RESUMO
This multi-institutional report describes 8 cases of rhabdomyosarcoma in horses. Four neoplasms were in the tongue and other areas of the mouth or head, 2 were in the abdominal wall, and 1 each was in right shoulder muscles and heart. Four rhabdomyosarcomas that were less than 10 cm in diameter were treated by surgical excision or radiation with no recurrence. Two neoplasms greater than 10 cm in diameter in the abdominal wall and the right shoulder were considered inoperable and led to decisions to euthanize the horses. Two neoplasms were incidental findings at necropsy. All the neoplasms were classified as embryonal except for 1 pleomorphic rhabdomyosarcoma. These 8 cases were evaluated with 9 published case reports of equine rhabdomyosarcoma. For all cases, the most common sites were limb muscles (5/17) and tongue (4/17). Metastasis was reported in 4 of the previously published cases; none was found in this study.
Assuntos
Doenças dos Cavalos/patologia , Rabdomiossarcoma/veterinária , Neoplasias de Tecidos Moles/veterinária , Animais , Eutanásia Animal , Feminino , Doenças dos Cavalos/radioterapia , Doenças dos Cavalos/cirurgia , Cavalos , Masculino , Rabdomiossarcoma/patologia , Rabdomiossarcoma/radioterapia , Rabdomiossarcoma/cirurgia , Rabdomiossarcoma Embrionário/patologia , Rabdomiossarcoma Embrionário/radioterapia , Rabdomiossarcoma Embrionário/cirurgia , Rabdomiossarcoma Embrionário/veterinária , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/radioterapia , Neoplasias de Tecidos Moles/cirurgiaRESUMO
This report describes transient ulcerative dermatitis, severe thrombocytopenia, and mild neutropenia in 6 foals from 4 mares from geographically diverse regions of the United States. The foals presented at <4 days of age with oral and lingual ulcers, and crusting and erythema around the eyes, muzzle, and perineal, inguinal, axillary, trunk, and neck regions. There was a severe thrombocytopenia (0-30,000 platelets/microL), leukopenia (1900-3200 white blood cells/microL), and mild neutropenia (500-1800 neutrophils/microL). Four of the 6 foals had petechiae and ecchymotic hemorrhages and 3 had bleeding tendencies. Results of examination of a bone marrow biopsy from 1 foal were normal and results of a platelet surface immunoglobulin test in another were negative. Histopathology of the skin in all foals showed subepidermal clefting with subjacent vascular dilation, dermal hemorrhage, and superficial papillary necrosis. The foals were treated supportively with broad-spectrum antibiotics (5/6), corticosteroids (3/6), gastric ulcer prophylaxis (6/6), whole-blood transfusion (4/6), and platelet-rich plasma (1/6). The skin lesions and thrombocytopenia (>50,000 platelets/microL) improved in 2 weeks (4/6). Two foals had a decline in their platelet counts when the steroids were decreased and needed protracted treatment. All foals survived and were healthy as yearlings. Two mares that had 2 affected foals each, upon subsequent pregnancies to different stallions, had healthy foals when an alternate source of colostrum was given. The findings in the cases in this report suggest a possible relationship between colostral antibodies or some other factor in the colostrum and the thrombocytopenia and skin lesions, although further investigation is warranted to confirm or refute this hypothesis.
Assuntos
Dermatite/veterinária , Doenças dos Cavalos/sangue , Doenças dos Cavalos/patologia , Neutropenia/veterinária , Trombocitopenia/veterinária , Corticosteroides/uso terapêutico , Animais , Animais Recém-Nascidos , Antibacterianos/uso terapêutico , Transfusão de Sangue/veterinária , Colostro , Dermatite/tratamento farmacológico , Feminino , Antagonistas dos Receptores H2 da Histamina/uso terapêutico , Cavalos , Neutropenia/tratamento farmacológico , Estudos Retrospectivos , Síndrome , Trombocitopenia/tratamento farmacológico , Fatores de TempoAssuntos
Corpos Estranhos/veterinária , Doenças dos Cavalos/cirurgia , Cálculos da Bexiga Urinária/veterinária , Animais , Cistoscopia/veterinária , Corpos Estranhos/complicações , Corpos Estranhos/cirurgia , Migração de Corpo Estranho/veterinária , Cavalos , Masculino , Orquiectomia/efeitos adversos , Orquiectomia/veterinária , Infecções por Pseudomonas/etiologia , Infecções por Pseudomonas/veterinária , Infecções Estreptocócicas/etiologia , Infecções Estreptocócicas/veterinária , Cálculos da Bexiga Urinária/etiologia , Cálculos da Bexiga Urinária/cirurgiaRESUMO
OBJECTIVE: To determine the efficacy of polymyxin B-dextran 70 (PBD) for treatment of endotoxemic horses. ANIMALS: 15 horses during study 1 and 6 horses during study 2. PROCEDURES: 3 groups were used in study 1. Horses in groups 1 and 2 were given 30 ng of lipopolysaccharide (LPS)/kg of body weight, IV, over 60 minutes. Horses in group 3 were given saline (0.9% NaCl) solution. Beginning 15 minutes before LPS infusion and continuing for 75 minutes, horses in groups 1 and 3 were given PBD, IV. Horses in group 2 were given dextran 70. Blood samples were obtained for hemograms and determination of cytokine, lactate, and prostanoid concentrations. In study 2, horses were given ketoprofen (2.2 mg/kg) or saline solution 15 minutes before infusion of PBD. Fourteen days later, treatments were reversed, using a crossover design. Blood samples were obtained for measurement of thromboxane B2 (TXB2) concentration. RESULTS: For study 1, prior treatment with PBD completely blocked endotoxin-induced changes for heart and respiratory rates, rectal temperature, WBC count, and plasma tumor necrosis factor, interleukin 6, TXB2, and prostaglandin F1 concentrations. There was transient tachypnea, sweating, and increased plasma TXB2 concentration in horses given PBD (with or without LPS). Prior treatment with ketoprofen eliminated all PBD-induced signs and prevented the increase in plasma TXB2 concentration. CONCLUSIONS: Signs of endotoxemia were prevented in horses by treatment with PBD, although its use was associated with mild adverse effects. CLINICAL RELEVANCE: When used in combination with a cyclooxygenase-inhibiting drug, PBD has potential for treatment of horses with endotoxemia.
Assuntos
Antibacterianos/uso terapêutico , Anticoagulantes/uso terapêutico , Dextranos/uso terapêutico , Endotoxemia/veterinária , Doenças dos Cavalos/tratamento farmacológico , Polimixina B/uso terapêutico , Animais , Antibacterianos/farmacologia , Anticoagulantes/farmacologia , Temperatura Corporal , Estudos Cross-Over , Inibidores de Ciclo-Oxigenase/farmacologia , Dextranos/farmacologia , Combinação de Medicamentos , Endotoxemia/tratamento farmacológico , Feminino , Frequência Cardíaca , Hematócrito/veterinária , Cavalos , Infusões Intravenosas/veterinária , Interleucina-6/sangue , Cetoprofeno/farmacologia , Contagem de Leucócitos/veterinária , Lipídeo A/metabolismo , Lipopolissacarídeos/imunologia , Lipopolissacarídeos/farmacologia , Masculino , Polimixina B/farmacologia , Distribuição Aleatória , Tromboxano B2/sangue , Fator de Necrose Tumoral alfa/análiseRESUMO
OBJECTIVE: To assess the effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in clinically normal horses and to develop guidelines on the use of these agents for treatment of peptic ulcer disease in horses. DESIGN: Prospective, randomized, controlled trial. ANIMALS: 5 clinically normal adult horses with chronically implanted gastric cannulas. PROCEDURE: Each horse received all 5 treatments (30 g of aluminum hydroxide/15 g of magnesium hydroxide, 12 g of aluminum hydroxide/6 g of magnesium hydroxide, 10.5 g of bismuth subsalicylate, 26.25 g of bismuth subsalicylate, and 5% methylcellulose control) with only 1 experiment performed each day. Gastric pH was measured via a glass electrode inserted through the gastric cannula for 1 hour before treatment and continued for 2 hours after treatment. Food or water was not given to the horses during the experiment. Measurements of gastric pH obtained during posttreatment hours were compared with pretreatment gastric pH values. RESULTS: Only a dose of 30 g of aluminum hydroxide/ 15 g of magnesium hydroxide resulted in a significant increase in gastric pH over baseline or control values. Mean pH was 5.2 +/- 0.62 and 4.59 +/- 0.48 for posttreatment hours 1 and 2, respectively. CLINICAL IMPLICATIONS: Oral administration of 30 g of aluminum hydroxide/15 g of magnesium hydroxide to adult horses should result in a mean hourly gastric pH > or = 4.0 for at least 2 hours.