7%, respectively. DA were most prevalent in Class III SM (80.8%) and in hypodivergent GP (82.5%), although this was not statistically significant. Tooth agenesis ( P < .01) and microdontia ( P = .025) were significantly more common among hypodivergent GP and Class III SM, respectively. CONCLUSIONS: The results of this study support the idea that DA are preferentially associated with certain patterns of malocclusion.
Assuntos
Má Oclusão/etiologia , Anormalidades Dentárias/complicações , Adolescente , Adulto , Cefalometria , Criança , Feminino , Humanos , Masculino , Má Oclusão/diagnóstico por imagem , Má Oclusão/patologia , Má Oclusão Classe I de Angle/etiologia , Má Oclusão Classe I de Angle/patologia , Má Oclusão Classe II de Angle/etiologia , Má Oclusão Classe II de Angle/patologia , Má Oclusão Classe III de Angle/etiologia , Má Oclusão Classe III de Angle/patologia , Radiografia Dentária , Radiografia Panorâmica , Anormalidades Dentárias/diagnóstico por imagem , Anormalidades Dentárias/patologia , Dente Impactado/complicações , Dente Impactado/patologia , Adulto JovemRESUMO
Basal bodies and centrioles are conserved microtubule-based organelles the improper assembly of which leads to a number of diseases, including ciliopathies and cancer. Tubulin family members are conserved components of these structures that are integral to their proper formation and function. We have identified the ε-tubulin gene in Tetrahymena thermophila and detected the protein, through fluorescence of a tagged allele, to basal bodies. Immunoelectron microscopy has shown that ε-tubulin localizes primarily to the core microtubule scaffold. A complete genomic knockout of ε-tubulin has revealed that it is an essential gene required for the assembly and maintenance of the triplet microtubule blades of basal bodies. We have conducted site-directed mutagenesis of the ε-tubulin gene and shown that residues within the nucleotide-binding domain, longitudinal interacting domains, and C-terminal tail are required for proper function. A single amino acid change of Thr150, a conserved residue in the nucleotide-binding domain, to Val is a conditional mutation that results in defects in the spatial and temporal assembly of basal bodies as well as their stability. We have genetically separated functions for the domains of ε-tubulin and identified a novel role for the nucleotide-binding domain in the regulation of basal body assembly and stability.
Assuntos
Corpos Basais/fisiologia , Infecções por Cilióforos/metabolismo , Tetrahymena thermophila/fisiologia , Tubulina (Proteína)/fisiologia , Corpos Basais/metabolismo , Ciclo Celular/genética , Ciclo Celular/fisiologia , Centríolos/genética , Centríolos/metabolismo , Infecções por Cilióforos/genética , Microtúbulos/genética , Microtúbulos/metabolismo , Microtúbulos/fisiologia , Tetrahymena thermophila/genética , Tetrahymena thermophila/metabolismo , Tubulina (Proteína)/genética , Tubulina (Proteína)/metabolismoRESUMO
Introdução - Devido às diferenças econômicas que atingem grande parte da população, torna-se difícil a aquisição da escova e da fita dental convencionais. Nesse sentido, o presente trabalho visa analisar a eficácia da remoção de biofilme dental com escovas e fitas dentais alternativos e comparar a eficácia desses aos métodos convencionais de higienização. Material e métodos - As escovas alternativas foramconfeccionadas com palitos de picolé e bucha vegetal. Já as fitas dentais alternativas foram obtidas de tiras de saco plástico de 50kg de farinha de trigo. Participaram da pesquisa 45 alunos da Faculdade de Odontologia da Universidade Federal do Pará em duas etapas: evidenciação 1 (remoção do biofilme evidenciado com escovas efitas dentais convencionais) e evidenciação 2 (remoção do biofilme evidenciado com escovas e fita dentais alternativas), com intervalo de 7 dias entre elas. Foi utilizado o índice de OLeary para quantificar o biofilme nas duas etapas do experimento.Resultados - Foi observado significativa eficácia na remoção do biofilme dental,tanto da escova, quanto da fita dental alternativa com nível de significância p<0,05. Os métodos alternativos e convencionais de remoção do biofilme não demonstraram diferenças estatisticamente significantes entre eles. Conclusão - Escova e fita dentalalternativas podem ser utilizadas com segurança para a higienização bucal, sendo uma opção de custo mais acessível e de fácil confecção, no qual aproximam o acesso à saúde bucal da população carente.
Introduction - Due to the economic differences that affect the most of population, becomes difficult the acquisition of conventional tooth brush and dental tape. Accordingly, this paper aim to evaluate the effectiveness removal of dental biofilm with alternative tooth brush and dental tape and to compare its effectiveness againstconventional methods of cleaning. Materials and methods - The alternative tooth brush was confectioned with Popsicle stick and vegetal bush. The alternative dental tape was obtained from strips plastic bag of 50kg. Forty five students of the Instituteof Odontology of Federal University of Para participated in two steps: evidence 1 (evidenced biofilm remotion with conventional tooth brush and dental tape) and evidence 2 (evidenced biofilm remotion with alternatives tooth brush and dental tape), with a break of 7 days between the evidences. The Oleary index was used to quantify the biofilm in two steps of the experimental procedure. Results - It was observed a significant efficacy in the dental biofilm remotion, that both alternative tooth brush anddental tape obtained a significance level of p<0,05. The alternative and conventional methods of removal of biofilm do not demonstrated statistically significant differences between them. Conclusion: Alternative tooth brush and dental tape can be used with safety for bucal cleanness, suggesting a cheaper option and an easier confection, turning possible the access of the bucal health to poor population.