1.
Bioorg Med Chem Lett
; 15(8): 2173-6, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15808491
RESUMO
A pyrene dihydrodioxin has been synthesized, shown to bind to duplex DNA by intercalation, and cleave the phiX 174 supercoiled plasmid upon irradiation with UV light. This compound also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.