RESUMO
We report a case of bladder located gastric heterotopy, which has never been described, to our mind in the scientific literature. We discuss the diagnosis and the physiopathological mechanisms that may have been involved in the genesis of such a lesion.
Assuntos
Coristoma/patologia , Doenças da Bexiga Urinária/patologia , Dor Abdominal/etiologia , Adulto , Humanos , Masculino , EstômagoAssuntos
Anticoncepcionais Orais , Neoplasias da Mama/induzido quimicamente , Doença Hepática Induzida por Substâncias e Drogas , Anticoncepcionais Orais/classificação , Anticoncepcionais Orais/farmacologia , Anticoncepcionais Orais/normas , Anticoncepcionais Orais/provisão & distribuição , Feminino , França , Neoplasias dos Genitais Femininos/induzido quimicamente , Humanos , Educação de Pacientes como Assunto , Seleção de Pacientes , Fatores de Risco , Acidente Vascular Cerebral/induzido quimicamente , Tromboembolia/induzido quimicamenteRESUMO
A new sensitive method for the quantitative determination of imipramine and desipramine in single rat thyroids using gas chromatography-mass spectrometry with selected ion monitoring, after enzymatic hydrolysis and liquid-liquid extraction has been developed. The technique was deemed suitable for microanalysis of single rat thyroids and for other solid tissues, using smaller sample sizes than usually required for traditional determination methods. The quantification was linear from 10 to 200 nmol/l (i.e., from 0.25 to 5 microg/g) for imipramine and from 100 nmol/l to 2000 nmol/l (i.e., from 2.4 to 47 microg/g) for desipramine, and the limits of detection (less than 25 ng/g tissue for both compounds) were better than those previously reported. Recoveries, repeatability and reproducibility of this technique were satisfactory. It has been successfully applied in a preliminary study of the concentration-time profiles of imipramine and desipramine in the thyroid of rats treated with either of these drugs.