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1.
J Avian Med Surg ; 34(1): 17-25, 2020 03 29.
Artigo em Inglês | MEDLINE | ID: mdl-32237678

RESUMO

The aim of this study was to describe the anesthetic effects of an injectable anesthetic protocol, based on ketamine, midazolam, and medetomidine, followed by inhalational sevoflurane, in 8 elegant-crested tinamous (Eudromia elegans) undergoing experimental surgery. Initial doses for both injectable agents were tested in 1 bird and then refined with an algorithm based on the effects observed in the pilot procedure. Heart and respiratory rates, as well as nociceptive reflexes, were evaluated before anesthesia (baseline) and intraoperatively, at 10 minute intervals. The time from injection to anesthetic induction and surgical anesthesia, as well as the time from atipamezole injection to recovery, was recorded for each bird. The median doses of medetomidine and ketamine were 0.075 mg/kg and 33 mg/kg, respectively. Anesthetic induction was achieved within 10 (range, 4-45) minutes from intramuscular injection, whereas time to surgical anesthesia was 22 ±16 minutes. The baseline heart rate values were significantly higher than those measured intraoperatively at any time point (P = .001). Intraoperatively, 5 of 8 tinamous (63%) developed cardiac arrhythmias. Other encountered complications were regurgitation in 2 birds (25%), cardiac arrest in 1 bird (13%) soon after injection of the anesthetic agents, and prolonged recovery in another bird (13%), which was euthanized. Necropsy of the 2 fatal outcomes (25%) showed evidence of hepatic lipidosis in both (100%) and intramyocardial fat accumulation in 1 bird (50%). This report highlights the challenges of tinamou anesthesia. Cardiac complications are common in this species, and close monitoring of intraoperative cardiovascular variables is recommended for prompt recognition and treatment.


Assuntos
Anestesia/veterinária , Anestésicos/administração & dosagem , Aves/fisiologia , Anestésicos/efeitos adversos , Anestésicos Inalatórios/administração & dosagem , Animais , Feminino , Injeções Intramusculares/veterinária , Complicações Intraoperatórias/induzido quimicamente , Complicações Intraoperatórias/veterinária , Ketamina/administração & dosagem , Masculino , Medetomidina/administração & dosagem , Midazolam/administração & dosagem , Sevoflurano/administração & dosagem
2.
Vet Anaesth Analg ; 46(1): 84-89, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30528216

RESUMO

OBJECTIVE: To describe the anaesthetic, physiological and side effects of intramuscular (IM) medetomidine and ketamine, followed by inhalational anaesthesia with sevoflurane, in Nile crocodiles (Crocodylus niloticus). STUDY DESIGN: Observational trial. ANIMALS: Ten juvenile captive-bred Nile crocodiles undergoing surgical implantation of skeletal beads and muscular electrodes. METHODS: During preanaesthetic examination, the following variables were assessed: heart (HR) and respiratory (fR) rates, and response to palpebral, corneal and toe- and tail-pinch withdrawal reflexes. The crocodiles were injected IM with an initial combination of medetomidine and ketamine and re-evaluated at 5 minute intervals for 20 minutes, or until they appeared unresponsive. If that did not occur, the drugs were redosed according to a decision tree based on the observed effects. The righting, biting and palatal valve reflexes were assessed in the unresponsive crocodiles, and used to confirm anaesthetic induction. Anaesthesia was maintained with sevoflurane in oxygen. At the end of surgery, medetomidine was antagonized with IM atipamezole. RESULTS: The decision tree identified 0.3 mg kg-1 medetomidine and 15 mg kg-1 ketamine as a useful drug combination, which resulted in anaesthetic induction and surgical anaesthesia 16 ± 8 and 16 (25-20) minutes after injection, respectively. Compared to baseline, HR and fR significantly decreased after anaesthetic induction (p < 0.001), but then remained stable throughout surgery. Intraoperatively, cloacal temperature [27 (26-30) °C] did not change over time (p = 0.48). The total dose of atipamezole was 2 (1-3) mg kg-1 and time to recovery was 36 (20-60) minutes. Perioperative complications were not observed. CONCLUSIONS: and clinical relevance Medetomidine and ketamine, injected IM and followed by sevoflurane anaesthesia, may be regarded as a useful anaesthetic technique for juvenile Nile crocodiles undergoing minimally invasive experimental surgery.


Assuntos
Jacarés e Crocodilos/fisiologia , Anestesia/veterinária , Anestésicos Inalatórios/farmacologia , Hipnóticos e Sedativos/farmacologia , Ketamina/farmacologia , Medetomidina/farmacologia , Medição da Dor/veterinária , Sevoflurano/farmacologia , Anestésicos Combinados , Anestésicos Inalatórios/administração & dosagem , Animais , Feminino , Hipnóticos e Sedativos/administração & dosagem , Ketamina/administração & dosagem , Medetomidina/administração & dosagem , Medição da Dor/efeitos dos fármacos , Sevoflurano/administração & dosagem
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