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1.
Sci Total Environ ; 807(Pt 3): 151053, 2022 Feb 10.
Artigo em Inglês | MEDLINE | ID: mdl-34673065

RESUMO

The State of Nevada, USA Administrative Code requires a 12-log enteric virus reduction/inactivation, 10-log Giardia cyst reduction, and 10-log Cryptosporidium oocyst reduction for Category A+ reclaimed water suitable for indirect potable reuse (IPR) based on raw wastewater to potable reuse water. Accurately demonstrating log10 reduction values (LRVs) through secondary biological treatment prior to an advanced water treatment train enables redundancy and resiliency for IPR projects while maintaining a high level of public confidence. LRVs for Cryptosporidium and Giardia resulting from secondary biological treatment are not fully established due to a wide range of performance variabilities resulting from different types of secondary biological treatment processes employed in water reclamation. A one-year investigation of two full-scale northern Nevada (e.g. ≤4 mgd; 1.5 × 107 L/day) water reclamation facilities (WRFs) was conducted to monitor Cryptosporidium oocysts and Giardia cysts in untreated wastewater and secondary effluent. This study aimed at establishing secondary treatment LRVs, monitor WRF performance and attempted to correlate performance to protozoan reduction. California's IPR regulations, in which Nevada IPR regulations were modeled after, were based on a maximum concentration of 5-logs (cysts/L) of Giardia and 4-logs (oocysts/L) of Cryptosporidium. The recovery-corrected Giardia and Cryptosporidium concentrations measured in untreated influent (20 samples each at each WRF) were below 5-log cysts/L at the 99th percentile (maximum 4.4-log cysts/L) and 4-log oocysts/L (maximum 2.7 log oocysts/L), respectively. Both secondary treatment WRFs produced secondary effluent that is consistently better than federal and the State of Nevada requirements and perform within an operating envelop for other secondary facilities. Given the results, it appears that a minimum conservative estimate for LRVs for well-operated secondary activated sludge treatment plants (at the 5th percentile) of 0.5 LRV credit for Cryptosporidium and 2.0 LRV for Giardia is warranted. These minimum LRVs are consistent with a conservative review of the available literature.


Assuntos
Cryptosporidium , Giardia/isolamento & purificação , Purificação da Água , Cryptosporidium/isolamento & purificação , Nevada , Oocistos/isolamento & purificação , Águas Residuárias
2.
Regul Toxicol Pharmacol ; 60(1): 1-19, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20056125

RESUMO

The detection of drugs in drinking water sources has raised questions related to safety. In the absence of regulatory or other official guidance, water utilities are faced with a problem of which drugs should be monitored and the detection limits that should be required. The US FDA summarizes data required for drug approval and post marketing adverse reaction reporting. The use of these data as a means of arriving at concentrations in water where adverse health effects are minimal or non-existent was explored. The minimum therapeutic dose was assumed an appropriate point of departure. Appropriate uncertainty factors could be applied depending upon the qualitative and quantitative nature of the data that are available. Assumptions inherent in US FDA's approval of drugs for use in subsets of the population relative to the broader concerns that arise for exposures of the entire population had to be considered. Additional questions are; whether the drug under consideration is carcinogenic, carries pregnancy and lactation warnings, approval for limited vs. chronic use, exposures to multiple compounds that could act in additive or synergistic ways, and the seriousness of toxicities that are observed. Aside from these considerations, a combined uncertainty factor of 1000 appeared adequate.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Reciclagem/métodos , Eliminação de Resíduos Líquidos/métodos , Poluentes Químicos da Água/efeitos adversos , Purificação da Água/métodos , Abastecimento de Água , Animais , Animais de Laboratório , Relação Dose-Resposta a Droga , Monitoramento Ambiental , Humanos , Preparações Farmacêuticas/análise , Preparações Farmacêuticas/normas , Reciclagem/normas , Medição de Risco , Eliminação de Resíduos Líquidos/normas , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/normas , Purificação da Água/normas , Abastecimento de Água/análise , Abastecimento de Água/normas
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