Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 7 de 7
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Eat Weight Disord ; 17(3): e194-9, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23086255

RESUMO

OBJECTIVE: Aim of the study was to evaluate tumour necrosis factor α (TNF-α) axis and oxidative status in patients with anorexia nervosa (AN) seeking a possible correlation with both nutritional status and evolution of the disease. SUBJECTS AND METHODS: Thirty-nine consecutive women with AN and an age-matched healthy control group were studied. Patients were 26±9 yr, with a body mass index (BMI) of 13.9±2 kg/m(2). TNF-α, its receptors TNF-R55 and TNF-R75, and oxidative status markers (selenium, ascorbic/ dehydroascorbic acid, retinol, α-tocopherol, selenium-dependent gluthatione peroxidase, reduced/oxidated gluthatione) were measured. A correlation with both nutritional indexes (body weight, BMI, albumin, prealbumin, transferrin, lymphocyte count) and disease duration was investigated. Pearson's correlation and unpaired Student's t-test were used to compare patients and controls. RESULTS: TNF-α and oxidative status markers were significantly higher in patients than controls and TNF-α was directly related to dehydroascorbic acid (p<0.05). Both TNF-R55 and TNF-R75 were higher in patients with duration of disease longer than one year as compared to controls and patients with shorter duration. Receptors inversely correlated with BMI (p<0.05 and p<0.01) and directly with disease duration (p<0.05). Inverse correlation between disease duration and BMI was present (p<0.01). CONCLUSIONS: The study showed activation of TNF-α axis and oxidative stress in AN patients, as well as correlation between the two systems. Due to the correlation between TNF receptors and both BMI and disease duration, a possible role of pro-inflammatory cytokines in the evolution of the eating disorder is suggested.


Assuntos
Anorexia Nervosa/metabolismo , Estresse Oxidativo , Receptores Tipo II do Fator de Necrose Tumoral/metabolismo , Receptores Tipo I de Fatores de Necrose Tumoral/metabolismo , Fator de Necrose Tumoral alfa/metabolismo , Adolescente , Adulto , Índice de Massa Corporal , Peso Corporal , Estudos de Casos e Controles , Progressão da Doença , Feminino , Humanos , Estado Nutricional
2.
Minerva Gastroenterol Dietol ; 39(4): 159-65, 1993 Dec.
Artigo em Italiano | MEDLINE | ID: mdl-8161614

RESUMO

The use of total parenteral nutrition (TPN) in bone marrow transplant recipients is well recognized. These patients, as a result of treatment with chemotherapy and immunosuppressive agents, undergo catabolic stress. In stressed patients attention has been focused on the optimal calorie: nitrogen ratio of total parenteral nutrition formulations. Theoretically, TPN formulas of low calorie: nitrogen ratio impede body protein catabolism. In bone marrow transplant patients negative nitrogen balance may persist despite high nitrogen intake. The purpose of the present study is to determine the effect of increasing nitrogen intake on nutritional and metabolic parameters in bone marrow transplant patients. The metabolic effect of an increased nitrogen dose during TPN was studied in 33 bone marrow transplant patients, divided into 2 groups. Patients were given total parenteral nutrition formulas providing a protein intake of 1.4 +/- 0.2 g of protein/kg IBW/day for the first group, and 2.3 +/- 0.12 g of protein/kg IBW/day for the II group. Total calories, non protein and protein, were held constant at 40 kcal/kg IBW/day for all patients. Data have been calculated for 4 weeks starting from the first week pretransplant. As we had expected, the patients who are the object of the present study were well nourished at the time of hospital admission, confirming the description of bone marrow transplant recipients published by other transplant centers. Relative body weight, total serum protein, albumin, prealbumin and cholesterol were not significantly different at any study period.(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Transplante de Medula Óssea , Fenômenos Fisiológicos da Nutrição , Adulto , Análise de Variância , Transplante de Medula Óssea/estatística & dados numéricos , Terapia Combinada , Feminino , Humanos , Leucemia/epidemiologia , Leucemia/metabolismo , Leucemia/terapia , Linfoma/epidemiologia , Linfoma/metabolismo , Linfoma/terapia , Masculino , Nutrição Parenteral Total/métodos , Nutrição Parenteral Total/estatística & dados numéricos , Análise de Regressão , Transplante Autólogo
3.
Minerva Gastroenterol Dietol ; 38(3): 161-5, 1992.
Artigo em Italiano | MEDLINE | ID: mdl-1299338

RESUMO

Crohn's disease involves a great risk of malnutrition. Malabsorption, bacterial contamination, frequent abdominal surgery, meal-related pain, protein loss through the damaged mucosa contribute to creating nutritional problems. Malnutrition can worsen the outcome, both in medical and surgical patients, and deteriorate an often already altered immune response. Weight loss, low levels of blood protein, electrolytes, micronutrients and vitamins are usually related to the extension of the mucosal damage. Nutritional assessment can be difficult due to oedema and bleeding, who interfere with both clinical and laboratory evaluation. The exact amount of nitrogen, lipids, minerals stool loss can be useful. It is widely accepted the use of nutritional support in Crohn's disease, but many Authors do not agree concerning the route (enteral or parenteral) and the kind of nutrient to be used. Still controversial is the role of nutrition: just support or real therapy? Most recent hypothesis concerning the pathogenesis of Crohn's disease indicate food and/or bacterial antigens as involved in determining the pathology. The "bowel rest", considered for many years as a fasting period necessarily supported by parenteral nutrition, can also be obtained by the temporarily reduction or stop in presenting those antigens to the bowel mucosa. This new concept can be achieved not only by parenteral nutrition, but with an enteral elemental diet as well. The elemental diet contains all nutrients in the simplest way and thus succeeds in lowering or eliminating the antigenic power. The reported results seem to indicate an equivalence of enteral and parenteral nutrition; anyway enteral is advisable when feasible, being more physiological and less expensive and involving a lower risk of serious complications.(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Doença de Crohn/terapia , Nutrição Enteral , Nutrição Parenteral , Doença Aguda , Doença Crônica , Humanos
4.
Minerva Dietol Gastroenterol ; 35(4): 251-5, 1989.
Artigo em Italiano | MEDLINE | ID: mdl-2516299

RESUMO

Infection and sepsis remain major causes of death in medical and surgical services, despite the availability of potent antibiotics, aggressive surgery and close monitoring of patients in intensive-care units. Actually the terminology to define this type of events in multiple organ failure: we considered the role of intestine in its pathogenesis and its management.


Assuntos
Intestinos/fisiologia , Insuficiência de Múltiplos Órgãos/etiologia , Animais , Alimentos Formulados , Humanos , Infecções/complicações , Enteropatias/complicações , Intestinos/imunologia , Camundongos , Insuficiência de Múltiplos Órgãos/terapia , Nutrição Parenteral Total , Ratos
5.
Minerva Dietol Gastroenterol ; 35(4): 231-5, 1989.
Artigo em Italiano | MEDLINE | ID: mdl-2695859

RESUMO

The recognition of potentially noxious physiological substances in the intestinal milieu, prompted the use of an "elemental" semi-hydrolysed formula diet in the prophylaxis of experimental acute ischemic enteropathy. An elemental diet protects the intestinal mucosa of rodents from radiation injury and facilitates mucosal healing. Clinical trials have shown the benefits of this form of treatment in the prevention of acute radiation enteritis and therapy of delayed enteropathy and Crohn's disease.


Assuntos
Alimentos Formulados , Enteropatias/dietoterapia , Doença Aguda , Animais , Criança , Doença de Crohn/dietoterapia , Cães , Humanos , Enteropatias/etiologia , Intestinos/irrigação sanguínea , Isquemia , Camundongos , Lesões por Radiação/complicações , Lesões por Radiação/etiologia , Lesões Experimentais por Radiação/complicações , Radioterapia/efeitos adversos , Ratos
6.
Arch Pathol Lab Med ; 112(1): 82-5, 1988 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-3337621

RESUMO

A case of metaplastic breast carcinoma was subjected to an immunohistochemical study to characterize its apparent fibrosarcomatous and chondrosarcomatous elements. Polyclonal and monoclonal antibodies against epithelial cell components such as keratin proteins, epithelial membrane antigen, membrane and cytoplasmic antigens of human mammary carcinoma cells, and carcinoembryonic antigen were used, as well as antibodies against the mesenchymal antigens, desmin, and vimentin. The cells with a mesenchymal appearance had an epithelial derivation, as shown by the presence of epithelial cell markers and absence of mesenchymal cell markers.


Assuntos
Neoplasias da Mama/patologia , Carcinoma/patologia , Sarcoma/patologia , Neoplasias da Mama/genética , Neoplasias da Mama/imunologia , Carcinoma/genética , Carcinoma/imunologia , Epitélio/fisiopatologia , Feminino , Humanos , Imuno-Histoquímica , Metaplasia , Pessoa de Meia-Idade , Fenótipo
7.
Cancer ; 59(3): 477-83, 1987 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-2431761

RESUMO

An immunohistochemical study was performed to identify the histogenesis of solid cell nests (SCN) found in 30 of 202 thyroids obtained at autopsy. Immunoperoxidase staining was used to detect the presence of calcitonin, thyroglobulin, thyroxin, low and high molecular weight keratins, and carcinoembryonic antigen (CEA). Results showed that cells forming solid nests had immunoreactivity for calcitonin, low molecular weight keratin, and CEA, but not for thyroglobulin, thyroxin and high molecular weight keratin. Thus, SCN do not result from tangentially cut thyroid follicles (absence of staining for thyroglobulin and thyroxin), nor from a squamous metaplastic process (absence of staining for high molecular weight keratin), but instead they are formed by C-cells because they showed calcitonin immunoreactivity, and neurosecretory granules.


Assuntos
Glândula Tireoide/patologia , Idoso , Autopsia , Calcitonina/análise , Feminino , Humanos , Hiperplasia/patologia , Técnicas Imunoenzimáticas , Queratinas/análise , Masculino , Pessoa de Meia-Idade , Tireoglobulina/análise , Glândula Tireoide/análise , Tiroxina/análise
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA